흰쥐 대뇌피질에서 아드레날린성 수용체의 개체발생에 관한 자기방사법적 연구

이명곤,이승원,국지현,정윤영,이은주,김종근,배춘상 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예

김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.

비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

후천성 면역부전증후군 환자에서 발생한 Cryptosporidium parvum 감염 2예의 보고

오명돈,최강원,신형식,김성민,최희정,강현재,김윤준,채종일 대한감염학회 1996 감염 Vol.28 No.5

Cryptosporiduim is an intracellular protozoan parasite and known as an important pathogen causing diarrheal illness in animals and man since 1970's. With the advance of epidemic of Acquired Immunodeficiency Syndrome(AIDS), Cryptosporidium has emerged as one of important pathogens in AIDS patients and is responsible for chronic diarrhea, cholecystitis, biliary tree obstruction and respiratory illness. Despite frequent reports of cryptosporidial diarrhea in other countries there has been no report of human cryptosporidial infection in AIDS patients so far in Korea. We report two cases with chronic cryptosporidial diarrheal illness in AIDS patients. C. parvum oocyst was identified by fecal smear with modified acid fast staining. In one patient the diarrheal illness was improved after 4 weeks supportive management only. But fecal excretion of oocyst continued after clinical improvement of the diarrheal illness. Another patient was died of respiratory failure after recurrent diarrheal illness. Cryptosporidial infection should be considered in differential diagnosis of chronic diarrhea especially, in AIDS patients.

동종골수이식 환자에서 발생한 지역사회발생 Parainfluenza virus 3형 폐렴 1예

신종욱,조요한,강철인,김성한,이상윤,김의석,오명돈,이환종,박선양,김병국,최강원 대한감염학회 2002 감염 Vol.34 No.5

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

뇌·심혈관질환 예방을 위한 사업장 지원 프로그램의 단기효과 분석

곽우석,원종욱,이정배,이명숙,강은주,노재훈 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 뇌 심혈관질환은 주요한 사망원인이며 우리나라 산업재해 보상에 있어 중요 부분을 차지하고 있다 따라서 한국산업안전보건공단은 2000년도부터 지역 산업보건기관을 통해 많은 사업장에 뇌 심혈관질환 예방 프로그램을 지원해왔다 본 연구는 이 프로그램이 근로자의 뇌 심혈관질환 발병위험도 개선에 미치는 단기영향을 평가하고자 수행되었다 방법 2007년도 집중관리 프로그램 대상자 중 전후 발병위험도 평가가 가능했던 5,902명(53.3%)을 대상으로 혈압 콜레스테롤 비만도 및 발병위험도를 전후 비교하였다 발병위험도 평가는 KOSHA CODE H-11-2004 지침을 사용하였다 결과 평균 수축기 및 이완기 혈압이 4.9 mmHg 3.1mmHg 감소하였으며 총콜레스테롤과 비만도(BMI)는 각각 8.4 g/dL 0.1 kg/㎡ 감소하였다 흡연율은 6.0% 감소하였으며 규칙적인 운동 시행률은 23.1% 증가하였다 전체적인 발병위험도 개선율은 49.1%였다 결론 국가 지원의 뇌 심혈관질환 예방 프로그램은 단기적으로 좋은 성과를 나타냈다 향후 연구에서는 사업장 단위의 장기적인 영향과 비용-효과에 대한 분석이 이루어질 필요가 있다 Objectives Cardiovascular disease is the leading cause of death and a major source of workers' Compensation claims in Korea Since 2000 the Korea Occupational Safety and Health Agency (KOSHA), working through local occupational health institutions has supported cardiovascular disease prevention programs at a number of companies in Korea The purpose of this study was to assess the short term effects of this effort Methods A total of 11,077 workers at risk were enrolled in the workplace cardiovascular disease prevention program and 5,902 workers (53.3%) completed the 1-year course during 2007 The program consisted of a medical checkup and health counseling for the workers by occupational health nurses The guidelines for this prevention program were adopted from KOSHA Code H-11-2004 To determine the program's effectiveness the workers risks for cardiovascular disease were assessed before and one year after completion of the program Results The intervention led to significant reductions in the mean systolic and diastolic blood pressures of 4.9 mmHg and 3.1 mmHg respectively Mean total cholesterol and BMI were also reduced significantly by 8.4 g/dl and 0.1 kg/㎡ The rate of smoking was decreased by 6.0% and the percentage of workers engaging in regular exercise was increased by 23.1% of the 3,530 workers with the low risk and above the overall cardiovascular risk was improved in 1,734 (49.1 %) of them Conclusions The cardiovascular disease prevention program supported by the Korea Occupational Safety and Health Agency reduces cardiovascular diseases risks among workers and may improve the health status of workers in Korea

진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예

진상만,박종선,김홍빈,오명돈,최강원,김희연,국윤호,김남중 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Mycobacterium genauense는 최근에 알려진 미코박테륨으로서, 식욕 부진, 체중 감소, 설사, 림프절 병증 등 파종성 Myocobacterium avium-intracellulare complex 감염과 유사한 임상상을 보이며, 위장관 침범을 잘 하는 것으로 알려져 있으나 아직 국내에서 증례는 보고된 바가 없다. 저자들은 진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 환자는 상복부 동통과 발열, 설사로 내원하였다. 십이지장의 미란성 병변에서 시행한 조직검사에서 항산균이 가득 차있는 거품세포가 관찰되었으며, 이 검체에서 16S rRNA 유전자의 중합연쇄반응 검사를 시행하여 Mycobacterium genavense를 확인하였다. Mycobacterium genavense, first identified in 1990, is known as a pathogen that mimics disseminated Myocobacterium avium-intracellulare complex (MAC) infection with particular propensity for the gastrointestinal tract. In Korea, no case with the organism has been reported. Herein we report a case of Mycobacterium genavense infection that manifested with erosive lesion of duodenum in a patient with acquired immune deficiency syndrome. The patient presented with epigastric pain and fever, diarrhea. Duodenal biopsy showed histiocytic infiltration with numerous acid-fast bacilli. Identification of the mycobacterial isolate by the polymerase chain reaction restriction analysis of 16S rRNA gene revealed Mycobacterium genavense.

면직물과 면/닥섬유 혼방직물의 질감이미지와 선호도 평가

신주동, 김여원, 최종명 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

The purpose of this study was to examine the subjective evaluation of texture images and preferences for cotton and cotton/mulberry blended fabrics in order to suggest the fabric planning for environment-friendly fashion products. Fifty male and female university students evaluated the texture images and preferences of cotton and cotton/mulberry blended fabrics dyed with natural indigo dye. For statistical analysis, frequency, mean, factor analysis, t-test, F-test and Pearson correlation. The results were as follows: The texture images of cotton and cotton/mulberry blended fabrics were classified into 4 factors: 'stiffness', 'elasticity', 'weight', and 'smoothness'. They evaluated significant differences according to the fiber content in the texture images for the fabrics. Also, there were partially significant differences by the gender in the texture images for the fabrics. Female students were more sensitive than males for the 'stiffness' and 'elasticity' factor. They were more preferred cotton fabrics than cotton/mulberry blended fabrics in terms of tactile and purchase preferences. The preferences of tactile were no different according to the gender, but there was significant difference according to the gender in terms of purchase preference.