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안정기,이기천,허승식,이종선,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1
Nizatidine is a newly introduced potent H2-receptor antagonist of acid secretion with long duration of action. For evaluation of clinical efficancy and safety, twenty one patients with endoscopically proved thirteen gastric ulcers and eight duodenal ulcers were treated with nizatidine 300mg at bed time via per os for 6 weeks. The results were as follows 1. The rate of complete endoscopic healing of duodenal ulcer 92.3% and 87.5% after 6 weeks. The overall healing rate of peptic ulcer was achieved in 89.9% at 6 weeks. 2. Clinical symptoms disappeared in 84.6%, 92.3% and 100% of patients with duodenal ulcer and 75.0%, 87.5% and 87.5% patients with gastric ulcer at 2, 4 and 6 weeks respectively. 3. There were not developed any symptoms and signs suggesting side effect of drug. In conclusion, data from this study suggest that nizatidine 300mg p.o. at sleeping time is effective and safe in treatment of peptic ulcer disease, and is well tolerated on a short-term basis.
박헌진,안정기,이종선,김영건 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
Hypwelipiswmia is commonly observed in the diabetics, especially with cardiovascular complications. We studied lipid profiles and cardiovascular complication in the 191 adult onset DM patients. The results are as follows: 1. The age distribution was from 24 years old to 82 years old. Male patients were 99 persons, famale patients were 92 persons. The mean disease duration was less than 2 years in the 77 patients, more than 5 years in the 79 patients. 2. Upon the classification between sexes, the mean age was 55±1(SEM) years in the male group, 53±1(SEM) years in the female group. The mean disease durtion was 6.4±1(SEM) years in the female group, longer in the male group (P<0.05). The triglyceride level was 210±16(SEM)㎎% in the male group, 214±13(SEM)㎎% in the female group. The fasting blood sugar level was 147±6(SEM)㎎/dl in the male group, 158±8(SEM)㎎/dl n the female group. The cholesterol level was 229±5(SEM)㎎/dl in the male group, 248±5(SEM)㎎/dl in the female group, higher in the female group (P<0.05). 3. The cardiovascurlar complicatioin (Hypertension, Myocardial infarction, Myocardial ischemia, Angina, Gangrene, Proliferative retinopathy) were present in the 60 patients from 191 patients. Hypertension was present in the 48 patients, and the most prevalent. The mean age and carrdiovascular complication were higher in the more than 5 years of mean disease duration group(mean age 57.99±1.14(SEM)㎎ year) than less than 5 years group(mean age 52.12±0.10(SEM)㎎ year) (P<0.001, P<0.01). 4. The mean disease duration (7.40±1.01(SEM) years), mean triglyceride levels(271±1.01(SEM)㎎%), and mean cholestrerol levels( 257±8㎎.dl) in the cardiovascularly complicated group were higher than those of non-complicated group (P<0.01). 5. The triglycerdie level was high in the obese group (230±14SEM㎎%) than non-obese group (184±15SEM㎎%) (P<0.05). The obese patients were more prevalent in the female group than male group significantly. 6. Considering obesity and cardiovascular complications, the triglyceride value was higher in the obese complicated group(300±30SEM㎎%) than obese non-complicated (197±14SEM㎎ %) or non-obese non-complicated (168±13SEM㎎ %) group (P<0.001). The cholesterol level was higher in the obese complicated group (267±10SEM㎎/dl) than obese non-complicated (230±5SEM㎎/dl) or non-obese non-complicated group(229±7SEM㎎/dl) (P<0.05). 7. Classifying upon insulin response pattern, the obese patients were found in the response pattern, low response pattern, flat type pattern(no response pattern) in the decreasing number of order (P<0.01). The cardiovascular complications were found in the low response group, response group, and flat type pattern (no response) in the decreasing number of order ( P<0.05). The combined cases of obesity and cardiovascular complications were found in the low response group, response group and flat type group(no response) pattern in the decreasing number of order (P<0.01). The mean disease duration was longer in the flat type group (no response) (4.48±0.6SEM years) than the response group(2.43±0.90SEM years) (P<0.05). The mean triglyceride value was higher in the response group (267.38±154.75SEM㎎%) than the flat type(no response group) (198.35±154.05SD㎎%) (P<0.05). So, we conclude that in the NIDDM, obesity control(die control, ideal body weight mainterice, and hyperlipidemia control) is essential for better DM control and cardiovascular complication control.
김영건,안정기 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
Colonofiberscopy has become a procedure in the study of patients with symptoms and signs suggestive of colonic disease. In recent years, it has become an essential procedure to diagnosis and treatment of colonic disease. Colonofiberscopy and sigmoidoscopy were performed on 454 cases who has been visited and were suspected of colonic disease to the Department of Internal Medicine, Chungnam University, College of Medicine, from November 1986 to November 1989. 1. The observed patients were 125 cases with the most predominent age group in the fifties. 2. In clinical symptom and sins, abdominal pain was most common (187 cases; 41.1%), and the next was diarrhea (108 cases; 23.8%), hematochezia (92 cases; 20.3%). 3. Regarding the cause of abnormal colonoscopic findings, colorectal cancers were found in 86 cases(18.9%), benign polyp 33 cases(7.2%), chronic nonspecific colitis 47 cases(10.3%), ulcerative colitis 12 cases(2.6%) and tuberculous colitis 5 cases(1.1%). 4. The comparison was made between barium enema and colonoscopy. Eighty among 131 cases (61.1%) were an identical diagnosis by both examinations.
김성철,안정기,박헌진,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1
The therapeutic effect of famotidine was evaluated in 24 patients with endoscopically proven peptic ulcer, 10 cases of gastric ulcer and 14 cases of duodenal ulcer. All 24 patients were treated with famotidine 20 mg b. i. d. for 8 weeks. We followed up endoscopic examination at week 4, 6, and 8, and observed changes of symptom every 2 weeks. The results were as follows: 1. The rates of patients completely healed in gastric ulcer group were 60% at week 4, 90% at week 6, and 90% at week 8. 2. The rates of patients completely healed in duodenal ulcer group were 79% at week 4, 93% at week 6, and 100% at week 8. 3. The overall rates of patients completely healed in both groups were 71% at week 4, 92% at week 6, and 96% at week 8. 4. The rates of patients completely relieved from each symptom were 60-100% within 2 weeks. 5. There were no symptoms and signs suggesting side effects of drug. In this stuy, we concluded that famotidine is effective in the treatment of gastric and duodenal ulcer and is well tolerated.