니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

UO2 소결체에 고온연소반응을 이용한 SiC 코팅

김봉구,최용,김정원,이영우,손동성,김길무 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.5

Multi-layer coating of silicon carbide and graphite on UO₂ nuclear pellet was carried out with a fluidized bed type chemical vapor deposition unit to enhance the inherent safety of the nuclear pellet and to develop a renovative coating process. Silane, propane and argon gases were used as the source and carrier gases to deposit silicon and pyrolytic carbon. Combustion reaction was performed in an inert argon atmosphere, which conditions were pre-determined by numerical evaluation of the combustion reaction between silicon and carbon to synthesize silicon carbide. Microstructural observation of the combustion products by scanning electron microscopy showed that the inner and outer pyrolytic carbon layers were equiaxed structure. Chemical analysis by Auger electron spectroscopy and X-ray diffractometry revealed that the middle layer formed by a combustion reaction was fine crystalline beta-silicon carbide.

췌장암에서 Cyclooxygenase - 2 발현의 역할

김은경,이용욱,이규택,최규완,박동일,백승운,이준행,이종균,고광철,이풍렬,이종철,김재준,김완선,공구 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3

Background/Aims: Accumulating evidence suggests that the use of NSAID may reduce the incidence of colorectal cancer. The likely mechanisms of these effects by NSAID is cyclooxygenase-2 (COX-2)-related inhibition of tumor proliferation and induction of apoptosis. The aim of our study was to examine possible roles and clinical significance of COX-2 expression in pancreatic cancer. Methods: Seventy-two pancreatic adenocarcinoma tissue specimens were obtained from surgical resection. After the immunohistochemical staining of the specimens, we examined proliferation activity (assayed by Ki-67 expression), apoptosis (by TUNEL stain), and microvessel density (by CD34 expression). We also investigated the relationship between the immunohistochemical expression of COX-2 and various clinicopathological characteristics. Results: The COX-2 positive rate in pancreatic epithelial cells was 41.7%. Proliferation index (PI) was significant higher in COX-2 positive specimens comparing to negative specimen (p=0.015) and the increase in intensity of COX-2 expression correlated with increasing PI (p=0.036). Apoptotic index (AI) was significantly higher in positivee COX-2 expression than in negative expression (p=0.044), but there was no significant difference in AI/PI between the COX-2 positive and negative specimens (p=0.44). The expression of COX-2 protein did not correlate with microvessel density, sex, age, differentiation, tumor size, stage, metastasis or patients survival. Conclusions: The expression of COX-2 enzyme in pancreatic cancer contributes to tumor proliferation, but is not related to apoptosis, angiogenesis or clinical characteristics. Further study is needed to examine the clinical usefulness of NSAID and COX-2 selective inhibitors.

리튬 2 차 전지의 양극재료인 스피넬 망간산화물의 용해와 용량감소

오승모,이종화,홍진규,장동훈 한국공업화학회 2001 공업화학 Vol.12 No.2

Effect of Dietary fat on Colon Carcinogenesis

김(이)동연 한국지질학회 1993 韓國脂質學會誌 Vol.3 No.1

식이지방과 대장암

김(이)동연,Lupton,Joanne R . 한국지질학회 1993 韓國脂質學會誌 Vol.3 No.1

허혈성 대장염의 임상 양상과 예후 인자

이미숙,손희정,강태욱,최규완,박동일,백승운,이준행,고광철,이종철,임윤정,이풍렬,김갑철,김재준 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.2

Background/Aims: Colonic ischemia is recognized as the most common vascular disorder of the intestines in the elderly. The severity of the disease may vary considerably with the prevalent benign transient forms, being amenable to conservative treatments and the severe gangrenous forms, requiring surgery. Correct diagnosis is usually made after the ischemic episode is over and colonic ischemia is frequently misdiagnosed. The aim of this study is to identify the clinical patterns and prognostic factors of ischemic colitis. Methods: We found 60 patients with nonoccusive ischemia of the large intestine, We analyzed age, sex, symptoms, signs, associated disease, location, endoscopy, hematologic, histologic, radiologic finding and treatment, retrospectively. Results: The mean age was 60.2±6.3 years. The most common symtoms were abdominal pain or bloody diarrhea. The most common sign was diffuse abdominal tenderness. The most common hematologic findings were anemia and leukocytosis. Associated medical illnesses wer diabetes, rhematoid arthritis and cerebrovascular accident, et al. Both computed tomography (CT) and endoscopy were useful diagnostic tools. The most common involved site was sigmoid colon. 46 patients were treated conservatively and 14 patients were managed surgically. Conclusions: Male gender, those with rebound tenderness, severe anemia, right or total colon involvement as well as rheumatoid arthritis had a poor prognosis. Both CT and endoscopy were useful in predicting prognosis.

