영양물 정주시의 체내호르몬 반응에 관한 연구 : 위암환자에서 본 영양물 투여시의 insulin 및 HGH 반응 Insulin and growth hormone responses following oral or intravenous alimentation in patient with far advanced gastric cancer

이진오,성호경,고주환,유용운,이종원,김진용,이장규 대한핵의학회 1975 핵의학 분자영상 Vol.9 No.2

심히 진행된 위암 환자에서 경정맥 포도당 투여시의 insulin 및 성장 호르몬 반응을 관찰하고 경구 투여시와 비교 검토하였다. 다시 위암 환자에게 아미노산 용액을 투여하고 혈중 insulin 농도와 성장 호르몬 농도 및 혈당량을 경시적으로 측정하고 정상인에서의 결과와 비교하여 다음의 결과를 얻었다. 1) 위암 환자에게 포도당 용액을 경구 부하하면 혈중 포도당 농도의 상승은 감소되었다. 2) 위암 환자에게 포도당 용액을 경구투여하였더니 insulin 반응은 정상인에서보다 감소되어 경정맥투여시와 유사하였다. 3) 위암 환자에게 포도당 용액 또는 아미노산용액을 경정맥 투여하여 성장 호르몬 농도의 상승을 관찰하였다. 4) 위암 환자에게 아미노산 용액을 정맥내로 투여하면 정상인에서와 같이 경구투여시에 비하여 insulin 반응의 감소가 관찰되었다. 5) 위암 환자에게 포도당 경정맥 투여시의 insulin 반응이 경구 투여시와 유사한 점에 대하여 고찰하였으며 아미노산 경정맥 투여시에는 insulin 반응에 유의할 필요성을 지적하였다. Glucose tolerance, insulin and growth hormone responses following glucose for amino acids administration by means of parenteral or oral load were studied in patients with far advanced gastric cancer. Hormone responses following nutrients load showed in patients with gastric cancer were compared to those of healthy subjects. Results were as follows: 1) Blood sugar appearance following oral glucose administration was diminished in patients with far advanced gastric cancer. 2) The insulin responses of gastric cancer following oral glucose were also diminished as compared to that of normal subjects and were identical with parenteral route. 3) Parenteral administration of glucose or amino acids to patients with gastric cancer resulted in a increase of plasma growth hormone level. 4) Lower insulin response to amino acids was observed on parenteral administration in patient with gastric cancer as in healthy subjects. 5) Author discussed that the low insulin response after oral glucose administration showed in gastric cancer, and any additional insulin requirement arise when longer periods of parenteral amino acid administration are necessary, as in the patient with malnutritions. $quot;

변형된 트랜스듀서 및 FM을 이용한 이식형 인공중이 시스템의 전력효율 개선

윤영호,원철호,송병섭,정영숙,김명남,박세광,이상흔,조진호 경북대학교 전자기술연구소 1997 電子技術硏究誌 Vol.18 No.2

In design of implantable middle ear system, it is necessary that the system has a high power-transfer efficiency because die internal circuit of the system has no power source. The FM transmission method transfers the signal power more efficiently than AM method because AM signal has large carrier component which act as the loss. Therefore, an implantable middle ear system using FM transmission and receiving method is proposed. And the new shape of vibrating transducer which vibrate more efficiently than the conventional type was designed. This tranducer is consisted of coil and small T-type cylindrical permanent magnet. The differences between conventional methods and proposed methods are investigated and compared through quantitive analysis. The advantages of proposed methods are proved by experiments.

3 차원 모델을 이용한 주조과정에서의 용탕의 충전 및 응고과정에 관한 수치적 연구

조인성,목진호,이진호 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.9

A numerical algorithm which simulates a three-dimensional casting process in a rectangular mold was developed and tested. To analyze filling process, the VOF method is used with the SIMPLER algorithm and, to analyze solidification process, the Equivalent Specific Heat method is used also with the SIMPLER algorithm. Though the complete symmetric plane assumption in z-direction was adopted in a two-dimensional analysis, it was shown that flow patterns during filling, a point of time when the residual flow decayed and the intensity of natural convection differed in each plane in a three-dimensional analysis due to z-directional velocity components and boundary conditions. In addition, the heat transfer analysis in a mold were also done and results showed that the mold temperature varied in considerably wide range which was different from the convectional analysis of constant heat sink temperature assumption.

