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Jaeeun Song,Eulah Cho,Inn-Kyu Cho,Dongin Lee,Jiyoung Kim,Harin Kim,Seockhoon Chung 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.10
Objective This study aimed to explore the mediating effects of cancer-related dysfunctional beliefs regarding sleep and intolerance of uncertainty on the effect of depression, insomnia, and anxiety on fear of progression (FoP). Methods We retrospectively reviewed medical records of patients with cancer who visited the Sleep Clinic for cancer patients in Asan Medical Center for the first time between December 2021 and March 2022. Data collected included age, sex, types of cancer, staging, current treatment modalities, and history of surgical procedures. In addition, psychological symptoms were rated using the Insomnia Severity Scale (ISI), Patient Health Questionnaire-9 items (PHQ-9), State subcategory of the State and Trait of Anxiety Inventory (STAI-S), Short form of Fear of Progression Questionnaire, Cancer-related Dysfunctional Beliefs about Sleep scale (C-DBS), single item of pain and fatigue, Connor Davidson Resilience Scale 2-item (CD-RISC2), and Intolerance of Uncertainty-12 (IUS-12). The predictive variables for FoP were determined by linear regression analysis. Results The FoP was significantly correlated with age (r=-0.289), ISI (r=0.178), PHQ-9 (r=0.703), STAI-S (r=0.377), fatigue (r=0.452), CD-RISC2 (r=-0.270), IUS-12 (r=0.585), and C-DBS (r=0.427, all p<0.01). A mediation analysis showed that intolerance of uncertainty and dysfunctional beliefs about sleep mediated the relationship of FoP with insomnia, depression, or anxiety. Conclusion Psychological support for intolerance of uncertainty and cancer-related dysfunctional beliefs about sleep in patients with cancer may be beneficial to reduce their FoP.
Anisakis pegreffii Larvae in Sea Eels (Astroconger myriaster) from the South Sea, Republic of Korea
Jaeeun Cho,Hyemi Lim,Bong-Kwang Jung,Eun-Hee Shin,Jong-Yil Chai 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.3
Anisakis simplex sensu stricto (s.s.), Anisakis pegreffii, Anisakis berlandi (=A. simplex sp. C), and Anisakis typica are the 4 major species of Anisakis type I larvae. In the Republic of Korea (Korea), A. pegreffii, A. berlandi, and A. typica larvae in fish hosts has seldom been documented. In this study, molecular analysis was performed on Anisakis larvae from the sea eels (Astroconger myriaster), the major source of human anisakiasis in Korea, collected from Tongyeong City, a southern coastal area of Korea. All 20 sea eels examined were infected with Anisakis type I larvae (160 larvae; 8 per fish). Their species were analyzed using PCR-RFLP patterns and nucleotide sequences of internal transcribed spacers (ITS1, 5.8 subunit gene, and ITS2) and mitochondrial cytochrome c oxidase 2 (cox2). Most (86.8%; 112/129) of the Anisakis type I larvae were A. pegreffii, and 7.8% (10/129) were A. typica. The remaining 5.4% (7/129) was not identified. Thus, A. pegreffii is the major species of anisakid larvae in sea eels of the southern coast of Korea.
