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Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats
Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3
The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.
Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats
Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3
The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.
물시멘트비 및 단위수량에 따른 고품질 재생잔골재를 사용한 재생콘크리트의 공학적 특성에 관한 실험적 연구
문형재,송민섭,김재환,장종호,김용로,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
The purpose of this study is to investigate and analyze experimentally and positively engineering properties of recycled concrete using high quality recycled fine aggregate according to w/c ratio and unit water contents. And it is intend to present fundamental data for the mix design and the improvement of quality. The results are as follows; According to the increase of W/C ratio, the addition ratio of superplasticizer was reduced, the strength of compressive and tensile showed low and carbonation depth and chloride penetration depth showed high. And according to the increase of unit water contents, the addition ratio of superplasticizer was reduced, the strength of compressive and tensile showed low and carbonation depth and chloride penetration depth showed high.
최형섭,조인철,변종환,문병현,허종수 한국환경농학회 2003 한국환경농학회지 Vol.22 No.1
호수 유입 하천인 황강의 1996~2001년 년도별 평균 수질은 COD 3.1~4,2 mg/L, T-N 2.460~3.550 mg/L, T-P 0.111~0.201 mg/L이였다. 호수내의 평균 수질은 COD가 1996년 1.9 mg/L에서 2001년 2.7 mg/L로 매년 조금씩 종가하는 것으로 나타났다. 호수내의 1996~2001년 년도별 평균 T-N 농도는 1.393~l.792 mg/L 이었으며, T-P농도는 0.018~0.023 mg/L 이였다. 식물성 플랑크톤의 발생 정도를 나타내는 Chl-α와 T-N, T-P와의 상관계수는 각각 0,382, 0.372였으며, 또한 수온과 강우량에 대한 상관계수는 각각 0.589, 0,526이였다. 따라서 합천댐의 경우 식물성 플랑크톤의 발생이 T-N, T-P보다 수온 및 강수량과 더 밀접한 관계가 있는 것으로 나타났다. 그리고 호수의 영양단계는 중영양~부영양 단계에 있는 것으로 평가되었다. The yearly average water qualifies of the Whang river, which flows into the Hapcheon lake, were COD 3.1~4.2 mg/L, T-N 2.460~3.550 mg/L, and T-P 0.111~0.201 mg/L during 1996~2001. The yearly average COD concentration of Hapcheon lake was increased from 1.9 mg/L (in 1996) to 2.7 mg/L (in 2000). However, T-N and T-P concentration of Hapcheon lake did not show increasing trend over the 6 year period. During 1996~2001, the yearly average concentrations of T-N, T-P were 1.383?1.792 mg/L, 0.018~0.023 mg/L, respectively. The correlation coefficients between chlorophyll α and T-N, T-P, rainfall intensity, water temperature were 0.382, 0372, 0.589, and 0.526, respectively. Therefore, the rainfall and water temperature appeared to play an important role for the variations of chlorophyll α concentration in the Hapcheon lake. Trophic state of the Hapcheon lake were evaluated to be in the range of mesotrophic to eutrophic.
慶北 漆谷郡 河濱池에서 採集한 淡水魚의 吸蟲類 被囊幼蟲의 奇生狀
林宗燮,文柱煥,鄭東一,崔東翊 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.3
1990年 4月부터 同年 9月까지 慶北 漆谷郡 河濱池에서 淡水魚를 投綱, 낚시, 사발모지等으로 採集하여 吸蟲類 被囊幼蟲의 魚種別 寄生狀을 調査하였다. 河濱池에서 採集된 5種의 淡水魚에서 5種의 吸蟲類 被囊幼蟲을 同定하였던 바 몰개(Gnathopogon atromaculatus)에서는 5種의 吸蟲類 被囊幼蟲이, 참붕어(Pseudorasbora parva)에서는 3種의 被囊幼蟲이 檢出되었고, 강준치(Erythroculter erythropterus)와 납지리(Paracheilognathus rhombea)에서는 各各 1種의 被囊幼蟲이 檢出되었다. 붕어(Carassius carassius)에서는 吸蟲類 被囊幼蟲이 전혀 檢出되지 않았다. 肝吸蟲 被囊幼蟲의 寄生率과 寄生程度는 몰개에서 各各 58.9% 및 2.0個로 가장 높았으며, Metagonimus屬 被囊幼蟲은 몰개에서만 그 率 3.6%, 그 程度 1.0個로 檢出되었다. 그외의 3種의 吸蟲類 被囊幼蟲, Cyathocotyle orientalis, Metacercaria hasegawai, Pseudexorchis major는 各各 7.4個, 1.0個, 1.0個의 寄生程度를 나타내었다. 이번 調査로 慶北 漆谷郡 河濱池는 吸蟲類의 輕微한 浸潤池임과 河濱池에서 醫學的으로 重要한 淡水魚 宿主는 몰개였다. From April to September, 1990, fresh-water fish collected in Habin pond, Chilgok country, Kyungpook Province, were examined for the determination of the prevalence and intensity of infestation with digenetic larval trematodes. From 5 species of fresh-water fish collected, 5 species of metacercariae were identified. Gnathopogon atromaculatus, the korean shiner, was found to be infested by 5 species of the metacercariae whereas Pseudorasbora parva, the southern top-mouthed minnow, by 4 kinds. Erythroculter erythropterus, the white fish, and Paracheilognathus rhombea, the flat bitterling, were infested with 3 kinds of metacercariae. However, no digenetic larval trematode was demonstrated from Carassius carassius, the crusian carp. The rate and intensity of infestation with Clonorchis sinensis was the highest in G. atromaculatus, 58.9% and 3.4 cysts per gram of flesh, respectively. Metacercaria of Metagonimus species was detected from G. atromaculatus alone. The intensity of fish with the remaining 3 kinds of metacercariae, Cyathocotyle orientalis, Metacercaria hasegawai, and Metorchis orientalis, 7.4, 1.0 and 1.0 cyst per gram of the flesh, respectively. In the light of these results, it seemed likely that Habin pond might be enzootic focus of digenetic larval trematodes and G. atromaculatus might be a fish host of the greatest medical importance.
Moon Sub Choi,Jong kuk Lee,Joonho Richard Hwang,Hwan oong Lee 한국무역연구원 2014 貿易 硏究 Vol.10 No.6
By constructing a novel proprietary pharmaceutical database, we assessed whether the corporate transparency of Korean exchange-listed pharmaceutical companies affects event-study returns upon Korea Food and Drug Agency approvals of new drugs. The empirical findings are as follows: First, the evidence is that new drugs are priced in the announcement returns. Second, product innovation is appraised higher by the investors when the company is well-governed in terms of trading venue, R&D intensity, balance sheet variables, payout policy, valuation, and years of operation. Lastly, shareholders are wealthier with innovative new products promised by trustworthy managers.