열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

안면부에 발생한 고정형 스포로트리쿰증 3례

최윤애,류영욱,정재봉,송준영,이규석 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

We experienced 3 cases of fixed type cutaneous sporotrichosis confined to the face. Case 1 was a 32-month old child, affected over the nose. Case 2 was a 25-year old man, affected over the left cheek. Case 3 was a 71-year old man, affected over the nose. Histopathologically, chronic granulomatous inflammation with pseudoepitheliomatous hyperplasia was observed. Mycologically, typical dark brown to black colored colonines with moist, wrinkled and membranous surfaces were cultured. All patients were completely cured by oral administration of saturated KI and itraconazole combined therapy in a short period(40-90 days).

말기신부전 환자의 혈색소 순환 : 투석 방식에 따른 양상 비교 및 관련 인자들에 대한 고찰

최재혁,김준섭,원기범,박준형,탁우택,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈색소 순환은 말기신부전 환자에서 인체 재조합 적혈구 조혈 인자를 투여하여 빈혈을 치료하는 동안 빈번히 관찰되며 이는 환자의 입원과 사망률과 관계가 있다고 알려져 있다. 이에 저자는 투석중인 말기 신부전 환자를 대상으로 혈색소 순환 양상과 이와 연관된 인자들을 알아보고자 하였다. 혈색소 순환의 관련 인자들을 알아보기 위하여 투석 치료를 받고 있는 환자 40명 (혈액투석 환자군: 20형, 복막투석 환자군: 20명)을 대상으로 투석 시작부터 1년 동안의 환자의 나이와 성별, 투석시작 1년간의 평균 Hb, 수혈 횟수, 총입원 횟수, 감염으로 인한 입원 횟수, 혈청 ferritin 농도, 혈청 transferrin saturation (TSAT), 철분제제 복용 유무, 일주일 동안 투여된 rHuEPO 양, rHuEPO의 변화량, 알부민, C-reactive protein (CRP) 및 입원 원인 등을 후향적으로 조사하였다. 전체 환자 40명 중 33명 (82.5%)에서 혈색소 순환이 관찰되었다. 혈액투석 환자군에 비해 복막투석 환자군에서 혈색소 순환 첫수가 유의하게 높았다 (p=0.037).혈색소 순환 발생군과 혈색소 순환 미발생군의 관련인자들을 비교하였을 경우 혈색소 순환 발생군에서 총 입원 첫수 (p=0.01), 감염으로 인한 입원 횟수 (p=0.036)가 유의하게 많았으며, 혈중 알부민 수치는 유의하게 낮았다 (p=0.003).그러나 두 군간의 나이, 성별, 수혈 횟수, 혈청 ferritin농도, 혈청 transferrin saturation (TSAT) 및 혈청 철분 농도는 유의한 차이가 없었다. 혈색소 순환의 빈도는 일주일 동안 투여된 r-HuEPO변화량과 양의 상관관계를 보였고 (p=0.003),혈중 알부민 수치와 음의 상관관계를 보였다 (p=0.013). 복막투석 환자군에서 혈액투석 환자군에 비해 혈색소 순환이 유의하게 높게 발생하였다. 일주일 동안 투여된 r-HuEPO 변화량, 입원 및 혈청 알부민 수치는 투석 시작부터 1년 동안의 혈색소 순환과 관련이 있었다. Hemoglobin cycling is frequently observed during treatment of anemia with recombinant human erythropoietin (r-HuEPO) in patients with end stage renal disease (ESRD) it is also reported to be associated with hospitalization and morbidity. We analyzed hemoglobin cycling and potential associated factors in patients on dialysis. Forty new dialysis patients (20 hemodialysis, HD and 20 peritoneal dialysis, PD) were recruited during their first year. Age, gender, mean hemoglobin level, frequency of transfusion, frequency of hospital admission, frequency of admission due to infection, serum ferritin, transferrine saturation, iron levels, rHuEPO dose per week, serum albumin, and c-reactive protein were retrospectively evaluated in order to examine the possible correlations with hemoglobin cycling. Thirty-three patients (82.5%) were identified in the hemoglobin cycling group. The PD group had a higher frequency of hemoglobin cycling than did the HD group (p=0.037). The hemoglobin cycling group showed a significantly higher frequency of hospital admission (P=0.001), admission due to infection (p=0.036) and a lower serum albumin level (p=0.003) than the other group, but there was no significant difference between the groups for age, gender, frequency of transfusion, serum ferritin, transferrine saturation, and iron levels. The frequency of hemoglobin cycling showed a positive correlation with the i-HuEPO dose variation per week (p=0.003) and a negative correlation with serum albumin level (p=0.013). The PD group had a higher frequency of hemoglobin cycling than the HD group, and the change of rHuEPO dose per week, hospitalization and serum albumin were associated with the hemoglobin cycling during the first year of dialysis.

