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李慶善,尹錫山,金時泰 한양대학교 한국학연구소 1988 韓國學論集 Vol.14 No.-
The purpose of this study lies in grasping of the whole character of Korean poetry in the modernization period. As a method of research, this study divides the modernization period into two terms. Then it examines how the poetic patterns of each term originated and died away. Furthermore, this study closely examines the individual characteristics which the poetic patterns of each poetry had and focuses on comprehending the generl character of the literature in midernization period by integrading those characteristics. As a result, we come to a conclusion that literature in the modernization period has played a decisive role in laying the foundation for the full-scale modern literature in the swirl of tension between maintenance(tradition) and change(alien culture). As a preliminary to solving the task of this study, this study has surveyed the historical background of the modernization period centering on each class in charge of literature and traced how each class chose a certain pattern of poetry according to their characteristics. As a result, we came to the conclusion that the social and cultural background which are the historical requisite to the formation of the literature of the modernization period was instrumental to understanding the basic characters and forms of the literature in the midernization period.
누적외상성질환 위험 요인의 정량적 평가 및 관리를 위한 점검표 개발 : 자동차 조립 작업을 중심으로
이윤근,김현욱,임상혁,박희석 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.1
Objectives : This study was designed to develop and standardize a checklist for ergonomic risk factors, and to provide ergonomic guidelines for managing cumulative trauma disorders (CTDs) in automobile assembly lines, Methods : The Checklist for Ergonomic Risk Factors(CERF-1) was developed based on the results of previous studies, and then modified after performing pilot study. Information on the symptoms possibly related with CTDs was obtained using a self-reported questionnaire from 465 automobile assembly workers. Their job conditions were examined to assess risk factors through both direct observation and video analysis. Results : Rate of detecting risky job through CERF-1 was 85.6%, and was similar to that (88.8%) by Occupational Safety and Health Adminstration(OSHA) checklist but higher than that (63.7%) by American National Standards Institute(ANSI) Z-365. Relationship of the exposure scores derived from CERF-1 with levels of symptom was greater (r=0.49) than OSHA(r=0.28) and ANSI Z-365 (r=0.22). Considering the relationship, jobs scoring higher than 16 could be classified as the Risk Job, and lower than 16 as then Low Risk Job. Sensitivity and specificity of the Risk Job were 92.5% and 31.5 %, respectively. Odds ratio (OR) after age adjus-tment was 5.69 (95% confidence interval 3.15-10.29) for the Risk Job, and these ORs were significantly different from those of the Low Risk Job. The exposure scores were quite valid, in that the scores at the main survey were significantly correlated with those at the follow-up survey, as suggested by test-retest(r=0.88) and inter-rate reliability(r=0.80) Conclusions:The CERF-1, developed in this study, will be an efficient tool for evaluation of risk jobs for CTDs in automobile assembly lines, and can be used easily by health care providers.
다량의 하부위장관출혈이 병발된 Vibrio vulnificus 패혈증 1예
최주연,유진홍,한석원,이대훈,최민호,박순민,김연식,김선우,신완식,강문원,강성구 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2
최근 저자들은 Vibrio vulnificus 감염에 의해 패혈증 및 이차성 피부 병변을 보인 42세의 남자 환자의 치료중 하부 위장관 출혈이 병발된 1예를 경험하였기에 보고하는 바이다. We experienced a case of Vibrop vulnificus septicemia which showed an unusual manifestation such as hematochezia. The patient was a 42-year-old man with chronic liver disease. The blood and wound culture revealed the organism. During intensive care, he suffered from massive hematochezi for several days. Colonoscopy and abdominal CT showed findings suspicious of ischemic colitis. To our knowledge, this is the first unusual case of V.vulnificus infection which showed massive lower gastrointestinal bleeding.
