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측뇌실의 삼각부에서 발생한 다형성 교모세포종: 증례 보고
최승준,최혜영,김형식,황희영 대한영상의학회 2010 대한영상의학회지 Vol.63 No.5
Glioblastoma multiforme (GBM) within the lateral ventricle is relatively rare and it is predominantly found in the frontal horn or body of the ventricle. It is highly unusual to find a GBM in the trigone of the lateral ventricle. We present here a very rare location of a GBM (the trigone of the lateral ventricle). 측뇌실에서 발생하는 다형교모세포종은 드문 것으로 알려져 있으며 대부분이 측뇌실의 전두각에서 보고되었다. 저자들은 41세 남성에서 측뇌실의 삼각부에서 발생한 다형교모세포종 1예를 경험하였기에 영상소견을 보고한다.
최승준,김신영,김현옥,권정란,이상원,신영학 대한진단검사의학회 2012 Laboratory Medicine Online Vol.2 No.4
Background: Leukoreduced blood components are recommended for prevention of non-hemolytic febrile transfusion reactions, HLA alloimmunization, platelet transfusion refractoriness, and transfusion-transmissible diseases. In addition, prestorage leukoreduction may be advantageous to poststorage leukoreduction. The authors investigated the current status of usage of leukoreduced blood components in Korea. Methods: We surveyed 2,373 medical facilities, where blood components were supplied from Korean Red Cross blood centers and/or Hanmaeum blood center during one year period between January and December 2009. The survey was conducted about the current situation of usage of leukoreduction by web-based program (http://bms.cdc.go.kr), and 743 facilities answered and were analyzed. Results: The leukoreduced RBC components comprised 10.3% (prestorage leukoreduction, 91,066 units, 5.7%; poststorage leukoreduction 73,192 units, 4.6%) of the total 1,593,098 units of RBC components used in 743 medical facilities. The leukoreduced platelet concentrates comprised 33.1% (458,552 units) of the total 1,386,184 units of platelet concentrates used in 397 medical facilities. If 1 single donor platelet is counted as 6 platelet concentrates, 48.9% of the total platelet components used were leukoreduced. Conclusions: The proportion of leukoreduced blood components to the total blood components used in Korea was much lower than that in Unites States of America, especially lower in the use of prestorage leukoreduction of RBC components. Further studies are required for cost-effectiveness and demand-supply amounts of leukoreduced blood components, and appropriate prestorage leukoreduction has to be performed in Korea based on these studies. 배경: 백혈구제거 혈액제제는 비용혈 발열성수혈반응, HLA 동종면역, 혈소판 수혈불응, 수혈전파성감염 등의 부작용을 예방하기 위하여 사용되고 있다. 특히, 저장 전 여과법은 저장 후 여과법에 비하여 각종 수혈부작용을 예방하는데 더 효과적이다. 본 연구에서는국내 백혈구여과제거 혈액제제의 사용현황에 대하여 조사하였다. 방법: 2009년 1월 1일부터 12월 31일까지 1년간 대한적십자사 혈액원 또는 대한산업보건협회부설 한마음혈액원으로부터 수혈용 혈액제제를 공급받은 전국 의료기관 2,373개 기관을 대상으로 설문조사를 시행하였다. 설문조사는 개발된 웹 기반의 프로그램(http://bms.cdc.go.kr)을 통하여 이루어졌으며, 설문조사에 응답한 743개의 의료기관의 자료로 연구를 수행하였다. 결과: 743개 설문 회신 의료기관에서 1년간 사용된 1,593,098단위의 적혈구제제 중에서 prestorage LR-RBC는 91,066단위(5.7%),poststorage LR-RBC는 73,192단위(4.6%)로 백혈구여과제거 적혈구제제의 총 비율은 10.3%이었다. 397개 혈소판제제 사용 의료기관에서 1년간 사용된 1,386,184단위의 농축혈소판제제 중 458,552단위(33.1%)가 백혈구여과제거 농축혈소판제제로 사용되었다. 1단위의 성분채혈혈소판제제를 6단위의 농축혈소판제제로 환산할 경우 전체 혈소판제제 사용량의 48.9%가 백혈구여과제거가 시행되었다. 결론: 국내의 백혈구여과제거 농축적혈구의 점유율이 미국에 비하여 많이 낮으며, 특히, 저장전 백혈구여과제거 농축적혈구제제의 제조도 적게 이루어지는 것으로 나타났다. 향후 국내 실정에 맞는 백혈구여과제거 혈액제제의 효용성 및 비용-효과적인 면에 대한 연구들이 필요하며, 이들을 바탕으로 국내 실정에 맞는 저장전백혈구여과제거술이 시행되어야 할 것으로 사료된다.
