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Scopolamine Hydrobromide 및 $\ell$-Hyoscyamine의 생체이용성에 미치는 위산도의 영향
김창영,함성호,한상수,손동환,고건일,김재백,Kim, C. Y.,Ham, S. H.,Han, S. S.,Sohn, D. H.,Ko, G. I.,Kim, J. B. 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2
The effects of gastric acidity on the bioavailability of scopolamine hydrobromide and ${\ell}$-hyoscya-mine were studied in rabbits. Each drug was administered orally at dose of 0.2mg/kg to gastric acidity controlled rabbits. The plasma concentration of scopolamine and ${\ell}$-hyoscyamine were determined by selected ion monitoring in GC/MSCScopolamine; m/Z= 138, ${\ell}$-Hyoscyamine; m/z= 124). Rabbits with hypoacidity showed significantly higher Cp and AVC than rabbits with hyperacidity after oral administration of each drug. From the results of this experiment, it is desirable that dosage regimen of dose of scopolamine and hyoscyamine should be adjusted when the drugs should be administered with antacids in clinical practice.
광전자실험을 이용한 $Y(Pr)Ba_2Cu_4O_8$ 물질의 체인 전자 구조분석
부영건,정원식,한가람,김창영,Boo, Y.G.,Jung, W.S.,Han, Ga-Ram,Kim, C. 한국초전도학회 2012 Progress in superconductivity Vol.13 No.3
$Y(Pr)Ba_2Cu_4O_8$ system is one of the most studied high temperature superconductors. Substitution of Pr for Y in this system suppresses $T_c$ and superconductivity finally disappears at a high Pr doping. There are competing theories for the suppression of $T_c$ but systematic experimental results are very rare. In order to find the change in Fermi surface topology which can affect the superconductivity, we have performed angle-resolved photoemission studies on single crystal samples of $YBa_2Cu_4O_8$ and $PrBa_2Cu_4O_8$. While the Fermi surface of $YBa_2Cu_4O_8$ shows a similar topology to those of other cuprates, we observe only 1D like band structures in $PrBa_2Cu_4O_8$. We find no significant differences in the chain band for both samples.
광전자 분석 실험을 이용한 $Ba(Fe_{1-x}Ru_x)_2As_2$ 물질의 전자구조분석
정원식,김용관,김범영,엄만진,김준성,김창영,Jung, W.S.,Kim, Y.K.,Kim, B.Y.,Matsunami, M.,Kimura, S.,Eom, M.J.,Kim, J.S.,Kim, C. 한국초전도학회 2011 Progress in superconductivity Vol.12 No.2
We performed angle resolved photoelectron spectroscopy (ARPES) studies on Ru doped $BaFe_2As_2$ with various Ru contents. Ru, which is doped into a parent compound $BaFe_2As_2$ and substitute Fe, does not donate or accept electrons. However, it induces superconductivity. From ARPES data along the high symmetry cuts and Fermi surface maps, we investigate the electron correlation and carrier density at the Fermi level. We observe that the Fermi velocity increases with Ru doping, suggesting reduction in electron correlation. In addition, we address issues on local vs. itinerant pictures for the magnetism in $BaFe_2As_2$.
각분해 광전자분석 실험을 이용한 $Sm_{1.82}Ce_{0.18}CuO_4$ 물질의 온도에 따른 가짜 갭 연구
송동준,최환영,김철,박승룡,김창영,Song, D.J.,Choi, H.Y.,Kim, Chul,Park, S.R.,Kim, C.,Eisaki, H. 한국초전도학회 2010 Progress in superconductivity Vol.11 No.2
There are theoretical and experimental evidences for the pseudo-gap in electron doped cuprates being due to interaction between electrons and anti-ferromagnetism(AFM). A remaining issue is on how AFM correlates with pseudo-gap, and eventually with superconductivity. To elucidate the issue, we have performed temperature dependent angle-resolved photoemission studies of an e-doped cuprate superconductor $Sm_{2-x}Ce_xCuO_4$(SCCO) x=0.18 at 20K and 150K. In the case of $Nd_{2-x}Ce_xCuO_4$, the most well known e-doped cuprate, pseudo-gap disappears at around 100 K for x=0.17. Our experimental result reveals that the pseudo-gap of SCCO exists even at 150K for x=0.18. This result implies that the AFM of SCCO survives even in x=0.18, which agrees with previously reported phase diagram of SCCO. Yet, the superconductivity disappears around x=0.18 for both NCCO and SCCO in spite of the difference in the magnetic order. This result sheds a light on the disappearance of superconductivity on the over-doped side.
이승관 ( S K Lee ),이창규 ( C K Lee ),류정록 ( J R Ryu ),검석수 ( S Su Kim ),김상섭 ( S S Kim ),김창영 ( J Y Kim ),장철수 ( Chou I Soo Chang ) 대한임상검사과학회 1993 대한임상검사과학회지(KJCLS) Vol.25 No.1
Calcium exists in serum in three forms, as the free ion and as complexes with proteins and with smaller molecules; of these, the ionized species is the one that in physiologically active. For this reason some investigators tried to find the most convenient method for estimating calcium IOns. In this study, we compared three measurements (Zeisler, Mario and Hanna method) for inoized calcium to our Nova 7 method. Patient comparison results for ISE(x) compared to the other three methods. (y) are : Zeisler=0.579x+0.944, r=0.394, n=50;Mario =0.435x+l.469, r=0.216, n=50;Hanna=O. 905x+0.749, r=0.479, n=50. In conclusion, all performance characteristics of the nomogram method evaluated in this study were found to be incompatible to the Nova 7 method for serum ionized calcium analySIS.
Microcapsule의 可笑化 時間과 藥物의 溶出에 關한 硏究
김창영,고건일,김재백 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
Microencapsulated phenacetin were prepared by coacervation of aqueous Cellulose Acetate Phthalate(C.A.P) solutions. Appropriate solutions were made by dissolving C.A.P. in an equivalent concentration of Disodium hydrogen phosphate. The C.A.P. shells are plasticized by imbibition with 5% Glycerol solution and that dissolution rate determined in 0.1N Hydrochloric acid solution containing 0.4% sodium lauryl sulfate. As a result, plasticized microencapsulated phenacetin during 2 minutes, 5 minutes and 8 minutes correlated between dissolution rate and plasticizing time in microcapsules. Plasticized microencapsulated phenacetin during 12 minutes and 15 minutes was not correlated between dissolution rate and plasticizing time in microcapsules. And the other, microcapsuies were dyed with Methylene blue solution. As a result, nonmicroencapsulated phenacetin was not dyed. but microencapsulated phenacetin was dyed with Methylene blue solution.