북한 고등중학교 「지리」 교과서 분석 연구

최석진,남상준,류재명,손용택,이동엽 한국사회과교육연구회 2000 사회과교육 Vol.- No.33

이 연구는 남북한 통일을 대비하여 북한 고등중학교 지리 교육과정 및 교과서를 비교·분석한 것이다. 남북한의 학제와 지리과 영역의 교육과정상의 위치가 다르고 북한의 교육과정을 입수할 수 없었기 때문에, 입수한 북한의 고등중학교 1학년부터 5학년의 지리교과서 5종(1991년도부터 1993년도 발행분)을 대상으로 분석하여, 남한 6차 교육과정의 중학교 사회와 고등학교 공통사회(한국지리) 및 세계지리 내용을 비교 분석하였다. 연구 결과는 다음과 같다. 첫째, 남북한 중등학교 지리교육은 교육과정상의 편제에서 북한은 고등중학교 전학년에 걸쳐서 지리가 독립과목으로 편제되어 있으나, 남한은 중학교 사회과에 통합되어 있고, 고등학교에서는 공통사회에 포함되었으며 세계지리가 선택과목으로 되어있는 등 지리교육 내용계열과 조직체계도 차이가 난다. 둘째, 지리 교육의 이념과 목표에서, 남한은 민주시민 양성을 목표로 하여 개인의 지리교육적 성취가 주된 것이나, 북한은 집단 구성원으로서의 개인 양성에 중점을 두고 있다. 이러한 차이점은 정치체제의 차이에서 비롯된 것이며 지리교육 내용의 구성과 강조점등에서 많은 차이점을 나타내게 하고 있다. 셋째, 지리교육 내용 구성과 서술 등에 차이가 있다. 국토지리와 세계지리 및 계통지리와 지지의 배열과 비중 등이 다르며, 내용의 서술에서도 차이점을 볼 수 있다. 특히, 북한에서는 국토지리와 자연지리의 비중이 높으며, 주요 개념과 용어 설명에서 남한과 다른 점이 보인다. 넷째, 교과서의 구성과 교수-학습 방법 및 자료 사용에서 차이점이 보인다. 북한에서는 실습, 실험 등이 강조되면서 실제적인 기능 향상에 많은 비중을 두고 있으며, 사진에 비해서 그림을 사용하는 삽화의 비중이 높다. 교과서의 외형적 체제와 지질 등에서 차이가 큰데, 이 점은 경제력의 차이에서 비롯된다. 본 연구 결과 남북한은 모두 지리교육을 중등학교에서 중요시하고 있으며, 지리교육을 통하여 소기의 목표 달성에 노력하고 있으나, 서로간에 상당한 차이점도 발견할 수 있었다. The purpose of this study is to understand the similarity and differences of the geography textbook between north and south Korea in preparation for the unification. Five geography textbooks for the first through fifth grade in secondary school were used in the analysis of the geography curriculum for secondary schools in North Korea. The major findings of the study are as follows: First, South Korea takes an integration approach to teach geography as part of the social studies education whereas North Korea treats geography as an independent subject throughout secondary school. Second, South Korea aims at nurturing democratic citizen, emphasizing individual achievement, whereas North Korea puts emphasize nurturing citizenship within community. Third, difference is noted in the organization and content of the geography curriculum between the two Koreas. North Korea puts more emphasis on national geography and natural geography than does South Korea. Forth, North Korean textbook is different from that of South Korea in that the former emphasizes on performance skills through hands-on practice and training. Also North Korean textbook uses more drawings than pictures. Despite differences in various aspects of curriculum and textbooks, there are a great deal of overlap in essential concepts and contents covered in two Koreas' geography textbooks. Both Koreas value geography education in the secondary schools and make efforts to fulfil the educational objectives in geography.

