혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

위암 환자에게 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김상용,김영건 忠南大學校 癌共同硏究所 1991 癌共同硏究所 硏究誌 Vol.1991 No.-

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

정맥 자가 진통 조절법을 사용하는 유방암 수술환자에서 경구 항구역제 전투약의 효과

이현정,김혜진 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Objective: This study was designed to evaluate the effect of premedication of ramosetron orally disintegrating tablet (ODT), a potent 5-HT3 receptor antagonist, for prophylaxis and treatment of postoperative nausea and vomiting (PONY) undergoing breast cancer surgery using patient controlled analgesia (PCA). Material and Method: 130 women classified ASA physical status Ⅰ-Ⅱ, aged 24-60 yr, undergoing elective breast cancer surgery, were randomized. A standard general anesthetic technique and postoperative PCA using fentanyl and ketorolac were used. Patients were assigned to one of three groups; group A (no prophylactic antiemetics were administered), group B (4 mg of ondansetron ODT was administered 30 minutes before induction), and group C (0.1 mg of ramosetron ODT was administered 30 minutes before induction). Episodes of nausea and vomiting, the use of rescue antiemetics, degree of pain, adverse events, and level of satisfaction were checked during 24 hr after the operation. Results: The overall incidence of PONY during the 24 hours after the operation in group B and C were decreased. The incidence of nausea after 6 hours after the operation and the frequency of the use of rescue antiemetics were significantly lower compared with group A and B. The patients in group C were more satisfied with control of PONY than others. Conclusion: This study results suggest ramosetron ODT was an effective way to prevent PONY in breast cancer surgical patients using PCA.

기(氣)수련이 정신건강 프로파일에 미치는 효과

정영자,정현익,이명수,서채문 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This cross-sectional investigation evaluated the trend of psychological changes by Qi-training using a self-report inventory of emotional distress, Symptom Check List-90-Revision (SCL-90-R). Forty-one normal healthy subjects (mean age: 21.0±5.4) and one hundred-twenty-three Qi-trainees (divided into three groups, primary, middle and high level) participated in this study. Primary level group has received 1-4 months Qi-training (mean age: 22.0±7.8, n = 41); middle level group has 5-12 months Qi-training (mean age: 20.0±7.8, n = 41); and high level group has more than 1 year Qi-training (mean age: 22.7± 6.7, n = 41). Our results show that all of psychologucal symptom scales of Qi-trainees over lyear were significantly lower scores compared to controls. In addition, high level group had lower global indexes scores than control. A significant negative correlation was found between the Qi-training period and all SCL-90-R subscales except phobic anxiety. These results suggest that Qi-training is effective in protection as well as reduction of psychological symptomatology.

