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Mitomycin이 Mouse 간장의 인산염분해 효소에 미치는 영향
정호삼,신규석,이군자,이규식 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1
Mitomycin (MC), a wide spectrum antibiotic and anticancer drug, is isolated from streptomyces caespitosus. MC decomposes DNA in cancer cell by forming a complex with DNA and inhibits division of cancer cells by interfering with the biosynthesis of DNA. In the normal cell, MC cross linkes with DNA and inhibits synthesis of RNA and protein. Therefore MC causes many complication in the MC treated patient. The authers have investigated the effect of MC on the mouse liver histochemically observing the change in the activities of alkaline phosphatase and ATPaes. Male mouse, DDY strain, weighing about 20 grams was used as experimental animals. The experimental animals were divided into the control and MC treated group and given food and water unlimited. The animals treated with 4mg of MC per kilogram of body weight were sacrificed at 6, 12, 24, 36 and 48 hour after administration. The animals of control groups were administered only water for injection. The liver specimens were fixed in 10% formalin solution at 4℃ and sliced at 14㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase were observed by the Gormori's method and those of ATPase were observed by the Wachstein-Meisel's method for histochemical study. The result are as follows. 1. As the time passed, the activity of alkaline phosphatase activity was decreased in the hepatic lobule. Negative reactions were showed in the central and intermediate zone of the lobule of 36 hours of MC treated group. Trace activities of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. 2. As the time goes by, the activity of adenosine triphosphatase was decreased in the hepatic lobule. Negative reactions were observed in the entire hepatic lobule of 36 hours of MC treated group. Weak activity of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. Consequently, it is suggested that MC causes decrease in activities of hepatic alkaline phosphatase and ATPase due to live damage by cross linking of DNA with the drug in the hepatocyte and destructive change of organelles of the cell.
김명환,신규석,변종훈,두창준,소군호,고정석,진교현,김서종 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.2
A choledochal cyst is relatively rare lesion in the biliary system, and a carcinoma arising from such a cyst is rarely reported. Until now, a case of a hepatocellular carcinoma combined with a choledochal cyst had not been reported. A 45-year-old woman was recently admitted due to abdominal pain. An abdominal computed tomography revealed a 5 cm-sized low attenuative mass involving the right anterior and left medial segment of the liver and gallbladder fossa. An endoscopic retrograde cholangiopancreatogram showed fusiform dilatation of the common bile duct, but anomalous union of pancreaticobiliary duct was not observed. Fine-needle aspiration of the liver was conducted and yielded a hepatocellular carcinoma. On celiac arteriography, a hypervascular hepatic mass was also found. Transarterial chemoembolization was performed. It is believed this may be the first case of a choledochal cyst combined with a hepatocellular carcinoma in the literature. Hence, this case is herein reported with a review of related literatures.
악성 복수 및 간 전이를 동반한 췌장의 Mucinous Ductal Ectasia 1예
김미영,김명환,김봉석,신규석,변종훈,두창준,소군호,진교현,김서종,고정석 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.6
A 71-year-old man was admitted due to abdominal distension and periumbilical pain. He was diagnosed as having mucinous ductal ectasia (MDE) of the pancreas three months prior, but refused an operation. Three months later, an abdominal computed tomography revealed more dilated pancreatic duct, newly developed liver metastasis and ascites in comparison with previous findings. Fine-needle aspiration cytology of the cystic lesion in the pancreatic head was conducted and yielded adenocarcinoma. Also, an ascitic fluid cytology determined adenocarcinoma. This patient was diagnosed to be inoperable and received palliative chemotherapy and pain control. The patient expired 5 months after the initial diagnosis.