자궁경부의 점액성 선암종과 동반된 양측 난소의 점액성 낭성암종

권계현,곽정자,진소영,이동화 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.2

Ki-1양성 대세포림프종의 세침흡인 세포학적 소견 - 1예 보고 -

권계현,곽정자,진소영,이동화,Kwon, Kye-Hyun,Kwak, Jeong-Ja,Jin, So-Young,Lee, Dong-Wha 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

Ki-1 lymphoma is a sort of high grade large cell lymphoma and defined on the basis of the reactivity of the tumor cells with monoclonal antibody Ki-1. On fine needle aspiration cytology, the reported case is rare and the differential diagnosis is not easy, especially from undifferentiated carcinoma and Hodgkin's lymphoma. We experienced a case of fine needle aspiration cytology of Ki-1 positive large cell lymphoma in a 61-year old male patient. Fine needle aspiration cytology from the cervical lymph node disclosed hypercellular smears with large single cells on polymorphous lymphoid background. The tumor cells had abundant dense cytoplasm and large nuclei with Irregular profiles. Although most cells were mononuclear binucleated and multilobed/multinucleated cells were also seen Immunohistochemistry was done and revealed strong positive staining for Ki-1 antigen.

늑골에 발생한 연골아세포종의 세침흡인 세포학적 소견 - 1예 보고 -

권계현,진소영,이동화,Kwon, Kye-Hyun,Jin, So-Young,Lee, Dong-Wha 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1

Chondroblastoma is a benign bone tumor accounting for less than 1 % of bone tumor. It infrequently involves the flat bones, among which ribs are particularly rare. On fine needle aspiration cytology, the diagnostic smear consists of chondroblasts, osteoclast-like giant cells, and chondroid matrix. The cytologic hallmark to differentiate from other giant cell-containing lesions is chondroblasts. We experienced a case of chondroblastoma in a 13-year-old female. Fine needle aspiration cytology from the 5 th rib revealed dispersed chondroblasts and osteoclast-like giant cells on hemorrhagic background. Chondroblasts had round to oval nuclei with fine, evenly distributed chromatin and distinctive grooves or indentation. Their cytoplasm was well-defined.

우리나라와 미국 초등 과학 교과서의 천문 영역 내용 비교 분석

권계현 ( Kye Hyeon Kwon ),박일우 ( Il Woo Park ) 한국초등과학교육학회 2010 초등과학교육 Vol.29 No.2

Astronomy areas in the elementary science textbooks of Korea and the U.S.A. have been compared to find advantages and disadvantages of Korean textbooks. The analysis objects are the 7th national curriculum science textbooks for Korea and the Macmillan McGraw-Hill(MMH) science textbooks for the U.S.A. The results are as follows: First, in contexts, Korean science textbooks contain mostly inquiry activities and partly reading materials. However, MMH ones contain mostly explanations including photographs, related activities, and various reading materials. Second, in the contents and order, the observation activities of constellations are emphasized in Korean science textbooks, while the MMH ones explain solar system up to the universe in details. In addition, Korean science textbooks deal with one subject only once during the whole elementary course while MMH ones deal with one subject repeatedly in several grades. Third, in the frameworks of the international mathematics and science study (TIMSS) 2007, Korean science textbooks do not introduce some contents presented in TIMSS 2007, whereas MMH textbooks introduce every one of them in time. Fourth, the major subjects such as change of moon phases, constellations, the solar system, and change of seasons are handled independently in Korean science textbooks without strong correlation, while they are systematically done related with the rotation and the revolution of the earth in MMH ones.

핵자기 공명 단층 촬영술로 조기 진단한 임상적 헤르페스 바이러스 뇌염

권계현,진소영,오건세,이광호,안무영,김대호,이지윤,우준희,김효석 대한감염학회 1994 감염 Vol.26 No.3

목적 : 헤르페스바이러스뇌염은 치료가능한 뇌염중 하나이므로 조기 진단이 치료와 예후에 결정적 역할을 한다. 그러나 확진하는 방법은 뇌생검과 이에 따른 바이러스의 분리동정이므로 임상적으로 이용하기가 어렵다, 비관혈적인 조기 진단법으로 MRI의 가능성이 등장하여 이를 임상적으로 응용할 수 있는지 연구하였다. 방법 : 저자들은 임상적 헤르페스성 뇌염 환자 8예에서 MRI를 시행하고 임상적 특징, 요추천자, 혈청학적 항체검사소견과 1예에서의 뇌생검소견을 비교하였다. 아울러 acyclovir의 치료효과도 검토하였다. 결과 : 임상적 헤르페스성 뇌염 환자 8예 가운데 뇌 CT는 2예에서 저밀도 소견이 관찰된 반면 MRI는 8예에서 일측성 혹은 양측성 측두엽에 증가된 음영소견을 보여 조기 진단이 가능하였으나 acyclovir를 투여하였음에도 불구하고 1예는 사망하였다. 결론 : 비록 관찰대상이 많은 수는 아니었으나 임상적 헤르페스성 뇌염 환자 8예에서 MRI가 조기진단으로 효과적인 방법임을 보여 주었다. Acyclovir 치료기간은 14일보다는 연장되어야 할 필요성이 제기되었음을 기록하였다. Background : Herpes simplex encephalitis is a rare complication of herpetic infection and the course in untreated patients is usually one of rapid deterioration over several days that progresses to coma and death. The only confirmative method of diagnosis is brain biopsy. Because prompt treatment with acyclovir can be lifesaving, early diagnosis of Herpes simplex encephalitis is essential. Many physicians prefer other methods to brain biopsy due to some complication. Methods : We studied brain MRI(magnetic resonance imaging) as a noninvasive and early diagnostic method in eight cases of clinically suspected herpes simplex encephalitis restrospectively. Results : Clinical symptoms are fever, headache, impaired orientation to time person, and place, altered mental status with rapid progression to confusion and disorientation. Laboratory examination showed CSF pleocytosis especially of lymphocytes. MRI of eight patients(especially T2-weighted images) demonstrated widespread high signals in the unilateral or bilateral temporal lobes, which is not always depicted in brain CT. Among eight patients seven improved with early administration of acyclovir, however, one patient died even though 10 days of acyclovir. Conclusion : Brain MRI is thought to be a noninvasive diagnostic method with superiority of detecting early temporal lobe lesions consistent with herpes simplex encephalitis.

