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양미연 ( Mi Yean Yang ),유양선 ( Yang Seon Ryu ),고희자 ( Hee Ja Ko ),박세경 ( Se Kyng Park ),박종숙 ( Jong Sook Park ),박춘식 ( Chun Sik Park ),박재성 ( Jae Sung Park ),백상현 ( Sang Hyen Bak ),고은석 ( Eun Suk Ko ),박정미 ( Jeon 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.1
Sarcoidosis is a multi-systemic granulomatous disorder of unknown etiology. The characteristic pathological finding is the presence of non-caseating granulomas. The lungs are primarily affected, however other organs may be involved causing various symptoms and ambiguous laboratory findings can be present. There are a few reported cases of sarcoidosis with elevated tumor markers. We describe a 68-year-old woman presenting with sarcoidosis showing elevated serum carcinoembryonic antigen (CEA). The possibility of cancer arising from serum CEA such as gastrointestinal cancer, breast cancer and lung cancer was excluded. A transbronchial lung biopsy demonstrated a non-caseating granuloma without necrosis. As a result prescribed 30 mg prednisolone daily to the patient and serum CEA was decreased after 1 month of treatment. We report a case of pulmonary sarcoidosis with elevated serum CEA.
기관과 대장에 발생한 원발성 mucosa-associated Lymphoid tissue 림프종
배준용 ( Jun Yong Bae ),나현식 ( Hyun Sik Na ),최재성 ( Jae Sung Choi ),최준호 ( Jun Ho Choi ),박성규 ( Sung Gyu Park ),장안수 ( An Soo Jang ),고은석 ( Eun Suk Ko ),백상현 ( Sang Hyun Paik ),박재성 ( Jae Sung Park ),박춘식 ( Choon 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.2
전이성 병소에 의해 발생한 급성 충수염의 천공으로 진단된 전신병기 소세포폐암
신동원 ( Dong Won Shin ),최문한 ( Moon Han Choi ),박승식 ( Seung Sik Park ),박성우 ( Sung Woo Park ),김기업 ( Ki Up Kim ),장안수 ( An Soo Jang ),박춘식 ( Choon Sik Park ),임철완 ( Cheol Wan Lim ),고은석 ( Eun Suk Ko ),백상현 ( San 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.3
The incidence of appendiceal metastatic cancer is quite low. In particular, in small cell lung cancer, there is a very low incidence of a metastasis to the appendix. A 75-years old man with right lower quadrant pain, cough and sputum was transferred to our hospital. Abdominal CT revealed acute appendicitis with a perforation. The patient underwent surgery. The frozen sections of the tissue obtained during surgery, indicated a malignancy, but a right hemicolectomy was not performed due to the patient`s poor general condition. The histology findings of the appendix were identified as a small cell carcinoma. The abdominal CT scan and chest x-ray at admission day showed a mass in the right lower lobe, and a further evaluation of the lesion was performed including positron emission tomography and flexible bronchoscopy with a biopsy. The pathology findings of the lung mass were also small cell lung cancer. The specimens from both sites stained positive for cytokeratin, cluster designation 56, synaptophysin, chromogranin-A and thyroid transcription factor 1. It was concluded that the appendiceal small cell cancer originated from the lung. (Tuberc Respir Dis 2008;65:230-234)
이동화,김익수,김진홍,이문성,원종호,조성원,심찬섭,임상복,고은석 대한소화기내시경학회 1990 Clinical Endoscopy Vol.10 No.1
Inflammatory fibroid polyp is a relatively rare, benign polyp which is composed of fibraus connective tissue, blood vessels, and infiltration of eosinophils. The majority of inflammatory fibroid polyps has been reported with pathologic specimen in stomach and small intestine. We performed the gastrofiberscopy and endoscopic ultrasonogram of an inflammatory fibroid polyp, which reveals central ulcerated polypoid mass originated in the submucosa of antral portion of the stomach. So we report a case of endoscopic and endoscopic ultrasonographic findings of inflammatory fibroid piolyp in stomach. The etiolagy and pathology are discussed with the review of the literatures.
포상기태(Hydatidiform mole)에 의해 발생된 심한 갑상선중독증 1예
이재학,박종근,권순효,목지오,윤지성,김여주,박형규,김철희,김상진,이해혁,남계현,권계현,고은석,변동원,서교일,유명희 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.4
저자들은 무월경의 11주의 27세 환자에서 심한 갑상선중독증을 동반하고, β-HCG가 1,123,0001U/L으로 크게 증가되었으나, 흡입소파술 시행후 임상 증상과 갑상선기능 그리고 β-HCG가 모두 정상으로 호전된 포상기태 (Hydatidiform mole) 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Human chorionic gonadotropin(HCG) is one of the glycoproteins families synthesized by the placenta, and consists of 2 noncovalently joined subunits, namely, α' and . The α' and -subunits have a structural homology with the α' and -subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so -HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG, accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic diseases (GTD), such as a hydatidiform mole or a chorio- carcinoma. However, the clinical symptoms of hyperthyroidism in GTD are rarely observed. A 27-years-old woman, admitted due to an amenorrhea of 11 weeks duration, with thyrotoxic symptoms, such as weight loss, palpitation, sweating, tremor, heat intolerance and anxiety, was evaluated. Her serum free T4 level was 8 times higher than normal, and her serum -HCG level was over l,OO0,00OIU/L. She had a curettage operation, with the pathological findings of a complete hydatidiform mole. These thyrotoxic symptoms developed due to a hydatidiform mole, and were accompanied with a highly increased serum β-HCG level. After evacuation of the molar tissue, the thyroid hormone and thyrotoxic symptoms normalized. Here, this case is reported, with brief review of the literature (J Kor SOC Endocrinol 18:420425, 2003).