Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

편의점(CVS)의 포장디자인 전략에 관한 연구

최영규,김용우,김현철 서울保健大學 1997 論文集 Vol.17 No.1

Recently according to the individualization and differentiation in consumers` lifestyles, there are many changes in the distribution types of products. Especially owing to the increase of women in the work force, the single population and the night active population, in the past few years the rapidly growing convenience stores are becoming fixture in our society as a popularized retailer. Accordingly, going beyond the primary role of preserving contents and protecting quality, package design at a convenience store, on the premise of it being self-service, serve as a means of sales promotion strategy, to induce the purchase by communicating information and favorable image to the consumer. Developing package design with consideration to these special features of a convenience store must be improved by satisfying the following points: · to produce positive corporate image by developing private brands for a differentiation strategy. · to induce impulse buying owing to direct advertising by developing package designs which considers P.D.P. functions. · to stimulate the consumers` desire to purchase and to revitalize the store atmosphere by package design which maximizes effects of the displays. · to produce brand logotypes that has outstanding communicative properties and that can be long remembered. · to develop a color strategy which suggests a product's features, can touch the consumer's sensibility, and can minimize stress to the eyes. · to produce a systematic layout which leads to visual order of detail design elements.

신비체험과 해리성향과의 관계

최낙경,이상혁,우용일,이만홍,현용호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

신비체험은 종교의 핵심경험이라고 일컬어질 만큼 종교계에서 가치 있게 평가되고 있으며 여러 사회집단에서도 관심의 대상이 되어왔다. 오래 전부터 심리학자들과 정신의학자들이 신비체험에 대해 관심을 가져 왔지만 그것의 개인적이고 주관적인 특성 때문에 과학적인 접근이 어려웠으며 단지 신비체험의 특성을 나열하고 묘사하는데 그쳤다. 최근 일부 정신병리학자들은 신비체험을 해리현상의 하나로 보는 주장도 있다. 한편 해리는 어린 시절의 외상경험과 연관이 있고 정신병리가 많을수록 해리경향성이 높아진다는 보고가 있어 왔다. 본 연구는 종교인중 신비체험을 경험하지 않은 사람(비신비체험군) 35명을 대조군으로 하여 종교인중에서 신비체험을 경험한 사람(신비체험군) 42명과 해리경향성, 정신병리, 외상경험을 비교하였다. 연구도구로는 한국어판 해리경험 척도, 간이정신진단검사, 외상유무를 묻는 질문지를 이용하였다. 그 결과, 해리경향성은 신비체험군이 비시비체험군보다 유의미하게 높았으며 외상경험도 유의미하게 높게 보고하였다. 그러나 정신병리상의 두드러진 차이는 발견되지 않았다. Mystic experience is highly evaluated so as to be called as core of experience in the religious world and also becomes the subject of concern among various social groups. Psychologists and psychiatrists are concerned about it, but because of its individuality and subjectivity, the scien-tific approach was difficult so that only the description of mystic experience has been researched fo far. There is a current report saying that mystic experience is the one of the dissociative pheno-menon. And there are a lot of reports saying that dissociation is related to childhood trauma experience and rises as much as psychopathological tendencies exist. Consequently, based on the reference that mystic experience is connected with dissociation, the study has been progressed to find out the level of dissociation, psychopathology and trau-ma experience for religious people who experienced mystic experience but excluding patients. Among them, it has been compared between group of non-mystic experience(n=35) and group of mystic experience(n=42). We used Dissociative Experience scale-Korean version(DES-K), Symptom Checklist-90-Revised(SCL-90-R), questionnaire about trauma. The result is that the group of mystic experience had a significantly higher tendency to have dissociation and trauma experience than group of non-mystic experience. However, the differ-ence of psychopathology has not been found.