Na-hyaluronic acid 국소점안이 각막상피 찰과상 치유에 미치는 영향

정장현(Jang Hyun Chung),김은아(Eun Ah Kim),안정숙(Chung Sook Ahn),권계랑(Kae Rang Kwon) 대한안과학회 1996 대한안과학회지 Vol.37 No.6

원발성 난소 소세포암 2례

조인숙,남계현,김태희,김정식,이해혁,이권해,권계원 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Two cases of primary small cell carcinoma of the ovary occurred. One was a case of 43-year-old woman associated with hypercalcemia and the other was a case of 40-year-old woman with pulmonary type. Ovarian small cell carcinoma of the hypercalcemic type have clinicopathological, immunohistochemical, ultrastructural, and flow cytometric features that from differ from those of small cell carcinomas of the pulmonary type. It is important for therapeutic reasons to distinguish these two types of ovarian tumors from each other and from a variety of malignant small cell tumors that ovary primarily or secondarily. So, we reported these cases with a brief review of the concerned literatures.

코로나19 판데믹 사태에서 대한진단검사의학회의 초기 대응 현황

윤승규,고대현,김영은,노경호,이재현,조진희,지미숙,홍기호,박형두,권계철 대한진단검사의학회 2021 Laboratory Medicine Online Vol.11 No.4

The coronavirus disease (COVID-19) pandemic originated in Wuhan, China, at the end of 2019. The cause of COVID-19 is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus phylogenetically similar to the SARS virus. The symptoms of COVID-19 are non-specific, and transmission of SARS-CoV-2 can occur through contact with infected persons as well as asymptomatic carriers. Therefore, it is vital to diagnose COVID-19 by detecting the virus in respiratory samples. In the early period of the COVID-19 outbreak, infected people were identified through a rapid and accurate diagnosis. Accordingly, an initial response, such as appropriate quarantine and treatment, was critical in preventing the spread of the disease. This report briefly reviews the literature on COVID-19 and shares the experience of the Korean Society for Laboratory Medicine for the early establishment of molecular diagnostic testing with the cooperation of stakeholders. 코로나바이러스감염증-19 (코로나19)는 2019년 말에 중국에서 시작되어 전세계로 전파된 대유행을 발생시켰다. 코로나19의 원인 병원체는 SARS 바이러스와 계통학적으로 유사한 신종바이러스로 밝혀 졌기에 SARS-CoV-2로 명명되었다. 코로나19의 증상은 비특이적이고, 환자뿐만 아니라 무증상 감염자에 의한 전파가 가능하기 때문에 환자의 호흡기 검체에서 바이러스를 검출하는 것이 진단에 필수적이다. 따라서 코로나19 사태 초기에는 신속하고 정확한 진 단을 통하여 감염자를 감별하고 적절한 격리 및 치료 등의 대처가 질병 확산 예방에 중요했다. 본 논문에서는 코로나19에 대해 간략 한 문헌 고찰과 함께 대한진단검사의학회가 유관 학회, 산업계, 정 부 등의 유기적인 협력을 바탕으로 정확한 분자진단검사법을 조기에 전국적으로 정착시킨 과정과 경험을 공유하고자 하였다.

육아종성 대장염에 동반된 국소성 거대 가성용종증 -1예 보고-

곽정자,권계현,진소영,이동화 대한병리학회 1994 Journal of Pathology and Translational Medicine Vol.28 No.1

세침흡인 검체의 전자현미경 검색으로 진단된 전이성 악성 흑색종 1예

이동화,진소영,권계현,Lee, Dong-Wha,Jin, So-Young,Kwon, Kye-Hyun 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2

Electron microscopy (EM) can provide a valuable contribution to light microscopy (LM) In the Interpretation of fine needle aspiration cytology (FNAC) specimen, especially in the diagnosis of the tumor. However, considerable care in processing the specimen is mandatory to recover the cells and avoid altering the fine structures. We experienced a case of malignant melanoma in 33-yrs-old female, diagnosed by EM study of FNAC specimen from the axillary mass, who was initially thought as disseminated carcinomatosis on LM study. The technique of EM study on FNAC specimen consisted of washing the needle and syringe in 2.5% glutaraldehyde after a rapid stain (Diff-Quik), which was used to obtain a preliminary diagnostic impression and to assure the adequacy of the EM specimen. After centrifugation in the steps of fixation and dehydration, the sediment was made into an epon block and examined. The whole processing time of EM study can be shortened within 7 or 8 hours, and results can be available within 48 to 72 hours. Our experience suggests the EM study on FNAC can be a useful diagnostic method in the diagnosis of difficult FNAC cases.