Cho Hanwool,Yoo Jaeeun,Kim Hyunjung,Jang Hyunsik,Kim Yonggoo,Chae Hyojin 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.2
Background: Automated urine sediment analysis has been developed to address the limitations of microscopic examination of dysmorphic red blood cells (RBCs). We evaluated the urinary RBC distribution (URD) parameter of a recently launched automated urinary flow cytometry analyzer, UF-5000 (Sysmex, Kobe, Japan), to differentiate glomerular hematuria (GH) from non-GH (NGH). Methods: Samples submitted for urine sediment analysis from patients with hematuria (>20 RBCs/μL) were divided into derivation (N=156; 101 GH, 55 NGH) and validation cohorts (N=107; 60 GH, 47 NGH). The clinical diagnosis of GH or NGH was established based on clinical data review. Differences in UF-5000 parameters (URD, small RBC, lysed RBC, RBC-P70FSC, RBC-SF-FSC-W, mean forward-scattered light, and mean side-scattered light) between GH and NGH, and areas under the ROC curves (AUC) were analyzed in the derivation cohort. The derived ideal cut-off value was evaluated in the validation cohort. We applied the Kitasato criteria to compare the diagnostic performance. Results: URD (%), differed significantly between GH and NGH (P<0.001) in the two cohorts. The AUC of URD was 0.814 and 0.806 in the derivation and validation cohorts, respectively. Using a cut-off of >20.1%, the sensitivity was 99.0%/89.4% and the specificity was 50.9%/63.3% in the derivation/validation cohort. When the Kitasato criteria were applied, the sensitivity and specificity were 80.2% and 52.7%, respectively. Conclusions: URD is a rapid, objective, and quantitative measure that can be used to differentiate GH and NGH.
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer
Cho, Charles J.,Jung, Jaeeun,Jiang, Lushang,Lee, Eun Ji,Kim, Dae-Soo,Kim, Byung Sik,Kim, Hee Sung,Jung, Hwoon-Yong,Song, Ho-June,Hwang, Sung Wook,Park, Yangsoon,Jung, Min Kyo,Pack, Chan Gi,Myung, Seun Springer-Verlag 2018 Digestive diseases and sciences Vol.63 No.7
ITER Storage and Delivery System R&D in Korea
Seungyon Cho,Min Ho Chang,Sei-Hun Yun,HyunGoo Kang,Ki-Jung Jung,Hongsuk Chung,Daeseo Koo,Yongkyu Kim,Jaeeun Lee,Kyu-Min Song,Soon-Hwan Sohn,KwangSin Kim,Duk-Jin Kim IEEE 2010 IEEE transactions on plasma science Vol.38 No.3
<P>Korea is supposed to develop the ITER tritium storage and delivery system (SDS), which is one of the main components of the ITER tritium plant. For successful procurement, there are several ongoing R&D activities in the detailed design phase. Investigation of design parameters of the storage and delivery beds has been performed. Small and large-scale mock-ups of ZrCo beds are used to test the capability of desirable rapid delivery and recovery performance and to establish the pertinent procedure of in-bed calorimetry. An experimental apparatus is prepared to develop the integration and verification technologies for the unit processes of the tritium SDS. The performance test of a tritium-compatible metal bellows pump is examined, and the results show a reasonable agreement with the catalog data of the pump. A tritium storage and delivery bed simulator has been developed to simulate various bed operation scenarios under normal and abnormal conditions. A prototype of the SDS simulator is fabricated, and the bed operation scenario generation program to be applied to this simulator is developed. The design requirement of the tritium loading station (TLS) calorimeter is prepared based on a benchmarking mock-up calorimeter, namely, Korea Electric Power Research Institute Tritium Laboratory (KEPTL) calorimeter. Documents for the procurement of the TLS calorimeter will be developed through the experience on the KEPTL calorimeter operation.</P>
