GMAHN 환경에 적응하는 에러 복구기능을 이용한 AODV 라우팅 프로토콜

정찬혁,오세덕,배진승,이기원,장양근,이광배,김현욱,유충렬,하재승 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

Mobile nodes in ad hoc mobile networks typically communicate over wireless channels and are capable of movement. These are networks that support multihop communication and can be formed on a temporary basis. This paper proposes a solution that allows mobile nodes to access the wired Internet and to roam from base station to base station. And we also develop the efficient method that adapts in Global MANET which can be changed over time. It is observed that we can reduce not only error detection time but also network load, thus increasing the data reception rate in Global MANET Environment.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.

과산화수소의 농도와 적용시간이 상아질의 깊이에 따라 레진 수복물의 미세인장결합강도에 미치는 영향

손정룡,이계영,강유미,오영택,이광원,김태균 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.5

본 연구의 목적은 심부 상아질과 치수실 상아질에 H₂O₂를 각기 다른 적용시간과 농도로 적용하였을 때, 레진수복물과의 미세인장결합강도에 미치는 영향을 평가하는 것이다. 준비된 각각의 치아에 전형적인 근관와동을 형성하고 다음과 같이 무작위로 1개의 대조군과, 4개의 실험군으로 나누었다: 1군, 전처리를 시행하지 않았다; 2군, 20% H₂O₂를 20분, 10분, 5분간 적용하였다; 3군, 10% 를 20분, 10분, 5분간 적용하였다; 4군 5% H₂O₂를 20분, 10분, 5분간 적용하였다; 5군, 2.5% H₂O₂를 20분, 10분, 5분간 적용하였다. 위와 같이 처리한 후 와동 내를 Superbond C&B(Sunmedical, Co., Shiga, Japan)로 충전하였다. 각 치아는 증류수에 24시간 저장한 뒤 심부 상아질과 치수실 상아질로 잘라 미세인장결합강도 시험을 시행하였다. 각 군에서 측정된 미세인장결합강도를 3-way ANOVA와 Tukey post hoc test로 통계 처리하였다(p < 0.05). 실험 결과 모든 군에서 심부 상아질(D1)의 미세인장 결합강도가 치수실 상아질(D2)보다 높게 나타났다. 평균 결합강도는 H₂O₂의 농도와 적용 시간이 증가할수록 감소하였다. 통계분석에서 상아질의 깊이, H₂O₂농도와 적용 시간이라는 세 가지 변수간의 교호작용 효과는 없으나(p > 0.05). 상아질의 깊이와 H₂O₂농도 사이, H₂O₂농도와 적용 시간 사이에서는 교호작용 효과가 있었다(p < 0.05). SEM 관찰에서는 H₂O₂의 농도가 증가할수록 상아세관이 좀 더 개방된 양상을 보였다. The purpose of this study was to examine the effect of hydrogen peroxide at different application time and concentrations on the microtensile bond strength of resin restorations to the deep and the pulp chamber dentin. A conventional endodontic access cavity was prepared in each tooth, and then the teeth were randomly divided into 1 control group and 4 experimental groups as follows: Group 1, non treated; Group 2, with 20% Hydrogen peroxide (H₂O₂); Group 3, with 10% H₂O₂; Group 4, with 5% H₂O₂; Group 5, with 2.5% H₂O₂; the teeth of all groups except group 1 were treated for 20, 10, and 5min. The treated teeth were filled using a Superbond C&B (Sun medical Co., Shiga, Japan). Thereafter, the specimens were stored in distilled water at for 24-hours and then sectioned into the deep and the chamber dentin. The microtensile bond strength values of each group were analyzed by 3-way ANOVA and Tukey post hoc test(p < 0.05). In this study, the microtensile bond strength of the deep dentin (D1) was significantly greater than that of the pulp chamber dentin (D2) in the all groups tested. The average of microtensile bond strength was decreased as the concentration and the application time of H₂O₂ were increased. Analysis showed significant correlation effect not only between the depth of the dentin and the concentration of H₂O₂ but also between the concentration of H₂O₂ and the application time(p < 0.05), while no significant difference existed among these three variables(p > 0.05). The higher H₂O₂ concentration, the more opened dentinal tubules under a scanning electron microscope(SEM) examination.

