기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

거대 난소 종양의 염전 1예

김미영,이해혁,유애리,박정희,이임순,정수호,고은석,레앙소팥,배동한,김태희,이권해 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

..

유방암과 섬유선종의 방사선학적 소견 : 유방 단순촬영술과 유방 초음파검사 소견의 비교 연구 Studies on mammographic and ultrasonographic findings evaluation

임한혁,최득린,고은석,이혜경,임철완,이상진,홍현숙,최교창,김영화,박재성 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose : To evaluate the utility of mammography and ultrasonography in study of morphologic differential diagnosis between malignant and benign mass. Materials and Methods : Average age of patients with breast cancer was 48.4 year-old, and that of fibroadenoma was 29.4 year-old. The equipments used for examination were MF-159 high frequency mammography(Bennet Co.) and Acoustic image 5200S. We evaluated mammographic findings about breast parenchymal pattern, calcification, margin and size of the mass associated tumor nature, and ultrasonographic findings about shape, height and width, internal homogenicity and echo pattern, wall contour, boundary echo, and posterior shadow in breast mass. Thirty-seven of mammographic findings and 34 cases of ultrasonogreaphic findings in pathologically proven breast cancer and 34 case of mammographic findings and 71 cases of ultrasonographic findings in breast fibroadenoma were reviewed retrospectively. Results : In mammographic study, the parenchymal patterns of breast cancer according to Wolfe classification were NI(16.2%), PI(24.3%), P@(37.8%), and DY(21.6%) and those in fibroadenoma were NI(3.1%), Pl(11.7%), P2(35.2%),and DY(50%). Mammographic findings about presence of calcification were as follows; only calcification(16.2%), only mass(51.3%), and mass with calcification(32.5%) in breast cancer, and only mass(91.2%), mass with calcification(8.8%) in fibroadenoma. The features of mass margins were classified as ill-defined margin(45.9%), well-defined(5.4%), and well-defined with partial spiculation(48.6%) in breast cancer and ill-defined(20.5%), well-defined(73.5%), and well-defined with partial spiculation(5.8%) in fibroadenoma. The mass were grouped by size; 1-2cm(37.8%), 2-4cm(45.9%), and 4-6cm(16.3%) in breast cancer and 1-2cm(79.4%), 2-4cm(17.6%), and 4-6cm (3.0%) in fibroadenoma. On ultrasonographic study, the shape of masses in breast cancer were lobulated(82.3%),oval(14.7%), and round(3.0%),and those in fibroadenoma were lobulated(14.0%), oval(57.7%), and round(18.3%). The cases that the height was longer than width were 32.3% in breast cancer and 0% in fibroadenoma. The findings about homogenecity and echo patterns were as follows; hypoechoic(52.9%) and mixed(47.1%) in breast cancer and hypoechoic(2.8%), hypoechoic(63.4%), and mixed(33.8%) in fibroadenoma. The margin of masses were smooth in 85.9% of fibroadenoma, and irregular in 73.6% of breast cancer. The boundary echoes of masses and decreased posterior echo shadow were seen only in 61.8% and 55.9% of breast cancer, respectively. Conclusion: The margin and calcifications are more clearly delineated on mammography but breast cancer and fibroadenoma, both are more commonly developed in dense parenchymal pattern(P2+DY),and there findings are easily obscured in mammography. So ultrasoography is very useful in these masses evaluation, especially amoung young patients.

요골 두 아탈구와 동반된 상완골 내 상과 골절 : 1예 보고 A Case Report

이한용,유기원,정진영,송주현,고해석,강용구,손문익 대한골절학회 2003 대한골절학회지 Vol.16 No.2

주관절 손산 중 상완골 내 상과 골절은 단독으로 혹은 주관절 탈구와 동반되어 발생하는 것이 일반적이다. 저자들은 15세 남자 환자의 좌측 요골 두 아탈구가 동반된 상완골 내 상과 골절을 경험하였다. 도수 정복을 시도하였으나 요골 두 아탈구의 정복을 얻을 수 없어 관혈적 정복술로 치료하엿다. 6개월추시 결과 후휴증이 없는 정상적인 관절 상태를 확인할 수 있었다. 연령, 원인 , 손상 기전으로 분석해 보면 이 동반 손상은 발생하기 매우 어렵고, 문헌 탐색 결과 현재까지 동일한 증례를 찾아볼 수 없었으므로 보고하는 바이다. It has been known that fracture of medial epicondylar apophysis of distal humerus may be isolated of associated with elbow deslocations. We have experienced a case which medial epicondylar fracture of the distal humerus was associated with subluxation of the radial head. Initially, we had tried reduction of subluxated radial head by closed method, but failed. Finally open reduction gad been performed. At 6 month after open reduction, clinical and radiological result were excellent. As it is difficult for those associated injuries to occur simultaneously and the similar cases never have been reported yet, we would like to present this case with a review of the literature.

