항암제와 Lactobacillus casei HY2782의 병용투여에 의한 항암효과의 증강

윤상군,배형석,김경태,백영진 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

S-180 복수암을 유발시킨 생쥐에 대한 BCG, OK-432와 LC2782의 항암효과 비교실험 결과 LC2782를 투여한 생쥐의 평균 생존율은 192%(p<0.001)였으며, OK-432 와 BCG를 투여한 생쥐의 평균 생존율은 각각 141%(p<0.01), 112%였다. 3LL 고형암을 유발시킨 생쥐에 대한 BCG , OK-432와 LC2782의 항암효과 비교실험 결과, LC2782를 투여한 생쥐의 암 억제율은 62%(p<0.05)였으며, OK-432 와 BCG를 투여한 실험군의 암억제율은 90%(p<0.05)와 76.2%(p<0.05)로서 OK-432가 가장 높은 암억제 효과를 나타냈다. 또한 S-180 복수암을 유발시킨 5-Fu와 CP를 단독 투여한 경우의 평균 생존율은 각각 115%와 99%였으나, 5-Fu와 CP를 LC2782 와 병용 투여한 경우의 평균 생존율은 각각 226%(p<0.001)1와 244%(p<0.00)1를 나타내어 단독 투여시보다 2배 이상 생존율이 증가하였다. 3LL 고형암을 유발시킨 생쥐에 5-Fu 와 CP를 LC2782와 병용 투여한 경우의 암억제율은 99.3%(p<0.05)와 73%(p<0.025)였다. Augmentation of antitumor activity of antitumor drugs in combination with Lactobacillus casei Hy2782 (LC2782) was studied against Sarcoma-180 (S-180) and Lewis lung carcinoma (3LL). Antitumor drugs used in this study were 5-fluorouracil (5-Fu) and cyclophosphamide (CP). The prolongation effect of LC2782 on the life span of mouse intraperitoneally implanted with S-180 was stronger than that of OK-432 and BCG, while the inhibitory effect of OK-432 and BCG on the growth of 3LL solid tumor was a little stronger than that of LC2782. Average survival rates of mice administrated LC2782, OK-432 and BCG were 192%, 141%, and 112%, respectively, when that of the control was 100%. Intralesional administration of 5-Fu, CP, 5-Fu+LC2782 and CP+LC2782 resulted in 93%, 69%, 99% and 73% inhibition rates against 3LL solid tumor proliferation. The combination therapy of 5-Fu or Cp with LC2782 significantly prolonged the life span of S-180-inoculated ICR mice. Average survival rates of mice administrated 5-Fu and CP alone were 115% and 99%. Furthermore, survival rates of mice administrated 5-Fu and CP in combination with LC2782 were 226% and 244%, respectively.

관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

볼링운동이 정신지체학생의 보행 형태와 자세에 미치는 영향

김기형,최윤희,김희진,최영진,이재수 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

The purpose of this study was to investigate the effects of bowling exercises on gait pattern and posture students with mental retardation and social interaction with students without disabilities. The videography method was used to obtain kinematical variables of gait pattern for pre & post tests of bowling exercises. The posture of students with mental retardation and interaction with students without disabilities were recorded onto video tapes. Analyzing the recorded data from all experiments led to the following conclusions: irregular gait pattern and posture of the students with mental retardation can be corrected or improved substantially through bowling exercises. And the inclusive exercises program with students without disabilities can show the model appropriate behavior, encourage social interaction, and promote positive self-esteem to the students with mental retardation.