박제선,윤경구,이주형,용석응 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-
This study was conducted to evaluate durability of concrete which are increasingly demanded recently. Concrete durability properties incorporating waste foundry sand was performed with the variable of W/C ratio, Sand/Waste foundry sand ratio and Air entrainment-Non air entrainment. Cylinder specimens were made and subjected to freezing and thawing cycle at -18℃ and 4℃. Dynamic modulus of elasticity were as F/T cycle increase. The results show that decreasing W/C ratio and AE concrete makes improved resistance of freezing and thawing improved. Especially, resistance for freezing and thawing is improved by Fine aggregate/Waste foundry sand ratio which is 50%, 25%, 0% in a row.
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Lee, Yun Sok,Li, Pingping,Huh, Jin Young,Hwang, In Jae,Lu, Min,Kim, Jong In,Ham, Mira,Talukdar, Saswata,Chen, Ai,Lu, Wendell J.,Bandyopadhyay, Guatam K.,Schwendener, Reto,Olefsky, Jerrold,Kim, Jae Bum American Diabetes Association 2011 Diabetes Vol.60 No.10
<P><B>OBJECTIVE</B></P><P>Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced insulin resistance. However, it is unanswered whether inflammation triggers systemic insulin resistance or vice versa in obesity. The purpose of this study was to assess these questions.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We fed a high-fat diet (HFD) to wild-type mice and three different immuno-compromised mouse models (lymphocyte-deficient Rag1 knockout, macrophage-depleted, and hematopoietic cell-specific Jun NH<SUB>2</SUB>-terminal kinase–deficient mice) and measured the time course of changes in macrophage content, inflammatory markers, and lipid accumulation in adipose tissue, liver, and skeletal muscle along with systemic insulin sensitivity.</P><P><B>RESULTS</B></P><P>In wild-type mice, body weight and adipose tissue mass, as well as insulin resistance, were clearly increased by 3 days of HFD. Concurrently, in the short-term HFD period inflammation was selectively elevated in adipose tissue. Interestingly, however, all three immuno-compromised mouse models were not protected from insulin resistance induced by the short-term HFD. On the other hand, lipid content was markedly increased in liver and skeletal muscle at day 3 of HFD.</P><P><B>CONCLUSIONS</B></P><P>These data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions. The early-onset insulin resistance during HFD feeding is more likely related to acute tissue lipid overload.</P>
Yun-Sok Lee 한국항해항만학회 2003 한국항해항만학회지 Vol.27 No.6
In order to keep the safety of maneuverability under the lateral berthing, it is necessary to estimate the magnitudes and properties of the hydrodynamic forces acting on ship hull quantitatively. In this paper, CFD technique is used to calculate the steady lateral force according to the water depth for Wigley model under the unsteady lateral berthing. The numerical results are analysed into the steady lateral force and the transitional lateral force, and some of reviews for the safety of maneuverability relating to the lateral berthing are discussed based on the computed hydrodynamic forces.
Identification of Ku70/Ku80 as ADD1/SREBP1c Interacting Proteins
Yun Sok Lee,Hae-Young Koh,Sang Dai Park,Jae Bum Kim 한국통합생물학회 2004 Animal cells and systems Vol.8 No.1
In vertebrates, multisubunit cofactors regulate gene expression through interacting with cell-type- and gene-specific DNA-binding proteins in a chromatin-selective manner. ADD1/SREBP1c regulates fatty acid metabolism and insulin-dependent gene expression through binding to SRE and E-box motif with dual DNA binding specificity. Although its transcriptional and post-translational regulation has been extensively studied, its regulation by interacting proteins is not well understood. To identify cellular proteins that associate with nuclear form of ADD1/SREBP1c, we employed the GST pull-down system with Hela cell nuclei extract. In this study, we demonstrated that Ku proteins interact specifically with ADD1/SREBP1c protein. GST pull-down combined with peptide sequencing analysis revealed that Ku80 binds to ADD1/SREBP1c in vitro. Additionally, western blot analysis showed that Ku70, a heterodimerizing partner of Ku80, also associates with ADD1/SREBP1c. Furthermore, co-transfection of Ku70/Ku80 with ADD1/SREBP1c enhanced the transcriptional activity of ADD1/SREBP1c. Taken together, these results suggest that the Ku proteins might be involved in the lipogenic and/or adipogenic gene expression through interacting with ADD1/SREBP1c.