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진행성 비소세포폐암에서 Heme oxygenase-1 발현과 Cisplatin을 포함하는 항암화학요법의 치료반응과의 연관성
양두경 ( Doo Kyung Yang ),노미숙 ( Mee Sook Roh ),이경은 ( Kyung Eun Lee ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Hee Bang ),김보경 ( Bo Kyung Kim ),서효림 ( Hyo Rim Seo ),김민지 ( Min Ji 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.3
CT 유도하 경피적 흉부 세침생검 후 발생한 뇌 공기 색전증 1례
양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),서성환 ( Sung Wan Suh ),손유정 ( You Jeong Sohn ),김경태 ( Kyoung Tae Kim ),유정남 ( Jung Nam Yoo ),김종국 ( Jong Kuk Kim ),노미숙 ( Mee Sook Roh ),최필조 ( Pil Jo Choi ),김기남 ( 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.5
악성 종양 표지자가 상승된 만성 흉수를 동반한 종격동 기형종
엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Heui Bang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.2
Most mediastinal teratomas are histologically well-differentiated tumors and benign. The majority of patients with a mediastinal teratoma are asymptomatic and their tumors are usually discovered incidentally on chest radiography. On rare occasions this tumor will rupture spontaneously into the adjacent organs. A 72-year-old female patient was admitted for dyspnea and she had a multiloculated pleural effusion in the left lung field. Although repeated pleural biopsy and pleural fluid cytology did not prove the presence of malignancy, we assumed that this was a malignant effusion because it revealed consistently high levels of carcinoembryonic antigen and carbohydrate antigen 19-9, and the chest CT scan did not show typical fat or bone density in the mass. Secondary infection and an uncontrolled septic condition due to pleural empyema finally compelled the patient to undergo a surgical operation. Mature teratoma was the final diagnosis and she has done well without recurrence for 2 months.
손유정 ( You Jeong Sohn ),박수경 ( Soo Kyung Park ),김슬기 ( Seul Ki Kim ),김기남 ( Ki Nam Kim ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),최필조 ( Phil Jo Choi ),방정희 ( J 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.1
Background: Eosinophilic lung disease (ELD) or eosinophilic pneumonia is recognized as a heterogeneous group of disorders characterized by varying degrees of pulmonary parenchymal or blood eosinophilia. The spectrum of diseases that can be primarily or secondarily associated with pulmonary eosinophilia is diverse. We evaluated the clinical features of ELD in 25 patients. Method: Twenty-five patients diagnosed as ELD were evaluated. Data were obtained prospectively using the standard form of evaluation to find the cause of ELD. Result: The most common cause of ELD was a parasitic infection (n=7,28%) and the others were idiopathic hypereosinophilic syndrome (n=6,24%), Churg-Strauss syndrome (n=4,16%), simple pulmonary eosinophilia (n=4,16%), drug (n=2,8%), and mycoplasma infection (n=2,8%). At radiographic presentation, the ground-glass opacity was 45% (n=11), consolidation was 32% (n=8), and nodule was 24% (n=6). Mean peripheral blood cosinophil counts were 4,104.6 ± 867.6/μL. The mean serum total IgE levels measured by CAP were 3,309.0±688.9 kU/L in the parasite infection group. However, peripheral blood eosinophil counts or serum total IgE levels were not significantly different among the disease groups classified by causes of ELD. Organs with eosinophilic infiltration other than the lungs were the stomach (n=3), liver (n=3), skin (n=2), heart (n=1), and nerve (n=1). Conclusion: Further and careful examinations are required to evaluate the causes of ELD. Moreover, we would like to stress the evaluation of curable causes, especially infectious disease such as parasite. (Korean J Asthma Allergy Clin Immunol 2006;26:46-51)
