임플란트의 표면처리 유형에 따른 골 치유 양상

고영한,김영준,정현주 전남대학교 치과대학 2001 구강과학 Vol.13 No.1

It is well known that the apposition of bone at implant surface would be influenced by the microstructure of titanium implants. The purpose of this study was to compare bone healing around the screw­shaped titanium implant with three different surface topographies in the canine mandibles by histological and biomechanical evaluation. All mandibular premolars of six mongrel dogs were extracted and implants were placed one month later. The pure titanium implants had different surface topographies: smooth and machined (Steri­Oss^ⓡL Group Ⅰ): acid­etched (Osseotite^ⓡ: Group Ⅱ); sandblasted and acid­etched (ITI^ⓡ, SLA: GroupⅢ) surface. The fluorescent dyes were injected on the 2nd (calcein), 4th (oxytetracycline HCI) and 12th (alizarin red) weeks of healing Dogs were sacrificed at 4 and 12 weeks after implantation. The decalcified and undecalcified specimens were prepared for histological and histometrical evaluation of implant­bone contact. Some specimens at 12 weeks after implantation were used for removal torque testing. Histologically, direct bone apposition to implant surface was found in all of the treated groups. More mature and dense bone was observed at the implant ­ bone interface at 12 weeks than that at 4 weeks after implantation. Under the fluorescent microscope, thick regular green fluorescent lines which mean early bone apposition were observed at the implant ­ bone interface in Group Ⅲ, while yellow and red fluorescent areas were found at the implant ­ bone interface in Group Ⅰ and Ⅱ. The average implant ­ bone contact ratios at 4 weeks of healing were 54.3% in Group Ⅰ, 57.7% in Group Ⅱ and 62.2% in Group Ⅲ. In Group Ⅰ, implant ­ bone contact ratio was significantly lower than Group Ⅱ and Ⅱ (p<0.05). The average implant ­ to ­ bone contact ratios at 12 weeks after implantation were 64.3% in Group Ⅰ, 66.7% in GroupⅡ, and 71.2% in GroupⅢ. There was no significant difference among the three groups. In Group Ⅰ andⅡ, the implant ­ bone contact ratio at 12 weeks increased significantly in comparison to ratio at 4 weeks (p<0.05). The removal torque values at 12 weeks after implantation were 90.9 N㎝ in Group Ⅰ, 81.6 N㎝ in GroupⅡ and 77.1N㎝ in GroupⅢ, which were significantly different (p<0.05). These results suggest that bone healing begin earlier and be better around the surface ­ treated implants compared to the smooth surface implants. The sandblasted and acid ­ etched implants showed the most favorable bone response among the three groups during the early healing stage and could reduce the waiting period prior to implant loading.

흉요추부 굴곡-신연 손상에서 척추체의 골절 양상

고영도,김종오,윤여헌,유재두,정준모 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 흉요추부 굴곡-신연 손상에 동반되는 척추체의 골절 양상을 알아 보고자 하였다. 대상 및 방법 : 흉요추부 굴곡 - 신연 손상 21례의 방사선 검사를 검토하여 골절된 척추체의 위치, 전후방 추체 높이, 손상된 분절의 후만각, 척추체 골편의 척추관내 침범 정도 및 척추체의 분쇄 정도를 관찰하였다. 결과 : 총 21례 중 압박 골절이 11례, 방출성 골절이 9례 있었다. 척추체 골절은 85%에서 굴곡-신연 손상된 분절내에서 하부 척추체에 위치하였다. 전방 추체 높이는 평균 27% 감소하였고, 압박 골절이 동반된 경우 18%, 방출성 골절이 동반된 경우 40% 감소하였다. 후방 추체 높이는 평균 1% 감소하였고, 압박 골절이 동반된 경우 1% 증가하였으며, 방출성 골절이 동반된 경우 4% 감소하였다. 손상된 분절의 후만각은 평균 19.5도이었고, 압박 골절이 동반된 경우는 15.4도, 방출성 골절이 동반된 경우는 26.8도이었다. 방출성 골절이 동반된 9례 중 골편의 척추관내 침범은 평균 27%이었으며, 척추체의 분쇄 정도는 71.4%에서 경미하였다, 결론 : 흉요추부 굴곡-신연 손상에서 척추세의 골절은 매우 흔하며 분절내 하부 척추체에 호발하였다. 가해진 힘에 비하여 전후방 추체 높이의 감소, 척추관내 침범 및 분쇄 정도가 적었으며, 이는 굴곡력이나 축성 부하의 효과가 신연력에 의해 일부 상쇄되었기 때문이다. Purpose : To evaluate the configuration of vertebral body fractures in flexion-distraction injuries of thoracolumbar spine. Materials and Method : We investigated the location of fractures, anterior or posterior vertebral body height, kyphotic angle of injured segments, canal encreachment and severity of comminution on radiologic examinations of 21 cases. Result : There were 11 compression fractures and 9 burst fractures. 85% of fractures were located in the inferior vertebrae of injured segments. Anterior vertebral height decreased by 27% on average with decrease of 18% in compression fractures and 40% in burst fractures. Posterior height decreased by 1% on average with increase of 1% in compression fractures and decrease of 4% in burst fractures. The average kyphotic angle of injured segments was 19.5˚ with 15.4˚ in compression fractures and 26.8˚ in burst fractures. The canal encreachment in 9 burst fractures was 27% on average, and the comminution of vertebral body was mild in 74%. Conclusion : The fracture of vertebral body in flexion-distraction injuries of thoracolumbar spine was very common, and located on the inferior vertebare of injured segment. The decrease of vertebral height, canal encreachment and severity of comminution was relatively less than the estimated from mechanism of injury, with offset effect of distraction force.

