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HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절
김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.
스포츠 브랜드 아이덴티티에 따른 브랜드 자산 비교 연구
김도균,정아람 경희대학교 체육대학 한국체육과학연구소 2004 體育學論文集 Vol.32 No.-
The purpose of this study is to identify youth' brand equity with regard to sports brand identity. The subjects included 107 male and 106 female teenagers who live in the Seoul area and who were selected by a multi-stage sampling method. Data were collected by suing a questionnaire about sport corporations' brand equity, and the subjects were asked to indicate the degree of importance they place on certain variables on 1 5 point Likert scale by the self administration method. The scales were deemed reliable since the Cronbach a for the brand awareness and brand preference, brand association image, hand equity scales were .8325, .7289, .8247, .7582 respectively. As result, the following conclusion were drawn: 1. The brand identity element is important and recognized. 2. The brand which it prepers most was NIKE, character and high class it is with it appeared with the reason. 3. According to the specics of the population statistics(sex, area, grade) each brands showes differences in the brands equity(brand awareness and brand preference, brand association image, brand equity). 4. There was a difference to the brand equity(brand awareness and brand preference, brand association image, brand equity) which it follows in population statistics quality(sex, area, grade) of the outside brand. 5. There was a difference to the brand equity(brand awareness and brand preference, brand association image, brand equity) which it follows in population statistics quality(sex, area, grade) of the domestic brand. 6. There was a difference to the brand equity(hand awareness and brand preference, brand association image, brand equity) which it follows in population statistics quality(sex, area, grade) of the domestic brand and outside brand.
도로표지판용 반사지와 EL시트에 대한 휘도와 시인성의 관계
김도균,이종달 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2
It is well known that fluorescent traffic signs have conspicuity that is far superior to that of normal color signs. This study was conducted to test the hypothesis whether increasing the property of luminance, while leaving all other sign features the same, does increase the legibility distance. Six diamond-shaped signs were fabricated. The experiment enforced for day and night. The investigated sign board included Reflective Sheeting Engineer Grade(normal), Reflective Sheeting High Intensity Grade(higher), Diamond Grade TM LDP Reflective Sheeting(the highest), EL(electro luminescence)sheet. The traffic sign legends used Landolt rings to avoid word familiarity issuses. It was found that increasing of the luminance actually did statiscally significantly increase the legibility distances. The increasing ranged from 9.3 to 39.4 percent when increasing the property of luminance. In the case of EL sheet was from 34 to 57.3 percent(increase the legibility distances).
김도균,이준호,유승엽,장정수,권영수 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
The electrical properties of Maleate copolymer (C_(18)MA-VE_(2)) and Itaconate copolymer (C_(18)ITA-VE_(2)) Langmuir-Blodgett (LB) films for in-plane were investigated to develop the gas sensor. The C_(18)MA-VE_(2) and C_(18)ITA-VE_(2) were used as sensitive materials and deposition on the slide-glass substrate using LB method which could control the thickness in the molecular order (Å). The current-voltage (I-V) characteristics were measured to investigated the response characteristics in chloroform, acetone, ethanol and methanol gases. The conductivity of sensitive films were 10^(-)7[S/cm] for an in-plane. The change of conductivity was occurred by behavior of organic gases, which mean that the behavior of organic gases could be analyzed using conductivity change and application to gas sensor. In the experimental results, the relation between sensitive films and organic gases could be divided by three-type. Thus, we could analyze the modeling of the response characteristics of organic gases using the conductivity change of sensitive films.
RAPD(Random Amplified Polymorphic DNA)법을 이용한 한약재의 판별 연구
김대원,김도균,안선경,조동욱 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
Conventionally, identification and classification methods of natural products include the morphological survey and assay of chemical disposition. Using these methods, however, is not satisfying for the precise identification of natural products because they are often variable in the compositions, genomic DNA analysis such as RAPD, RFLP and Amp-FLP can be adopted for this purpose. In this study, various ginsengs and bear gall bladder were tested for the development of genetic identification and classification method. Varieties of ginsengs such as, P. ginseng, P. quinquefolium, P. japonicus and P. notohinseng, were genetically analyzed by RAPD. Also, DNA isolated form Bear blood and gall bladder, Ursus thibetanus, Ursus americanus and Ursus arctors, were analyzed by the same method. The results demonstrated that the identification and classification of bear gall bladder and various ginsengs were possible by RAPD analysis. Therefore, this method was thought to be used as a additional method for the identification of other natural products.
기계적 합금화에 의한 Al-Fe 및 Al-Fe-Ce 합금의 고온 변형거동
김선진,이도인,안인섭,허보영,조권구 국립경상대학교 공과대학 부설 첨단소재연구소 1992 尖端素材 Vol.2 No.-
The deformation behavior of a mechanical alloyed Al-Fe and Al-Fe-Ce alloy was studied in the temperature range of 300℃ to 500℃. The steady state for Al-8wt.%Fe powder was obtained after 1000 minutes of mechanical alloying at the process condition of 2wt.% stearic acid, 46:1 of grinding media/powder weight ratio, and 300 rpm of impeller revolving velocity. The relative densities of Al-8wt.%Fe alloy powders reached almost 100% after 1 hour sintering at 470℃ under vacuum state. With increasing the amount of PCA, hardness of the sintered alloys increased but the relative densities were not affected. It was also found that decrease in hardness and tensile strength after high temperature aging treatment was reduced with increasing the amount of Ce addition.