뇌동맥류성 지주막하 출혈 후 지연허혈신경결함에 대한 평가에 있어서의 Acetazolamide단일광자방출전산화 단층촬영술의 역할

김형중,김은영,하윤,윤승환,박형천,박현선 The Korean Neurosurgical Society 2004 Journal of Korean neurosurgical society Vol.35 No.2

동양 복식의 연구 동향 분석

은영자,최윤혜,형승희 啓明大學校 生活科學硏究所 1999 科學論集 Vol.25 No.-

In this study, we investigate the transition of studies in the history of the Eastern costume every 5 years from 1959 to 1998 by sorting the researches into 8 classes in accordance with their topics, in order to grasp earlier and current trends in the discipline and seek a desirable direction to future research. The results of this study are summarized as follows. 1. Research papers in costume are published steadily since 1970, but it appears that the quantity of papers has increased since 1990. Master's theses make the majority of the total researches, occupying 44.8%. 20.4% of the papers appear in college periodicals or else, and 19.6% in Journal of the Korean Society of Costume. The rests are 4.5% in Journal of the Korean society of Clothing and Textiles, 3.7 % in Journal of Korean economic association, and 2.1% in Research Journal of the Culture in order. 2. Based on the classification of the topics of the papers, we have loamed that studies in materials such as patterns, textile, and colors occupy 19.5% making themselves the majority. Other topics are presented in similar frequency. 3. The most frequent topic in Men's costume is the study on Simuy, a Korean traditional jacket and Topho, a Korean traditional coat. The researches in Men's costume, focusing on historical changes, morphology, and colors, are generally performed in bibliographic historical methodology or through analyses of archaeological materials such as relics and paintings. Some papers present ways of draft from the viewpoint of clothing construction. And others include studies on variations of life emotion reflected in local properties and costume and the comparative study of the aspects of costume appeared in Confucian books and I-Ching (易經). 4. The majority of researches on Women's costume are concerned with the Korean traditional jacket Chogori, in which the focus is put on the form of Chogori and some other details. Then, the Korean traditional dress Chima-Chogori, ceremonial dresses, and the Buddhist costume are major research subjects in Women's costume in order. They analyze types and forms of the above mentioned clothes, and hence characterize contemporary aesthetic senses to corroborate the cultural inherence and beauty of the Korean traditional costume. 5. Researches on accessories, in general, concentrate on the diversity of the sorts of them, but lack enough varieties and independence in that they tend to only review the earlier work. Therefore, they need be more diverse and varied in subjects. Nonetheless, it has been found from the papers on accessories that the accessory is not so much a part of costume as an independent object of the discipline. 6. Of the subjects of Studies on materials such as patterns, textile, and colors, the pattern is the most prominent, and the researches on the pattern applied to design and the comparison with other nations' patterns has been increasing, from which we have learned that those researches will be important references in future research. In the case of textile, much work on that in Corye, a Dark Age in the field of costume study has been presented currently, which seems to signify a new breakthrough should be open. 7. Most papers on military and police uniforms have to do with history of changes based on bibliographic data, and investigations into dancing clothes, musicians' costume, and the shamanist costume are also mainly concerned with changes or systems of costume. On the other hand, studies on Kisaeng' Clothes discuss the Chosun Kisaeng's Costume and idiosyncrasies of their status. 8. About a half of papers on archaeological costume and paintings deal with exhumed clothes and textile and record paintings, from which we can tell that the researches in these topics take part in the positivistic study of the history of costume. 9. In the field of the comparative study of costume, researchers have most frequently compared the Korean costume with the Chinese costume, especially concentrating on clothes rather than on ornaments and accessories. On the other hand, it is expected that more interest should be taken in the Japanese costume, because it is not sufficiently investigated in comparison with the Chinese costume. Moreover, it is desirable to extend research interest to countries other than those in the Northeastern Asia since the tendency of the discipline has been to give more attention to the Northeastern Asia than other areas. Needless to say, the comparative study requires the researchers to have enough knowledge of historical backgrounds and local characteristics of other countries. 10. Researches on the costume in the enlightening period and the post-independence era are different than those on other periods' costume in that they are generally interested in the change of costume and the factors of the change.

