서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

側腦室內 Hexamethonium이 家兎賢臟機能에 미치는 影響

李載欣 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1

1. The effects of hexamethonium, given into the lateral ventricle, on the renal function of the rabbits were examined, and its influence on the renal effects of intraventricular carbachol were also examined. 2. Intraventricular hexamethonium(300 ㎍/Kg) tended to slightly decrease urine flow rate, renal blood flow and glomerular filtration rate, but urinary excreted amounts of sodium, Cosm and free water reabsorption were decreased significantly from 20 or 40 min. after intraventricular hexamethonium. 3. Intraventricular carbachol (2㎍/ Kg) produced statistically significant diuresis, natriuresis and increased change of Cosm without significant changes of glomerular filtration rate and renal blood flow rate. 4. The effects of intraventricular carbachol were not influenced by the intraventricular hexamethonium pretreatment, but completly abolished by the intraventricular atropine pretreatment. From these above results, it is suggested that the centrally mediated diuresis of carbachol is not due to renal hemodynamic changes or ADH release, but related to other central muscarinic natriuresis.

일차배양된 설치류 호흡기 상피세포로부터의 점액소 분비에 대한 수종 약물의 영향

이충재,석정호,이재흔,허강민,박지선,배소현,노삼길,박상철 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

1. PKC activator인 PMA는 일차배양 HTSE세포로부터의 뮤신분비를 0.1μM 농도에서 30%, 1μM 농도에서 80% 가량 증가시켰다. 2. 식물 유래 성분으로, flavonoid의 일종인 TFR은 일치배양 HTSE 세포로부터의 뮤신분비를 10μM 농도에서 50%, 100μM 농도에서 80% 가량 증가시켰다. 3. 양이온성 폴리펩티드인 PLL 및 PLA는 일차 배양 HTSE 세포로부터의 뮤신분비를 0.01 - 10μM 농도에서 용량의존적으로 감소시켰다. 4. 결론적으로, 본 연구에서 얻어진 결과들은 새로운 거담제 및 점액용해제나 단백분해 효소제가 아닌 호흡기 류신의 생성/분비를 조절해 줄 수 있는 신개념의 약물을 개발함에 있어 극히 일부분이나마 단서를 제공하고 있다고 하루 수 있을 것이다. In the present study, we tried to investigate whether phorbol myristate acetate(PMA), trihydroxymethoxy-flavanone rutinoside(TFR) and cationic polypeptides significantly affect mucin release(secretion) from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of each agent to assess the effect on 3H-mucin release. The results were as follows : (1) Both PMA and TFR significantly increased mucin release from cultured HTSE cells ; (2) Cationic polypeptides including po1y-L-lysine(PLL, mw 7,500) and poly-L-arginine(PLA, mw 10,800) significantly inhibited mucin release from cultured HTSE cells, in a dose-dependent manner. This finding suggests us that PMA and TFR be further studied for the possible use as mild expectorants and cationic polypeptides might function as a regulator for hyper-secretion of mucus, both by direct acting on airway mucin-secreting cells, during the treatment of chronic airway diseases.

側腦室內 Neostigmine이 家兎 腎臟機能에 미치는 影響

李載欣 충남대학교 대학원 1976 論文集 Vol.6 No.-

Effect of neostigmine administered intracerebroventricularly on the renal function of rabbits was investigated. 1) Intraventricular neostigmine induced decrease after initial increase of urine flow and changes of renal plasma flow, glomerular filtration and urinary sodium and potassium excretion in proportion to urine flow approximately, but did not influence to filtration fraction and reabsorption of sodium and potassium. 2) Correlation coefficient between changes of two parameters among urine volume, renal plasma flow, glomerular filtration and urinary sodium excretion was statistically significant. 3) Increasing changes of various parameters of renal function induced by intraventricular neostigmine were inhibited by intravenous atropine pretreatment and decreasing changes of the parameters partially inhibited by the blocking agent Pretreatment with intravenous regitine potentiated diuretic action and inhibited antidiuretic action of intraventricular neostigmine. Front the above results, it is suggested that the effect of intraventricular neostigmine on the renal function of rabbit is due to renal hemodynamic changes by central parasympathetic and sympathetic activation

正常血壓白鼠와 單一腎臟 및 腎動脈結紮高血壓白鼠에서의 心筋 Na^+, K^+-ATPase에 關한 硏究

李載欣,沈雲澤 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2

人蔘이 닭의 血中葡萄糖 및 遊離脂肪酸濃度에 미치는 影響

李神雄,李載欣,黃炳斗,琴基昌 충남대학교 의과대학 지역사회의학연구소 1974 충남의대잡지 Vol.1 No.1

Effect of Panax Ginseng on the plasma glucose and free fatty acid levels of the normal chicken and experimentally induced-hyperglycemic chicken, and on the release of glucose and glycogen contents in the chicken liver slices was investigated. 1) Plasma glucose levels was not influenced, but plasma FFA level decreased significantly by intravenous administration of Panax Ginseng in the normal chicken. 2) Epinephrine-induced hyperglycemic and hyperlipemic response and hyperglycemia induced by pancreatic ligation were inhibited by Panax Ginseng, and in the glucose tolerance test, Ginseng shortened the recovery time to normal glucose level. 3) In the chicken liver slices, Panax Ginseng inhibited the release of glucose from the specimen, but did not affect glycogen contents of the tissue.

재생간의 성장과정에 따른 ^3H-ouabain의 결합에 관한 연구

이재흔,허강민 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

To study the changes of Na, K-ATPase in the regenerating liver cell prepared the sinusoidal and canalicular membrane from normal and regenerating rat liver after partial hepatectomy, and Na, K-ATPase activity and ^3H-ouabain binding were measured. 1. In the control liver, Na, K-ATPase activity of sinusoidal membrane was 23.8μmole Pi/mg protein/hr and that of canalicular was 7.0 μmole Pi/mg protein/hr. But the numbers of ^3H-ouabain binding sites were almost same in both membranes. 2. In the regenerated liver for 3 days, the activity of Na, K-ATPase of sinusoidal membrane was decreased about 50% as compared to that of control liver. 5 days after partial hepatectomy, the activity of Na, K-ATPase was restored. 3. Ouabain concentration for the inhibition of Na, K-ATPase activity(IC_50) of sinusoidal membrane in the regenerated and control liver were 5.0 X 10 exp(-5)M and 3.8 X 10 exp(-5)M respectively. 4. In the ouabain binding experiment of sinusoidal membrane, there were little difference in Kd values between both group, but B_max in the regenerated liver was decreased about 50% compared to that of control liver. From the above results, it is suggested that the decreased Na, K-ATPase activity in the sinusoidal membrane during regeneration is due to the decreased numbers of ouabain binding sites, and Na, K-ATPase is distributed in canalicular membrane as well as sinusoidal membrane.