비정상 질확대경검사 소견을 보이는 환자에서 환상투열요법의 직접적 적용에 관한 연구

우헌탁,이철민,박교훈,조용균,최훈,김복린,이홍균 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: Large Loop Excision of the Transformation Zone (LLETZ) has been widely used for evaluating cervical dysplasia/cancer. We performed this study to evaluate if colposcopically suspected cervical high-grade dysplasia or cancer could be directly evaluated and treated with LLETZ. Methods: 93 women who were scheduled for colposcopic evaluation because of an abnormal cervical cytology report were included in the study in Sanggye Paik Hospital from Jan to Dec 2001. Mean age of the study population was 38.6±9.0. colposcopy directed punch biopsy was not performed and histologic diagnosis was made by LLETZ. Sensitivity and specificity of colposcopic evaluation was calculated and compared with those of cervical cytology. Results: On histopathological examination by LLETZ, 11(11.8%) patients had invasive cancers including 3(3.2%) adenocarcinomas. The sensitivity and specificity of colposcopy for the detection of cervical dysplasia or cancer was 71.7% and 72.3% respectively, wile those of cytology was 56.5% and 74.5% respectively. Conclusion: LLETZ may be adequately performed for the diagnosis and treatment of cervical dysplasia/cancer based on the results of pap smear and colposcopy without punch biopsy. Cost benefit might be anticipated while cost-effectiveness analysis is necessary in the future.

PCR을 이용한 국내 및 수입 축산물 유래 Listeria monocytogenes의 유전학적 분석연구

우용구,이수화,이철현,최정수,류재두,김영일,이오수,김봉환 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.2

One hundred-fifty two of Listeria strains were isolated from domestic chicken carcasses, a slaughter-houses from nationwide from 1996 to 1997 and imported livestock products from a ten foreign countries including the USA, China, France and Thailand. To substitute the laborious and time consuming procedures of clinical laboratory standard diagnostic methods, the rapid and specific multiplex PCR(M-PCR), which was designed to amplify a three kinds of genes simultaneously f3r specific detection and differentiation of L. monocytogenes(LM) by one step procedure, was established. The LM strains confirmed with M-PCR were analysed to their genetic diversities by RAPD using the two primers(D87 & MMTl), and also evaluated on their discriminatory abilities(na) between two primers. our study also conducted the REP-PCR and ERIC-PCR for evaluation of the possibility of REP and ERIC elements for genetic subtyping of LM strains. According to the REP-PCR and ERIC-PCR fingerprinting patterns, LM strains were divided into 7(ERIC-type) and 4(REP-type) major clusters at the relative clone cut off value of 80%. According to the computer analysis of PCR results using the GelCompar Ⅱ software, ERIC-PCR(DI=0.955) had expressed the most high discriminatory ability and followed by REP-PCR(DI=0.952), RAPD(D87; 0.954, MMT1; 0.937), in order. The combined analysis of the present PCR results was also expressed the reliable and useful discriminatory ability(DI=0.916). This study suggested that PCR based methods could be used as an reliable, reproducible, rapid, and highly discriminatory method for the genetic differentiation of genus Listeria.

현성 당뇨병이 없었던 알코올 간경화증 환자에서 발생한 공기증신우신장염 1례

최재혁,이용국,김강,김준섭,강혁주,탁우택,이정호,구관민 東國大學校醫學硏究所 2007 東國醫學 Vol.14 No.1

공기증신우신장염은 신실질의 괴사와 자발적인 공기 형성과 연관된 드문 감염질환이다. 대부분 혈당이 잘 조절되지 않는 당뇨 환자들에게서 발생하며 드물게 요로 폐색, 요로 결석, 종양 등에서도 발생한다. 과거 초기의 수술적 치료가 우선시 되었으나 최근에는 항생제 및 조기 진단으로 인해 내과적 치료만으로 성공한 사례가 증가하고 있다. 저자들은 현성 당뇨병이 없었던 알코올 간경화증 환자에서 발생한 공기증신우신장염을 내과적 치료 및 경피적 배농술만으로 치료한 예가 있어 보고하는 바이다. Emphysematous pyelonephritis is an uncommon infection of the kidney associated with parenchymal necrosis and spontaneous gas formation. Most cases occur in diabetic patients and rarely in urinary tract obstruction, stone or tumor. At past, surgical treatment was prior to internal treatment, but recently, successful cases of internal treatment have increased because of the development of antibiotics and early diagnosis. We report an emphysematous pyelonephrtis in 61 years-old non-overt diabetic woman with alcoholic liver cirrhosis, successfully treated by antibiotics and percutaneous drainage.

