관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

쑥의 翰燥方法에 따른 脂肪酸 變化에 관하여

김덕웅(Duck-Woong Kim),최강주(Kang-Ju Choi) 한국식품영양과학회 1985 한국식품영양과학회지 Vol.14 No.2

생쑥의 건조방법에 따른 지방산 변화를 검토하기 위하여 강화도산 생쑥을 陽翰, 陰翰, 熱風陽燥 및 冷凍翰燥시켜 ethyl ether extract함량과 그 구성 지방산의 함량 변화를 조사하였다.<br/> 1. Ethyl ether extract의 함량은 冷凍翰燥된 쑥이 5.68%로 가장 높았고 熱風翰燥된 쑥이 2.45%로 가장 낮았다.<br/> 2. GLC에 의한 지방산 분석 결과 11종의 지방산 중 주된 지방산은 필수 지방산인 linoleic acid와 linolenic acid외에 palmitic acid가 다량 함유되어 식품 영양학적인 면에서 고무적인 것으로 사료된다.<br/> 3. 건조 방법에 따른 건조쑥의 지방산의 종류에는 차이가 없었으나 그 조성은 상이하였다. 즉 冷凍翰燥된 쑥은 酸化되기 쉬운 高度 不飽和脂肪酸(C_(18:2)+C_(18:3))의 함량이 높을 뿐만아니라 低沸點脂肪酸들의 감소가 가장 적었다. 한편 熱風翰燥된 쑥은 低沸點脂肪酸들이 상당량 감소되었으나 高度 不飽和脂肪酸은 陰翰 및 陽翰시킨 쑥보다 다소 안정하였으며 陽翰시킨 쑥의 변화가 가장 현저하였다. This study was carried out to investigate changes in the compositions of fatty acids according to the different drying methods of raw mugwort. Raw mugwort from Kang-wha was dried with four methods such as sundrying, shady sun-drying, heated oven-drying and freeze-drying. Total contents and fatty acid compositions of the ethyl ether extracts from the dried mugworts were examined. Total contents of the ethyl ether extracts showed remarkable differences with drying methods; freeze-dried mugwort had the highest content (5.60%), while oven dried mugwort revealed the lowest content (2.45%). Eleven fatty acids and four unkown peaks were identified by gas-liguid chromatography; major fatty acids were linoleic acid, linolenic acid and palmitic acid. Fatty acids of mugworts dried by 4 different methods were the same in kinds, but different in their compositions. The content of polyunsaturated fatty acids (C_(18:2)+C_(18:3)) was the highest and the loss of low volatile fatty acids was the least in mugwort dried by the freeze-drying method. The volatile fatty acids considerably decreased in oven-dried mugwort. However, the contents of polyunsaturated fatty acids were a little higher in ovendried mugwort than in sun-dried and shady sun-dried mugwort, and the lowest in sun-dried mugwort.

Evaluation of Renal Toxicity by Combination Exposure to Melamine and Cyanuric Acid in Male Sprague-Dawley Rats

Son, Ji Yeon,Kang, Yoon Jong,Kim, Kyeong Seok,Kim, Tae Hyung,Lim, Sung Kwang,Lim, Hyun Jung,Jeong, Tae Cheon,Choi, Dal Woong,Chung, Kyu Hyuck,Lee, Byung Mu,Kim, Hyung Sik Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.2

Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.

Evaluation of Renal Toxicity by Combination Exposure to Melamine and Cyanuric Acid in Male Sprague-Dawley Rats

Ji Yeon Son,Yoon Jong Kang,Kyeong Seok Kim,Tae Hyung Kim,Sung Kwang Lim,Hyun Jung Lim,Tae Cheon Jeong,Dal Woong Choi,Kyu Hyuck Chung,Byung Mu Lee,Hyung Sik Kim 한국독성학회 2014 Toxicological Research Vol.30 No.2

Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.

강릉시 의료기관 수요공급 분석

김상아,곽연희,박웅섭,송재석,이상욱,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

This study was conducted to use for the Community Health Care Plan through the demand-supply analysis of medical institution in Gangneung. The study data were obtained from the Korean National Health Insurance Corporation and the government of Gangneung. The major findings is follows; First, the hospital beds in Gangneung was 793 beds, but supply was 2,187 beds. Second, the demand of clinic in rural area was 43, and supply was 21. But demand of clinic in urban area was 115, and supply was 144. Third, the pubic medical institution in rural covered 4.7% of outpatient demand, and that in urban covered 0.9% of outpatient demand.

