조선업의 작업환경측정결과를 이용한 노출평가의 문제점과 해결방향 : 유사노출군을 중심으로

노영만,임현우,김석일,박효만,정재열,박숙경,김현욱,정치경,이원철,김정만,김수근,고상백,Karl Siber,김은아,최정근 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.2

Statistical approaches for analysis of data from the limited number of samples in ship building industry(SBI) collected by an industrial hygienist for checking compliance to an occupational standard were considered. Sampling for com-pliance usually has been guided by judgment selection, rather than true randomness, resulting in the creation of compliance samples which approximate a censored sample from the upper tail of the exposure distribution. Similar exposure groups(SEGs) including welding and painting process were established to assess representative values in each groups after reviewing the whole production line in SBI. For the convenient statistical approaches, the code has assigned to each SEGs. The descriptive statistics and probability plotting were used to yield the representative values in each SEGs. In the first step, SEGs of 558 were established from 5 ship building companies, The 38 SEGs showed the uncertainty are divided into each 5 companies and assessed the repre-sentative values again. The 44 SEGs in each companies was not showed the normal and lognormal distribution was analyzed each data. And also, recommendation was suggested to resolve the uncertainty in each groups.

간질 중첩증 환아에 대한 임상적 고찰

이승현,노영일,양은석,문경래,박영봉,박상기 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

스트레스관리 프로그램이 만성정신분열병환자의 증상과 삶의 질에 미치는 효과

박현경,구정완,노영만,이강숙,박정일 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.1

This study examined the effects of stress-management programs on the symptoms and quality of life in the chronic schizophrenics. The subjects were the chronic schizophrenics who were registered and managed by one of the public health care centers in Seoul. The stress-management programs were provided 10 times. Positive and negative syndrome scale (PANSS) and quality of life were surveyed before and after the stress-management programs. The results were as follows. 1. The differences of positive symptoms, negative symptoms and general psychopathological symptoms before and after stress-management program were significantly different between the group which were provided with stress-management programs and the group which were not provided. 2. The differences of the quality of life before and after stress-management program were significantly different between the group which were provided with stress-management programs and the group which were not provided. These results indicate that stress-management programs have effects on relieving the symptoms and improving the quality of life of schizophrenics. Ultimately these results also suggest that stress-management programs be used as the supplementary means to treat schizophrenics.

활동기와 동면기 살모사의 위장관 점액세포내 점액질에 관한 조직화학적 연구

한현주,박래백,임영민,김효성,박경수,노영복 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

살모사(Aekistrodon halys Pallas)의 위장관 점액세포내 점액질을 활동기와 동면기로 나누어 조직화학적으로 비교관찰하였다. 일반관찰을 위하여 H-E 염색을, 조직화학적 소견을 관찰하기 위하여 PAS reaction, Ab2.5 염색, AB1.0염색, AB2.5-PAS 염색, AB1.0-PAS 염색 AF1.7 염색 및 AF1.7-AB2.5 염색등을 시행하였다. 위(胃)는 표면점액세포와 점액경세포의 점액질을, 소장은 은롸롸 융모의 점액세포를 관찰한 결과를 다음과 같이 요약하였다. 1. 활동기와 동면기의 위점막에서는 현저한 차이는 없으나, 소장점막은 동면기에는 점막 주름수가 감소하고 높이가 낮아지며 점액세포가 위축되었다. 2. 위 표면점액세포는 활동기에 중성점액질과 약간의 Sialomucin을 포함한 산성점액질로 구성되었으나, 동면기에는 중성점액질과 Sialomucin이 약간 감소하였다. 3. 위 점액경세포는 활동기에 중성점액질만을 포함하고 있었으나, 동면기에는 Sialomucin을 포함한 산성점액질이 소량 검출되었다. 4. 소장 점액세포는 활동기에 산성점액질과 중성점액질로 구성되었으며 산성점액질에는 Sulfomucin과 Sialomucin이 포함되어 있었으나, 동면기에는 Sulfomucin과 Sialomucin이 다소 감소하였다. This study was performed in order to investigate the histochemical properties and compositions of the mucosubstances in the mucous of the gastrointestinal tract of Vipers, Agkistrodon halys Pallas, in active and hibernating phases. The specimens from stomach and small intestine were fixed in 10% neutral buffered formalin, embedded in paraffin wax, sectioned at a thickness of 4㎛, and stained with Hematoxyling-eosin for general histological observation and with PAS reaction, Alcian blue pH 2.5 or 1.0, Alcian blue pH 2.5-PAS or 1.0-PAS reaction, Aldehyde fuchsin pH 1.7, and Aldeliyde fuchsin pH 1.7-Alcian Blue pH 2.5 for histochemical finding. The mucous compositions in mucous cells of the gastrointestinal tract examined by their stain reaction were neutral mucin, acidic mucin, sulfomucin, sialomucin, The results obtained were as follows; The folds of the gastrointestinal tract in the hibernating phase, compared with the active phase, shrink and lower. Also, the shrinkage of epithelial cells were observed in the hibenating phase. The surface mucous cells of the stomach in the active phase composed mainly neutral mucin and a little amount of acidic mucin including sialomucin, but in the hibernating phase neutral mucin and sialomucin slightly decreased. The mucous neck cells of the stomach in the active phase constituted mainly neutral mucin, In the hebernating phase the mucous neck cells were composed of neutral mucin and a little amount of acidic mucin contained sialomucin. The mucous cells of the small intestine in the active phase consist of neutral mucin, acidic mucin including sulfomucin and sialomucin but in the hibernating phase sulfomucin and sialomucin slightly decreased.

