20세기 한국 임상의학의 발자취

宣熙湜 대한의사협회 1999 대한의사협회지 Vol.42 No.12

놀이학습프로그램이 초등학생의 사회성 발달에 미치는 영향

박성식,임선희 금오공과대학교 2007 論文集 Vol.28 No.-

피부미용사의 스트레스와 근골격계 자각 증상과의 관련성

이은희,전선복,이무식,김남송,장문정 한국미용학회 2001 한국미용학회지 Vol.7 No.3

The purpose of this study was to examine the relationship of skin beauty artist's stress to musculoskeletal subjective symptom to identify what factors are related to skin beauty artist's musculoskeletal subjective symptom. The subjects in this study were 211 selected skin beauty artists. A survey was conducted from March 11 to 31, 2001, with standardized self-reporting questionnaire to find out the general characteristics, perceived stress level and musculoskeletal subjective symptom. The findings of this study were as below; l. All the skin beauty artists investigated were female. 110 skin beauty artists (52.1%), more than half them, were highschool graduates, 117(55,5%) were unmarried, and the mean career was 52,74 months(four years and four months). The daily mean working hours were 10.61, and the actual daily mean working hours were 7.94. 2. For health habit. 19(9.0%) skin beauty artists were smoker, which indicated that most of them didn't smoke. 136(64.5%) people, more than half them, drank alcohol, and just 72(34.1%) got exercise. 3. In regard to the relationship of general characteristics to stress, the unmarried group was more stressed as they got a score 69.25(SD 12.45), compared to the married group that got 66.30(SD 11.50). The difference between the two group was significant (p<005). The nondrinking group were more stressed out with 69.42(SD 11.50) than the drinking group with 65.87(SD 12.97). The difference between the two was significant(P<0.05). The group that didn't get exercise were more stressed with 70.17(SD 12.11) than the workout group with 64.26(SD 11.27), and the difference between the two was significant(P<0.05). By career, the group that had worked for 34 months or less were more stressed with 70.47(SD 12.38) than the other group that had worked for more than 35 months with 65.87(SD 11.48). And the difference between the two was significant. 4, As for the correlational relationship between musculoskeletal symptom to relevant variables, stress was positively correlated to musculoskeletal symptom and the pain of neck, shoulder, back, arm, hand, wrist, waist and leg. Their stress had a positive correlational relationship with the symptom in every part. The younger people made more complaint of the symptom of shoulder, back and leg, and those who had worked for less period were more stressed out. The findings of this study suggested that there was a relationship between stress and musculoskeletal subjective symptom. To prevent stress and musculoskeletal subjective symptom, there should be an attempt to ease stress. The break time should be offered regularly during working hours, and amicable human relations should be kept. The right health habit should be formed in daily living, and stretching exercise and health care should be done more thoroughly.

