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Efficacy of Supplementation with vit B6, B12, and Folate in Patients with Alcoholic Liver Disease
( Sy Ko ),( Hs Ahn ),( Kp Kim ) 한국정맥경장영양학회 2015 한국정맥경장영양학회 학술대회집 Vol.2015 No.-
Background and aims: Although three essential B-vitamins (vitamin B6, vitamin B12, and folate) play a critical role in the methionine metabolic cycle related to the pathogenesis of experimental alcoholic liver disease (ALD), the effectiveness of B-vitamin supplementation is not known in clinical situation. The aims of this study were to identify changes between serum levels of methionine metabolites after 4 weeks of B-vitamin supplementation and determine the relationship between aberrant methionine metabolic cycle and B-vitamin supplementation in patients with ALD. Methods: At baseline, serum levels of liver function biochemical parameters, B-vitamins (vitamin B6, vitamin B12, and folate), and methionine metabolites (homocysteine, S-adenosylhomocysteine) were measured in 20 ALD patients and 20 healthy subjects. Among these 20 ALD patients, 10 patients (Group A) received 4-week B-vitamin supplementation, which included vitamin B6, vitamin B12, and folate. The other 10 patients (Group B) received 4-week B-vitamin supplementation without folate. Methionine metabolite levels, homocysteine and S-adenosylhomocysteine, were measured using stable isotope dilution liquid mass spectrometry. Results: Two groups of ALD patients showed an overall improvement in liver function biochemical parameters and B-vitamin levels after 4 weeks of B-vitamin supplementation. Serum homocysteine and Sadenosylhomocysteine levels tended to show reduction in the Group A patients after 4 weeks of B-vitamin supplementation, which included folate (p = 0.209 for HCY and p = 0.038 for SAH). Conclusions: Short-term abstinence and B-vitamin supplementation including folate may help improve nutritional status and methionine metabolite levels related to the aberrant methionine metabolic pathway. Efficacy of B-vitamin supplementation may require the regimen including folate supplementation.
Skin-capsular Mismatch According to Knee Positions for Instrument Insertion via Arthroscopic Portals
( Jung Ro Yoon ),( Venkatesh Kp ),( Taik Sun Kim ),( Deuk Soo Lim ),( Jae Hyuk Yang ) 대한슬관절학회 2011 대한슬관절학회지 Vol.23 No.4
Damage to soft tissues, chondral surfaces, and the menisci may result from imprise or overly aggressive establishment of portals in arthroscopic knee surgeries. In this note, we address the relationship between the skin and the capsule at portal sites according to knee positions. Understanding the skin-capsular mismatch may facilitate arthroscopic procedures and indirectly reduce the operation time.
이재관(JK Lee),김종화(JH Kim),강순범(SB Kang),김종환(JW Kim),서경필(KP Suh) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.8
Patients who have had cardiac valve replacement are being seen increasingly often as candidates for antenatal care. The outcome of 23 pregnancies in 14 patients with bioprosthetic cardiac valves is analyzed and reported here. The results were summarized as follows: 1. Twenty three pregnancies in 14 patients with bioprosthetic cardiac valves resulted in 11 healthy, 2 low birth weight infants, 2 spontaneous abortions, 7 elective terminations of pregnancy, and one tubal pregnancy. 2. Pregnancy and labor seemed to have been tolerated relatively well in these patients. 3. There were 3 males and 10 females among the 13 infants born. 4. Birth weights ranged from 2,140 to 3,670g(mean 3,030). 5. Apgar scores at five minutes ranged from 4 to 10 (mean 9.1). 6. There were no instances of congenital malformations, maternal or fetal hemorrhagic complications. 7. There were 4 spontaneous vaginal deliveries, 7 elective vacuum extraction deliveries, 1 elective forcep delivery, and 1 cesarean section. 8. All patients received prophyllactic broad-spectrum antibiotics for infective endocarditis, and no nistances of endocarditis developed. 9. There were no stillbirth, no neonatal deaths, and no maternal deaths. 10. There were 2 instances of thromboembolism; one in the immediate postoperative period, and the other 5 years after valve replacement. All seemed to be unrelated to pregnancy. 11. Anticoagulants were not used in pregnancies which went to term except one patient, in whom coumarin was administered until 6th week of gestation. 12. One pregnancy was complicated with premature labor, one with gestational edema, one with preexisting chronic active hepatitis, five with worsening of cardiac status (one of the five, with newly developed atrial fibrillation). 13. 34.8% of all pregnancies after cardiac valve replacement were unwanted ones, and at the same time preventable `risk factors`.
Ectopic Gestation 시의 환부의 절제에 따른 hCG치의 감소상황
오세량,한세준,정종일,고성민,이용은,홍관표,김영미 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.10
자궁외임신에서 이환된 난관조직을 완전절제하는 수술과 난관을 보존할 수 있는 수술을 시행하여 융모조직으로 부터 생산되는 hCG량과 수술에 따라 hCG량의 감소를 관찰한 결과 다음과 같은 견해를 보였다. 즉 수술후 최초의 hCG량을 알아야만 hCG치가 계속되는 시간을 알 수 있으며 수술후 hCG량을 방사면역측정법으로 최소한 24일까지는 측정하여야 하고 hCG치의 감소 및 소실상황을 관측하여야하는 것으로 추정되었다. A Study was undertaken to determine the length of time serum of β-subunit of human chorionic gonadotropin (β-hCG) could be detected following removal of ectopic pregnancy. The disappearance pattern of β-hCG was almost equal in complete removal of trophoblastic tissue and in conservative surgical treatment. The initial hCG titer is the most significant factor determining the length of time in which positive titers will be detected.