http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김응주(Eung Ju Kim),서홍석(Hong Seog Seo),임성윤(Sung Yoon Lim),김미나(Mina Kim),나진오(Jin Oh Na),최철웅(Cheol Ung Choi),김진원(Jin Won Kim),임홍의(Hong Euy Lim),나승운(Seung-Woon Rha),박창규(Chang Gyu Park),오동주(Dong Joo Oh) 대한임상노인의학회 2009 대한임상노인의학회지 Vol.10 No.4
연구배경: 대동맥의 탄성은 관상동맥질환 환자에서 비정상인 것으로 알려져 있으나, 대동맥 탄성도의 지표들 중 하나인 대동맥 팽창성이 관상동맥질환과 독립적으로 연관되어 있는 지는 확실치 않다. 방법: 관상동맥 조영술을 받은 일련의 373명 중 급성관동맥 증후군, 과거 심근경색, 중등도 이상의 의미 있는 판막질환, 좌심실 구혈율 40% 미만, 심방세동, 관상동맥 성형술이나 관상동맥 우회술의 병력이 있는 사람들을 제외한 총 305명(관상동맥질환 환자군 107명, 대조군 198명)을 관찰하였다. 심장초음파를 이용하여 대동맥 판막으로부터 3 cm 원위부의 상행대동맥 직경을 측정한 후 2×(대동맥 내경의 변화)/(확장기 대동맥 내경×맥압) 공식으로 대동맥 팽창성(cm²×dyn⁻¹×10⁻⁶)을 구하였다. 결과: 수축기, 확장기 혈압과 맥박수는 양 군간 차이가 없었으나 대동맥 팽창성은 환자군이 유의하게 대조군 보다 낮았다(1.15±0.30 vs. 3.00±0.25, P<0.001). 다변량분석에서 대동맥 팽창성은 나이, 성, 고혈압, 당뇨병, 고지혈증과 흡연을 보정하고도 관상동맥질환과 유의한 상관성(P<0.001)을 보였다. 더욱이 대동맥 팽창성은 1∼3혈관질환으로 표현한 관상동맥질환의 심한 정도와 반비례하는 양상이었다(P<0.001). 결론: 대동맥 팽창성은 관상동맥질환의 독립적 위험 표지자이며 관상동맥질환의 심한 정도와 상관있는 것으로 생각된다. Background: Elastic properties of aorta have been known to be abnormal in patients with coronary artery disease (CAD). However, aortic distensibility (AD), one of the elasticity indexes, has not been ascertained whether it is independently associated with CAD. Methods: We prospectively enrolled 305 subjects (107 patients with CAD and 198 patients without it) among 373 consecutive patients undergoing coronary angiography for the assessment of suspected CAD. Patients with acute coronary syndrome, previous myocardial infarction, valvular heart disease more than mild, left ventricular ejection fraction <40%, atrial fibrillation, and history of coronary intervention or surgery were excluded. Aortic diameters were measured at a level 3 cm above the aortic valve using echocardiography. AD (cm²×dyn⁻¹×10⁻⁶) was calculated from the aortic diameters and brachial artery pressure using the formula: 2×(change in aortic diameter)/(diastolic aortic diameter ×pulse pressure). Results: Systolic, diastolic blood pressure and pulse rate were similar in both CAD and control subjects. AD was significantly lower in patients with CAD than controls (1.15±0.30 vs. 3.00±0.25, P<0.001). In multivariate analysis, AD remained significantly associated with CAD (P<0.001) after adjustment for age, gender, hypertension, diabetes, hyperlipidemia and smoking. Moreover, AD showed significant inverse relationship with the severity of CAD, expressed as one-, two-, and three-vessel disease (P<0.001). Conclusion: Our findings suggest that impaired AD is an independent risk marker for CAD, as well as significantly associated with the severity of CAD.
경피증 환자에서 D-Penicillamine 치료중 발생한 IgA 신증
이정용 ( Jung Yong Lee ),김응주 ( Eung Joo Kim ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),원남희 ( Nam Hee Won ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1
IgA nephropathy can occur rarely as a complication of D-penicillamine treatment, but it is exact pathogenesis remains unclear. If a patients has gross or microscopic hematuria during D-penicillamine treatment, D-penicillamine induced IgA nephropathy should be suspected as a cause of hematuria. In those cases, renal biopsy should be taken for diagnosis and proper management. We experienced a case of IgA nephropathy confirmed by renal biopsy in a 39-years-old female patient with scleroderma during D-penicillamine therapy and report this case with a review of literature.
UWB 기반 이동형 앵커 위치 궤적을 고려한 측위 기법
박소진(So Jin Park),김학주(Hak joo Kim),강산희(San Hee Kang),김응주(Eung Ju Kim),송진우(Jin Woo Song),김용훈(Yong Hun Kim) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
The positioning technique using UWB anchors with a fixed position requires much time in the infrastructure construction. This paper proposes a positioning system using mobile anchors to estimate the tags position quickly. Moreover, the proposed system saves historical information on the mobile anchor to select the optimal data combination. As a result, the proposed positioning system uses fewer anchors than the anchors required for conventional UWB positioning. The proposed method confirmed through simulation that it takes a short time in the calculation process and showed that it could stably estimate the tags position.
아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향
최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4
연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.
김응주,박원도 인제대학교 2001 仁濟醫學 Vol.22 No.1
Liddle's syndrome is a rare cause of hypokalemic hypertension. This syndrome is associated with mutations of gene encoding or -subunit of ENaC (amiloride sensitive epithelial Na channel) of cortical collecting duct of the kidney resulting in excessive sodium reabsorption, potassium wasting and metabolic alkalosis. Secondary to the persistently expanded extracelluar volume, plasma retrain activity, plasma and urine aldosterone levels are suppressed, which differentiate this syndrome from primary aldosteronism. This syndrome is transmitted in an autosomal dominant pattern. Treatment consist of low salt diet and ENaC antagonist, triamterene or amiloride. We report a case of Liddle's syndrome, a 40 year old man who came under the medical attention for evaluation of incidentally found hypertension and hypokalemia. On presentation, he showed a high blood pressure(160/100mmHg) with serum potassium 3.4mEq/L, total CO2 32.1. He complained of no symptoms such as abdominal pain, cramps, muscle weakness, and any other neuromuscular symptoms referable to metabolic abnormality or hypertension per se. The hypertension and hypokalemia did not respond to amlodipine, a calcium channel blocker, but did respond dramatically to the administration of amiloride, an ENaC antagonist. He is doing well now with normotension and normokalemia. We report a case of totally asymptomatic Liddle's syndrome who came to hospital for evaluation of incidentally found hypertension and hypokalemia. What we noted in this case is that being asymptomatic itself can cause delay in seeking medical attention and establishing a proper diagnosis and treatment. Probably the incidence of Liddle's syndrome has been underestimated due to the lack of suspicion. It will be prudent to keep this syndrome in mind when evaluating a patient with hypokalemic hypertension, regardless of the presence of symptoms.