염화비닐 노출 근로자의 시료채취시기에 따른 요중 thiodiglycolic acid의 농도 변화

김현수,김치년,원종욱,차봉석,이경종,노재훈 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 본 연구는 염화비닐 및 폴리염화비닐수지 제조공장의 VCM 노출 근로자들을 대상으로 소변 시료채취 시기에 따른 요중 TDGA 농도의 변화를 알아보고자 하였다. 방법: VCM 및 PVC 제조공장 남성 근로자 31명을 대상으로 공기중 VCM 개인노출평가를 실시하였으며 소변내 TDGA 배설 양상을 알아보기 위해 3일 휴식 후 척 작업 시작 전(TDGA1), 1일 작업종료 후(TDGA2), 1일 작업 한 다음날 작업 전(TDGA3) 소변을 채취하였다. VCM에 노출되지 않은 대조군 30명에 대해 작업종료 후 소변을 채취하였다. 공기 중 VCM의 측정 및 본석은 NIOSH 공정시험법 No. 1007에 따라 실시하였다. 요중 TDGA 분석을 위하여 소변을 trimethylsilyldiazomethane(2.0 M in diethyl ether)으로 메틸화 반응하여 가스크로마트그래피/펄스불꽃광도검출기로 분석하였다. 결과: VCM 노출 후 요중 TDGA가 배설되어 감소하는 시기를 조사하기위해 대조군과 VCM 노출 근로자들의 3일 휴식 후 작업 시작 전 요중 TDGA 농도 (TDGA1)를 비교한 결과 각각 0.179±0.271 mg/g creatinine, 0.218±0.443 mg/g creatinine으로 통계학적으로 유의한 차이가 없었다. 1일 작업 종료 후 요중 TDGA 농도(TDGA2)는 0.434±0.623 mg/g creatinine, 1일 작업 한 다음날 작업전 요중 TDGA 농도(TDGA3)는 0.767±1.056 mg/g creatinine으로 순차적으로 증가하였다. 하루 노출량을 평가하기 위해 공기 중 VCM 농도와 요중 TDGA와의 단순회귀분석 결과 1일 작업한 다음날 작업 전 요중 TDGA 농도(TDGA3)와 공기 중 VCM 농도와의 관련성은 R^(2)=0.4215로 1일 작업종료 후 요중 TDGA 농도(TDGA2)보다 높았다. 결론: VCM 노출 후 3일이 경과하면 대조군의 요중 TDGA 농도 수준으로 감소하여 요중 TDGA의 배설 반감기가 3일 이내인 것으로 판단된다. 또한, 하루 근무하고 그 다음날 작업 전에 채취한 요중 TDGA 농도(TDGA3)가 전날 근무시의 VCM노출량과 상관성이 가장 높아 하루 동안의 VCM노출을 평가하기 위한 유용한 생물학적 지표로 사용할 수 있을 것으로 판단된다. Objectives: The study was performed to investigate the changes of urinary thiodiglycolic acid (TDGA) concentration in workers exposed to vinyl chloride monomer (VCM) according to the time of sampling urine. Methods: The personal exposure to airborne VCM was assessed and urinary TDGA concentration was sampled in 31 workers employed in a VCM and polyvinyl chloride (PVC) manufacturing factory. Urinary TDGA was sampled three times: before the start of the shift after 3 days off (TDGA 1), after the end of the first-day shift (TDGA2) and before starting the following day shift after completing the one- day shift (TDGA3). Urinary TDGA in 30 workers who had not been exposed to airborne VCM was sam- pled after the end of the shift. A gas chromatography/pulsed flame photometric detector (GC/PFPD) was utilized to analyze TDGA concentration in urine after the urine was methylated with trimethylsilyldia- zomethane (2.0M in diethyl ether). Results: The creatinine level was 0.179±0.271 mg/g in the control workers and 0.218±0.443 mg/g in the workers before the start of the shift after 3 days off (TDGA1), showing no significant difference (p=0.7035). Urine samples were compared according to sampling time in order to investigate the change of urinary TDGA concentration in the case of continuous exposure to airborne VCM. In VCM-exposed workers, urinary creatinine concentration was 0.434±0.623 mg/g in TDGA2 and 0.767±1.056 mg/g in TDGA3, which indicated a gradual but significant increase (p=0.024). In terms of the statistical correlation between airborne VCM and urinary TDGA to evaluate exposure dose per day, of the three urinary TDGA concentrations, TDGA3, showed the highest degree of regression (R^(2)=0.4215) with 8h-TWA airborne VCM concentration. Conclusion: Based on this result, the excretion half-life of urinary TDGA was assumed to be less than 3 days, because the concentration of urinary TDGA at 3 days after exposure to airborne VCM was decreased to the level of urinary TDGA concentration in the control workers. The concentration of urinary TDGA increased in the case of continuous shift, due to the accumulation of residual metabolites of TDGA. It was considered that TDGA3 can be applied as a useful biological index to evaluate the exposure dose of airborne VCM during one day because TDGA3 showed the highest correlation with the exposure dose of airborne VCM in the previous shift day.

