白茯笭이 肥滿誘導 흰쥐의 體重, 副睾丸,脂肪組織, 血液 및 遺傳子 變化에 미치는 影響

류은경,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : These experimental studies were designed to investigate the effects of Poria cocos extract on the weight control and the lipid metabolism of the obese rats induced by high fat diet. They were designed to find out what was changed in the serum, and how the leptin and the leptin m-RNA were affected. Methods : The measurement has been performed for 6 weeks with obese rats. Results: 1.In the sample I (fat diet & Poria cocos group), the weight decrease significantly occurred throughout the whole research period, whereas in the sample II(normal diet & Poria cocos group), the ratio of weight decrease was significantly observed at the 4th, 5th, and 6th week(p < 0.05) 2.In the sample I, the epididymal fat weight and average size significantly decreased at the 6th week(p < 0.05). 3.In the sample I, the number of epididymal fat cell significantly decreased at the 3rd & 6th week(p < 0.05). 4.With the view of hematologic findings, I observed the increasing tendency of glucose in the sample I & II, and the significant decreasing of triglyceride at the 6th week(p < 0.05). 5.The leptin decreased in the sample I, whereas it came to increasing tendency in the sample II(p > 0.05). 6.The leptin m-RNA decreased a little in the sample I, whereas it increased in the sample(p > 0.05).

관상동맥질환의 중증도와 혈중지질치 및 아포지단백과의 상관관계

임현주,황종현,류재근,정병천,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 관상동맥질환의 위험인자로서 혈청지질 및 혈장 지단백에 대한 관심이 높아지고 있고 또 아포지단백이 관상동맥 질환을 일으키는데 다른 지질보다 더 중요하다는 연구가 많이 발표되고 있으나 우리나라에서는 아포지단백에 대한 연구가 그리 많지 않은 편이다. 이에 저자등은 혈중지질치와 새로운 위험인자로 알려지고 있는 아포지단백치를 측정하고 이들과 관상동맥질환 중증도와의 상관 관계를 알아보았다. 대상 및 방법 : 관상동맥질환이 의심되어 관상동맥조영술을 실시한 69명의 환자를 대상으로 하였으며 12시간 이상 공복후 혈청을 채취하여 총콜레스테롤, 중성지방, HDL-콜레스테롤, 아포지단백 AI (ape AI), 아포지단백 B (ape B)를 측정하였다. 관상동맥조영상 50%이상의 협착이 있는 혈관의 수 (lesion number), 최대협착을 합한 값 (lesion score), 각 분절의 최대협착을 합한 값 (total score), 가장 심한 협착 값 (peak stenosis) 등으로 관상동맥 중증도를 알아본 다음 이들과 혈청지질치, 아포지단백과의 상관 관계를 비교해 보았다. 상관 관계는 Spearman's correlation coefficient를 구하였다. 결과 : 관상동맥질환의 중증도와 각 지질치 간의 상관 관계를 비교해 보았을때 lesion number와 관계있는 것은 연령 (r=0.2789), 중성지방치 (r=0.2829)이며 lesion score와 관계있는 것은 연령(r=0.2911), 중성지방치0 (r=0.3316), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2361), apo B 치(r=0.2759), apo AI과 apo B의 비 (-0.3154)로 나타났다. Total score는 연령 (r=0.3100), 총콜레스테롤치 (r=0.2452), 중성지방치 (r=0.3022), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2770), apo B치 (r=0.2927), apo AI과 apo B의 비 (r=-0.3408)와 연관이 있었고 peak stenosis는 중성지방 치(r=0.3305), ape B 치 (r=0.2968), apo AI과 apo B의 비 (r=-0.3977)와 관계가 있었다. 연령으로 조정하여 partial correlation을 좌면, 관상동맥조영술상 중증도는 중성지방치 (r=0.3408), apo B 치(r=0.2877), apo AI과 apo B의 비 (r=-0.3460)와 유의한 상관 관계가 있었다. 이중 ape AI과 ape B의 비는 lesion score (r=-0.2640), total score (r=-0.3057), peak stenosis (r=-0.3460)와 유의한 상관관계를 보였다. 결론 : 이상의 결과로 보아 apo B치 그리고 apo AI과 apo B의 비가 관상동맥 중증도의 예견인자로 다른 혈중 지질 치보다 더 유용하다는 것을 알 수 있었다. Objectives : Recently, it was reported that the measurements of apolipoprotein levels may be valuable in the clinical assessment of coronary artery disease severity. However there are a few reports regarding to the relationship between coronary artery disease severity and apolipoprotein levels in Korea. Thus, we measured serum lipid and apolipoprotein levels and studied the relationship between coronary artery disease severity and serum lipids and apolipoproteins levels. Subjects and Methods : The 69 patients who underwent coronary angiography to evaluate chest pain were subjected to this study. We measured the levels of serum cholesterol, triglycerides, HDL cholesterol, apolipoprotein AI(apo AI) and apolipoprotein B(Apo B) and measured the severity of coronary artery disease by lesion number, lesion score, total score and peak stenosis. Then, we studied the relationship between coronary artery disease severity and apolipoproteins and calculated the correlation coefficient. Results : The results were as follows. There are significant correlation(r=0.3) between age, triglycerides, apo B levels, apo AI/B ratio and coronary artery disease severity. In controlling for age, tyiglycerides, apo B levels and apo AI/B ratio shows significant correlation(r=0.3) with coronary artery disease severity. Especially, apo AI/B ratio shows significant correlation(r=0.3) with lesion number, total score and peak stenosis. Conclusion : These results suggest that the apo B levels and the ratio of apo AI/B can be used as significant independent predictor for coronary artery disease severity rather than other serum lipid levels.

