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갑상선 여포상 선종과 암종의 감별진단에서 p27KIP1, MIB-1, bcl-2, p53 발현의 유용성에 대한 연구
강미선(Mi Seon Kang),윤혜경(Hye Kyoung Yoon),김상효(Sang Hyo Kim),윤기영(Ki Young Yoon),이충한(Choong Han Lee),최경현(Kyung Hyun Choi),허방(Bang Hur),노미숙(Mi Sook Roh),홍숙희(Sook Hee Hong) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2
Objectives: The most important differential point of follicular carcinoma from adenoma is capsular invasion or angioinvasion of follicular cells. Serial sections for examination of levels of tumor margins are necessary to watch the invasion. However, the interpretation of capsular invasion or angioinvasion is sometimes not feasible on the routine staining of tumor tissue. The aim of this study is to evaluate the clinical significance of expressions of p27KIP1, MIB-1, bcl-2 and p53 in differential diagnosis of follicular adenoma and carcinoma. Materials and Methods: 16 cases of follicular carcinoma and 26 cases of follicular adenoma were entered on study of immunohistochemical stains for p27KIP1, MIB-1, bcl-2 and p53. In carcinoma cases, correlation between the above markers, patient's age, tumor size, infiltration pattern and metastasis was studied. Results: p27KIP1 labelling index (LI) of follicular carcinoma and adenoma was 4.89±6.92 and 14.52±9.17, respectively, but there was no significant difference between adenoma and carcinoma (p=0.2560). MIB-1 LI of carcinoma and adenoma was 4.11±3.89 and 0.80±0.75, respectively, and MIB-1 LI was significantly higher in carcinoma (p=0.0000). bcl-2 expression was seen in 2(12.5%) of 16 carcinoma cases and 130(50.0%) of 26 adenoma cases, and bcl-2 expression rate was higher in adenoma than in carcinoma(p=0.014). In one adenoma and one carcinoma case, p53 expression was noted. In follicular adenoma with atypia compared to adenoma without atypia, lower p27KIP1 LI, higher MIB-1 LI and lower bcl-2 expression rate were seen. In follicular carcinoma, MIB-1 LI was significantly higher in invasive carcinoma(p=0.045) and was relatively increased in tumors larger than 3.0cm, showing angioinvasion and distant metastasis. But p27KIP1 LI was higher in cases over 40 years old(p=0.008) and with conspicuous capsular invasion. There were no positive correlations between expressions of MIB-1, bcl-2 and p53. Conclusion: MIB-1 labelling index and bcl-2 expression could be helpful for differential diagnosis of follicular adenoma and carcinoma, but p53 showed very low expression rate and no significance in differential diagnosis. p27KIP1 labelling index reveals decreasing tendency in carcinoma compared with adenoma, MIB-1 LI was considered as a poor prognostic marker in follicular carcinoma, but p27KIP1 LI was higher in carcinoma cases over 40 years old with showing conspicuous capsular invasion. Further study for the significance of p27KIP1 labelling index in follicular neoplasms is necessary to evaluate diagnostic value of follicular carcinoma.