Jung, Jaeeun,Lee, Sugi,Cho, Hyun-Soo,Park, Kunhyang,Ryu, Jea-Woon,Jung, Minah,Kim, Jeongkil,Kim, HyeRan,Kim, Dae-Soo Elsevier 2019 Genomics Vol.111 No.2
<P><B>Abstract</B></P> <P>Non-coding RNA is no longer considered to be “junk” DNA, based on evidence uncovered in recent decades. In particular, the important role played by natural antisense transcripts (NATs) in regulating the expression of genes is receiving increasing attention. However, the regulatory mechanisms of NATs remain incompletely understood. It is well-known that the insertion of transposable elements (TEs) can affect gene transcription. Using a bioinformatics approach, we identified NATs using human mRNA sequences from the UCSC Genome Browser Database. Our in silico analysis identified 1079 NATs and 700 sense-antisense gene pairs. We identified 179 NATs that showed evidence of having been affected by TEs during cellular gene expression. These findings may provide an understanding of the complex regulation mechanisms of NATs. If our understanding of NATs as modulators of gene expression is further enhanced, we can develop ways to control gene expression.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 179 NATs affected by TEs, among 1079 NATs identified in human mRNA. </LI> <LI> TE-regulated NATs could be contributed to variation of gene expression. </LI> <LI> These results will help to figure out the regulatory mechanisms of NATs. </LI> </UL> </P>
이재은 ( Jaeeun Lee ),조영아 ( Youngah Cho ) 한국사회복지연구회 2015 사회복지연구 Vol.46 No.4
이 연구의 목적은 서울시 자원봉사센터 자원봉사 관리자의 역량모델을 개발하는데 있다.이러한 연구 목적을 달성하기 위해 문헌분석을 통해 역량을 추출하고, 우수성과자 대상 행동사건면접을 통해 자원봉사 관리자의 잠정적 역량모델을 구안하였다. 이후 전문가 검토와 설문조사를 통해 타당성을 검증하고 최종적으로 서울시 자원봉사센터 자원봉사 관리자 역량모델을 개발하였다. 행동사건면접은 자원봉사 관리 업무 경력 5년 이상의 우수성과자를 10명을 대상으로 진행하였으며, 서울시 자원봉사센터의 자원봉사 관리자가 응답한 122부의 설문응답 자료를 분석에 활용하였다. 연구 결과, 서울시 자원봉사센터 자원봉사 관리자 역량 모델은 공통역량, 리더십역량, 직무역량으로 구분되었으며, 공통역량은 신뢰형성, 책임감 등5개 역량으로 구성되었다. 리더십 역량은 다시 직급에 따라 관리자 역량은 갈등관리 등 6개, 실무자 역량은 자기관리 등 6개로 구성되었다. 마지막으로 직무역량은 기획홍보, 활동지원, 자원관리로 구분되며 기획홍보 직무역량은 자원봉사센터 운영전략수립 등 4개, 활동지원 직무역량은 자원봉사 사업기획 등 4개, 자원관리 직무역량으로는 자원봉사 DB 및 실적관리등 2개로 구성되었다. 모든 역량에는 역량정의와 행동지표가 함께 개발되었으며, 설문조사 결과 평균 긍정률은 90.1%로 이 연구에서 개발한 역량모델이 타당한 것으로 나타났다. 이 연구는 자원봉사 관리자의 역량기반 교육의 기초를 마련하였다는 데 의의가 있으며 자원봉사 관리자의 체계적인 역량 수준 진단과 교육과정 개발에 활용할 수 있을 것이다. The purpose of this study was to develop and validate a competency model for volunteer managers of the Seoul Volunteer Center. To achieve this goal, BEI was conducted for ten high-performers with experience in volunteer management minimum five years. Survey was conducted for volunteer managers working at Seoul Volunteer Center, 122 data was analyzed for validation test. The findings of this study were as follows. First, Volunteer managers competency was separated by foundational competencies, leadership competencies, job competencies. Second, Five foundational competencies were developed other than ‘trust building’ and "sense of responsibility". Third, Leadership competencies was separated again depending on rank as manager leadership and staff leadership. Twelve leadership competencies were developed other than "conflict management" and "self management". Finally, job competencies were consist of planning & PR, activity support, resource management. Ten job competencies were developed other than "establishing volunteer centers operating strategy", "planning volunteer project", and "managing DB & result". All competencies were developed including with its definition and behavioral indicators. Survey results showed 90.1% average positive rate that means the competency model was valid. This study is significant for laying the foundation of competency-based HR of volunteer managers and will be utilized in systematic diagnosis and curriculum development of volunteer managers.