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흰쥐에서 HELIKITTM의 급성 및 아급성 경구독성시험
김창종(Chang Jong Kim),조철형(Chul Hyung Cho),최현호(Hyun Ho Choi),심상수(Sang Soo Sim),김정례(Jeong Rye Kim) 대한약학회 1999 약학회지 Vol.43 No.2
Acute and subacute oral toxicity of HELIKITTM (13C-urea) were carried out in Sprague-Dawley rats of both sex. The toxicity of HELIKITTM was compared with urea (12C-urea which is used for control). In acute toxicity studies, we daily examined number of deaths, clinical signs, body weights and pathological examination for 14 days after single oral administration of HELIKIT or urea (12C-urea) at a dose of 5000mg/kg. The subacute oral toxicity was investigated in Sprague-Dawley rats treated with HELIKITTM at a dose of 40, 200 and 1,000mg/kg/day or 12C-urea at a dose of 1,000mg/kg/day for 4 weeks. In acute toxicity studies, HELIKITTM and urea did not show any toxic effect in rats and oral LD50 value was over 5,000mg/kg in rats. In subacute toxicity studies, no death occurred and no drug-related changes were found in clinical observations: body weight, food consumption, opthalmoscopy, auditory test, urinalysis, hematology, blood chemistry, gross pathological examination or organ weight between HELIKITTM, urea and control groups. In histopathological examinations, the slight thickening of mucosa of the limiting ridge in the stomach was noted in the animals treated with HELIKITTM at a dose of 1,000mg/kg/day and also the changes in urea group at a dose of 1,000mg/kg/day was found, but all of these changes in the stomach regressed after withdrawal of the test article for 2 weeks and reversibility of the effect was revealed. These results indicate that the non toxic dose level of HELIKITTM was 1,000mg/kg/day in the 4 weeks-repeated dose study, suggesting that the substitution of 13C for carbon in urea molecule has no effect on the toxicity of urea and changes in stomach are reversible.
이상준,정민자,조윤화,한지윤,김정례 ( Sang Jun Lee,Min Ja Jung,Yoon Whoa Cho,Jee Yoon Han,Jeong Rye Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
We report two cases of recurrent extramarnmary Pagets disease after wide local excision. Both cases involved the scrotum and the penoserotal junction, respectively. On histopathological examination, we could observed many Paget cells confined to the epidermis and the hair follicle, but not invading the underlying dermis in both cases. There was no evidence of internal malignancy. Both cases were treated with wide local reexcision. (KOr J Dermatol 1997;35(3): 561 565)
김봉석,박성기,이성규,변종훈,김정례,소군호,진교현,김서종,고정석,노용호 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Primary adrenal lymphoma is extremely uncommon. The tumor is accidentally discovered by abdominal ultrasonography(USG), computed tomography(CT) or magnetic resonance imaging (MRI) in patients with nonspecific symptoms and diagnosed at operation or autopsy. In this case, a 60-year-old man was admitted for the evaluation of mild left frank discomfort for two months before admission. The abdominal USG was performed and showed the dense masses in both adrenal glands. The laboratory tests including blood count, chemistry and hormonal tests showed the normal levels except for the basal ACTH level of 108 pg/ml(normal range: 9∼52 pg/ml). The 123I MIBG scan was normal. The bilateral adrenalectomy was done. The tumor was diagnosed as diffuse large B-cell non-Hodgkin's lymphoma(NHL) according to the Revised European-American lymphoma(REAL) classification. He was treated with the adjuvant combination chemotherapy of CHOP(cyclophosphamide, adriamycin, vincristine and prednisolone) but expired due to sepsis after the secod chemotherapy. We describe the first case of primary bilateral adrenal NHL in Korea. Primary adrenal lymphoma should be included in the differential diagnosis of suprarenal mass.(Korean J Med 59:423-427, 2000)
유세포분석기로 확진한 남매에서 발생된 혈소판 무력증 2 예
김동진,박경식,김재삼,이숙경,성낙현,백석기,허완재,임채호,현정례,박훈기,남이현,김춘섭 대한내과학회 1996 대한내과학회지 Vol.51 No.2
Glanzmann's thrombasthenia is a rare autosomal recessive genetic disorder of platelet function. It is caused by the deficiency or abnormality of the major platelets glycoprotein(GP)IIb-IIIa complex. Glanzmann's thrombasthenic platelets show no aggregation in response to the stimulation of ADP and platelet agonist(epinephrine, collagen), but it show aggregation in response to ristocetin. The platelet membrane glycoprotein IIb-IIIa complex is involved in cell to cell interaction and cell to matrix fibronectin interaction. Because the binding of fibrinogen allows platelets to aggregate, the binding of platelets on the subendothelium. The absence of defect of this receptor cause the platelet bleeding disorder called Glanzmann's Thrombasthenia. We experienced two cases of Glanzmann's thrombasthenia in 16-year-old female and 15-year-old male. They are from the same family, but they parents and older sister had no history of bleeding tendency. The 16-year-old female showed frequent epistaxis, showed frequent gum bleeding for the past 5 years, and she was prone to bruise since she was 11-year-old. Her 15-year-old brother showed similar symptom. On platelet aggregation test, mother showed normal response, but her two child showed no response to ADP, epinephrine and collagen, but showed normal response to ristocetin. They were diagnosed as Glannnann's Thrombasthenia by the analysis of Glycoprotein on platelet membrane by Flow-cytometry. The review of the literature was made briefly.
이홍복,이성규,변종훈,전인석,김웅봉,두창준,김정례 대한내분비학회 1988 Endocrinology and metabolism Vol.3 No.2
Adrenal myelolipoma is uncommon, nonfunctioning benign tumor, is composed of hemato-poietic cells and fat cells, which simulates the bone marrow. In most cases, this tumor is found incidnetally at autopsy. The advent of cross-sectional abdominal imaging technique has increased the incidence of this tumor, and the importance of the tumor has emphasized among the adrenal diseases. This tumor can be diagnosed by ultrasound and CT which show avasculr, highly fatty mass chatacterestically, and can be confirmed by fine-needle aspiration. Myelolipoma, in most, does not need any treatment, especially surgical removal. So, clinician do his or her best to avoid useless operation on facing such nonfunctioning adrenal tumor.