백서에서 치아이동 후 보정기간 동안 교합이 치주조직섬유의 재형성에 미치는 영향

정권희,박영준,이기헌,황현식 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.2

본 연구는 실험적 치아이동 후 보정기간 동안 교합이 치주조직섬유의 물리적 강도에 미치는 영향을 알아보고자 시행되었다. 체중 200g 내외의 Sprague-Dawley계 백서 수컷에서 상악 양측 제1대구치와 2대구치 사이에 교정용 고무줄을 삽입하여 4일 동안 치아를 이동시킨 다음, 각 실험동물의 하악 좌측 베1, 2, 3대구치를 발치하여 우측은 대합치가 있는 교합측으로, 좌측은 비교합측으로 구분하였다. 상악 제1대구치와 2대구치 사이의 인접면에 유지구를 형성하고 광중합형 레진으로 채워 보정을 시행한 후 시작 0일, 4일, 8일, 12일, 16일 또는 20일 경과한 후 백서를 희생시킨 다음, 만능물성 시험기를 이용하여 상악 제1대구치를 발치할 때 필요한 최대인장강도를 측정 좌우간 비교 분석하여 다음과 같은 결과를 얻었다. 1. 교합측은 비보정군에서 보정 4일, 8일, 12일, 16일, 20일군으로 갈수록 최대인장강도사 증가하였고, 보정 12일군 이후부터 통계적으로 유의한 차이를 보였다(p<0.05). 2. 비교합측은 비보정군에서 4일, 8일, 12일, 16일, 20일군으로 갈수록 최대인장강도가 증가하는 경향을 보였으나 통계적으로 유의한 차이를 보이지 않았다(p<0.05) 3. 교합측과 비교합측의 최대인장강도를 비교한 결과 보정 8일군까지 통계적으로 유의한 차이를 보이지 않았으나 (p>0.05), 보정 12일군 이후 보정 20일군까지 통계적으로 유의한 차이를 보였다(p<0.05). 이상의 결과는 실험적 치아이동 후 보정기간 동안 교합이 치주조직 섬유의 재형성에 영향을 미침으로 보정장치의 선택, 기간설정 등 보정계획서 교합에 대한 고려가 필요함을 시사하였다. The purpose of this study was to valuate the effect of occlusion on the mechanical strength of periodontal fibers during retention periods after experimental tooth movement. In the Sprague-Dawley male rats weighing 200g or more, the intraoral elastics were inserted into the both right and left interproximal space between upper first and second molars for tooth movement. After 4 days later, the left lower first, second, and third molars were extracted for differentiating the non-occlusal side from the occlusal side in the same mouth. At the same time the elastics were removes and than light cured resin was placed in the space between upper first and second molard following undercut was made for retention bilaterally. From the beginning of retention, 7 rats were sacrificed at 0, 4, 8, 12, 16, 20 days respectively. For evaluating of magnitude on the mechanical strength of periodontal tissue, the maximal shear load of the upper first molars were measured bilaterally during extraction using Instron Universal Testing Machine. The results of this study were obtained as follows : 1. In the occlusal side, the maximal shear load was increased from no retention to retention 20 days group as time was going and statistically difference was shown from retention 12 days group (p<0.05). 2. In the non-occlusal side, the maximal shear load was increased slightly from no retention 20 days group as time was going but there was no statistically difference (p>0.05) 3. The result compared with the maximal shear load between occlusal and nonocclusal side showed no statistically difference until retention 8 day group (p>0.05), but showed statistically difference from retention 12 day to 20 day group (p<0.05). These results show that occlusion had an effect on mechanical strength of the periodontal fibers during retention periods after experimental tooth movement; therefore, it is suggested that occlusion should be considered while the retainer types and retention period are planned.

장상피화생과 Helicobactor pylori와의 상관 관계에 관한 연구

이복희,김대수,이현숙,진영주,윤세진,송형근,성노현,정현용,이동호 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

In 1965 Lauren divided advanced gastric carcinoma into two main types-namely, "intestinal" and "diffuse" type carcinoma, which differ not only morphologically but also in their clinical and epidemiological characteristics. Moreover, a different histogenetic process has been postulated by many authors that intestinal type gastric carcinoma might arise from areas with intestinal metaplasia. Since Warren and Marshall reported the presence of Helicobacter pylori in the stomach in 1983, strong evidence has been obtained that there is a close relationship between Helicobacter pylori and chronic gastritis, atrophic gastritis, intestinal metaplasia, and intestinal type gastric carcinoma. To study the relationship between intestinal metaplasia and Helicobacter pylori infection, we performed gastroscopic biopsies and CLO tests taken from patients with epigastric pain. Only 87 patients with macroscopically suspected antral gastritis were included. The prevalence of intestinal metaplasia in gastric antral biopsies increased from 33.3% in the age group<30 years to 63.6% in the age group 60 years. When all patients were divided into two age groups-namely, (i)<50 years(n=41) and (ii)≥ 50 years(n-=46), intestinal metaplasia was found significantly more often in patients ≥ 50 years. ((i) 39.2%, (ii) 54.3%, p<0.0001). The prevalence of Helicobacter pylori in gastric antral biopsies decreased from 66.7% in the age group<30 years to 62.5%, in the age group in the age group 50 to 59 years. When all patients were divided into the same two age groups-namely(i)<50 years and (ii)≥50 years, the prevalence of Helicobacter pylori did not differ between two groups in a statistically significant way. The mean age of intestinal metaplasia positive patients who were also Helicobacter pylori positive was 48±11.0(mean±S.D.)years, whereas the mean age of intestinal metaplasia positive patients who were Helicobacter pylori negative was 52±9.7(mean±S.D.)years. In conclusion. although our data do not prove a causal relationship between Helicobacter pylori infection and the histogenesis of intestinal metaplasia, we suggest that Helicobacter pylori plays an important role in the development of intestinal metaplasia in the gastric mucosa. Whether Helicobacter pylori has to be present at all times during this process or is only necessary as a 'trigger', needs further research.