규소에 있어서 붕소의 확산에 대한 2차원적 수치해석 모델

고관영,송준호,윤석길 울산대학교 1992 공학연구논문집 Vol.23 No.2

본 연구에서는 불활성 분위기에서 규소에 대한 붕소의 예비석출과 주입에 대한 확산모델을 세워 수치해석법으로 최종 농도분포를 계산하였다. 확산계수의 모델로서는 공공기구를 사용하였으며, Fair모델을 사용하였다. 붕소의 표면농도는 내삽법에 의해 구하였다. 확산 방정식의 선형화 방법으로는 유한 차분법을 사용하였으며, 해법으로는 Stone의 SIP 방법을 적용했다. 시뮬레이션 결과와 실험치의 비교로부터 제시된 모델의 유효성을 확인하였다. In the present work, the final impurity distributions in silicon through boron diffusion processes in inert atmosphere were calculated using computer aided numerical analysis methods. The diffusion coefficients of substitutional impurities were modeled with vacancy mechanism. It is assumed that the boron diffusion is governed by Fair model. The surface concentration of boron was approximated by the interpolation. For the linearization of diffusion equation the finite difference method was utilized. For the linearization of diffusion equation the finite difference method was utilized. For the solution of the resulting simultaneous equations the strong implicit procedure by Stone was used. It is observed that the simulated results of boron diffusions have been well-fitted to the experimental results.

結核病棟 入院患者 喀痰에서 分離한 Nocardia屬의 同定과 藥齋 減受性에 關한 實驗

高春明,金駿杰,李正碩,李一善,李沅泳 최신의학사 1974 最新醫學 Vol.17 No.9

This study was. carried out for the identification and drug susceptibility of Nocardia species iso?lated from the sputum of pulmonary tuberculosis patients at Severance Hospital from May, 1973 to May, 1974. The results as follows: 1. Among the 138 experimental specimens, eleven of the Nocardia species were identified by the methods of direct microscopic observation and culture characteristics. 2. Of the eleven Nocardia species, 6 of the Nocardia species were identified N. asteroides, 3 of the N. brasiliensis and 2 of the strains could not identified with a ordinary methods. 3. Antimicrobial activity of experimental strains to the several antibiotics, Ampicillin, Oxacilin and Cloxacillin were excellent against to the tested groups and Streptomycin, Chloramphenical and Gantrisin were also moderated effective to the experimental group.