개선된 하프변환을 이용한 훼손된 타원 검출

강창원,양환석,이정재,김남중,이웅기 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

This paper considers the problem of detecting elliptical curves using Advanced Hough transform. Storage and efficiency problems are over come by decomposing the problem into two stages. The first stage uses a novel constraint as the basis for a Randomined Hough transform to detect the ellipse centre while the second stage finds the remaning parameters using simple but efficient focusing implementation of the Advaned Hough transform. The method is applicable in many situations where previous Hough transform schemes would fail. Results are demonstrated for comolicated image data containing several occluding ellipses.

단조강(SF45A)재의 표면피로크랙 성장 거동에 관한 고찰

金健鎬,정재강,최종로,방웅주 군산대학교 1993 群山水産專門大學 硏究報告 Vol.28 No.1

Fatigue life prediction of fatigue fracture is very important problem. This paper is observed on the surface small crack growth behaviour of smooth specimen. This results were as follows. Surface small crack are created small crack of high density in about 50% of fatigue life, retarded crack growth due to crack coalescence in about 60% and 85%, and when distributed small cracks are growing, it was growthed few large cracks. On the other hand, To analyze crack growth rate used stress intensity factor was difficult due to existed small crack stegnant range.

강릉시 사망원인 분석

김상아,곽연희,박웅섭,송재석,이상욱,박덕영,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

This study was conducted to use for the Community Health Care Plan through analyzing the specific cause of death in Gangneung. The study subject were death in Gangneung that happened from January 1, to December 31 in 2000, and that were enrolled as the citizen of Gangneung. The causes of death were classified according to the 56 selected list for ranking of causes of death in Korean National Statistical Office in order to compare the data of nation. We also estimated Years of Potential Life Lost in order to evaluate the burden of disease in Gangneung.

호남지역 철기시대 주거의 건축적 특성에 관한 연구

김재웅,박강철 대한건축학회 2004 대한건축학회논문집 Vol.20 No.9

Relics m the Iron Age excavated In the Honam region has Increased from the 1990' s by reason of excavating to construct the west coast highway. Even though many research of the relics has made progress, a study on the dwellings has not Therefore, this study examines the floor plan shape, pillar hole and Its arrangement and inner facilities of dwellings 10 Honam region during the Iron Age In order to find out their architectural characteristics The research results are as follows Floor plan shape is mainly square-shaped, which contrasts to that of the Bronze Age, a mainly circular type Diameter of pillar hole is mostly 27~41cm and its depth is 22-35cm As the diameter became larger, the deeper It is, but diameter of middle Size has variety of depth The four column types(四柱式) are divided into four(square, rectangular, trapezoid, indeterminate) but square type is the most popular In particular, span of the square type are mostly between 23 3-279cm The Span Size is similar to that of main room m traditional korean low-class houses in Jeonnam region The four column type In the Bronze Age have the span below 23m, is smaller than that m the Iron Age and Its arrangement is not regular This evidence seems to lead to that the basic span of traditional korean low-class house 10 this region had been fixed from the Iron Age

교량 탐사용 로봇 개발

김덕후,김효곤,조국,강민성,박상덕,손웅희 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

The purpose of maintaining of bridges was to secure of them and expend its life. They wereneeded to have a regular safety check. But, most parts of a bridge were not able to access easily for people so it was difficult to maintain. To improve it, the flight mechanism and mobile mechanism were combined to examine with moving when they were attaching to bridges up and down. The flight mechanism is a co-axial-rotor-helicopter shape that cut the body down and can be done hovering. The mobile mechanism was shaped to move every direction with holding the position of a robot. These robot platforms showed possibilities to use them not only for observation and patrol but they could be used for a new usage with transformation of flying robots. This paper was focused on location maintaining when a robot was examined a bridge. The flight mechanism would only have thrust and adhesive force, the mobile mechanism would be used for moving. Therefore, defining the mechanistic model of the mobile mechanism has proved the validity of the model through simulations and experiments.