METRx™ 기구를 이용한 후방 경추부 추궁추간공 제거술의 예비 결과

박형천,윤승환,박종운,하윤,현동근,김은영,박현선,임대철 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objectives: Posterior cervical microscopic laminoforaminotomy has been a preferred procedure for a posterolateral cervical disc or foraminal stenosis. However, neckpain from wide skin incision and muscle injury are some of disadvantages. The authors performed cervical microscopic laminoforaminotomy with METRx™ tubular dilator system and were compared the results with classical cervical microscopic foraminotomy. Methods: Six patients underwent posterior cervical microscopic laminoforaminotomy using the METRx™ during 6 months. We have selected 10 patients from our institution as a comparison group. Preoperative and postoperative pain score composed of the radicular and neck component was examined and disability score also recorded. Diameters and lengths of laminoforaminotomy on the postoperative CT also were compared with two methods Results: Postoperative pain scores to the radiculopathies were not different but postoperative pain scores to the neckpain on the follow up periods were significantly different. The average vertical and transverse diameters of the laminoforaminotomy defect on the postoperative CT scans were not different between two groups. Average hospital stay of the classical methods was 8.8±7.5 days comparison with 4.5±0.54days of new procedure. Conclusions: Posterior cervical microscopic laminoforaminotomy with METRx™ systems seems to provide similar decompression and clinical results as classical methods compared to classical methods and shows superior results for postoperative neckpain and hospital stays.

골형성부전증 10예의 임상적 특징

이형숙,김현주,조재현,이승원,김현아,최준혁,송영준,김대중,이관우,정윤석 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경 및 방법: 골형성부전증은 비교적 희귀한 유전병으로 교원질 대사 장애로 인한 골의 취약성과 다발성 골절 및 척추측만증 등을 특징으로 한다. 유전방식과 표현형의 발현 정도에 따라 다양한 임상 양상을 보이며, 임상적 중증도에 따라 4가지 형태로 분류된다. 지금까지 국내 보고는 분만과정이나 태아 진찰시 골격이상으로 발견된 증례보고가 주였다. 저자들은 비교적 경미한 임상 양상을 보이는 예를 포함한 다수의 골형성부전증 환자들의 전반적인 임상적 특징에 대해 보고하는 바이다. 결과: 2001년 6월부터 2003년 2월까지 골형성부전증으로 진단받은 6 가계, 10예를 대상으로 하였다. 평균 나이는 27.3(5∼56)세였고 소아가 2예였다. 모두 상염색체 우성으로 유전되었으며, 제 I형이 4예, 제 III형이 4예, 그리고 제 IV형이 2예였다. 전 예에서 다수의 골절 경험이 있었고, 골밀도 저하와 골피질 두께 감소 소견이 관찰되었다. 전신의 평균 골밀도는 0.690(0.421∼1.039) g/cm²였다. 골형성지표로 측정된 sAlk는 소아의 경우만 증가되어 있었고, 골흡수지표로 측정된 uDPD의 평균치는 12.9(4.4∼36.3) nM/mM Cr으로 증가된 소견을 보였다. mobility score는 대부분 3,4단계에 속해 있었다. 중증형일수록 진단 시의 mobility score가 낮은 경향을 보였다. 결론: 한국인 골형성부전증 환자의 임상적 특징을 살펴본 결과 기존의 보고된 II형 외에도 I, III, IV형이 다양하게 존재함을 알 수 있었으며, 모든 예에서 상염색체 우성으로 유전됨을 확인할 수 있었다. 또한 모든 예에서 증가된 골흡수로 인한 골밀도 저하와 골절을 확인할 수 있었다. Osteogenesis Imperfecta (OI) is a relatively rare hereditary disease, which is characterized by multiple bone fractures and spine scoliosis, due to the fragility of bone, and is often associated with blue sclerae, deafness and dentinogenesis imperfecta. Four types of OI can be distinguished, according to the clinical findings. Although mutations affecting type I collagen are responsible for the disease in most patients, the mechanism by which the genetic defects cause abnormal bone development remains to be fully understood. Here, the clinical characteristics of 10 OI patient cases are reported, with a review of the literature. All the cases, including 4 type I, 4 type III and 2 type IV, inherited OI as an autosomal dominant trait. All the subjects had multiple old fractures and decreased bone densities. In this study, the biochemical marker of bone formation, serum alkaline phosphatase, was found to be increased only in the pediatric OI patients, while the biochemical marker of bone resorption, urinary deoxypyridinoline, was increased in all cases. The mobility score was found to correlate with the severity of the type on diagnosis (J Kor Soc Endocrinol 18:496∼503, 2003).

