Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

질적인 통합보육 프로그램 개발을 위한 일반유아교육과정의 수정전략의 개념과 실제

조윤경,홍은주 한국영유아보육학회 2003 한국영유아보육학 Vol.0 No.32

Adaptation of child-care program should be implemented for children with disabilities to participate meaningfully in class activities and works in general class with peers without disabilities. The reason to use the adaptation strategies is based on the principle of partial participation which meant for supporting the active participation of each child in inclusive class. This study is intended to develop the efficient and qualitative inclusive program and to find the more appropriate methods to implement. According to the results of application of adaptation of general early childhood curriculum to 30 children of disabilities for one year in Mookryun child-care center, the concepts, procedure, concrete methods, and practices of adaptation are introduced and suggested.

실제적 자아이미지와 이상적 자아이미지 차이에 따른 여성 의류시장 세분화

조윤주 한국의류산업학회 2003 한국의류산업학회지 Vol.5 No.5

The purpose this study is to segments apparel market based on difference real-self image and ideal-self image. The objects of the study were to prepare for the establishment of marketing strategy and alternative plan intended to users which are needed in subdivided market, after analyzing according to what the subdivided market is divided into due to the difference real-self image and idea-self image and what difference do they show as a demographic special quality or as a general active special quality in each subdivided market. Factor analysis was performed to determine the leading difference real-self image and ideal-self image, and cluster analysis was employed to identify groups of respondents based on the delineated five image difference factors. Based on the finding, three distinct groups were formed: ideal-self image seeker group, moderators group, real-self image seeker group. And logistic regression was used to assess the relative importance that demographic characteristics play in determining the segmentation. The results of this study show statistically significant differences among the three groups in terms of demographic. Marketing and management implications for effectively targeting the segments are discussed.

신이식환자에서 Thiopurine Methyltransferase의 활성이 Azathioprine 치료에 미치는 영향

조주연,배균섭,유경상,이소영,장인진,신상구,김상준,하종원,안규리 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1

처분장근처에서 침식에의한 Sr 화학종의 평형

조윤정,김성현,이인화,김시욱,고문주,박성규,이범규 조선대학교 환경연구소 2000 環境硏究 Vol.16 No.1

Leaching and adsorption equilibria of Sr Chemical Species from the near field of a repository has been studied in solidified cement with Fe and oxidized Fe. The absorption percent, Ads %, and distribution coefficient, K_d were calculated using equilibrium concentration to predict the extent of leaching and adsorption. In the mixed aqueous solutions the Ads % increase as Cement(C)/Water(W) ratios increase and K_d was decreased for Sr. These behaviors were discussed by adsorption and equilibrium of spiked ions. Oxides Fe promoted adsorption of spiked ions, but pure Fe had no effect. E_h values were also estimated and discussed to elucidate oxidation-reduction environment of experimental system.

여대생의 체형 인식도와 만족도 차이 연구

조윤주 대한가정학회 2003 Family and Environment Research Vol.41 No.11

The purpose of this study is to demonstrate the actual somatotype and perceptual somatotype, and to compare actual somaotype with ideal somatotype, and to explore segmentation based on perception of slim/obese somatotype. The respondents included 201 female student volunteers, aged 19 to 27, who were enrolled at university in Busan. Data were analyzed by paired t-test, correlation analysis, cluster analysis, and ANOVA. The results were as follows: The subjects tended to be satisfied with long and slim. slim limbs, and preferred to be tall in height and light in weight. And perceptual somatotype was related to satisfaction of somatotype. Cluster analysis was female college students to identify groups of respondents based on the perception of somatotype(all the body. the upper half of the body, the lower half of the body)difference factors. Based on the finding, three distinct groups were formed: slim tendency group. moderators tendency group. obese tendency group. There were a significant among slim tendency group, moderators tendency group, and obese tendency group base on the perceptual somatotype. There were significant differences among the three groups in terns of perception of somatotype and satisfaction of somatotype.

광주시 대기오염과 일별 사망의 상관성에 관한 시계열적 연구 : 1998~2001년

조용성,이종태,김윤신,현연주,박원석 대한보건협회 2003 대한보건연구 Vol.29 No.2

This study is performed to examine the relationship between air pollution exposure and mortality in Gwangju for the years of 19% - 2001. Daily counts of death were analyzed by general additive Poisson model, with adjustment for effects of seasonal trend, air temperature, humidity, and day of the week as confounders in a nonparametric approach. Daily death counts were associated with CO(current day), 03(6 day before), PMdcurrent day), NO₂(1 day before), SO₂(2 day before). Increase of 29.74 pg/m (interquartile range) in PM_(10)was associated with 1.4 % (95% CI = 0 % - 2.8 %) increase in the daily number of death. This effect was greater in children(1ess than 15 aged) and elderly(more than 66 aged). We concluded that Gwangju had 1 - 24 % increase in mortality in association with IQR in air pollutants. Daily variations in air pollution within the range currently occurring in Gwangju might have an adverse effect on daily mortality. These findings also support the hypothesis that air pollution, at levels below the current ambient air quality standards of Korea, is harmful to sensitive subjects, such as children or elderly.

여성 기성복 재킷의 치수 분석 : 신체치수와 제품치수의 비교를 중심으로

조윤주,백경자,이정란 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.3

The purpose of this study is to analyze the sizing system and size designation of ready-made jackets for women. We survey the sizing system and size labeling that have been used and presently practiced by the domestic garment industry of ready-made woman's jacket. In addition, 264 tailored jackets are measured for the sake of this study. The jackets are classified into 3 groups(young, missy, and madame) according to the target age of the brand. The result shows that size labeling involves body measurements(85-94-160), size code(55, 66) or simplified letter(S, M, L). However, the correspondence of size information and ease tolerances of jackets is not consistent and each company has its own sizing system. There are significant differences among young, missy, and madame group on the bust girth of apparel in 66size code. The average apparel size pitch measurement distributions(bust girth and hip girth respectively) of young group are 9cm and 13cm in 55 size code, those of missy group are 7 cm and 3 cm in 66 size code, and those of madame group are 6cm and 4cm in 77 size code. The ease of bust girth and hip girth in missy group are much more than other groups.

장애아동의 통합 어린이집에서 일반 초등학교로의 전이 지원 모형개발

조윤경,홍은주,이은정 한국영유아보육학회 2002 한국영유아보육학 Vol.0 No.28

The comprehensive transition program supporting the three children with disabilities served in integrated day-care center, proceeded to elementary regular school was implemented. The program was consisted of the direct supporting services from 8:30 a.m. to 12:30 p.m. by supporting teacher stayed in the first grade class included with the three children with disabilities. And the after-school program was carried out in day-care center consisted of small group learning, music therapy, special physical education, community-based training, parent counseling and education. The transition support was lasted for 15 months, as 3 months for preparation and 12 months for program implementation. The results indicated that three children with disabilities showed the positive increases in academic achievement and behavior adjustment in the first grade class compared with the level of initial performance. Based on these outcomes, the future directions for improving the transition support model were discussed.

Silymarin 함유제형, 레가론 캅셀 140^R 및 타 실리마린 제제의 약동학적 특성에 관한 비교 연구

조주연,배균섭,정인숙,유경상,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2