병원성 칸디다 혈증에 관한 임상적 고찰

고경식,권선희,김병준,김구엽,서환조 대한감염학회 1995 감염 Vol.27 No.5

목 적 : 최근 칸디다혈증의 발생율이 매우 증가하여 병원 감염의 중요한 원인으로 대두되고 있다. 이에 저자등은 칸디다혈증에 대한 임상적 특성을 알아보기위하여 다음과 같이 연구하였다. 방 법 : 1988년 1월부터 1993년 12월까지 경희대학부속병원에서 발생하였던 병원성 칸디다혈증 61예를 대상으로 의무기록지를 검토하였다. 결 과 : 1) 연도별 발생 빈도는 1988년 부터 1933년까지 각각 2예, 7예, 9예, 11예, 15예, 17예로 증가하였으며, 최근에는 non-albicans 균주에 의한 감염이 증가하고 있었다. 2) 연령분포는 4-83세였으며 평균연령은 51.0±17.4세였고, 남자 32예, 여자 29예였다. 50대와 60대가 57.3%로 가장 많았다. 3) 균주별 발생빈도는 C. albicans 30예, C. tropicalis 13예, C. parapsilosis 10예, C. glabrata 6예, C. guilliermondii 1예, C. krusei 1예로서 C. albicans가 가장 많았다. 4) 기저질환으로 뇌혈관계질환이 25예(41%)로 가장 많았으며, 외과적질환 11예(18%), 고형악성종양 10예(16.4%), 혈액종양질환 9예(14.8%), 기타 내과적질환 6예(9.8%)였다. 5) 균주간 선행인자는 비슷하였으나, C. albicans와 C. tropicalis에서는 수술을 시행받은 예가 많았고, C. parapsilosis는 정주 영양 공급을 받은 경우가 많았다. 6) Amphotericin B 치료군(20예)과 fluconazole 치료군(11예) 사이에 예후에서 유의한 차이는 없었다. 7) 총 61예중 28예에서 사망하여 사망율은 45.9%였으며 정형외과적 수술을 시행받은 경우(83.3%)와 C. glabrata인 경우 사망율이 가장 높았다(83.3%). 결 론 : 칸디다 혈증은 중요한 병원 감염으로 대두되고 있으며 최근에는 non-albicans 진균주에 의한 병원성 칸디다 혈증의 발생율이 증가하는 추세이다. Background : The aim of this study is to determine the annual occurrence of nosocomial candidemia, the relation between Candida species and underlying illness, the relation bewteen Candida species and predisposing factors, and also to compare between the outcome of candidemia of the amphotericin B treatment group and that of the fluconazole treatment group. Methods : We reviewed medical records of 61 cases with nosocomial candidemia between 1988 and 1993 in Kyung Hee University Hospital retrospectively. Results : Two cases occurred in 1988, 7 in 1989, 9 in 1990, 11 in 1991, 15 in 1992, and 17 in 1993. The incidence of candidemia by non-albicans species has increased during this period and accounted for 64.7% in 1993. The infecting candida species were C. albicans(30 cases, 49.2%), C. tropicalis(13 cases, 21.3%), C. parapsilosis(10 cases, 16.4%), C. glabrata(6 cases, 9.8%), C. guilliermondii(1 case, 1.8%), and C. krusei(1 case, 1.8%). The most common underlying disease was cerebrovascular disease(41%) followed by surgical disease(18%), solid cancer(16.4%), hematological malignancies(14.8%), and other medical illness. There were no significant differences between the amphotericin B treatment group(n=20) and the fluconazole treatment group(n=11) in mortality. Overall mortality was 45.9%. The highest mortality was in patients with previous orthopaedic surgery(83.3%) and with C. glabrata candidemia(83.3%). Conclusion : Candidemia emerged as an important hospital infection and candidemia caused by non-albicans species has significantly increased in recent years.