PGA2 induces the expression of HO-1 by activating p53 in HCT116 cells

Hyein Lee,Sang-Sun Lee,Ji-Young Park,Yun-Jeong Choe,이선영,Ho-Shik Kim,H.-S. Kim 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.2

Prostaglandin (PG) A2 which is a cytotoxic PG, was reported to induce the expression of heme oxygenase (HO)-1 via activation of p38MAPK to keep U2OS cells from cell cycle arrest in G2M phase. The expression of HO-1 is primarily regulated at the level of transcription. But the transcription factors that are responsible for PGA2-induced HO-1 expression were not clarified yet. Here, we report that PGA2-induced transcription of HO-1 is mediated by p53, a tumor suppressive transcription factor. In HCT116 cells, PGA2 treatment led to the phosphorylation of p53 and an increase of p21WAF1 transcription as well as the activation of HO-1 transcription. Knocking p53 down via RNA interference or inhibiting the p53’s transcriptional activity by pifithrin-α treatment led to suppression of the increase in the level of both HO-1 expression and activity of HO-1 promoter. Pretreatment of NU- 7441, a chemical inhibitor of DNA-activated protein kinase (DNA-PK), prevented both the PGA2-induced phosphorylation of p53 and an increase of HO-1 transcription. In addition, N-acetyl-l-cysteine, a scavenger of reactive oxygen species (ROS), also mimicked the effect of NU-7441 on the PGA2-induced activation of p53 and HO-1 transcription. Collectively, these results suggest that PGA2 induces the expression of HO-1 via activation of p53, which is mediated by the ROSDNA- PK pathway.

Effect of finish cooling temperature on microstructure and mechanical properties of high-strength bainitic steels containing Cr, Mo, and B

Kyung Sung, H.,Ho Lee, D.,Yong Shin, S.,Lee, S.,Yong Yoo, J.,Hwang, B. Elsevier Sequoia 2015 Materials science & engineering. properties, micro Vol.624 No.-

Six low-carbon high-strength bainitic steels containing Cr, Mo, and B were fabricated by controlling finish cooling temperature, and the effect of bainitic microstructure on tensile and Charpy impact properties were investigated. All the specimens were composed primarily of bainitic ferrite, together with small amounts of granular bainite, acicular ferrite, martensite-austenite constituent. These bainitic microstructures were more critically affected by the finish cooling temperature than by the alloying elements. The H-series specimens with a high finish cooling temperature had larger amount of acicular ferrite and smaller amount of granular bainite and bainitic ferrite, compared to the L-series specimens with the low finish cooling temperature at the same chemical composition. The L-series specimens exhibited higher strength and yield ratio, and lower uniform and total elongations than the H-series specimens because the volume fraction of BF was higher in the L-series specimens than in the H-series specimens. On the other hand, the energy transition temperature decreased with increasing the volume fraction of AF having fine effective grain size, while it increased with an increase in the volume fraction of GB having coarse effective grain size. Thus, the energy transition temperature of the H-series specimens with the high finish cooling temperature were slightly lower than that of the L-series specimens with the low finish cooling temperature because the H-series specimens had a larger amount of AF than the L-series specimens.

척수손상 환자를 위한 병원기반 사회복귀지원 프로그램의 개발 및 효과

호승희(S. H. Ho),유소연(S. Y. Yu),김예순(Y. S. Kim),방문석(M. S. Bang),이범석(B. S. Lee),김동아(D. A. Kim),김은주(E. J. Kim),김현경(H. K. Kim) 한국재활복지공학회 2015 재활복지공학회논문지 Vol.9 No.2