여름철에 스타킹과 양말 착용시의 생리적 반응 및 착용감

박은실,류현혜,성수광 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

The purpose of this study was to obtain the basic data for designing the physiologically comfortable stocking. The study investigated physiological responses and wearing sensation of healty female adults in twenties in wearing support type stocking and socks according to ambient temperature and humidity in summer. The various factors, such as rectal temperature, skin temperature, body weight loss, blood pressure pulse rate, wearing sensation were statistically analyzed according to the warm temperature ambient condition and ensemble of clothes. The results were as follows : 1. Mean skin temperature showed significant differences with ambient temperature and clothes. In the low humidity and temperature, mean skin temperature was highest in support stocking in order high supporting stocking 〉socks. In the high humidity and temperature, no significant difference on ensemble of clothes was indicated at the end of exercise. 2. Under the certain ambient humidity, mean skin temperature increased in proportion to the increasa of ambient temperature in all ensemble of clothes under the certain ambient temperature, 70% RH higher mean skin temperature was indicated without relation to ensemble of clothes in high temperature. 3. Maximum blood pressure showed significant differences with the increase or decrease of ambient temperature. But, minimum blood pressure increased according to the decreased of ambient temperature. Pluse rate increased in proportion to the increase of ambient temperature during exercise. 4. Comfort showed 0.1% of significant differences with ambient temperature, clothes and time. Phychological responces showed 'very hot' 'very uncomfortable' as exercise and ambient temperature op up. Under the high humidity and temperature, high humudaty and temperature, high support stocking was most comfortable.

최대/최소 경계 스키마 추출 기법을 이용한 XML 문서의 DTD 추출

박경현,최은선,이종연,박정석,류근호 충북대학교 컴퓨터정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.2

XML이 인터넷상의 데이터 교환의 표준으로 대두되면서 데이터 모델이나 플랫폼에 관계없이 데이터의 전송이 가능하게 되었다. 특히 데이터 중심의 XML 문서의 경우 전송시의 부하를 줄이기 위해 DTD없이 전송되는 경우가 일반적이다. 그러한 이유로 전송받은 XML 데이터의 저장 효율을 높이고 질의를 최적화하며 사용자에게 편의성을 제공해주기 위해서는 XML 데이터로부터 DTD 추출이 필수적으로 요구된다. 이 논문에서는 이러한 DTD를 추출하기 위해 반구조적 데이터의 스키마 추출 기법을 적용한다. 특히, 반구조적 데이터의 최소 경계 스키마를 추출하는데 데이터로그를 이용하는 기존의 방법보다 효율적인 방법인 시뮬레이션을 적용함으로써 보다 향상된 DTD 추출 기법을 제시한다. XML makes it possible for data to be exchanged regardless of the data model in which it is represented or the platform on which it is stored, serving as a standard for data exchange format on the internet. Especially, It is natural to send XML data without DTD on the internet when XML is data-centric XML. Therefore it is needed to extract DTD to store XML data efficiently, to optimize queries, and to help users browse XML data. In this paper, Techniques for upper/lower bound schema extraction are applied to extract DTD from XML data. Especially we propose an efficient technique for extracting DTD by using simulation which is better than datalog as a lower bound schema extraction method.

류마티스 관절염과 전신경화증의 중복증후군 1예

이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-

Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.

방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.

실내 기후동에서 개인형 국소냉방 장치의 기류 및 온도 분포해석

엄태인,장은숙,경남호,신기식,문승현,전영남,류창국 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

Numerical simulation is performed by the commercial code FLUENT for individual air condition system to calculate the velocity and temperature profiles around worker in climate room. The main calculation region is the space of ㄱ shape between wall and worker in the individual air condition system. The fresh air is emitted from 3 inlet attached on the right, left and center wall. Because the comfort of worker is closely related with the velocity and temperature of wind, these data are key role for design of the individual air condition system. This work is previous study for evaluation of thermal comfort of workers in room without much experiments according to metabolism and heat emission of human body. Numerical simulation results are as followings, 1. There is an possibility of the thermal comfort of worker is gotten worse due to the presence of dramatic change of wind velocity around worker. 2. Temperature gap exists in worker's body between top and bottom according to fresh air inlet velocity and position which is right, left and center of wall. 3. Calculation results of the skin temperature of worker are key data for evaluation of thermal comfort with experimental data in climate room. 4. Optimum condition of temperature, direction and velocity of fresh air will be obtain by numerical simulation for energy effective individual air condition system.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

수술실 오염도감소를 위한 수술실공조시스템에 대한 연구

김천숙,박은정,강규식,김지은,안기량,권진형,유시현,주영철,권순정 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background: The OR(operating room) should provide an optimum environment that is safe for the patient and the working personnel. The air ventilation system of OR has been studied to decrease the contamination of air. We investigated the flow and contamination of the air in OR at our hospital. Method: Cultures in OR were made and the number of bacteria and fungi were calculated. A two-dimensional model for the cross-section of an operation room is developed for the CFD (computational fluid dynamics) analysis. The characteristics of air flow in the empty operation room and in the occupied operation room are calculated by using a CFD program. Results: The current air ventilation system of our hospital does not deliver the clean air to the operating site efficiently in occupied OR. Conclusions: We suggested a new location of air ventilation system which improves air venting with little increase of the cost of equipment.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.