Effect of Prior Muscle Contraction or Passive Stretching on Eccentric-Induced Muscle Damage
최승준 대한고유수용성신경근촉진법학회 2019 PNF and Movement Vol.17 No.3
Purpose: This tutorial review investigated the effect of prior fatigue and passive stretches on eccentric contraction-induced muscle injuries, as well as the underlying mechanisms of eccentric contraction-related injuries. Methods: Contraction-induced muscle damage is the most common disabling problem in sports and routines. The mechanisms underlying the pathology and prevention of muscle damage lessened by prior fatigue or stretches are critical in assessing musculoskeletal injuries. Even though there are treatments to reduce eccentric contraction-induced muscle injuries, fatigue negatively influences them. Therefore, we reviewed previous studies on eccentric contraction-induced muscle injuries with prior treatments using the MEDLINE and PubMed databases. Results: Prior passive stretching had a preventative and therapeutic effect, but prior lengthening contractions did not. On the other hand, prior isometric contractions involving relatively small forces may not provide a sufficient stimulus to induce protection. As a result, high force isometric contractions may be necessary. The studies supported the positive effects of prior fatigue, concluding that it was a factor in determining the amount of damage caused by eccentric exercise. This was due to a reduction in force and increased temperature. Studies that did not support the positive effects of prior fatigue concluded that a shift in optimal length to a longer length and reduced energy absorption during lengthening are evidence that fatigue is not related to muscle injuries induced by lengthening. Conclusion: The variability of the experiment models, conditions, muscles, and treatment methods make it necessary to interpret the conditions of previous studies carefully and draw conclusions without making direct comparisons. Thus, additional studies should be carefully conducted to investigate the positive effect of fatigue on lengthening.
다양한 질병의 환자들이 입원하는 소아 중환자실에서 PRISM III의 적용
최승준,문청준,전윤홍,윤종서,김현희,김진택,이준성 대한중환자의학회 2011 Acute and Critical Care Vol.26 No.3
Background: We applied the pediatric risk of mortality (PRISM) III score to study patients in a pediatric intensive care unit (PICU), where children with various kinds of diseases were hospitalized. We analyzed whether this scoring system was useful to predict patient mortality in the PICU. Methods: We retrospectively analyzed the medical records of patients hospitalized in a 5-bed PICU at a tertiary general hospital. Children who were transferred to other hospitals and remained under pediatric intensive care were excluded from this study. Results: We studied a total of 105 children, which included 63 boys (60%) and 42 girls (40%). The mean age was 4.2 years (range 0−17 years). The children were admitted to the PICU for various conditions, including respiratory disease (31 children), neurological disease (30 children), congenital anomaly or neonatal disease (11 children), hemato-oncological disease (10 children), accident or poisoning (7 children), cardiovascular disease (5 children), sepsis (2 children), and the other miscellaneous diseases (9 children). The mean period of PICU stay was 9 days (range 2−66 days). Out of the 105 patients, 94 survived and 11 died. Thus, the mortality rate was calculated as 10.5%. PRISM III scores of the patients were between 0 and 38, with a mean ± SD of 5.0 ± 6.7. In comparison with previous studies on PICU patients with similar PRISM scores, the patients included in our study exhibited a higher mortality. The area under the curve for the prediction of mortality by PRISM III was 0.107. Among the variables included in PRISM III, Glasgow coma scale, pupillary light reflex, and platelet counts were associated with patient mortality. Conclusions: In a PICU with a wide spectrum of diseases, PRISM III was not a useful predictor of patient mortality.