제1형 당뇨병 환자에서 췌도세포 동종이식의 반복시행

양태영,정인경,서인아,오은영,조건영,오승훈,김성주,정재훈,민용기,이명식,이문규,김광원,도영수,주성욱 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

연구배경:췌도세포 이식은 시술이 간편하고 안전하기 때문에 반복이식이 가능하여 그 동안 여러 센터에서 반복이식의 성공을 보고한 바 있다. 국내에서도 본 병원을 비롯하여 몇몇 센터에서 췌도세포 이식이 활발히 시도되고 있으나 사람에서의 동종이식 및 동종 이식의 반복시행은 보고된 바 없는 실정이다. 저자 등은 국내 최초로 췌도세포 동종이식을 시행하여, 혈청 C­펩타이드가 증가하고 인슐린 요구량이 감소하였으며, 혈당농도와 당화혈색소의 안정을 보였다. 그러나 이식 70일 후 다시 인슐린 요구량이 증가하고 C­펩타이드가 감소하여 췌도세포 이식을 다시 시행한 바 있다. 2차 이식 후 70여일이 지난 현재 다시 혈청 C­펩타이드가 증가하고, 인슐린 요구량이 더 감소되어 췌도세포 이식에서 반복 시행의 유용성을 보고하는 바이다. 방법:환자는 32세 남자로 17년전 당뇨병 진단 후 인슐린 치료 중이었으며, 3년전 부터는 만성신부전증으로 혈액툭석을 하고있었다. 1999년 12월 25일 신장이식을 하였고 3일 후 췌도이식을 하였으며, 두번째 이식은 70일 후 시행하였다. 췌도분리는 변형된 Recordi방법과 비연속성 자당 농도차(discontinuous density gradient)를 이용하였으며 분리한 췌도는 배양 후 환자의 신장기능이 정상화되고 미생물학 검사에서 음성을 확인한 후 경피경간으로 간문맥을 접근하여 16G 폴리 에틸렌 카테터를 이용하여 간실질에 이식하였다. 결과:1차 췌도이식시 순수분리전 췌도수는 210,000개, 순수분리후 획득한 췌도수는 90,000개, 순도 95%, 세포양 1.0mL 이었고, 2차 췌도이식시 순수분리전 췌도수는 420,000개, 순수분리후 획득한 췌도수는 370,000개, 순도 95%, 세포양 1.5mL 이었다. 1,2차 모두 간문맥을 통해 약 20분에 걸쳐 간실질에 주입하였다. 췌도이식전 인슐린요구량은 75∼75U/일, HbA1e 8∼10%, C­펩타이드 0.6ng/mL 였으며, 1차 췌도이식수 7일째 인슐린 요구량은 40U/일, C­펩타이드 1.5ng/mL, FPS 109mg/mL 였고, 40일 추적관찰 후 인슐린 요구량이 36U/일, C­펩타이드 1.8ng/mL, HbA1e 6.5∼7.0%로 안정되었다. 그러나 이식 50일째부터 인슐린 요구량이 50∼56U/일, C­펩타이드 0.6ng/mL, FPS 130∼200mg/dL로 혈당 조절이 불안정하여 다시 췌도이식을 시행하였다. 2차 이식후 50일이 경과한 현재, 인슐린 요구량은 26U/일, C­펩타이드 1.8ng/mL, FPS 90∼120mg/dL로 다시 안정되었다. 결론:췌도이식은 반복이식이 가능하며, 본 환자의 경우 인슐린요구량 감소, 혈당의 안정화 및 C­펩타이드가 상승하여 이식한 췌도의 기능을 확인할 수 있었고, 향후 스테로이드 등 면역억제가 유지 용량으로 감량되면 인슐린 요구량은 더 감소될 것으로 기대된다. Over the past 20 years, significant advances have been made in human islet transplantation. However, cases of prolonged insulin independence after islet allotransplantation have rarely been reported and over time, a slight, gradual decrease in insulin secretion appears to occur, as suggested by the lower C-peptide. Although preliminary clinical success achieved over the past few years has been considerably higher with whole pancreatic transplant than with isolated islet grafts, both approaches remain experimental. Islet grafts might gain, over time, increasing credibility and might eventually provide an easier alternative in terms of grafting procedures and patient management, as compared with the more "traumatizing" whole-pancreas transplantation. Also, using islet, re-transplantation is possible. But it is not known whether re-transplantation of islet could be suitable for those patients who lost grafted islet function. The aim of the present study was to investigate the benefits of re-transplantation of islet in previously simultaneous islets-kidney transplant (SIK) patient who have lost graft function. Methods : The recipient was a 32 year old male. First islet transplantation was underwent at December 25, 1999. However, the grafted islets lost function after 70 days. So we performed re-transplantation of islets. The isolation of islet was conducted sterilely on a laminarflow hood and isolated by a modified Recordimethod. The islet was injected slowly into the liver via a cannular placed in the potalvein for 20 minutes. Results : Transplanted islets were 90,000 IEq at first islet transplantation, 370,000 IEq at second islet transplantation. The insulin requirement was reduced from 75-85 to 35-40 U/day, the basal C-peptide level was 1.5 ng/mL at 7 days posttransplant Unfortunately, the grafted islets lost function after 70 days. After second transplantation, the insulin requirement was reduced to 26 U/day. Conclusions : Despite the continuous need for exogenous insulin therapy, islet transplantation can prevent wide glucose fluctuations, thus resulting in normalization of glycemic control and improvement in HbAlc, and also, show that islets can be successfully and safely re-transplanted intraportally in patients who have lost previously grafted islet function (J Kor Diabetes Asso 457~466, 2000).