흰쥐에서 폐 방사선 조사 후 interleukin - 1α ( IL-1α ) 및 interleukin - 6 ( IL-6 ) 발현에 대한 연구
장광열(Kwang Yul Chang),손춘희(Choon Hee Son),양두경(Doo Kyung Yang),김기현(Ki Hyun Kim),이혁(Hyuk Lee),윤선민(Seon Min Youn),양광모(Kwang Mo Yang),허원주(Won Joo Hur),노미숙(Mee Sook Roh),정진숙(Jin Sook Jeong),한진영(Jin Yeong Han 대한내과학회 2002 대한내과학회지 Vol.62 No.4
연구배경: 방사선 조사는 흉부 종양의 치료에 중요한 역할을 하지만 방사선 폐렴 때문에 용량의 제한을 받는다. 이런 폐 손상의 기전을 이해함으로써 부작용을 줄이고 손상을 예방할 수 있는 방법을 찾기 위하여 폐 섬유화에 기인한다고 알려져 있는 interleukin-1 alpha (IL-6 α)와 interleukin-6 (IL-6)의 방사선 폐 손상에서의 역할을 알아보기 위하여 이 연구를 시작하였다. 실험 방법: 30마리의 흰쥐를 대상으로 우측 폐에 20 Gy를 단일 조사하고, 20주까지 2주 간격으로 흰쥐를 희생시킨 후 절제한 폐조직에 대하여 일반병리조직학적 검사 및 IL-1α와 IL-6에 대한 면역조직화학적 연구를 실시하여 결과를 분석하였다. 결과: 방사선 조사 1∼2주 후까지는 폐간질의 부종, 모세혈관의 울혈이 주된 소견이었다. 4주까지는 폐포내에 대식구 및 림프구 등의 단핵구와 단백양 물질이 증가하였고, 폐포간격에도 단핵구들의 침윤이 관찰되었으며 이러한 소견은 8주까지 진행되었다. 6주부터 20주까지 염증세포의 침윤과 더불어 점차 진행되는 폐섬유화를 관찰하였다. IL-1α 및 IL-6의 발현정도에 대한 염색은 전 기간을 통하여 증가하는 양상을 보였지만 3주 전후까지는 급격한 증가를 보였고 그 후부터는 감소하는 경향을 나타내었다. 염색반응은 주로 폐포간질, 폐포내 및 기관지주위의 대식구, 폐포세포, 혹은 혈관내피세포에서 관찰되었다. 12주에서 20주까지는 섬유모세포에서도 염색되었지만 섬유화가 진행된 병변에서는 그 염색정도가 약한 반면 주변 폐포부위의 염색정도는 강하게 나타났다. 방사선 조사로 유도한 흰쥐의 폐손상은 시간의 경과에 따라 방사선 폐렴에서 폐섬유화로 진행되었고 이러한 폐손상의 진행에 따른 IL-1α 및 IL-6의 발현에 대한 염색정도는 급격히 증가하여 3주경에서 최고치를 나타내다가 그 이후부터는 감소하였지만 조사 후 희생까지의 전기간에 걸쳐 증가되어 있었다. 결론: IL-1α 및 IL-6는 방사선 조사 후 섬유화성 진행을 보이기 전단계에서 발현되어 폐섬유화 유발인자로 작용하는 것으로 생각된다. Background: One of the limitation during the irradiation of malignant tumor is hazard to normal tissue although it is important and effective tool for treating malignant tumor. We studied the role of interleukin-1 alpha (IL-1α) and interleukin-6 (IL-6) in the radiation-induced lung injury especially on fibrosis. Methods: We irradiated right-side lungs of thirty Sprague-Dawley rats with single fraction of 20 Gy and then sacrificed the animals until 20th week at intervals of two weeks. Both irradiated and unirradiated lung tissues were stained hematoxilin and eosin, Masson trichrome, reticulin and immunohistochemical staining for IL-1α and IL-6. The degree of the staining for IL-1α and IL-6 were examined semiquantitatively. Results: Two weeks after irradiation interstitial edema and capillary congestion appeared, followed by increase of the monocytes infiltration and proteinaceous material during 4th and 8th week. After eight weeks of irradiation, collagen and reticulin fibers were detected along alveolar wall. 12th to 20th week, fibrosis in interstitium, decreased number of alveoli and thickening of bronchial wall were observed. The degree of immunohistochemical staining for IL-1α and IL-6 was increased rapidly during the first three week and then decreased slowly, but remain increased until 20th week. Conclusion: Our Study demonstrate the early and persistent elevation of cytokines IL-1α and IL-6 by immunohistochemical stain in rat lung following pulmonary irradiation. We think cytokines are produced immediately after irradiation, make collagen genes turn on and perisist until the expression of late effects become apparent pathologically and clinically. (Korean J Med 62:453-464, 2002)
요골접근법에 의한 관상동맥 스텐트 시술의 가능성과 안정성
