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급성 골수성 백혈병에서 고용량 Cytarabine 을 이용한 공고요법
김도하(Do Ha Kim),이규형(Kyoo Hyung Lee),조재근(Jae Kun Cho),김선희(Seon Hee Kim),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Chul Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: This study was designed to evaluate the therapeutic efficacy of postremission therapy utilizing high-dose cytarabine in patients with newly diagnosed acute myelogenous leukemia and to assess the toxicities of the therapy. Acute promyelocytic leukemia (FAB M3) is excluded because it has very unique clinicopathologic characteristics. Methods: Those patients who achieved complete remission had first consolidation therapy with conventional dose cytarabine and daunorubicin but second and third consolidation was done with high-dose cytarabine (cytarabine 1gm/㎡ i.v. over 1 hour every 12 hours daily for 5 days) and daunorubicin. Overall survival and disease free survival were compared with previous conventional dose cytarabine and daunorubicin postremission therapy. Results: 1) Complete remission occurred in 62% (28 of 45 patients) and control group 48% (14 of 29 patients) (p=0.15). 2) The median survival of all 45 patients was not different significantly compared with control group (10 months vs 7 months, p=0.08). 3) The median disease free survival of 21 complete responders receiving at least one course of consolidation was 10 months and there was no significant difference compared with control group 7 months (p=0.47). 4) The toxicity including treatment-related motility, neutropenia duration was similar in both groups. Conclusion: Although our high-dose cytarabine consolidation therapy regimen appeared to have acceptable toxicity, its results did not show the superiority to previous conventional dose cytarabine consolidation regimen.
흥분독성 소뇌손상 백서모델에서 운동기술학습이 균형 및 협응력에 미치는 영향
김기도 ( Gi Do Kim ),민경옥 ( Kyung Ok Min ),심재환 ( Jae Hwan Shim ),정재영 ( Jae Young Jeong ),김용억 ( Young Eok Kim ),김경윤 ( Kyung Yoon Kim ),김계엽 ( Gye Yeop Kim ),심기철 ( Ki Cheol Sim ),김은정 ( Eun Jung Kim ),남기원 ( K 대한물리의학회 2010 대한물리의학회지 Vol.5 No.3
Purpose:This study is intended to examine the motor skill learning on balance and coordination in the cerebellar injured rats by 3AP. Methods:This study selected 60 Sprague-Dawley rats of 8 weeks. Experiment groups were divided into four groups and assigned 15 rats to each group. Group Ⅰ was a normal control group(induced by saline); Group Ⅱ was a experimental control group(cerebellar injured by 3AP); Group Ⅲ was a group of motor skill learning after cerebellar injured by 3AP; Group Ⅳ was a group of treadmill exercise after cerebellar injured by 3AP. In each group, motor performance test, histologic observations, synaptophysin expression and electron microscopy observation were analyzed. Results:In motor performance test, the outcome of group Ⅱ was significantly lower than the group Ⅲ, Ⅳ (especially group Ⅲ)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. Group Ⅲ, Ⅳ were decreased in degeneration of cerebellar neurons(especially group Ⅲ). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than group Ⅰ. Group Ⅲ`s expression of synaptophysin was more increased than group Ⅱ, Ⅳ. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. Conclusion:These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.
A Web-based 'Patterns of Care Study' System f or Clinical Radiation Oncology in Korea
김일한(Il Han Kim),지의규(Eui Kyu Chie),오도훈(Do Hoon Oh),서창욱(Chang-Ok Suh),김종훈(Jong Hoon Kim),안용찬(Yong Chan Ahn),허원주(Won-Joo Hur),정웅기(Woong Ki Chung),최두호(Doo Ho Choi),이재원(Jae Won Lee) 대한방사선종양학회 2003 Radiation Oncology Journal Vol.21 No.4
목 적: PCS 연구의 목적은 임상 방사선치료 QA의 표준 연구수단을 구축하고,방사선치료과 정의 기본요소를 결정하고, 협동 임상시험의 기반을 제공하고,외국과의 비교 연구를 위한 기본자료의 구축에 있다.우리나라 임상 방사선종양학의 PCS 연구기법으로서 구축한 웹 기반의 PCS시스템의 개발 및 특성을 보고하고자 한다. 대상 및 방법 : 본 시스템은 메인서버와 외부에 구축한 2중 백업서버로 구성되어 있다. 리눅스 운영 체제 및 MySQL 데이터베이스를 이용하여 프로그램을 완성하였다. PCS 대상이 되는 종양으로서의 개발 우선 순위는 1989년부터 1999년 사이에서 우리나라 전국의 방사선종양학과에서 치료빈도가 많은 순서를 근거로 결정하였다. 결 과: 2003년 초반에 웹 기반의 임상 PCS시스템이 구축되었다. 웹 주소는 www.pcs.re.kr이며, 우 선 유방암,직장암,식 도암, 후두암, 폐암 및 전이성 뇌종양을 대상으로 하였다. 완성된 개발 항목의 수는 1,000항목을 상회하였다.구축된 시스템은 사용자 편의성 충족, 기입 내용 중복 확인, 자료 기밀성, 자료 보존 및 사본 작성,이중 백업,통계 분석 지원 등 을 구현하였다. 문자화된 자료 외에 영상자료도 입력되도록 시스템을 구축하였다.아울러,임상시험승인 관련양식 지원, 무작위 자료 추출,방사선종양학과의 구조적 요소 파악 기능도 갖추었다. 결 론: 본 시스템은 PCS분야에서는 최초로 구축되고 작동되는 웹 기반 시스템이다.구축한 시스템을 통해서 단시간 내에 표본 자료의 수집이 가능하여 시간 및 비용을 절약할 수 있게 되었으나 구축자료의 신뢰도 확인을 별도의 검증과정은 필수적이다. 본 연구팀이 개발한 본 웹기반시스템은 향후 PCS 연구 또는 자료수집이 필요한 유사연구상황에 응용될 수 있는 표준적인 기법으로서의 활용되기를 희망한다. Purpose We report upon a web-based system for Patterns of Care Study (PCS) devised for Korean radiation oncology. This PCS was designed to establish standard tools for clinical quality assurance, to determine basic parameters for radiation oncology processes, to offer a solid system for cooperative clinical studies and a useful standard database for comparisons with other national databases. Materials and Methods: The system consisted of a main server with two back-ups in other locations. The program uses a Linux operating system and a MySQL database. Cancers with high frequencies in radiotherapy departments in Korea from 1998 to 1999 were chosen to have a developmental priority. Results: The web-based clinical PCS system for radiotherapy in www.pcs.re.kr was developed in early 2003 for cancers of the breast, rectum, esophagus, larynx and lung, and for brain metastasis. The total number of PCS study items exceeded one thousand. Our PCS system features user-friendliness, double entry checking, data security, encryption, hard disc mirroring, double back-up, and statistical analysis. Alphanumeric data can be input as well as image data. In addition, programs were constructed for IRB submission, random sampling of data, and departmental structure. Conclusion: For the first time in the field of PCS, we have developed a web-based system and associated working programs. With this system, we can gather sampled at a in a short period and thus save, cost, effort and time. Data audits should be performed to validate input data. We propose that this system should be considered as a standard method for PCS or similar types of data collection systems.