당뇨병-고지혈증 모델동물의 개발

오승현,노경진,박인선,민본홍,두호경,안세영,김용석,성제경 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3

Diabetic complication is one of major risk factors leading to vascular disease Such as atherosclerosis stroke, coronary heart disease and etc Several factors affecting the acceleration of diabetic vascular complication have been known such as hypertension hyperlipidemia, immune complex and genetic factors To screen and develop new therapeutics agents for diabetic vascular complication, it is strongly needed to develop animal models for diabetic complications However in rodents models, diabetic complications is not well developed Furthermore to asses￠ the possibility of new therapeutics for diabetic vascular complications, diabetic animal models which have the risk factors of diabetic complications is needed We aim to develop and establish an diabetic animal model which have diabetic complications with hyperlipidemia which is one of risk factors for diabetic complications We induced insulin-dependent diabetes by intra venous injection of streptozotocin (35 mg/kg/day) in RICO rats which is a spontaneous animal model for hyperlipidemia Our models (STZ RICO) showed hyperglycemia, persistent high level of plasma cholesterol and triglyceridemia with severe diabetic renal changes until 28 weeks after induction of diabetes STZ-RICO rats could be used for the evaluations of newly developed diabetic drugs.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

The influence of silver thiosulfate and thidiazuron on shoot regeneration from cotyledon explants of Brassica napus

Roh, Kyung-Hee,Kwak, Bo-Kyung,Kim, Jong-Bum,Lee, Kyeong-Ryeol,Kim, Hyun-Uk,Kim, Sun-Hee The Korean Society of Plant Biotechnology 2012 식물생명공학회지 Vol.39 No.3

The influences of ethylene inhibitors ($AgNO_3$ and silver thiosulfate) and cytokinins (BAP and TDZ) on shoot regeneration from cotyledon and hypocotyl explants of B. napus cv. Youngsan were investigated. The presence of $50{\mu}M$ Silver thiosulfate (STS) in shoot regeneration medium formed shoots at 60-68% after 3-4 weeks of culture, which was enhanced by 2-fold compared to that of Silver nitrate ($AgNO_3$). Moreover, cotyledon explants were more regenerative than hypocotyls; shoots from cotyledon explants began to occur 4-5 days earlier than that of hypocotyl explants. TDZ at a concentration of $8-10{\mu}M$ was effective for shoot regeneration, compared with BAP. Consequently, the optimal shoot regeneration response was observed in medium supplemented with $50{\mu}M\;STS+8{\mu}M\;TDZ$. In transmission electron microscopy (TEM) analysis, higher density of silver nanoparticles was shown to be accumulated widely inside the cell wall and plasmodesmata of regenerating leaf cultured in medium supplemented with $AgNO_3$. By contrast, in the cell cultured in medium with STS, fine-grained deposits were partly observed in the surroundings of the cell wall.

Optimization of Ce<SUB>(1-x)</SUB>Zr<SUB>(x)</SUB>O₂ catalysts for bio-diesel production

Kyung-Won Jeon,Dae-Woon Jeong,Jae-Oh Shim,Won-Jun Jang,Won-Bi Han,Hyun-Suk Na,Hak-Min Kim,Yeol-Lim Lee,Hyun-Seog Roh,Chang Hyun Ko 한국신재생에너지학회 2014 한국신재생에너지학회 학술대회논문집 Vol.2014 No.05

Firat Draft of Proteomic Analysis of Human Embryonic Stem Cells

Kyung Mi Choi,Kye Sung Kim,Kun Ho Choi,Do Kyun Kim,Kyung Jin Roh,Hyun Soo Yoon,Jung Bok Lee,Sun Kyung Oh,Shin Yong Moon,Je-Kyung Seong(성제경) 한국실험동물학회 2004 한국실험동물학회 학술발표대회 논문집 Vol.2004 No.-