景福宮·昌德宮·點景物 紋樣에 관한 硏究

최준형,이석래,이재근 한국정원학회 2002 한국전통조경학회지 Vol.20 No.1

The purpose of this study is to present basic materials on garden ornaments and their symbolism in traditional spaces. The subjects for this study are the Kyongbok Palace and the Changduk Palace that were the palaces of the Chosun Dynasty. The patterns of the garden ornaments in those palaces were investigated by comparison with past literature and traditional pattern collections. The findings of the research are as follows. Animal patterns were found on most of the stone statues and symbolized the expulsion of evil and the protenction of the King. They were used mainly in King’s Palace to emphasize the expulsion of evil and the protection of the King in official ceremonies. A stone mortar filled with water was used as a mirror and stonework, stone pedestals, chimneys, and stone boxes were mainly decorated with botanical patterns and used a lot in the royal villa and the living space for praying for the luck the user of the space. As shown above, there was a close correlation to space, the type of garden ornament, classification, and the symbolism of the patterns. A stepping stone used in mounting or dismounting a horse was used practically rather than ornately and there was usually no special ornament on the stone. However, on the stepping stone in the Sujung Annex, a decorated lotus pattern symbolized creation and prosperity with the purpose of calming the minds of the ministers. There were grass and flower patterns on only three sides of the stone box of Yonkyung Hall and therefore, it was considered functional and practical. The flag pedestal that measured the direction and velocity of the wind by using a flag was decorated with a wave pattern to sttongly emphasize the government. The stone mortar of Okrychun where common people enjoyed their lives and partied showed no special patterns and was located in the waterway to divert the flow of the water.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

골다공증에 의한 압박 골절의 치료에 있어서 경피적 추세 성형술의 의의

최재영,윤승환,조준,문창택,장상근 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Percutaneous vertebroplasty has recently been introduced as a therapeutic alternative for the treatment of pain associated with osteoporotic compression fractures and performed popularly at a few centers by neurosurgeons. This technique allows marked pain relief through stabilization of microfractures and strengthening of weakened vertebral body. Authors retrospectively analyzed the clinical outcome of 100 patients with osteoporotic compression fractures for investigating the therapeutic effectiveness of percutaneous vertebroplasty. They were treated with vertebroplasty from April to August 1999. Plain X-ray of all patients showed osteoporotic compression fractures at more than one level.

