Efficacy of Supplementation with vit B6, B12, and Folate in Patients with Alcoholic Liver Disease

( Sy Ko ),( Hs Ahn ),( Kp Kim ) 한국정맥경장영양학회 2015 한국정맥경장영양학회 학술대회집 Vol.2015 No.-

Background and aims: Although three essential B-vitamins (vitamin B6, vitamin B12, and folate) play a critical role in the methionine metabolic cycle related to the pathogenesis of experimental alcoholic liver disease (ALD), the effectiveness of B-vitamin supplementation is not known in clinical situation. The aims of this study were to identify changes between serum levels of methionine metabolites after 4 weeks of B-vitamin supplementation and determine the relationship between aberrant methionine metabolic cycle and B-vitamin supplementation in patients with ALD. Methods: At baseline, serum levels of liver function biochemical parameters, B-vitamins (vitamin B6, vitamin B12, and folate), and methionine metabolites (homocysteine, S-adenosylhomocysteine) were measured in 20 ALD patients and 20 healthy subjects. Among these 20 ALD patients, 10 patients (Group A) received 4-week B-vitamin supplementation, which included vitamin B6, vitamin B12, and folate. The other 10 patients (Group B) received 4-week B-vitamin supplementation without folate. Methionine metabolite levels, homocysteine and S-adenosylhomocysteine, were measured using stable isotope dilution liquid mass spectrometry. Results: Two groups of ALD patients showed an overall improvement in liver function biochemical parameters and B-vitamin levels after 4 weeks of B-vitamin supplementation. Serum homocysteine and Sadenosylhomocysteine levels tended to show reduction in the Group A patients after 4 weeks of B-vitamin supplementation, which included folate (p = 0.209 for HCY and p = 0.038 for SAH). Conclusions: Short-term abstinence and B-vitamin supplementation including folate may help improve nutritional status and methionine metabolite levels related to the aberrant methionine metabolic pathway. Efficacy of B-vitamin supplementation may require the regimen including folate supplementation.

계속근로자구강건강관리방안

고소영 산업구강보건협의회 1997 산업구강보건협의회지 Vol.6 No.1

Depth edge detection by image-based smoothing and morphological operations

Abid Hasan, Syed Mohammad,Ko, Kwanghee Society for Computational Design and Engineering 2016 Journal of computational design and engineering Vol.3 No.3

Since 3D measurement technologies have been widely used in manufacturing industries edge detection in a depth image plays an important role in computer vision applications. In this paper, we have proposed an edge detection process in a depth image based on the image based smoothing and morphological operations. In this method we have used the principle of Median filtering, which has a renowned feature for edge preservation properties. The edge detection was done based on Canny Edge detection principle and was improvised with morphological operations, which are represented as combinations of erosion and dilation. Later, we compared our results with some existing methods and exhibited that this method produced better results. However, this method works in multiframe applications with effective framerates. Thus this technique will aid to detect edges robustly from depth images and contribute to promote applications in depth images such as object detection, object segmentation, etc.

기계 학습을 통한 네트워크 트래픽 변화 예측

고태진 ( Tae-jin Ko ),양희규 ( Hui-gyu Yang ),샤이드무하마드라자 ( Syed Muhammad Raza ),김문성 ( Moon-seong Kim ),추현승 ( Hyun-seung Choo ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2

본 논문은 네트워크 트래픽에 대한 동적인 변화에 대응하기위해 기존의 네트워크 트래픽 데이터를 이용하여 기계 학습을 사용하여 학습시킴으로써 이후 네트워크 트래픽 동향에 대해 분류하여 예측하는 연구에 관한 논문으로, 기계 학습의 종류 중 MLP(Multi-Layer Perceptron)를 이용하여 실험하였는데 MLP 의 구조와 학습 반복 횟수에 따른 정확도의 차이와 테스트 데이터 실험 결과를 정리하였다. 또한 이를 통해 얻어진 결과는 어떻게 사용 될 지와 정확도를 높이기 위해서는 어떤 요소가 영향을 끼치는지에 대해 논문의 방식과 비교하여 설명한다.

랜덤 포레스트를 통한 네트워크 트래픽 변화 예측

고태진(Tae-Jin Ko),양희규(Hui-Gyu Yang),샤이드 무하마드 라자(Syed Muhammad Raza),김문성(Moon-Seong Kim),추현승(Hyun-Seung Choo) 한국정보과학회 2020 한국정보과학회 학술발표논문집 Vol.2020 No.7

배전원격관리를 위한 차세대 디지털 적산전력계 설계

고윤석(Yun-Seok Ko),임철수(Chul-Sy Lim),김관호(Kwan-Ho Kim),윤상문(Sang-Moon Yun),서성진(Seong-Jin Seo) 대한전기학회 2002 대한전기학회 학술대회 논문집 Vol.2002 No.7

Term low birth weight among immigrant parents

( Lee Je ),( Kim Sy ),( Kim Ry ),( Wie Jh ),( Ko Hs ),( Park Iy ),( Shin Jc ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The aim of this study was to analyze the relationship between maternal origin and risks of term low birth weight (TLBW) or macrosomia in Korea. Methods: Using Korean birth statistics from 2009 to 2015, we examined the association between maternal nationality and risks of TLBW (less than 2.5 kg) or term macrosomia (over 4.0 kg). Birth statistics included singleton live births in women, from 37 to 41 weeks gestation, during the period 2009-2015. Immigrant mothers were defined as women born in any country other than Korea, and were grouped by country of origin according to the World Bank Atlas definition of low-, and middle- to high-income countries. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with multivariate logistic regression analysis. Results: There were significant differences in neonatal birth weights between Korean and immigrant mothers (3.28 0.38 kg and 3.24 0.39 kg, respectively, p < 0.005). The incidence of TLBW was significantly higher (3.4% vs 1.6%, p < 0.05), in mothers from low income countries than those in Korean mothers. The incidence of overweight was significantly higher in mothers from middle to high income countries than it of Korean mothers (3.6% vs 4.8%, p < 0.05). In multivariate logistic regression analysis, the risk of low birth weight was higher in mothers from low income countries (OR, 1.274; 95% CI, 1.185-1.369), and the risks of overweight were higher in mothers from middle or high income countries (OR, 1.216; 95% CI, 1.157-1.278). Conclusion: After adjustment for relevant characteristics, the risk of TLBW was higher in immigrant mothers from low-income country, but the risk of overweight at birth was higher in immigrant mothers from middle or high-income country. Prenatal care and education needs to consider the origin of immigrant mothers.

