Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

( Joon Sul Choi ),( Ji Hyun Lee ),( Suk Ki Park ),( Beom Jin Shim ),( Won Kyu Choi ),( Sang Hyun Kim ),( Seon Chool Hwang ) 대한류마티스학회 2016 대한류마티스학회지 Vol.23 No.5

Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system re-ceptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers of drugs and drug combinations, and serotonin-norepinephrine reuptake inhibitor-induced serotonin syndrome is rare. It is often described as a sign of excess serotonin ranging from tremor in mild cases to delirium, neuromuscular rigidity, and hyperthermia in life-threat-ening cases. Diagnosis is based on the symptoms and patient`s history, and several diagnostic criteria have been developed. We experienced a rare case of fibromyalgia accompanied by tremor, hyperreflexia, spontaneous clonus, muscle rigidity, and diaphoresis after 10 days of single use of duloxetine 30 mg. Only one case of serotonin syndrome resulting from administration of duloxetine has been reported in Korea, however that case resulted from co-administration of fluoxetine. We report here on this case along with a review of the relevant literature. (J Rheum Dis 2016;23:332-335)

일부지역 대학생들의 미용시술 경험률과 건강장해에 대한 인식

최창원,노상미,양혜민,강태석,김태구,이다현,엄세준,이진영,배근량,정철,정해관,임현술 東國大學校醫學硏究所 2004 東國醫學 Vol.11 No.1

연구목적: 최근 신세대에게 대중화 되어가고 있는 모발염색, 이어링, 피어싱, 문신, 미용 성형수술 등의 미용시술의 실태를 조사하고 문제점을 파악하여 해결방안을 제시하고자 하였다. 연구대상 및 방법: 2003년 9월 17일에 경주시 소재 3개 대학교 재학생 566명을 대상으로 자기 기입식 설문지를 실시하였다. 설문지에는 모발염색, 이어링, 피어싱, 문신, 미용 성형수술 등의 경험률 조사와 시술장소, 시술장소의 위생정도, 시술 이후 부작용의 유무, 부작용 발생 이후 치료방법 등에 대한 항목을 포함하였다. 결과: 대학생들의 미용시술 경험률은 91.9%이었으며, 여학생과 남학생에 있어 경험률의 차이는, 여학생의 경우 모발염색, 이어링과 미용 성형수술의 경험률이 높았고, 남학생은 문신 경험률이 높았으며, 피어싱의 경우에는 큰 차이를 보이지 않음을 알 수 있다. 미용시술 장소로는 대부분이 병원이 아닌 불법 시술소가 대부분이었으며, 시술장소의 위생정도는 보통이라는 응답이 가장 많았고, 위생 정도에 관심이 없다는 응답이 다음으로 많았다. 부작용 빈도는 약 l0% 정도였다. 결론: 대학생들에게 미용시술이 보편화되고 대중화되었음을 알 수 있으나, 올바른 시술방법과 부작용에 대한 인식이 부족함을 알 수 있다. 따라서, 앞으로 미용시술에 따른 부작용의 심각성을 파악하는 연구가 활발히 이루어져야 할 것이며, 미용시술에 따른 부작용의 심각성에 대해 교육하고 홍보하는 것이 필요할 것으로 생각한다. Purpose: The purpose was to catch the state and the problem of esthetic procedures popularized recently to the new generation and to show the solution. Materials and Methods: This study, including 566 university students in Gyeongju was performed by a self-administered questionnaire at 17. September 2003. The questionnaire included questions on experience rate of hair dyeing, earrings, piercing, tatto, plastic surgery and the operating place, state of sanitary of operating place, the presence of adverse effect and treatment methods of the adverse effect. Results: The experience rate of esthetic procedure among university student was 91.9%. The experience rate of hair dyeing, earrings and plastic surgery was high in female, and the experience rate of tatto was high in male student and that of piercing was not significantly different between male and female students. The esthetic procedure was performed at a illegal place most commonly, not at a hospital. And then state of the sanitary of the operating place was medium The prevalence of the adverse effect was about 10%. Conclusions: The esthetic procedures was universal and popular to the university students, but university students was not aware of the operating method and advere effect. Thus, further investigations are warranted to assess the seriousness of esthetic procedures, and to educate and inform the seriousness of adverse effects of esthetic procedures to university student will be necessary.

복수와 장폐색증을 동반한 호산구성 위장염 1예

박준옥,이군순,주인고,최승준,김종민,한설혜,김양수,김태균,정재용,박유환 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.2

Eosinophilic gastroenteritis is an uncommon disease characterized by peripheral eosinophilia, eosinophilic infiltration of various areas of the gastrointestinal tract with gastrointestinal symptoms such as abdominal pain, vomiting, diarrhea and rarely ascites. This disorder was pathologically classified into three major types: predominant mucosal, predominant muscle layer and predominant subserosal. Although its etiology and pathogenesis was not yet definitely established, its treatment was steroid administration and the overall prognosis was favorable. We report a case of eosinophilic gastroenteritis with features of the predominant subserosal type, presented as an ascites and ileus.