백서 해마에서 카이닌산에 의한 조기유전자의 발현과 p42, p44 MAPK 및 EIK-1 인산화의 발달 단계에 따른 변화

정희연,김수진,김종흔,정선주,박주배,김용식,조수철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 어린 백서에게 카이닌산(kainic acid, KA)을 주사하여 발작을 일으킨 후, 해마에서 조기유전자 -c-fos, junB, 및 TIS1의 발현 유도 양상을 발달 단계별로 조사하여 전기경련충격(electroconvulsive shock, ECS)에서의 결과와 비교함으로써 백서 뇌 신호전달계의 성숙과정을 파악하고자 하였다. 그리고 KA 주사후 p42, p44 mitogen activated protein kinase(MAPK)의 인산화 및 그에 의해 활성화되는 것으로 알려진 전사인자 Elk-1의 인산화를 관찰하여, KA 주사후 MAPK 신호절달계를 통한 c-fos의 발현로 알려진 전사인자 Elk-1의 인산화를 관찰하여, KA 주사후 MAPK 신호전달계를 통한 c-fos의 발현 경로를 발달 단계별로 밝히고자 하였다. 방 법 : 생후 7, 14 21일 된 수컷 백서에서 KA를 복강내 주사한 후, 백서 해마에서 조기유전자의 발현 양상은 northern blot analysis로, p42, p44 MAPK와 Elk-1의 인산화는 immunoblotting으로 관찰하였다. 결 론 : 생후 7일된 백서의 해마에서는 ECS와는 달리, KA에 의한 세 가지 조기유전자의 발현이 관찰되지 않았다. 그러나 생후 14일부터 이들 조기유전자의 뚜렷한 발현을 관찰할 수 있었고 생후 21일에는 성숙한 백서와 같은 수준의 발현 양상을 볼 수 있었다. 세 가지 유전자 모두 백서의 연령과 KA 주사 후 시간에 따른 발현 유도 양상은 비슷하였다. p42, p44 MAPK는 생후 7일부터 상당한 수준의 기저치 인산화가 관찰되었으나, KA에 의한 인산화 증가는 생후 14일부터 관찰되었다. Elk-1의 인상화 역시 생후 7일부터 높은 수준으로 관찰되었으나 KA 주사 후 시간에 따른 Elk-1 인산화의 변화는 관찰할 수 없었다. 결 론 : ECS와 KA가 조기유전자 발현 양상에 차이를 보이는 것은 이들 유전자의 발현과 관련되어 활성화되는 신호전달경로의 차이 때문으로 생각된다. 백서 해마에서 KA에 의한 MAPK 활성화에 관여하는 신호 전달 기구는 연령이 높아짐에 따라 점차 성숙하고, MAPK의 활성화로 전달된 신호는 Elk-1 이외의 다른 경로를 통해 c-fos 발현을 조절하는 것으로 추측된다. Objectives : In order to investigate the maturational process of intracellular signal transduction system in rat brain, we studied the induction of the immediate early genes(IEGs)-c-fos, iunB, and TIS1 in each developmental stage after kainic acid(KA)-induced seizure in young rat hippocampus and then compared these with the results after electroconvulsive shock(ECS) And to elucidate the induction mechanism of c-fos via mitogen-activated protein kinase(MAPK) by KA in each developmental stage, we investigated the phosphorylation of p42, p44 MAPK and Elk-1 after KA treatment in young rat hippocampus. Methods : We examined the induction patterns of IEGs by northern blot analysis, and the phosphorylation of p42, p44 MAPK and Elk-1 by immunoblotting in rat hippocampus at post-natal day 7, 14, and 21(P7, P14 & P21), respectively after intraperitoneal injection of KA. Results : Unlike ECS, KA did not induce c-fos, junB, and TIS1 in P7 hippocampus. But these genes were apparently induced at P14 and to an adult level at P21. These three IEGs showed similar temporal patterns of induction in each developmental stage. Although the basal level of phosphorylated 42p, 44p MAPK was considerable in P7 rat hippocampus, the increase or phosphorylation after KA treatment was observed at P14. While the phosphorylation of Elk-1 was detected with high basal level in P7 rat, the amount of phosphorylated Elk-1 was not changed after KA treatment. Conclusion : Our results suggest that the differences in IEGs induction patterns between KA and ECS may be due to the differences in the activated signal transduction pathways. And our results also implicate that the signal transduction system involved in MAPK phosphorylation after KA treatment mature with aging and c-fos induction via MAPK activation may be regulated through some pathways other than Elk-1 in rat hippocampus.

3개 대학병원의 주 진단 코딩사례 평가

서순원,김광환,부유경,서진숙,서정돈,윤석준,이영성,이무식,정희웅 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.1

Background : Coding of principal diagnosis is essential component for producing reliable health statistics. We performed this study to evaluate the current practice of principal diagnoses determination and coding, and to give some basic data to improve coding of principal diagnosis. Method : Nineteen medical record administrators(MRAs) of 3 university hospitals participated in coding principal Dx. From August 1, 2001 to August 31, 2001. From each hospital, 10 medical records of patients with high frequency disease were selected randomly. Each 10 medical records were grouped into three(A,B,C). Then, these 30 medical records were given to each MRAs for coding. At the same time questionnaire was given to each of them. Questions were to prove how they decide and code the principal diagnosis among many current diagnoses ; how they decide and code the principal diagnosis when day see irrelevant diagnosis recorded as the principal diagnosis in medical record, when only tentative diagnoses were recorded without final diagnosis, and when different diagnoses were recorded in different sheets of same record. Agreement of coding among 3 hospitals were compared and survey results were analysed with SAS 6.12. Results : Agreement of coding was found in medical records 5-6 of each 10 medical records. Causes of disagreement were as follows. Difference of clinician’s opinion from each hospital; mixed use of guideline from KCD-3 and guideline from DRG; difference in 4th digit classification according to the absence of pathology report in the medical record; difference of abbreviations among hospitals. 57.9% of decided principal diagnosis after consulting to KCD-3 guideline. When there were difficulties in determining the principal diagnosis, 42.1% of MRAs decided principal diagnosis after discussion with the physician, 26.3% after discussion with fellow MRAs. Conclusion : There were differences in coding among hospitals. To minimize the difference, we suggest the development of disease-specific guidelines for coding in addition to the current general guideline such as KCD-3. To do this, Coding Clinic which can produce guidelines is needed.