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

The burden of symptomatic patients with chronic spontaneous urticaria: a real-world study in Korea

Young-Min Ye,Young-Il Koh,Jeong-Hee Choi,Mi-Ae Kim,Jung-Won Park,Tae-Bum Kim,Young-Hee Nam,Yoon-Seok Chang,Hae-Sim Park 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Chronic spontaneous urticaria (CSU) poses a considerable burden both on the quality of life (QoL) of individual patients and on healthcare systems. Real‑world data evaluating the disease burden of CSU are limited in this country. This study evaluated the disease burden and healthcare resource utilization (HRU) among symptomatic CSU patients. Methods: This multicenter, noninterventional, retrospective, and cross-sectional study assessed CSU patients symptomatic for more than 6 months despite step-wise H1-antihistamine medications. Primary outcomes included Urticaria Activity Score over 7 days (UAS7) and Chronic Urticaria QoL scale (CU-QoL). Secondary outcomes included EuroQol 5-Dimension 5-Level (EQ-5D-5L), Dermatology Life Quality Index (DLQI), association of disease activity with QoL, medications used for the past 6 months, and HRU. Results: Five hundred patients with CSU were enrolled. Mean disease duration was 3.7 years. Based on UAS7, 22.2% of patients were in well-controlled status and 31.2%, 28.4%, and 18.2% of them had mild, moderate, and severe disease, respectively. Mean CU-QoL and DLQI scores were 57.5 ± 29.7 and 10.2 ± 7.6, respectively, while the EQ-5D-5L utility score was 0.8 ± 0.2. H1-antihistamines were prescribed to 95% of patients, while omalizumab was prescribed to 33% of patients. Most patients (98%) had outpatient visits in the past 6 months. Negative correlations were noted between UAS7 and CUQoL, EQ-5D-5L, EQ-5D-5L visual analog scale scores, but a positive correlation was noted with DLQI score (p < 0.001 for all). The number of outpatient department visits increased with disease activity (p = 0.001). Conclusions: CSU affects QoL, leading to increased HRU, particularly in patients with severe disease.

Chemical Components and Antioxidant Active of Polygonum multiflorum Root Cultivated with Lentinula edodes Mycelals

Young-Woo Koh,Seong-Woo Jin,Hae-Shin Je,Kyung-Je Kim,Seung-Eon Ban,Seung-Bin Im,Sang-Wook Jeong,Jeong-Hoe Moon,Junseok Oh,Jae-Heoi Hong,Tae-Young Park,Kyoungsun Seo 한국버섯학회 2017 버섯 Vol.21 No.2

The purpose of this study was to expand the utility of the Polygonum multiflorum. Also, we fermented P. multiflorum by mushroom mycelial, and analyzed for chemical compositions and biological active of fermented P. multiflorum root. The crude protein content did not show a significant difference between control and fermented P. multiflorum root, crude fat, ash and crude fiber content of fermented P. multiflorum root were lower than control. The content of soluble nitrogen free extract of P. multiflorum root was significantly higher than fermented P. multiflorum root. The major amino acids of P. multiflorum root were determined the arginine. The content of arginine and glutamic acid were 586.67 mg%, and 283.78 mg%, respectively. Sixteen kinds of amino acids were detected in fermented P. multiflorum root, and the major amino acids were determined the arginine and threonine. The total amino acid contents of control and fermented P. multiflorum root were 3,469.03 mg%, and 3,630 mg%, respectively. As the results of antioxidant activity test, the antioxidant capacity of fermented P. multiflorum had a higher than the control. As the mushroom fermentation progresses, it is confirmed that the amino acid content and antioxidant capacity were increased, and it is expected to develop the product using the fermented P. multiflorum using mushroom mycelials.