Synergic Effect of Trimebutine Combined with Mosapride on Gastrointestinal Dysfunction and Visceral Pain Induced in Stress Models

( Young Joon Park ),( Uy Dong Sohn ),( Ji Hoon Jeong ),( Yoon Hee Chung ),( Sung Up Choi ),( Moo Yeol Lee ),( Eon Sub Park ),( Hyun Dong Je ),( Yun Sung Nam ),( Choong Ho Lee ),( Yong Sul Park ),( Zoo 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1

The present study was undertaken to determine whether combined treatment with prokinetic trimebutine and mosapride has a synergic effect on gastrointestinal motility and visceral pain associated with gastrointestinal dysfunction. To develop effective gastroprokinetic agents with greater potencies than trimebutine or mosapride for the treatment of gastrointestinal tract disease, a mixture of trimebutine and mosapride was designed and prepared. In the present study, treatment with trimebutine alone showed a dose-dependent effect on propelling movements of normal small and large intestine in mice, whereas mosapride effected only small intestine motility. Co-administration of trimebutine with mosapride, a well-established prokinetic drug, produced a synergistic influence on normal small intestine motility, but demonstrated an unclear effect on large intestine motility, with a slight tendency to reduce the propelling time. In a stress model, the small and large intestine motilities were significantly decreased. The reduction of intestine motility was restored to a normal level and the restoring effect was more pronounced in the combined treatment with trimebutine plus mosapride than treatment with trimebutine or mosapride alone. Furthermore, treatment with trimebutine plus mosapride significantly decreased acute visceral pain which was not controlled by trimebutine or mosapride alone. These data suggest that combination therapy with trimebutine plus mosapride has a synergic effect on small and large intestine motility and visceral pain control in gastrointestinal disorders

Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma

Ju, Yanghua,Choi, Seung-Jun,Lee, Hui-Su,Kim, Hyun-Sook,Won, Sul-Mui,Chun, Yoon-Hong,Yoon, Jong-Seo,Kim, Hyun-Hee,Lee, Joon-Sung The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.11

Purpose: Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question. Methods: We prepared Dermatophagoides farinae-sensitized mice as an asthma model, and then infected them with RSV and analyzed the changes in airway responsiveness and the cell populations and cytokine levels of bronchoalveolar lavage fluid. Results: RANTES synthesis increased in response to RSV infection in both control mice and in asthma model (D. farinae) mice. However, there was no significant difference in the amount of RANTES produced following RSV infection between control and D. farinae mice. RSV infection affected neither interferon-${\gamma}$ synthesis nor airway responsiveness in either control or D. farinae mice. Conclusion: RSV infection did not induce more RANTES in a murine model of asthma than in control mice.

교통사고 환자 103례에 대한 한방치료 만족도 조사

배길준 ( Kil Joon Bae ),정지원 ( Ji Won Jeong ),송민영 ( Min Yeong Song ),최진봉 ( Jin Bong Choi ),김성태 ( Seong Tae Kim ),권민구 ( Min Goo Kwon ),설재욱 ( Jae Uk Sul ),나성영 ( Sung Young Na ),김선종 ( Seon Jong Kim ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.3

Objectives The aim of this study is to identify the satisfaction of Korean medicine treatment by traffic accident. Methods This study was carried out 103 cases of traffic accident patients which had been treatment in Dongshin university Korean medicine hospital and Chung-Yeon Korean medicine hospital from June, 2014 to September, 2014. The survey used by preceding articles was accepted for assessment of the satisfaction degree of patients in this study. All data were coded by SPSS v18.0 and analyzed by descriptive maneuver, x2-test, T-test and correlation. Results According to the survey, 93.2% of patients included this study were hospitalized in the Korean medical hospital within 2 weeks from TA and 90.3% were satisfied with the current medical service. The answer that Korean medicine is superior to western medicine for TA treatment was the main reason for selecting Korean medical hospital. 46.6% of patientssatisfied Acupuncture treatment and 29.1% of patients satisfied Korean physical treatment. There were no differences in the satisfaction degree with sex, age, education and occupation. The satisfaction degree of the current Korean medical service was significantly correlated with doctor’s service, use the procedure and reuse intention. Conclusions We could see that the satisfaction of Korean medicine treatment is relatively high. The continuous and repetitive research is needed in order to improve the quality of Korean medicine hospital service and the satisfaction of patients by traffic accident. (J Korean Med Rehab 2015;25(3):65-79)

Quality Characteristics of Chicken Breast Surimi as Affected by Water Washing Time and pH Adjustment

Jin, Sang-Keun,Kim, Il-Suk,Choi, Yeung-Joon,Park, Gu-Boo,Yang, Han-Sul Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.3