정신지체 위험인자 파악을 위한 환자-대조군 연구

최영민,문신용,고경심,최진,황도영,전종관 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.5

목적: 정신지체에 대하여 산전요인과 환경 및 사회문화적 영향 등의 위험인자에 대해서는 역학연구가 부족한 실정이다. 따라서 한국인 정신지체 위험인자 파악을 위한 역학조사를 시행하여 본격적인 조사를 위한 정보를 제공하고자 하였다. 연구방법: 정신지체가 있는 환자군 88 명과 대조군 222 명, 총 310 명을 대상으로, 대상아의 어머니에게 설문을 이용하여 위험인자에 관한 정보를 비교하는 후향적 환자-대조군 연구를 수행하였다. 설문내용은 광범위하게 정신지체 위험인자들에 대한 질문이 포함되었고 어머니가 직접 기입하도록 하였다. 평균치의 비교에는 Student t 검정법을 사용하였고, 빈도의 비교에는 카이제곱검정법을 사용하였다. 정신지체의 위험도를 나타내는 교차비와 95% 신뢰구간 산출을 위하여 로지스틱회귀분석을 사용하였다. 결과: 정신지체와 양의 상관관계를 보이는 위험인자들은, 불충분한 산모의 체중증가, 낮은 부모의 교육정도, 빈번하게 식사를 거른 경험, 불안정한 결혼상태, 초산아 출산, 저체중아 출산 및 임신중의 투약경험 등이었다. 본 조사에서 표본수의 부족, 정보의 부정확에서 오는 비뚤림, recall bias 등 드러나는 한계점들은 극복해야할 과제였다. 결론: 정신지체 위험인자들이 일부 파악이 되었으며, 앞으로 본 조사의 한계를 극복하기 위하여, 많은 표본수를 확보하고 위험인자에 대한 정보를 전향적으로 수집하는 형태의 역학조사가 필요하다. Objective: Prenatal and environmental factors for mental retardation were not clearly identified in Korea. The objective of our study is to determine risk factors of mental retardation and to give informations for further large epidemiologic study. Methods: Using a case-control study design, 88 children with mental retardation as cases and 222 children without mental retardation as controls were selected and their mothers were asked about prenatal and environmental risk factors by questionnaires. For comparison of continuous variables we used Student t-test and for comparison of frequencies Chi-square test. Logistic regression was used for analysing the odds ratios and 95% confidence intervals for evaluating risk factors of mental retardation. Results: Risk factors, which showed positive association with mental retardation, were inadequate maternal weight gain, low matenal and paternal education level, inappropriate food intakes during pregnancy, unstable marital status, delivery of first baby, low birth weight infant and medication during pregnancy. Some limitations of this study were also mentioned. Conclusion: Some risk factors of mental retardations were determined and gave us useful informations for further epidemiologic studies.

Study on the polymorphism between brown midrib mutants and Hwangkeumchal using SSR markers toward sorghum QTL mapping on excessive water stress

JY Park,AR Kim,SY Yoo,JI Kim,TW Jung,SH Woo,HY Heo,TW Kim,TS Ko 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Excessive water stress can cause severe damage to sorghum and results in significant yield reduction. The aim of this study is to identify quantitative trait loci (QTL) for excessive water stress in sorghum. As a first step, two out of 21 bmr mutants were selected for their superior agronomic performance and Chlorophyll a fluorescence OJIP transient, and were crossed with an elite Korean cultivar, Hwangkeumchal, to construct mapping populations. One hundred ten out of 236 SSR primers showed polymorphism between two parens, which cover ten chromosomes of sorghum from different published SSR linkage maps of sorghum. Development of recombinant inbred lines from the crosses ‘25M2-0698 x Hwangkeumchal’ and ‘25M2-0404 x Hwangkeumchal’ are in progress using the single seed descendent method for generation acceleration.

Assessment of genetic diversity among Korean sorghum (Sorghum bicolor (L.) Moench) resources using SSR markers

JY Park,AR Kim,SY Yoo,JI Kim,TW Jung,SH Woo,HY Heo,TW Kim,TS Ko 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Grain sorghum is the fifth most important crop grown in the world for either a major food crop or animal feed. It is important to identify the genetic diversity of sorghum genetic resources for cultivar development and evaluation of sorghum accessions in Korea. Two hundred thirty six SSR primer sets, which are evely distributed across the sorghum genome, were used to assess the genetic variation of 23 sorghum accessions with a US cultivar, BTx623. Results showed that SSR markers were highly polymorphic among the sorghum collections and the average alleles per locus were 3.15 with the average of 0.436 PIC (polymorphism information content) values. The sorghum accessions in this study were unequally separated and were clustered into 4 groups. The results showed that there was a sufficient SSR polymorphism with SSR primers used among Korean sorghum accessions, and the development of genetic map and marker-assisted selection for cultivated sorghum would be feasible with further studies.