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Hyemi Song,Bong-Kwang Jung,Jaeeun Cho,Taehee Chang,Sun Huh,Jong-Yil Chai 대한기생충학열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.2
Anisakiasis is a zoonotic disease induced by anisakid nematodes, and endoscopic inspection is used for a diagnosis or remedy for it. Anisakis simplex, Anisakis physeteris, and Pseudoterranova decipiens had been reported to be the major species causing human infections, particularly, in Japan. However, in Korea, recent studies strongly suggested that Anisakis pegreffii is the major species of human infections. To support this suggestion, we collected anisakid larvae (n=20) from 20 human patients who were undergone gastrointestinal endoscopy at a health check-up center in Korea, and molecular identification was performed on the larvae using PCR-RFLP analysis and gene sequencing of rDNA ITS regions and mtDNA cox2. In addition, anisakid larvae (n=53) collected from the sea eel (Astroconger myriaster) were also examined for comparison with those extracted from humans. The results showed that all human samples (100%) were identified as A. pegreffii, whereas 90.7% of the samples from the sea eel were A. pegreffii with the remaining 9.3% being Hysterothylacium aduncum. Our study confirmed that A. pegreffii is the predominant species causing human anisakiasis in Korea, and this seems to be due to the predominance of this larval type in the fish (sea eels) popularly consumed by the Korean people. The possibility of human infection with H. aduncum in Korea is also suggested.
Placental expression of D6 decoy receptor in preeclampsia
( Geumjoon Cho ),( Eunsung Lee ),( Hyemi Jin ),( Jihye Lee ),( Yeunsun Kim ),( Minjeong Oh ),( Hyunjoo Seol ),( Sooncheol Hong ),( Haijoong Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies.The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during the third trimester of pregnancy. The expressions of D6 decoy receptor in the placenta were determined with real time reverse transcriptase polymerase chain reaction and western blotting.The mRNA and protein of D6 decoy receptor were detected in all of placentas from preeclamptic and normal pregnancies. Placental D6 decoy receptor mRNA expression was significantly lower in patients with preeclampsia than in patients with normal pregnancies. Western blot analyses revealed decreased protein expression in cases of preeclampsia.The expression of the D6 decoy receptor in preeclamptic placentas was significantly lower than in normal placentas. Further studies are needed to clarify the underlying mechanisms that link decreased expression of placental D6 decoy receptor and preeclampsia.
Anisakis pegreffii Larvae in Sea Eels (Astroconger myriaster) from the South Sea, Republic of Korea
Jaeeun Cho,Hyemi Lim,Bong-Kwang Jung,Eun-Hee Shin,Jong-Yil Chai 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.3
Anisakis simplex sensu stricto (s.s.), Anisakis pegreffii, Anisakis berlandi (=A. simplex sp. C), and Anisakis typica are the 4 major species of Anisakis type I larvae. In the Republic of Korea (Korea), A. pegreffii, A. berlandi, and A. typica larvae in fish hosts has seldom been documented. In this study, molecular analysis was performed on Anisakis larvae from the sea eels (Astroconger myriaster), the major source of human anisakiasis in Korea, collected from Tongyeong City, a southern coastal area of Korea. All 20 sea eels examined were infected with Anisakis type I larvae (160 larvae; 8 per fish). Their species were analyzed using PCR-RFLP patterns and nucleotide sequences of internal transcribed spacers (ITS1, 5.8 subunit gene, and ITS2) and mitochondrial cytochrome c oxidase 2 (cox2). Most (86.8%; 112/129) of the Anisakis type I larvae were A. pegreffii, and 7.8% (10/129) were A. typica. The remaining 5.4% (7/129) was not identified. Thus, A. pegreffii is the major species of anisakid larvae in sea eels of the southern coast of Korea.
( Yun Bin Lee ),( Hyemi Moon ),( Jeong-hoon Lee ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Fabien Zoulim ),( Juneyoung Lee ),( Jung-Hwan Yoon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Long-term antiviral therapy can effectively suppress viral replication and improve clinical outcomes in chronic hepatitis B patients, but it cannot eliminate the risk of hepatocellular carcinoma (HCC). We investigated the association of metabolic risk factors with the risks of cancer and all-cause mortality in chronic hepatitis B patients using the Korean National Health Insurance Service database. Methods: We collected baseline data on metabolic risk factors, including obesity, hypercholesterolemia, insulin resistance, and hypertension. The risks of developing HCC, non-HCC cancer, and overall death were analyzed according to the metabolic risk profile. The risks of HCC and non-HCC cancer were analyzed after adjusting death as a competing risk event. Results: The study population consisted of 317,856 adults with chronic hepatitis B. A total of 18,850 HCCs, 22,164 non-HCC cancers, and 15,768 deaths were observed during a median follow-up period of 8.5 years. The cumulative incidences of HCC (P<.0001; panel A), non-HCC cancer (P<.0001; panel B), and death (P<.0001; panel C) rose with increasing number of metabolic factors. The metabolic risk factor burden was positively associated with the risks of HCC, non-HCC cancer, and all-cause mortality (all P<.0001 for trend). Patients with ≥3 metabolic risk factors, compared to those without metabolic risk factors, showed adjusted hazard ratios of 1.23 (95% confidence interval [CI], 1.16-1.31) for HCC, 1.34 (95% CI, 1.27-1.41) for non-HCC cancer, and 1.31 (95% CI, 1.23-1.39) for all-cause mortality. Among patients receiving antiviral therapy for over 5 years, the risk-increasing association of the sum of metabolic risk factors with the risks of HCC and overall death was consistent. Conclusions: In this Korean nationwide cohort study, the burden of metabolic risk factors was associated with increased risk of HCC, non-HCC cancer, and all-cause mortality in patients with chronic HBV infection.