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알레르기성 비염 환자에서 절지동물성 특이항원의 양성율 및 항원간 일치율
황규윤,남해선,박준수,권준택,백병준,김장묵,오천환,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied. 1. The overall positive rate among 35 specific allergens was 59.4% (95 patients). 2. The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate. 3. Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0% (72 patients), 43.1% (69 patients), 28.1% (45 patients), and 8.8% (14 patients), respectively. 4.Significant agreement between arthropod allergens was observer (P < 0.05). 5. The obseved agreement between Df and Dp was 95.6%, showing most significant Kappa index (Kappa = 0.911, P < 0.001). There results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.
腦動脈瘤 患者에서 血淸 LDL, Total cholesterol, Phospholipids 및 HDL cholesterol 의 動態
黃性守,朴淵默,金乘來 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2
지주막하 출혈을 일으킨 뇌동맥류 환자에서 혈청 LDL, total cholesterol, phospholipids 및 HDL cholesterol치를 분석, 정량하여 정상 대조군과 비교, 검토하였다. 뇌동맥류 환자에서 혈청 LDL과 total cholesterol의 평균치(mean±SE)는 각각 286±21㎎/㎗ 및 215±10㎎/㎗로써 대조군에 비하여 상승치를 나타내었으며 내경동맥류에서 현저 하였고 신경학적 장애 소견이 심한 군에서 현저히 상승되어 있었다. 그리고 혈청 phospholipids의 평균치는 149±8㎎/㎗로써 신경학적 장애 소견에 관계없이 대조군에 비해 현저히 감소되었고 내경동맥류와 중대뇌동맥류에서 현저하였다. 뇌동맥류 환자에서 혈청 HDL cholesterol의 평균치는 29±2㎎/㎗, total cholesterol에 대한 HDL cholesterol의 백분비 평균치는 15.1%로써 대조군에 비해 차이 있는 변화는 없었다. On the intracranial aneurysmal patients with subarachnoid homorrhage, serum lipid and lipoprotein values, including LDL, total cholesterol, phospholipids and HDL cholesterol level, were studied. Mean values (mean±SE) of serum LDL and total cholesterol level in aneurysmal group were 286±21㎎/㎗ and 215±10 ㎎/㎗ respectively, showing higher level than those from normal control group, and the levels were more elevated in aneurysmal patients of internal carotid artery and aneurymal patients with severe neurological disorders such as grade 3,4 according to Botterell's classification. In aneurysmal group, serum phospholipids level was decreased remarkably by 149±8 ㎎/㎗ in mean value, compared to control group, and it showed no relationship with neurological deficits. However, it was decreased more in patients with aneurysm of internal carotid and middle cerebral artery. In aneurysmal group, mean value of serum HDL cholesterol level was 29±2㎎/㎗ with percent of HDL cholesterol to total cholesterol, 15.1%. The findings showed no significant difference between aneurysmal and control group.
( Sang Muk Hwang ),( Ji Hyun Yang ),( Sang Kyung Jo ),( Myung Seok Lee ),( Sang Hoon Park ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Acute kidney injury (AKI) is the most frequent and devastating complication in cirrhotic patients. Emerging evidences suggest that novel biomarkers could predict AKI earlier than conventional markers and better predict prognosis in these patients. To determine the incidence and prognosis of AKI in acutely decompensated cirrhotic patients and also test whether plasma cystatinc C, urine neutrophil gelatinase associated lipocalin (NGAL) or tissue inhibitor of metalloproteinase-2 (TIMP-2), insulin like growth factor 7 (IGFBP7) could predict the development of AKI and prognosis. Methods: This is a single center prospective observational study conducted between May 2015 and Dec. 2017 with acutely decompensated cirrhotic patients. AKI was defined by KDIGO (Kidney Disease Improving Global Outcomes) criteria and urine and plasma samples were collected at the time of admission. Performances of novel biomarkers as well as various functional, clinical parameters were compared. Results: Of 111 patients, 45 (40.5%) developed AKI during hospitalization and these patients showed significantly higher mortality (25% vs. 46.5%, P=0.02). Although initial BUN and serum creatinine were not different, plasma cystatin C and urine NGAL at the time of admission were significantly increased in patients who developed AKI and also death. Plasma cystatin C and urine NGAL were independently associated with the development of AKI after adjusting for clinical variables including age, co-morbidity and Child-Pugh score. [plasma cystatin C, odds ratio (OR) 2.09; 95% confidence interval (CI), 1.01- 4.35), urine NGAL, OR 1.04, CI 1.01-1.05]. Although these biomarkers failed to predict mortality independent of clinical variables, urine NGAL significantly improved the accuracy of MELD in predicting mortality. Conclusions: Novel biomarkers including plasma cystatin C or urine NGAL might be useful in earlier diagnosis of AKI and also in predicting mortality in acutely decompensated cirrhotic patients.
도시환경에서의 범죄예방 활동 지원을 위한 GIS 기반 지역방범지수 개발
석상묵(Sang-Muk Seok),권회윤(Hoe-Yun Kwon),송기성(Ki-Sung Song),이하경(Ha-Kyung Lee),황정래(Jung-Rae Hwang) 한국컴퓨터정보학회 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.1
In this study, we proposed GIS-based Regional Crime Prevention Index (RCPI) development method designed to support local governments with systematic crime prevention activities. The public interest in safe urban environment is increasing rapidly. The government is putting efforts into crime prevention activities to eliminate the criminal opportunities in advance. CPTED is method to prevent crimes in the city by improving environmental factors that cause crime. It is used by local governments to promote the crime prevention activities centering on the expansion of CCTVs and street lamps and the improvement of street environment. However, most policies were terminated as one-off programs and it is necessary to monitor the effect of such policies on a continuous basis. In order to alleviate issues, this study proposed RCPI as part of crime safety assessment in urban environments. The estimation of RCPI in City A of Gyeonggi-do showed relative differences in 31 districts (dong), indicating that it is also possible to evaluate the crime safety in the local community on the level of the administrative dong, the smallest administrative district in the urban environments. As a crime map, the RCPI will be used effectively as he reference to support the decision making process for local government in the future.