어린 왕자 연구 -영원한 아이(Puer Aeternus)-

고혜영 ( Hae Young Koh ) 건국대학교 동화와번역연구소 2013 동화와 번역 Vol.25 No.-

생텍쥐페리의 『어린왕자』는 한 성인의 내면에 존재하는 어린 소년, 그리고 그 소년을 통하여 우리 모두의 내면의 영원한 아이에게 헌정되었다. 영원한 아이, 라틴어로 푸에르 에테르누스는 고대에 태모신의 아들인 소년신의 이름이다. 창조적이고 신적인 젊음을 지닌 영원한 젊은이를 뜻하는 이 용어는, 다른 한편 어머니에 대한 과도한 의존으로 어머니 콤플렉스를 지닌 젊은이를 가리키기도 한다. 사하라 사막에서 화자가 만난 어린 왕자는 그가 오랜 동안 잊고 있던 내면의 존재, 어린 시절의 소년이었던 그 자신이다. 어린 왕자의 바오밥 나무와 장미는 여성상이 무시무시한 어머니와 어머니­아내로 나뉘어 있음을 보여준다. 이 소년은 화자를 샘으로 인도하고 삶의 비밀을 전수하여 생명을 주는 존재이지만, 한편 더 이상 자라기를 거부하고 장미라는 모성상에게로 돌아가기 위해 어른들 세상에서 벗어나려는 영원한 소년이다. 그러나 화자는 이 소년 덕분에 메마른 사막에서 벗어나 생명을 얻고 사람들 사는 세상으로 간다. 『어린왕자』는 어린 시절의 이상적인 이미지와 그 부정적인 모습을 함께 보여준다. 스스로를 실현하려는 생명력의 충동과 동시에 어린 시절을 벗어나지 못하는 유치증을 모두 보여주는 어린 왕자는 우리 내면에 존재하는 영원한 아이이다. 이처럼 대극을 융합하는 상징으로서의 어린이란 일견 퇴행적 요소로 보이기도 하지만 사실은 미래로 향하는 예견이다. Le Petit Prince est dedie a l`enfant qu`une grande personne a ete, et a travers cet enfant, dans notre for interieur, a l`enfant eternel. Puer Aeternus, enfant eternel en latin, est le nom de l`enfant-dieu de la Terre-Mere de l`antiquite. Ce terme, qui designe l`enfant eternel de la jeunesse divine et creative, designe aussi un certain type de jeune homme qui a un complexe maternel associe a une grande dependance a la mere. Le petit prince que le narrateur rencontre dans le desert du Sahara est un etre interieur depuis longtemps oublie, l`enfant qu`il a ete jadis. La rose et les baobabs du petit prince montrent que l`image de la femme se dedouble ici en Mere terrible et Mere-epouse. Le petit prince sauve le narrateur en le guidant a la source vitale et lui transmettant le secret de la vie. Mais il renonce a grandir et echappe au monde des grandes personnes pour retourner a la rose qui est l`image de la mere. Mais grace a lui, le narrateur peut sortir du desert rejoindre la terre des hommes. Le Petit Prince nous presente une image ideale de l`enfance en meme temps que son aspect negatif. Le petit prince est l`enfant eternel en nous-memes qui represente la force vitale qui se realise a soi-meme et l`infantilisme de ne pas sortir de cette periode. L`enfant, comme un symbole reunissant les contrastes, est une anticipation d`un developpement a venir meme si, a premiere vue, il semble s`agir d`un agent retrospectif.

전체성의 추구와 사랑

고혜영(Hae Young Koh) 한국프랑스학회 1998 한국프랑스학논집 Vol. No.

Le drama ternel de 1`homme est celui qua constituent la condition humaine et le refus de celle-ci et de sa limitation. L`attachement 1`ternel et le dsir de s`asaimiler 1`infini s`expriment par la recherche de la vie totale. La recheche du temps perdu de Proust nest qu`un aspect dune recherche plus essentielle, qui est celle du total. Dans son oeuvre, le fragilitk du sans du moi est le thyme principal et la constation du moi ae confond avec celle de 1`espace et du temps. La fragmentation du monde extrieur implique celle du moi du narrateur. En consequence, on peut remarquer chez le narrateur 1`obsesaion d`btablir la continuitk et la totalitk qui peuvent le rendre total et int88re. La volontk du total se traduit pour le narrateur par celle de la possession univeraelle. L`amour se prsente comma le premier moyen de raliser cette volontk en le faisant sortir de lui-mime et participer aux nouveaux mondea. Pour lui, 1`amour est un fbtichiame du voyage qui rend possible la multiplication de lui-mime. C`est 1`exotiame, le dpaysement, une sorte de mi8ration mtaphysique d`un monde vets un sutra. En poss~dant 1`tre aims, il pourrait raliser ce voyage mtaphysique. Mais, on ne peut pas poss~der comphtement 1`tre aims. Parce qu`on ne peut pas occuper tousles points de 1`espace et du temps de 1`autre. On est toitjours absent des fragments de sa vie. Ici, 1`amour se confond avec la jalousie, parce qu$quot;elle exprime 1`impossibilitk de coincides avec 1`etre aims. L`autre, dissmin dans le temps et daps 1`espace. chappe toujours la possession. Alors: travers 1`exp~rience de 1`amour, le narrateur s`aperoit que 1`espace et le temps sont les conditions de 1`absence et de la separation. Mais paradoxalement, par la jalousie qui est negative et funeste premiere vue, on peut raliser 1`expansion du moi. L`imaBination investigatrice et inquite stimule par la jalousie donne a 1$quot;univers la varitk et la profondeur, en devinant toute une srie des vies possibles de 1`etre aims. Et la douleur cause par la jalousie fait vivre toutes ces vies possibles comme plus intenses qu`aucune vie relle. Alors, pensant ~ tous les lieux ou a vEcu Albertine, d tous les instants qui ont compost la vie d`Albertine, le narrateur dit : (L`amour, c`est I`espace et le temps rendus sensibles au coeury