Minicell 분리에 관한 연구

고재문,김종세,김성준,노영복 조선대학교 기초과학연구소 1989 自然科學硏究 Vol.12 No.1

Minicell은 간상 박테리아의 극단에서 변이 세포분열에 의해 생산되는 작은 비성장체이다. 그것은 protein이나 RNA를 함유하나 chromosomal DNA가 조금 있거나 거의 없고 모양은 구형이다. 본 실험을 통해 얻은 결론은 다음과 같다. A. Minicell 생산이 왕성한 x1411 균주를 12시간 배양한 후 optical density는 ML media=0.25, M9 minimal media=0.5, x1776 broth media=0.7, 3×D media=0.9, LB media=1.0으로 나타났다. B. x1411 균주와 pOX7의 형질전환율은 2×10^5개/㎍·DNA로 나타났다. C. 변형된 방법에 의해 분리되어진 minicell양은 1.8×10^4cells/㎖로 나타났다. D. Minicell의 중심부와 극단에서 생성된다는 보고와는 달리 본 실험을 통한 관찰 결과 minicell은 중심부에서는 생성되지 않고 극단에서만 생성된다. E. 전자현미경을 통한 관찰 결과 host cell과 minicell의 크기비는 10:1 정도며, 모양은 host cell은 간상이고 minicell은 구형이다. Minicells are small non-growing bodies produced by aberrant cell divisions at the polar ends of rod-shaped bacteria. They are anucleate, contain RNA and protein but little or no chromosomal DNA fragment and approximately spherical in shape. The results are summarized as follows ; A. After culturing 12 hours, cell density of typical minicell-producing χ 1411 strains appeared to 0.25 in ML media, 0.5 in M9 minimal media, 0.7 in χ 1776 broth media, 0.9 in 3XD media and 1.0 in LB meda. B. The transformation rates between χ 1411 strains and pOX7 plasmid were 2×10^5 in each ㎍. DNA. C. Isolated minicells with modified method were 1.8×10^4 in each ml. D. some papers reported that minicells are produced at the polar ends and the central part, but in this experiment minicells were only produced at the polar ends. E. The results of observation with E.M. ; the ration of cell size between the host cell and the minicell was about 10 : 1, host cell was rod type in shape and minicell spherical type.

기능성 소화불량증에서 증상에 따른 고형식의 반위배출시간의 차이

김영호,이풍렬,성인경,손희정,김재준,고광철,백승운,이종철,최규완 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

치과용 세라믹스의 제조 및 특성 (Ⅰ)

고영호,한복섭,이준희 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.2

It has been investigated the Sintering Characteristics and Microstructure after the Manufacture of Dental Ceramics for Artificial Dental Tooth(Dental Crowns) in Dentistry. The Manufacture of High Thermal Expansional Leucite Crystals has been made by not Conventional Melting Process, but Sol-Gel Process, and composited with Class Frit that has low melting point to get Transparent Sintering Materials. The Crystal Forming Temperature of Leucite manufactured by Sol-Gel Process has been observed after Heat Treatment at various Temperatures. In Addition, The Manufacture Process is simpler than Conventional Melting Process and could be able to manufacture at about 400℃ low Temperature. Glass Frit that has low melting point was fabricated with about 10~30㎛ homogeneous amorphous Powders by means of Ball Milling and was transparent When fired. The Sintering Temperature could be controlled in accordance with the Powder Mixture of Leucite and Glass Frit. The Volume Fraction of Leucite Crystals in Glass Matrix has been increased by the appropriate Heat Treatment of Dental Porcelain.

γ-선 조사에 의한 연신된 선형저밀도 Polyethylene의 열자극 전류

김영전,이기선,이종규,고병준 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.2

We observed three TSC peaks at the temperature of 33℃, 42℃ and 58℃ from linear low density polyethylene which had been excited by γ-ray or electric field . Especially further experiment on elongated sample showed that the peak at 42 ℃ increased until the draw ratio reached 200%, but decreased above 200%. These peaks are closely related to the traps of the crystalline, amorphous and crystal interfacial regions. As a result of elongation non-uniformity of molecular chains caused physical cavities at the crystal interfacial region. Therefore the depth of the trap changed and the rate of the release of the carriers were increased. Because of the elongation the splitted phenomena of the lamellae structure of the sample has been suggested by the infrared absorption spectra of the elongated linear low density polyethylene film at the room temperature.

관동맥 스텐트 삽입후 발생한 스텐트 변연부 박리의 예측인자 및 추가적 치료후 임상적 의의에 관한 연구 : Predictor, Angiographic and Clinical Follow-up after Additional Procedures

두영철,박수종,김재삼,이준호,홍경순,박대균,한규록,오동진,유규형,임종윤,고영박,이광학,이영 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.