This study was carried out to compare the quality properties of chicken breast surimi manufactured by four different procedures/methods. Surimi was made from chicken breast by washing two (T1) or four times (T2) with water as well as by pH adjustments at 3.0 (T3) or 11.0 (T4). The contents of moisture and crude fat were significantly higher in the surimi manufactured from pH-adjusted material than after washing. Again, collagen and yield were significantly higher in chicken breast surimi manufactured from washed than pH-adjusted samples, whereas crude protein was higher in the pH-adjusted than washed surimi samples. There was no significant difference in myofibrillar protein content among the surimi manufactured after different washing times and differences following pH adjustments were found. T4 showed highest myofibrillar protein content rating among the surimi samples. All physical characteristics were higher in pH-adjusted chicken breast surimi than in T1 and T2 washed surimi samples. The pH-adjusted surimi had higher hardness, gumminess and chewiness than washed surimi samples (p<0.05). The chicken breast surimi made by pH adjustments had higher lightness (L*) than when made by washing times, whereas pH 3.0-adjusted surimi samples had lower whiteness (W) then the other surimi samples. Myoglobin content was significantly higher in the surimi manufactured from pH-adjusted chicken breast samples.

Non-cirrhotic portal hypertension in an ankylosing spondylitis patient

( Sukki Park ),( Ji Hyun Lee ),( Joon Sul Choi ),( Hyun Woo Kim ),( Beom Jin Shim ),( Won Kyu Choi ),( Sang Hyun Kim ) 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.1

Idiopathic non-cirrhotic portal hypertension (INCPH) is a disease with an uncertain etiology consisting of non-cirrhotic portal hypertension and portal pressure increase in the absence of liver cirrhosis. In INCPH, patients exhibit normal liver functions and structures. The factors associated with INCPH include the following: Umbilical/portal pyremia, bacterial diseases, prothrombic states, chronic exposure to arsenic, vinyl chloride monomers, genetic disorders, and autoimmune diseases. Approximately 70% of patients present a history of major variceal bleeding, and treatment relies on the prevention of complications related to portal hypertension. Autoimmune disorders associated with INCPH are mainly systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. To the best of our knowledge, a case of ankylosing spondylitis (AS) associated with INCPH has not been reported thus far. Therfore, we report our experience of a patient with AS accompanied by INCPH, who showed perisplenic varices with patent spleno-portal axis and hepatic veins along with no evidence of cirrhosis on liver biopsy, and provide a brief literature review.

Non-cirrhotic portal hypertension in an ankylosing spondylitis patient

Park, Sukki,Lee, Ji Hyun,Choi, Joon Sul,Kim, Hyun Woo,Shim, Beom Jin,Choi, Won Kyu,Kim, Sang Hyun Yeungnam University College of Medicine 2018 Yeungnam University Journal of Medicine Vol.35 No.1

Idiopathic non-cirrhotic portal hypertension (INCPH) is a disease with an uncertain etiology consisting of non-cirrhotic portal hypertension and portal pressure increase in the absence of liver cirrhosis. In INCPH, patients exhibit normal liver functions and structures. The factors associated with INCPH include the following: Umbilical/portal pyremia, bacterial diseases, prothrombic states, chronic exposure to arsenic, vinyl chloride monomers, genetic disorders, and autoimmune diseases. Approximately 70% of patients present a history of major variceal bleeding, and treatment relies on the prevention of complications related to portal hypertension. Autoimmune disorders associated with INCPH are mainly systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. To the best of our knowledge, a case of ankylosing spondylitis (AS) associated with INCPH has not been reported thus far. Therfore, we report our experience of a patient with AS accompanied by INCPH, who showed perisplenic varices with patent spleno-portal axis and hepatic veins along with no evidence of cirrhosis on liver biopsy, and provide a brief literature review.

S-694 Non-cirrhotic portal hypertension in an ankylosing spondylitis patient

( Sukki Park ),( Ji Hyun Lee ),( Joon Sul Choi ),( Hyun Woo Kim ),( Beom Jin Shim ),( Won Kyu Choi ),( Sang Hyun Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Idiopathic non-cirrhotic portal hypertension (INCPH) is a disease of uncertain etiology that consists of non-cirrhotic portal hypertension and portal pressure increase in the absence of liver cirrhosis (LC). Liver functions and structures remain primarily normal. The factors associated with INCPH include umbilical/portal pyremia, bacterial diseases, prothrombic states, chronic exposure to arsenic, vinyl chloride monomers, genetic disorders, and autoimmune diseases. Approximately 70% of patients present with a history of major variceal bleeding, and treatment relies on the prevention of complications related to portal hypertension. Autoimmune disorders associated with INCPH are mainly systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. To the best of our knowledge, a case of ankylosing spondylitis (AS) associated with INCPH has not been reported thus far. Herein, we report our experience of a patient with AS accompanied by INCPH, who showed perisplenic varix with patent spleno-portal axis and hepatic veins along with no evidence of cirrhosis on liver biopsy, and provide a brief literature review