연구원 활동 : 발표논문요약 ; < 전기공학분야 >

(Gun Hwang),(Hyun Sik Ahn),(Do Hyung Kim),(Tae Woong Yoon),(Sang Rok Oh),(Kwang Bae Kim) 고려대학교 공학기술연구소 1996 생산기술연구소보 Vol.3 No.-

Poster Session:PS 1134;Gastroenterology (Liver):Association of Erectile Dysfunction with Depression in Patients with Chronic Viral Hepatitis

( Gun Wung Na ),( Sang Goon Shim ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Chang Uk Jeong ),( Ji Eun Oh ),( Hyun Chin Cho ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Man Je Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: In men, erectile dysfunction (ED), which is defi ned as the inability to achieve or maintain an erection suffi cient for satisfactory sexual performance, is an important issue. There were extensive investigations in clinical and pathophysiological mechanisms with sexual dysfunction during the last decade. However, ED in patients with chronic viral hepatitis has been investigated in few and limited studies, which are often not comparable because they use different survey and patient-sampling methodologies. Moreover, few have evaluated the association of ED and depression in patients with chronic viral hepatitis. Therefore, we assessed the prevalence of ED, and their association with depression in patients with chronic viral hepatitis. Methods: This cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis between the age of 18 and 80 years were considered eligible. The exclusion criteria included well established causes of erectile dysfunction such as liver cirrhosis and alcohol abuse. Erectile dysfunction was assessed with the International Index of Erectile Function-5 (IIEF-5) scale. The Beck Depression Inventory (BDI) scale was used to assess depression of the patient. Results: The prevalence of erectile dysfunction among the patients with chronic viral hepatitis was 40%. Age, employment, peg-interferon, IIEF-5 scores and BDI scores were statistically associated with erectile dysfunction. And also, IIEF-5 scores correlated negatively with age, employment and BDI scores. In a multiple logistic regression analysis, age and depression were independently associated with erectile dysfunction. Conclusions : Patients with chronic viral hepatitis have a high prevalence of erectile dysfunction. Age and depression are independent factors of erectile dysfunction in male patients with chronic viral hepatitis. Evaluation of depression must be included to properly manage erectile dysfunction.