당뇨병 환자의 사례관리 실시 전후 혈당 및 자가관리 이행수준 변화

최용우,이용환,전만중,유병철 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : Diabetes mellitus is one of the common chronic disease in Korea. As most chronic diseases need continuous cares and behavioral controls, one of the effective managements for diabetes is maintenance healthy life style which is based on correct medical knowledge. So, we conducted this study to assess change of blood sugar levels and self-management behavior of diabetic patients following the case-management program enforced by National Health Insurance Corporation (NHIC). Methods : We conducted this study during the period from January 2006 to December 2006, 29 case managers performed the case management program for 672 diabetic patients in the districts of Busan, Woolsan, and Gyeongnam. We evaluated the effectiveness of the case management program based on the changes of blood sugar level, knowledge for diabetes and self-management behavior of diabetic patients. Data analysis was performed with t-test, paired t-test, McNemar X2-test and correlation analysis using SPSS program(ver 12.0). Results : After the case management program, smoking rate was reduced from 22.3% to 21.4% and exercise rate was increased from 65.0% to 80.2%(p<0.05). The knowledge standard of diabetics on 10-point scale revealed considerable increase from 6.05 before the management to 8.69 after the case management(p<0.05). All of diabetic self-management behaviors including nutrition management, self-test on blood sugar level, foot care, oral care and diabetic medication showed considerable improvement; the overall behavioral change, on a 5-point scale, improved from 3.25 to 3.75(p<0.05). The FBS level was improved from 138.4mg/dl to 131.5mg/dl and the blood sugar level 2 hours after a meal was improved from 203.7mg/dl to 183.5mg/dl(p<0.05). Conclusion : From the above results, we concluded that the case management program enforced by the NHIC showed positive behavioral changes on smoking and exercise, increased knowledge about diabetes as well as the level of nutrition management and also demonstrated decline of blood sugar levels. So, we need research of customized information for every patients rather than generally summarized information on diabetes and a self-dependent group formations for sustaining improved self-management after case management as well as development of education and training programs for case managers.

가막만 패류양식장의 수질 및 저질특성

최철웅,문성용,윤호섭,라성주,한종석,최상덕,이우범 國立 麗水大學校 環境問題硏究所 2002 環境硏究論文集 Vol.5 No.-

This study was performed to characterize the seasonal fluctuation of water quality and sediment environment from April, 2001 to November, 2001 in Gamak bay. Which was a productive area, but recently its fisheries conditional have been deteriorated because of increasing waste-water from municipal area, industry and autochthonous pollution by farm industry. In the survey of seawater quality, DO and COD concentrations were lowest in bottom layer at summer, but DIN and DIP contents were higher than those in surface layer. Eutrophication indices mean that eutrophication area move from south to north entrance via northern-west inner area with seasonal change from summer to autumn. In the survey of sediment environment, ignition loss(IL), chemical oxygen demand(COD), DIN and Dip were in the range of 3.8~15.7%, 10.3~60.6mg/g-dry, 5.053~1.810mg/ℓ and 0.065~0.324mg/ℓ , respectively. COD in sediment were highest at winter and spring. And, they were higher than sediment standard in the south inner area, which mean heavily polluted conditions with organic constituents.

Aluminium板의 環境破壞에 關한 基礎的 硏究

崔壯宇,金榮萬,李龍福 弘益大學校 1982 弘大論叢 Vol.14 No.2

It is known that the most of Enviroment Assisted Fracture affected remarkably by the various environmental effect are brittle fracture, and that the above field is very wide. In this paper, Environment Assisted Fracture is discussed from the view point of fracture mechanics. Aluminium and SUS304 Stainless Steel in solutions of several percentage of MgCl₂(10%, 15%, 20%) at the temperature(60℃±3℃)is investigated according to the crack growth, and the value of K is compared with the K obtained by the changes of deflection according to the crack growth. THe results of the experiment is summarized as following 1)The tendency of crack growth as time goes by is shown as 4 region in both materials. 2)The experimental value of K of SUS304 Stainless Steel is same as the calculated value from the variation of the compliance according to crack growth, but not in Aluminium.

單層 空心 코일 間의 結合係數의 特性에 關한 硏究

崔宇勝,李鎔求,金周弘 동국대학교 산업기술대학원 1993 산업기술논문집 Vol.1 No.-

The measurement method using voltage ratio is able to measure a coupling coefficient k which is a parameter of power transmission between coils. We verified that the coupling coefficient k between couples of the similar coil with different size equal reciprocally and the coupling coefficient k between two coils on the same axle differ little from the mutual diameter ratio. The coupling coefficient k on the distance between the center point of coils have linear change characteristics.