누낭비강문합술에서 얻은 누낭조직의 조직병리학적 소견과 임상적 연관성
정우진,허문정,노미숙,안희배,Woo Jin Jeong,Mun Chong Hur,Mi Sook Roh,Hee Bae Ahn 대한안과학회 2011 대한안과학회지 Vol.52 No.4
Purpose: To determine the correlation of the clinical characteristics and histopathologic findings of lacrimal sac after external dacyrocystorhinostomy (DCR). Methods: From March 2008 to June 2009, 49 lacrimal sac tissues of 47 patients were obtained after external DCR and divided according to fibrosis and inflammatory findings. The correlation of preoperative duration of symptoms with NLD obstruction, symptoms of recurrence and outcomes of the operation to the histopathologic findings were retrospectively evaluated. Results: The mean age of the patients was 58.83 ± 11.49 years and the mean duration of preoperative symptoms was 65.2 ± 69.05 months. Forty-three cases (88%) maintained good openings and 30 cases (61%) had no recurring symptoms over 6 months after the operation. Among the significant symptoms, severe subepithelial inflammations were observed more frequently at shorter duration. However, the fibrosis showed a positive relation with the preoperative duration of symptoms (Spearman correlation test, p<0.05). Most failures were found in the severe inflammation and fibrosis groups and were recovered with anti-inflammatory treatment. Conclusions: Inflammation and fibrosis of the lacrimal sac could be an important prognostic and predictive factor of outcomes of DCR. J Korean Ophthalmol Soc 2011;52(4):385-391
혈중 CA19-9이 지속적으로 상승되었던 기관지 확장증 환자
허정훈 ( Jung Hun Huh ),이수미 ( Su Mi Lee ),구태형 ( Tae Hyoung Koo ),신봉철 ( Bong Chul Shin ),엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),김기남 ( Ki 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.5
An elevated serum CA19-9 level is an indication of pancreatic and biliary tract cancer. However, it has recently become known that nonmalignant gastrointestinal diseases and a variety of nonmalignant respiratory diseases, such as idiopathic interstial pneumonia, collagen vascular disease associated lung diseases, diffuse panbronchiolitis and bronchiectasis, can also show an elevated serum CA19-9 level. We recently encountered a case of bronchiectasis with persistently elevated serum CA19-9, but without any evidence of malignant disease in endoscopic retrograde pancreatocholangiography, abdominal computed tomography, and positron emission tomography. After serial follow-up of 3 years and 10 months, there was still no evidence of cancer. It is believed that the elevated serum CA19-9 level was due to bronchiectasis. An elevated serum CA19-9 level should be interpreted carefully with the patients` clinical condition. (Tuberc Respir Dis 2008;64:383-386)
전신성 홍반성 루푸스 환자에서 발생한 거대세포바이러스 폐렴과 망막염
한승호 ( Seung Ho Han ),손유정 ( You Jeong Sohn ),박민아 ( Min A Park ),이상 ( Sang Lee ),유승훈 ( Seung Hoon Ryu ),임태형 ( Tae Hyung Lim ),정동성 ( Dong Sung Jung ),손영기 ( Young Ki Son ),노미숙 ( Mee Sook Roh ),박미경 ( Mi Ky 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Cytomegalovirus (CMV) is the member of the herpesviridae of virus, which are large DNA viruses that share the biologic properties of latency and reactivation. In patients with advanced acquired immune deficiency syndrome (AIDS) and those immunocompomised due to bone marrow transplantation or solid organ transplantation, CMV infection is the major cause of morbidity and mortality. CMV pneumonia is the most severe complication of these CMV disease. There have been reported a few cases of CMV interstitial pneumonitis occurring in a patient with SLE after intensive immunosuppressive therapy with prednisolone and cyclophosphamide, and there has been reported a case in Korea. Then we report a case of CMV pneumonia and retinitis occurring in a patient with SLE who was being treated with high dose steroid for 1 month, and was treated with ganciclovir and immunoglobulin.
김나래 ( Na Rae Kim ),정동해 ( Dong Hae Chung ),백정흠 ( Jeong Heum Baek ),박연호 ( Yeon Ho Park ),경희은 ( Hee Eun Kyung ),노미숙 ( Mi Sook Roh ),하승연 ( Seung Yeon Ha ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2
Squamous cell carcinoma of the rectum is extremely rare. Herein we report two cases of rectal squamous cell carcinoma. Case 1 was a 44-year-old Korean female presenting with abdominal pain and rectal bleeding for 3 months before her hospital visit. A colonoscopic examination revealed an ulcerated rectal mass 8 cm proximal to the anal verge. Chemoradiotherapy was administered following Hartmann``s procedure in case 1. The patient remained alive during 19 months of follow up. Case 2 was a 43-year-old Korean female who had severe constipation for 2 months. A barium enema and computed tomography of the pelvis showed a rectal mass adherent to the sacrum. Based on the results of a colonoscopic biopsy, a diverting colostomy was performed in case 2, with no further treatment. The pathologic findings showed that both tumors were composed of oval-shaped cells with abundant eosinophilic cytoplasm and intercellular bridges with keratin pearls, and thus were diagnosed as well-differentiated squamous cell carcinoma. Neither of the cases showed evidence of HPV infection. The pathogenesis of rectal squamous cell carcinoma has not been clarified. Herein we report two cases of rectal squamous cell carcinoma and briefly discuss the possible histogenesis. (Intest Res 2010;8:172-176)