본 연구는 척수손상 환자를 대상으로 병원기반 사회복귀 지원프로그램을 개발하고, 프로그램 시행 전·후를 비교 분석함으로써 프로그램의 효과성을 평가하고자 하였다. 재활병원에 입원해 있는 25명의 척수손상 환자를 대상으로 2~3개월 동안 일주일에 2번 평균 6.1개의 프로그램을 실시하였다. 프로그램 시행 전, 후 COPM, HADS, AD-R, WHOQOL-BREF를 통해 작업 수행도 및 만족도, 불안과 우울, 장애수용, 삶의 질을 비교하였으며, 퇴원 시 CIQ로 지역사회통합 수준과 퇴원 후의 사회복귀여부를 측정하였다. 자료분석은 기술통계와 대응표본 t검정(paired t-test)을 실시하였다. 연구결과 병원기반 사회복귀 지원프로그램 실시 후 작업 수행도 및 만족도, 장애수용, 삶의 질에 향상을 보였다(p<0.05). 또한 퇴원 후 25명의 척수손상 환자 중에서 10명이 가정, 학업, 직업으로 복귀하였다. 이를 통해 병원기반 사회복귀 지원프로그램이 척수손상 환자들이 퇴원 후 그들이 속한 지역사회로 돌아가는데 효과적임을 알 수 있었다. 척수손상 환자들이 가정과 사회로의 빠른 복귀를 위해서는 사회복귀를 위한 다양한 프로그램 개발과 더불어 체계적인 사회복귀 연계시스템이 이루어져야 할 것으로 사료된다. The purpose of this research attempted to developed the Community Reintegration support Program(H-CRsP) on patients with Spinal Cord Injury(SCI) and identity the effect. To assess the effectiveness of a Hospital based H-CRsP with a comprehensive team approach for treating inpatients with Spinal Cord Injury(SCI), offered by the Korea National Rehabilitation Hospital. Participants with SCI were recruited from the Korean National Rehabilitation Hospital. Twenty-five participants who met inclusion criteria were provided with a H-CRsP. A H-CRsP with modules related to the training of daily living skills, driving, vocations and school support activities, leisure or recreational activities, peer counseling, sexual rehabilitation, and others support activities. The 25 enrolled patients had been treated with average of 6.1 programs 2 times a week for over 2 or 3months. COPM, HADS, WHOQOL-BREF, AD-R were administered before the treatment(pre-test) and also at the time of discharge(post-test) to compare the treatment outcomes in the 25 program participants. Measured level of community integration by CIQ at discharge. The data were analyzed by such statistical methods as frequency and paired t-test analysis. Significant improvements were found on the Occupational Performance and Satisfaction, Acceptance of Disability, Quality of Life score in the COPM, AD-R, WHOQOL-BREF (p<0.05). In addition, 10 of the 25 patients returned to home, work or school. These results demonstrated the effectiveness of the H-CRsP in helping patients with SCI return their communities to which they belong. It considered development of the variety of programs and prepare systematically related system.

Distinct clinical courses according to presenting phenotypes and their correlations to <i>ATP7B</i> mutations in a large Wilson's disease cohort

Lee, Beom H.,Kim, Joo H.,Lee, Sun Y.,Jin, Hye Y.,Kim, Kwi‐,Joo,Lee, Jin‐,Joo,Park, Jung‐,Young,Kim, Gu‐,Hwan,Choi, Jin‐,Ho,Kim, Kyung M.,Yoo, Han‐,Wook Blackwell Publishing Ltd 2011 Liver International Vol.31 No.6

<P><B>Abstract</B></P><P><B>Introduction and aims: </B> Wide phenotypic and genotypic heterogeneities in Wilson's disease (WD) have been reported, hampering the study of their correlations. The goal of this study was to identify the factors related to these diversities.</P><P><B>Methods: </B> Clinical courses and molecular genetic characteristics were analysed in 237 unrelated Korean WD families. The average follow‐up period was 8.2 ± 5.8 years.</P><P><B>Results: </B> Presenting phenotypes were classified as H1 (12.2%), H2 (42.4%), N1 (21.6%), N2 (0.4%), NX (0.4%), presymptomatic (22.4%) and other (0.4%), modifying the guidelines by Ferenci and colleagues. Age at presentation was youngest and cirrhosis was rarest in the presymptomatic group. Decompensated cirrhosis was the highest in the H1 group. Favourable outcome was rarest in the N1 group. Forty‐seven (11 novel) <I>ATP7B</I> mutations were identified in 85% of the 474 alleles. Multiplex ligation‐dependent probe amplification assays in <I>ATP7B</I> and analyses of <I>ATOX1</I> and <I>COMMD1</I> genes identified no additional mutations. Yeast complementation assays demonstrated functional perturbation of the seven novel missense mutants. Five major mutations, p.Arg778Leu, p.Ala874Val, p.Asn1270Ser, p.Lys838SerfsX35 and p.Leu1083Phe, accounted for 63% of the alleles. H1 was more common, age at presentation was younger and N1+N2+NX tended to be less common in patients with nonsense, frame shifting or splicing mutations than in those with missense mutations alone. Patients with both mutations in the transduction (Td) or the ATP hinge domain showed presymptomatic or hepatic manifestations but no neurological manifestation.</P><P><B>Conclusions: </B> The presenting phenotype strongly affects the clinical outcome of WD, and is related to the <I>ATP7B</I> mutation type and location, providing an evidence for genotype–phenotype correlations in WD.</P>