Ameliorative Effects of Monascus pilosus-Fermented Black Soybean (Glycine max L. Merrill) on High-Fat Diet-Induced Obesity

Oh, Hong-Geun,Kang, Young-Rye,Lee, Hak-Yong,Kim, Jung-Hoon,Shin, Eun-Hye,Lee, Bong-Gun,Park, Sang-Hoon,Moon, Dae-In,Kim, Ok-Jin,Lee, In-Ae,Choi, Jongkeun,Lee, Ji-Ean,Park, Kwang-Hyun,Suh, Joo-Won 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.9

The purpose of this study was to examine the antiobesity effects of Monascus pilosus-fermented black soybean (F-BS) in C57BL/6 mice with high-fat diet (HFD)-induced obesity. F-BS (oral, 0.5 and 1.0 g/kg per body weight, twice per day) ameliorated obesity by reducing body and liver weight increases, and regulating blood glucose and cholesterol levels in C57BL/6 mice fed a control or HFD with oral administration of F-BS for 12 weeks. F-BS suppressed the growth of epididymal, retroperitoneal, and perirenal fat pads by preventing increases in the adipocyte size. Moreover, the levels of blood glucose, total cholesterol, and leptin were significantly lowered by F-BS administration in a dose-dependent manner. These results indicated that F-BS is a beneficial food supplement for preventing obesity, controlling blood glucose, and lowering cholesterol. Future research strategies should address the mechanisms that selectively regulate obesity, including hyperglycemia and hypercholesterolemia.

부산지역의 대기오염물질농도와 기상인자간의 통계분석

오광중(Kwang Joong Oh),곽진(Jin Kwak),정덕영(Deok Young Jung),손건태(Gun Tae Son) 大韓環境工學會 1998 대한환경공학회지 Vol.20 No.9

동일 산업 내 기업의 정보 환경에 따른 기업의 비대칭적 원가 행태

오광욱(Kwang Wuk Oh),이건(Gun Lee) 한국국제회계학회 2021 국제회계연구 Vol.- No.100

[연구목적] 본 연구는 동일 산업 내 기업의 정보 환경의 좋고 나쁨에 따라 해당 기업의 원가에 비대칭적 행태가 나타나는지를 검증한다. [연구방법] 2003년부터 2018년까지 19,804 기업-년도 표본을 이용하여 동일 산업 내 기업의 정보 환경의 차이에 따라 개별 기업의 원가 행태의 비대칭성에 대한 분석을 수행한다. 동일 산업 내 기업의 정보 환경을 측정하기 위해 Shroff et al. (2017)이 제시한 방법론을 사용하였다. [연구결과] 동일 산업 내 기업의 정보 환경이 좋은 경우 정보 환경이 좋지 않은 경우에 비해 상대적으로 경영자는 매출 증가 시에는 더 많은 자원(원가증가요인)을 소모하는 의사결정(상방탄력적)을 하고, 반대로 매출 감소 시에는 더 적은 자원을 소모하는 의사결정(하방경직적)을 하는 것으로 나타났다. 이러한 결과는 경영자가 매출(활동) 증감에 따라 자원 소모의 증감을 결정하는데 있어서 산업 내 기업의 정보환경이 중요하게 활용되고 있는 것으로 해석할 수 있다. [연구의 시사점] 본 연구는 기업이 향후 조정원가의 부담이 늘어날 수 있는 가용 자원 증가와 관련된 의사결정과정에서 동일 산업 내 정보 환경이 더욱 중요하게 작용된다는 점을 제시하고 있다. [Purpose] This study examines whether asymmetrical cost behavior is present according to the information environment measured using peer-firm information environment by same industry. [Methodology] The study empirically tests the asymmetric cost behavior according to heterogeneous information environment of firm using the 19,804 firm-year sample from 2003 to 2018 listed in KSE and KOSDAQ. In order to measure the information environment in the same industry, we operationally defined the individual firm-level information environment by combining peer information environment proxies of peer-firm in the same industry following Shroff et al.(2017). [Findings] Results suggest that, when the information environment of individual companies is good, managers that consume(upward elastic) more resources(increases in cost) for sales growth, while consume(downward direct) less resources for revenue reduction. These indicate that information environment plays as an important role in determining resource consumption. [Implications] This study contributes that information from peer-firm and its impact on individual firm information environment is important in the decision-making process involving the increase in available resources that may increase the burden of adjustment costs in the future.

개방성 경골 간부 골절의 임상적 고찰

조광희,강수일,이강현,오종건 최신의학사 1987 最新醫學 Vol.30 No.9