Dieulafoy 양 병변에 의한 십이지장게실 출혈 1 예

김상현,김경환,이동현,송철수,정노원,박상제,김은규,하홍성,나일환,황윤이,성은영,최익수,신영기 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1

Duodenal diverticula are first reported by Chomel in 1710. Duodenal diverticula are relatively common in adults with a prevalence of 23% in SRCP. The most duodenal diverticulum is asymptomatic. Complications such as obstruction, cholangitis, blliary stones, ulceration, perforation and hemorrhage can occur in approximately 10%. However, relatively few cases of bleeding from a duodenal diverticulum have been reported. The cause of bleeding from a duodenal diverticulum is uncertain and various suspected etiologies were suggested, such as ectopic gastric mucosa, stasis-induced ulceration, erosion into major vessels, aortoenteric fistuias, intradiverticujar polyp, aspirin-induced erosion. We report a case of a bleeding duodenal diverticulum by a Dieulafoy-like lesion and suggest this 1esion as one of posslble causes of blee4ng in duodenal diverticulum.

몰리브덴인산화물에서의 3- 피콜린의 가암모니아 산화반응 속도론

장태선,이동구,조득희,신채호,이영길 한국화학공학회 1997 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.35 No.3

수용액상에서 몰리브덴산암모늄염과 인산의 반응으로 P/Mo=1.0의 비율을 가진 몰리브덴인산화물을 제조하였다. 제조한 몰리브덴인산화물을 촉매로 사용하여 상압하에서 3-피콜린의 가암모니아 산화반응을 수행하였으며, 3-피콜린, 산소, 암모니아의 각각의 분압과 반응온도의 영향을 살펴보았다. 본 실험조건하에서 촉매활성은 반응 300시간까지는 계속적인 활성증가가 있었고 이후 500시간까지 안정상태를 유지하였다. 안정화 상태에서의 3-피콜린의 반응 속도식은 -r=kP₃_pP^0_(NH₃) P^γ_(o₂)[γ=0.2;0.25≤P_(o₂)(㎪)≤:5γ=0;5≤P_(o₂)(㎪)]으로 3-피콜린에 대해서는 1차, 암모니아에 대해서는 0차이었으며, 산소에 대해서는 0차와 0.2차로 구간에 따라 차이가 있었다. 3-피콜린의 전환율 증가에 따라 3-시아노피리딘의 선택도가 증가하였으며 동시에 아미드와 산의 선택도는 감소하였다. Molybdenum phosphate(P/Mo=1.0) has been synthesized with ammonium molybdate and phosphoric acid under aqueous solution. The kinetics of ammoxidation of 3-picoline over the molybdenum phosphate catalyst were investigated with the variation of reaction temperature and partial pressure of 3-picoline, oxygen, and ammonia, respectively at atmospheric pressure. The catalytic activity was increased until 300 hrs on stream and then maintained until 500 hrs on stream under our experimental conditions, At the steady-state conditions, the rate equation of 3-picoline ammoxidation was shown as -r=kP₃_pP^0_(NH₃) P^γ_(o₂)[γ=0.2;0.25≤P_(o₂)(㎪)≤:5γ=0;5≤P_(o₂)(㎪)]. The correlation between the conversion of 3-picoline and the selectivity of 3-cyanopyridine had the proportional relationship. As the selectivity of 3-cyanopyridine increases, the selectivity of amide and acid decreases.

성인에서 반복적인 위장관출혈로 발현한 공장 거대 중복성 낭종

김영호,이경수,이상수,문원,강태욱,최규완,박동일,도재혁,백승운,이풍렬,이종철,김재준,류민규 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Duplication of the alimentary tract is an unusual congenital anomaly which may occur at any level, from the oral cavity to the rectum. Jejunal duplication cyst is quite rare and most of them are presented in infancy with the symptoms of abdominal mass, obstruction, hemorrhage and perforation. But some cases has not been diagnosed till adult if duplication cyst was too small enough to cause symptoms. We report a case of a 28-year-old woman who presented with recurrent gastrointestinal hemorrhage as a result of an ulceration without ectopic mucosa in jejunal duplication cyst and was successfully treated with surgery.(Korean J Med 61:264-269, 2001)