레이더 강수 검증을 위한 초상세 종합 강수량 자료

오재호 ( Jai-ho Oh ),심지한 ( J. H. Shim ),오지원 ( J. W. Oh ),허모랑 ( M. R. Hue ) 한국물환경학회 2020 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2020 No.-

A method was developed to estimate a synthetic precipitation record for ungauged sites using irregular coarse observations. The proposed synthetic precipitation data were produced with ultra-high hourly resolution on a regular 1 × 1 km grid. The proposed method was used to analyze selected real-time observational data collected in South Korea from 2010 to the end of 2014. The observed precipitation data were measured using the Automatic Weather System and Automated Synoptic Observing System. The principal objective of the proposed method was to estimate the additional effects of orography on precipitation introduced by ultra-high-resolution (1 × 1 km) topography provided by a digital elevation model. The Global Forecast System analysis of the National Centers for Environmental Prediction was used for the upper atmospheric conditions, necessary for estimating the orographic effects. Precipitation data from 48 of the more than 600 observation sites used in the study, which matched the grid points of the synthetic data, were not included in the synthetic data estimation. Instead, these data were used to evaluate the proposed method by direct comparison with the real observations at these sites. A bias score was investigated by comparison of the synthetic precipitation data with the observations. In this comparison, the number of Hit, False, Miss, and Correct results for 2010-2014 was 74738, 25778, 7544, and 367981, respectively. In the Hit cases, the bias score was 1.22 and the correlation coefficient was 0.74. The means of the differences between the synthetic data and the observations were 0.3, -3.9, -14.4, and -34.9 mm h-1 and the root mean square errors (RMSEs) were 2.7, 8.3, 19.3, and 39.6 mm h-1 for the categories of 0.5-10.0, 10.0-30.0, 30.0-50.0, and 50.0-100.0 mm h-1, respectively. In addition, in each range, the 60% difference between the synthetic precipitation data and the observation data was - 1.5 to +1.5, -5.0 to +5.0, -17.0 to +17.0, and -33.0 to +33.0 mm h-1, respectively. Overall, the correlation coefficient of the synthetic precipitation data was >0.7 for 43 of the 48 test stations and the RMSE was <4 mm h-1 at 31 stations. The results are significant at all evaluation stations at the 0.05 significance level. This synthetic ultra-high resolution precipitation data may be used to verify the radar precipitation algorithm to overcome the limitation of the observation in operation.

New feasible quarantine disinfestation using ethyl formate for termites and ants on imported lumber

Kim Dong bin,Kim Kyung won,박민구,Roh Gwang Hyun,Cha Dong H.,Lee Byung ho 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.4

The interception of exotic ants and termites from stone and lumber imported into Korea is on the rise, including Solenopsis invicta. Currently, a relatively long exposure (24 h) of methyl bromide (MB) fumigation is the only practical disinfestation option for exotic ants and termites on imported stone and lumber. In this study, ethyl formate (EF) wase evaluated as a potential MB alternative to disinfest ants and termites in imported lumber, with a focus on S. invicta. As S. invicta is not established in Korea, we first determined whether Reticulitermes speratus, established in Korea, could be considered as an EF surrogate of S. invicta. From 1 h EF fumigation trials, workers of S. invicta were more sensitive to EF than those of R. speratus based on lethal concentration × time causing 99% mortality (LCt 99% ), supporting that R. speratus can be used as an EF surrogate of S. invicta. When R. speratus workers were further fumigated with EF for 4 h at four different temperatures, LCt 99% values for R. speratus workers were 108.00, 63.31, 77.24, and 67.24 g h/m 3 at 2, 5, 13, and 23 ◦ C, respectively. From scale-up (0.65 m 3 ) and commercial scale (76.4 m 3 ) trials containing two infestation-prone lumber species, lauan (Shorea spp.) and acacia (Acacia spp.), 140 g/m 3 EF at >5 ◦ C for 4 h resulted in the complete control of R. speratus workers, suggesting that 140 g/m 3 4 h-EF-fumigation may be applicable as a potential MB-alternative treatment for disinfestation of invasive S. invicta on imported lumber.

한국에서 지역에 따른 Helicobacter pylori 균주 내성

김재연 ( Jae Yeon Kim ),김나영 ( Na Young Kim ),김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),김광하 ( Gwang Ha Kim ),김정목 ( Jung Mogg Kim ),남령희 ( Ryoung Hee Nam ),김홍빈 ( Hong Bin Kim ),이동호 ( Dong Ho Lee ),정현채 ( H 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4

Background/Aims: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. Methods: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. Results: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. Conclusions: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations. (Korean J Gastroenterol 2011;57:221-229)