차광수(Kwang Soo Cha),김무현(Moo Hyun Kim),김혜진(Hye Jin Kim),양두경(Doo Kyung Yang),조정환(Jeong Whan Cho),박태호(Tae Ho Park),박형렬(Hyung Ryul Park),김봉근(Bong Keun Kim),김영대(Young Dae Kim),김종성(Jong Seong Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.2
N/A Objectives : Powerful anticoagulant and antiplatelet therapies after coronary stenting may carry the risk of increased bleeding complications if large-bore guiding catheters are introduced via the femoral artery. Recently smaller radial artery is introduced as an entry site for coronary interventions owing to miniaturization of equipments, easy hemostasis and lower access site complications, and little hand ischemia. The purpose of this study is to evaluate the feasibility and safety of coronary stent implantation via the radial artery. Methods : After a learning curve for transradial diagnostic coronary angiography, stent implantation was attempted in 131 consecutive patients, 135 lesions. Immediately after procedure, the introducer sheath was withdrawn and mobilization was initiated. Clinical follow-up was done for punctured radial arteries. Results : Procedural success and uncomplicated clinical course was achieved in 129(98%) patients, 133(99%) lesions. No stent embolization or migration within the coronary artery, and no procedure-related death, Q wave myocardial infarction or emergent bypass surgery were happened. No stroke or severe arm vessel complications were happened except 4(3%) cases of moderate hematoma. Failed 2 cases were in early period and stents did not pass the lesions due to inappropriate selection and poor backup of guiding catheters. During follow-up of 124±36 days, punctured radial arteries showed weak or absent radial pulse in 10(7%) patients, but no claudication or ischemia of hand was observed. Conclusion : Transradial coronary stenting was performed safely with high success rate and low complication rate. This study supports that transradial approach is a promising primary route for coronary stenting.
부산지역 알레르기 클리닉을 내원한 환자들에서 점박이응애와 집먼지진드기의 감작률
서효림 ( Hyo Rim Seo ),이수미 ( Soo Mi Lee ),구태형 ( Tae Hyung Koo ),신봉철 ( Bong Chul Shin ),김보경 ( Bo Kyung Kim ),허정훈 ( Jeong Hun Heo ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
Background: Recently, it has been demonstrated that the sensitization rate to two spotted mite (TSM, Tetranychus urticae) is as high as that to house dust mite (HDM) in respiratory allergy patients in the middle part of Korean peninsula. However, there are no published data on the sensitization rate to TSM in southern area of Korean peninsula. Objective: The aim of this study is to evaluate the sensitization rate to TSM in patients with allergic diseases in Busan area. Method: Skin prick tests were performed with 49 common inhalant allergens and TSM extracts on 519 patients with various allergic diseases between March 2005 and June 2007. We evaluated clinical characteristics and the sensitization rate to various inhalant allergens including TSM. Result: The sensitization rate to Dermatophagoides pteronyssinus (49.3%) was highest, followed by D. farinae (44.9%), TSM (32.9%), birch (17.0%) and mugwort (16.0%). Forty (7.7%) patients were sensitized to TSM only. Conclusion: TSM was the second most common sensitized allergen in patients visiting the allergy clinic in Busan area. These results suggest that TSM might be an important outdoor allergen in Korean peninsula. (Korean J Asthma Allergy Clin Immunol 2007;27:263-267)