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경막외 차단 후 합병증으로 오인된 다발성 흉추 전이 암 - 증례 보고 -
최용우 대한마취통증의학회 2007 Anesthesia and pain medicine Vol.2 No.3
We report here on a case of a patient who developed paraplegia after thoracic epidural block that was done for the management of postherpetic neuralgia, and the patient was later diagnosed with spine metastasis from prostate cancer. This patient developed paraplegia of both lower extremities 2 weeks after the epidural block. We took X-ray and performed MRI of the thoracic spine for the differential diagnosis of paraplegia associated with herpes zoster, complications of epidural block or other diseases. The diagnosis of the paraplegia was spinal cord compression at T8, and this was caused by metastatic tumor that originated from prostate cancer. When we encounter paraplegia after epidural block, we should also consider other diseases as well as the complications of epidural block like direct neural damage, abscess and hematoma. Especially when there is the possibility of cancer, early detection, an accurate diagnosis and timely treatment can provide the best chance to ameliorate further medical consequences and optimize the quality of life.
MXene-Based Biosensor with PEDOT:PSS for Detecting Concentration of Cortisol Based on EIS
최용우,유필진 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Cortisol which is should be controlled and measured condignly is a stress hormone. In this research, cortisol biosensing electrode including PEDOT:PSS/MXene was fabricated. Metallic MXene shows outstanding electrical conductivity and biocompatibility has been attracted attention as a one of next generation of 2D material. PEDOT:PSS was brought to develop electrostatic interaction and in order to attach MXene into substrate. In order to attach antibody to MXene, functional groups of MXene should be modified. Hydroxy group, one of functional group of MXene, can be reacted with oxalic acid. Then, carboxyl groups on modified MXene(m-MXene) can be reacted with amino groups forming amide bonding through EDC chemistry. Finally, passivation with BSA to prevent non-specific binding was implemented. EIS indicates outstanding performance in selectivity and sensitivity. This research suggests that MXene could be employed as a new type of biosensing platform.