한국 일부지역의 이주근로자의 근로조건과 산업재해실태 조사

최재욱,김정아,김해준,박종태 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

This study was conducted to evaluate and to recognize the status and the problems of working conditions, and industrial accidents for migrant workers in a group of 342 who lives in Ansan area, Kyunggi province. By the questionnaire written by 5 languages(English, Bangladesh, Indonesian, Chinese and Korean), the informations of socio-demographic factors, occupational conditions of engaged company and general & occupational health status were obtained from June, 1st to July 30th, 1998. We used the ANOVA to examine differences of working hours, days and average monthly wages between overseas industrial trainee and illegal migrant workers, and by using logistic regression, odds ratio of general risk factors for industrial accidents in migrant workers were calculated. The results obtained were as follows: 1. The major distribution of nationals were from Philippine, Indonesia, Bangladesh and China(92.1%), and the most of subjects were man(78.9%) and over high school graduate(81.9%). 2. Most migrant workers worked at small scale companies under 50 employees, and engaged in dye·textile·clothing·leather industry. The average working hours were 59.9 hours per week in overseas industrial trainee, 64.9 hours in illegal migrant worker respectively. 3. Trainees have transferred to another company for 1.89 times, and workers who have changed qualification from trainee to illegal status were 3.09 time, and illegal workers moved 2.36 times. The major portion of reason to move to another company were low salary and overdue salary. 4. Trainees, workers who have changed position from trainee to illegal status, and illegal workers knows 62.27%, 42.31%, and 20.45% in each about legal documentation for foreign industrial trainees in Korea "Regulations for protecting and managing of foreign industrial trainees in Korea " published on March 1995. Additionally, trainees and illegal workers have experienced medical examination by 52.3% and 18.2% respectively. 5. Industrial accident condition from Jun. 1st, 1997 to Dec. 31th, 1997 were as follows : in case of frequent rate, trainees and illegal workers were 30.04, 23.78 each, and 8.6%, 7.4% for industrial accident rate respectively. 6. The most common causes and types of industrial accident were inappropriate motions of body and abrasion, and body sites most vulnerable to injury were the hands and fingers. The results suggest that working status and industrial accidents of migrant workers are very poor in Korea. Therefore, occupational safety and health policy aimed at migrant workers are needed to protect the migrant workers.

6주간의 淸暑益氣湯 經口投與가 에너지대사 및 호르몬 변화에 미치는 영향

최용어,강명신,유종만,이규성,오재근,조준용 韓國體育大學校附屬 體育科學硏究所 1994 韓國體育大學校附屬 體育科學硏究所論文集 Vol.13 No.1

The purpose of this study was to investigate the effects of chung-seo-ik-gi -tang administration on the metabolic responses and hormones in 18 healthy-male elite boxes. All subjects were divided randomly with two groups, Chung-sea-ik-gi-tang Group(N=18) and placebo group(N=18) and perfored with 70% of HR max using bycicle ergometer unfil exhaustion. During the submaximal exercise, heart rate was maesured every two min. The blood samples were collected from antecubital vein by 10ml syranges(6ml/each) before immediately after exhaustion, recover-10 min, recover-20 min and recover-30 min. The samples were to analyzed for the level of glucose, lactate, TG, TC, HDL-C, insulin and catecholamine. The results of various blood parameters were summarized as follow; l. Energy substrates (plasma glucose, TG, TC, HDL-C) changes in group C were significantly different from group P. Plasma glucose in group C was significantly lowered at recover-10 min compared to group P (P<0.05). and also TG, TC and HDL-C in group C were significantly increased after 3 weeks compared to group P (P<0.05) whereas. Lactate accumulation in group C was significantly decreased after 3 weeks compared to group P (P<0.05). 2. Plasma insulin level was not showed significant difference between two groups. But insulin depression tendency after 3, 6 weeks in group C was allevated compared to group P. Increasing rate of norepinephrine in group C at Post-exhaustion after 3weeks lowered compared to group P. Norepinephrine in group C at rest periods after 3 weeks showed significant difference compared to group C. The results indicated that Chung-seo-ik-gi-tang had the effects of ergogenic aids on fatigue resistance and recovery from exhaustive exercise at the level of 70% HR max.

졸겔법에 의한 알루미나 박막의 제조 및 특성(Ⅰ) ; 코팅용 알루미나 sol의 합성

최세영,안준모,이재호,윤태일 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1

The properties of alumina sol for single layer Anti-Reflective film by dip-coating were investigated. Transparent alumina sol could be obtained by heating the sol within 2 hours after hydrolysis at room temperature. The particle size of sols decreased with increasing the amount of nitric acid, while the specific surface area and the total pore volume of heat treated gels increased, up to the ratio of 0.1 mol nitric acid per 1 mol alkoxide. Excess addition of nitric acid above 0.1 mol resulted in decrement of the specific surface area and the total pore volume, and broadness of the pore size distribution. The average pore diameter and the total pore volume of heat-treated gel at 400℃ with composition of 1 alkoxide·100 water·0.1 nitric acid in ratio were ?? and 0.315 cc/g, respectively.