백서에서 치아이동 후 보정기간 동안 교합이 치주조직 섬유의 재형성에 미치는 영향

정권희,이기헌,황현식,이석형 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.2

The purpose of this study was to evaluate the effect of occlusion on the mechanical strength of periodontal fibers during retention periods after experimental tooth movement. In the Sprague-Dawley male rats weighing 200 g or more. The intraoral elastics was inserted into the interproximal space of upper the first and second molars. After 4th day of teeth movement, the left mandibular first, second, and third molars were extracted for differentiating the occlusal side from the non-occlusal side in the experimental groups. The intraoral elastics was removed and then light cured resin was placed in the interproximal space between the bilateral upper first and second molars following undercut was made for retention. From the day beginning retention, 7 rats were sacrified at 0, 4, 8, 12, 16, 20 days respectively. For evaluating of degree on the mechanical strength of periodontal tissue, maximal shear load of the bilateral upper first molars were measured by use of Instron Universal Testing Machine. The results of this study were obtained as follows: 1. In the occlusal side from no retention group to 4-day, 8-day, 12-day, 16-day, and retention 20-day group as time was going maximal shear load was increased and there was statistically difference from retention 12-day group(p<0.05). 2. In the non-occlusal side from no retention group to 4-day, 8-day, 12-day, 16-day, and retention 20-day group as time was going maximal shear load was increased slightly but there was no statistically difference(p>0.05). 3. The result compared with maximal shear load between occlusal and non-occlusal side showed no statistically difference until retention 8-daygroup(p>0.05), and showed statistically difference from retention 12-day to 20-day group(p<0.05). These results show that the occlusion had an effect on mechanical strength of the periodontal fibers during retention periods after experimental tooth movement; therefore, it is suggested that consideration of occlusion is required for the type and length of retention at the time of retention planning.

Continuous wave of obturation technique에서 플러거의 다양한 적용 깊이에 따른 근단부 폐쇄효율 비교

이상진,박정길,허복,김현철 大韓齒科保存學會 2007 Restorative Dentistry & Endodontics Vol.32 No.6

이 연구와 목적은 continuous wave of obturation technique으로 근관 충전을 할 때, 다양한 heat source plugger의 깊이에 따른 근단부 근관 폐쇄능력을 비교하는 것이었다. 직전 형태 발거 소구치를 #35/.06크기까지 니켈티타늄 파일을 사용하여 성형 및 세정하였다. 성형과 세정이 완료된 치아를 heat source plugger의 적용 깊이에 따라 15개씩 5군으로 분류하였다: 3 mm, 4 mm, 5 mm, 6 mm, 7 mm. 양성 대조군을 제외한 모든 근관은 E&Q plus (Meta Biomed Co., Chungju, Korea)를 사용하여 #35/.06 gutta-percha cone으로 충전하였다. 모든 치아의 근첨공 주변 1 mm를 제외하고 nail varnish를 도포하였고 음성 대조군은 근첨공을 포함하여 전체 면을 도포하였다. 모든 시편을 1% 메틸렌블루 용액에 72시간 동안 보관한 다음 치근첨으로부터 1, 2, 3 mm 높이에서 수평으로 절단하였다. 각 단면을 12.5 x 2.5배 현미경하에서 관찰하고 디지털 카메라로 촬영하였다. 염색제 누출 평가를 위해 five-degree scoring system을 사용하였다. 각 절단면에서의 점수를 모두 합하여 한 시편의 점수로 사용하고 통계학적 분석을 하였다. 이 실험 조건하에서, 3 - 7 mm 까지의 heat source plugger의 적용 깊이는 근단부 폐쇄에서 유의한 차이를 나타내지 않았다. 5 - 7 mm의 Buchanan's protocol을 포함한 3 - 7 mm를 모두 임상 적용에서 받아들여질 만하다고 보인다. The purpose of this study was to compare apical sealing ability of continuous wave canal filling technique according to various heat source plugging depths. Eighty one extracted human premolars with straight root were cleaned and shaped to size 35 using .06 taper rotaiy NiTi file. After cleansing and shaping, the teeth were divided into 5 groups following the heat source probing depths from the apex ; 3, 4, 5, 6 and 7 mm. All specimens were filled using E&Q Plus with #35/.06 tapered gutta-percha cone. The positive control teeth were not filled. All teeth were coated with nail varnish except the apical 1 mm around the apical foramen. Negative control teeth were completely sealed include the apical foramen. All specimens were immersed in 1% methylene blue solution for 72 hours. Then the specimens were sectioned horizontally at 1, 2 and 3 mm from the root apex. Each sectioned surface was photographed using a digital camera attached to the stereomicroscope at 12.5 x 2.5 fold magnification. All points at 1, 2 and 3 mm were summed as final score of one specimen. Statistical analysis of the collected data was performed. Under the condition of this study, there was no significant difference between the heat source plugging depths of 3, 4, 5, 6 and 7 mm in apical sealing ability. All of apical heat source plugging depth from 3 to 7 mm including Buchanan's protocol -from 5 to 7 mm- seems to be acceptable in clinical application.