도시환경조성용 옛 농작물 선발

이정식,김양희,노희선 서울市立大學校 1996 論文集 Vol.30 No.-

To create good urban environment using old agricrltural crops, eight old crops were evaluated for growth and pollution injury at five districts in Seoul. The results are summarized as follows ; 1. In investigation of ten air pollutants in July and August, it was detected heavy contents at Kuroku districts, while Kwangzinku and Songpaku showed the least contents. There have resulted SO2 to be the most detection in Kuroku during experiment period. Whereas O3 showed them the most at Songpaku in August, while it was Soedaemunku in July. In dust content, Kuroku had the least in July, while Yongsanku was in August. 2. In the growths during three months of five districts in Seoul, Nicotiana tabacum was the worst, while five crops such as Perilla frutescens, Ricinis communis, Zea mays, Sorghum bicolor, Cassis tora were the best for growth. Yongsanku out of five districts was the worst them in general, however, there were the best growth in Sedaemunku. Perilla frutescens, Sorghum bicolor, Loix mayuen showed good overall everywhere. In pollution injury, it was quite different from distticts and crops, there showed more 3.0 grade of severe infury Gossypium nankion at Songpaku, Cassia tora at Kuroku, Nicoriana tabacum at Kuroku and Songpaku respectively. There were shown at Kuroku and Songpaku to be the heavy injury while three districts such as Seadaemunku, Yongsanku, Kwangzinku showed a little injury. 3. In contents of sulfur absorption in leaves among them, they were quite different from districts and crops. Sorghum bicolor, in Kwangzinku absorbed it the most, whereas there were the least it in Seodaemunku and Songpaku. Sorghum bicolor was the most absorption for it at Kwangzinku, while Ricinus communis at Kwangzinku, and Zea mays at Seodaemunku were analyzed the least for them. 4. Pollutant that showed overall the highest correlation coefficients with plant growths was O3, next was SO2 and NOx in order of them. The most crops had high correlation coefficients with O3. The crop which had high correlation coefficients for growth with O3 was particulary Perilla frutescens. They had correlation negatively between them in plant height, and plant width, while there were positively correlation between them with pollution injury. Sorghum bicolor showed also th have high correlation with O3, and Ricinus communis negatively correlation between O3 and plant width, and to have correlation positively between dust contents and no. of branches. Zea mays also gave results positively high correlation between O3 and injury leaves due to pollution while there were negatively high correlation for growth with it. Cassia tora showed also positively high correlation between pollution injury and O3.

부산대학교 재학생의 학업성취에 영향을 미치는 요인

전윤식,이성해,정영홍,박선자,김상구 釜山大學校 學生生活硏究所 1988 硏究報 Vol.24 No.1

The purpose of this study was to explain the factors that effect on a academic achievement of Pusan National University(PNU) students. In order to achieve the above purpose, two research problems were established as follows: 1. What are the personal-internal factors which effect on a academic achievement of PNU students? 2. What are the personal-exteranl factors which effect on a academic achievement of PNU students? Statistical methods applied were general descriptive statistics, Pearson's correlation method, multiple regression analysis. The statistical computations were done by SPSS. The results of this study are summarized as follows: 1.The personal-internal factor that effect on a academic achievement of PNU students is the learning skill. 2. The personal-external factors that effect on a academic achievement of PNU students are professor's fulfilling prophecy and the times of review of studies.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

빌트인 모터를 이용한 2축 제어 미세 가공기 개발

김건희,김효식,양순철,이상용,국명호,이선규,김윤중,홍권희 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

This paper describes development of low cost precision machine that has combined the Build-in Motor with a vacuum chuck. This study mainly aims to find out a cutting condition for maintaining optimum surface condition and to examine cutting characteristics of the precision machine that is equipped by diamond bites. The cutting materials is Al alloy. Several experiments were carried out to find out the main factors that affect the surface roughness such as principal axis RPM(rotation per minute), feeding speed, and cutting depth. As a result, we obtain The optimum cutting condition of the developed precision machine.