양성 및 음성 정신분열증 환자의 시각적주의폭에 관한 연구

최정인,이형영,윤진상 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.5

This study was performed to compare the visual attention span among three groups of 22 negative schizophrenics, 29 positive schizophrenics and 30 normal controls. The narrowing and broadening of attention span were tested by comparing correct recognition responses of peripheral visual stimulus. The results are as follows : 1) There was a significant difference in the total number of correct recognition responses among three groups; In controls, the total number of the correct recognition responses was highest and this was followed by positive schizophrenics(P<0.01). The number of the correct recognition responses was higher in larger stimulus size than in small stimulus size in all three groups(P<0.01). 2) Comparing groups and stimulus size; there was no significant difference in large stimulus size. In small stimulus size, there was significant difference between postivive schizophrenics and controls(P<0.05), between negative schizophrenics and controls(P<0.01), and between negative schizophrenics and positive schizophrenics(P<0.01). 3) Comparing groups and display angle, there was no significant difference in display angle 2˚ among three groups, while there was significant difference in display angle 12˚ between negative schizophrenics and controls(P<0.01), and significant difference in display angle 25˚ between negative schizophrenics and controls and between negative schizophrenics and positive schizophrenics(P<0.01), respectively. In summary, these results suggest that negative schizophrenics, unlike postive schizophrenics and controls, are only able to recognize large peripheral stimulus within a narrow display angle, because of narrowing of attention span.

척추손상 쥐의 지방유래 줄기세포와 미노사이클린의 운동기능 회복효과

장재혁,고현윤,차영선,박형욱,신용범,손현주 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

Carbon Nanotube Reinforced Metal Matrix Nanocomposites via Equal Channel Angular Pressing

Pham, Quang,Jeong, Young Gi,Yoon, Seung Chae,Hong, Sun Ig,Hong, Soon Hyung,Kim, Hyoung Seop Trans Tech Publications, Ltd. 2007 Materials science forum Vol.534 No.-

<P>Carbon nanotubes (CNTs) have been the subject of intensive study for applications in the fields of nanotechnologies in recent years due to their superior mechanical, electric, optical and electronic properties. Because of their exceptionally small diameters (≈ several nm) as well as their high Young’s modulus (≈ 1 TPa), tensile strength (≈ 200 GPa) and high elongation (10-30%) in addition to a high chemical stability, CNTs are attractive reinforcement materials for light weight and high strength metal matrix composites. In this study, bottom-up type powder processing and top-down type SPD (severe plastic deformation) approaches were combined in order to achieve full density of CNT/metal matrix composites with superior mechanical properties by improved particle bonding and least grain growth, which were considered as a bottle neck of the bottom-up method using the conventional powder metallurgy of compaction and sintering. ECAP (equal channel angular pressing), the most promising method in SPD, was used for the CNT/Cu powder consolidation. The powder ECAP processing with 1, 2, 4 and 8 route C passes was conducted at room temperature. It was found by mechanical testing of the consolidated CNT/Cu that high mechanical strength could be achieved effectively as a result of the Cu matrix strengthening and improved particle bonding during ECAP. The ECAP processing of powders is a viable method to achieve fully density CNT-Cu nanocomposites.</P>