Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

임신 40주와 출산 후 6주에 있는 20대 임산부 보행의 역학적 특성 비교

윤희중,문동안,정남주,금명숙,이경식,유실,김영란,한윤수 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 임신 40주와 출산후 6주간에 있는 임산부의 보행 동작의 특정을 규명함으로써 이와 관련된 연구자들에게 기초자료를 제공하고자 실시하였다. 이를 위해 임신 4주에 있는 임산부를 대상으로 1차 실험을 실시하였으며 동일한 대상자를 출산후 6주에 2차로 실험하여 자료를 수집하였다. 디지타이징 시 오차를 최소화하고 인체관절점의 분별을 위해 21개의 반사마커를 부착하였다. 10m의 보행주로를 걷는 동안 두 대의 비디오카메라를 이용하여60Hz로 자료를 수집하였으며 동시에 100Hz 지면반력자료를 수집하였다.수집되어진 자료는 DLT 방법을 사용하여 분석하였으며 이의 분석에 Kwon3d 프로그램을 활용하였다. 분석결과 다음과 같은 결론을 얻었다. 1. 임신 40주와 출산 후 6주의 보행 시 지지시간과 스윙시간의 비율이 다르게 나타났으며 보폭과 보간, 활보장은 임신 40주에서 더 큰 값을 보였다. 상체 전경각 역시 임신 40주에서 더 큰 값을 보였다. 힙관절, 무릎관절, 발목관절각도는 S1이 출산후 6주에서 큰 값을 보인반면 S2는 출산전후에 큰 변화를 보이지 않다. 2. 상하지면반력의 경우 FP1과 FP2는 임신 40주보다는 출산 6주에서 큰값을 보였지만 FP3는 임신 40주에서 보다 큰값을 보이고 있었다. 전후지면반력의 경우 출산전과 후 모두 Fy2에서 보다 큰 값을 보이고 있었다. This Study was to investigate kinematical characteristic comparison of the gait pregnant 40weeks and after delivery 6weeks 20´s women and provide the basic data. To accomplish this study, in the first, carry out an experiment with the pregnant women in the pregnant 40weeks on the videotape, and than the second, make an experiment with the kinematic data. Kinematic data were filtered with a low-pass, fourth-order Butterworth filter with an effective cut off frequency of 6Hz. The conclusions were drawn as follows; 1. Floor contact Periods(stance and swing rate) were differed from before and after the delivery and a pregnant 40 weeks was greater than after delivery 6 weeks in the step, width, stride. Also, a pregnant 40 weeks was greater than after delivery 6 weeks in the front angular. And the other angular components were represented similar pattern. 2. In the vertical load, delivery 6 weeks was grater than a pregnant 40 weeks in the FP1(first peak) and FP2(valley). And FP3(second peak)was represent that a pregnant 40 weeks was greater than delivery 6 weeks. Also, in the horizontal shear, Fy2(progressional force)was greater than Fy1(breaking force) about time of the delivery.

한국과 스웨덴의 생활체육에 관한 비교 연구

윤상화,남동현 龍仁大學校 體育科學硏究所 1998 體育科學硏究論叢 Vol.8 No.1

This study is with regard to the physical Education and Sports of Sweden, and has the purpose to give the assistance to the development of Physical Education and Sports in Korea, by use of the characteristics in the Physical Education and Sports of Sweden. As the results of this study, we would like to suggest the under-mentioned for the development of Korea Physical and Sports. 1. The Korean Physical Education and Sports Program must use the geographical conditions. 2. We must its importance to the Social Physical Education from the administration based on the Elite Physical Education, and thus it is necessary to make it as 2 base in the Korean Physical Education. 3. We make promote the Physical strength from the young times and guide to be interested in the use of leisure by the strict performance of School Sports Time. 4. The person graduated from the Dept. of Social Physical Education of each University or Social Sports Instructor are sure to be dispatched in the General Sports Field, and thus it is necessary to take charge of the sports guidance for the public sincerely. 5. The Social Sports Class of Health Class related to the housewives is operated in each Village Ward Office or upon the school during the vacation, and thus progress the concern on Physical Education, and acknowledge the service credits for the students who perform the voluntary service in the program, and thus it is necessary to promote the participation degree. 6. We are out of the department which takes charge of the formal Social physical education, and thus it is necessary to make the research part for the national-wide network. 7. The law on promotion of national sports is changed to the compelling law, and then it is strongly required which the Government shows the powerful will on the Sports Making as Living.

남ㆍ북한 체육행정의 비교연구

윤상화,남동현 龍仁大學校 1997 용인대학교 논문집 Vol.14 No.-

It can be considered that the origin and development of Athletic Activities goes together with the Culture of Mankind in the wide meaning. At present, there exist about 160 countries in the world. All these countries take the policy on sports as the main principles and devote themselves to taking precedence in the formation of National physique and in the competition of International Sports. It is shown that the fundamental bloc, which currently forms the political tendency in the world, is largely brought from three types. That is to say, one is bloc of Freedom countries, another is that of Communist, and the other is, what is called, the new neutral bloc. However, the system of the most specially-compared two types is that of Freedom & Communist Bloc. This has characteristics that the former performs the policy based on the makes and executes the system upon the totalitarian and nationalistic basic idea. Also, in is not too much to say that the clear characteristics of these 2 bloc make the recent and modern age to the confrontation of idelogy, and acts the front contract through every scope in the extreme situations. Even if the Domino Circumstances as like the sinking of Communist bloc happen together with the downfall of ex. Soviet Union, we will need to understand that one of most dangerous countries in the world is North Korea and we, which confront with its line, must recognize these situations. Moreover, the South Korea and the North Korea are one Nation, but are divided by other power and authority, and it is well-known that the South Korea is threatened by the North Korea even today which half a century is approaching since our division of Nation. In these current situations, the research on part of politics, economy, society and education for the Unification will be important to us, and the person who majors in the Athletic Science performs the study on the Athletic Administration of Ex. Communist Countries and North Korea or their sports policy in the academic scope, and thus will understand their systems and the understanding how the physical educational is used to bring up any human. This purpose of this paper is to provide against the unification of the further-developed South Korea and North Korea, that is to say, demecracy and socialism, and then to support the insufficient points of each other, and then to look for the mutual union. Accordingly, we wit compare the Sports Group and Policy of South Korea and North Korea and then suggest the more-advanced development directions in this study.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

통풍성 관절염의 임상적 고찰

윤채중,정승문,김영학,김동규,허광식,김태원,배학연,정종훈,이승일,김평남 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

통풍은 Purine 대사의 이상으로 발생하는 질환으로, 고뇨산혈증인 사람의 전부가 통풍으로 발현되지 않고 증상의 출현 양상이 다양하여 진단과 치료에 주의가 필요하며, 조기에 적절한 조치를 한다면 충분히 조절이 가능한 질환이다. 본대학 내과학교실에서는 통풍으로 치료한 32명의 환자에서 임상양상, 병력과 검사소견을 분석하여 다음과 같음 결과를 얻었다. 1. 32명 모두 남자이며, 최초 발병 시기는 24세에서 72세로 평균 43.8±11.9세이었으며, 30대에서 40대까지가 19명(59.4%)으로 대부분을 차지하였다. 내원 당시 나이는 27세에서 75세까지로 평균 52.3±10.4세였으며, 내원시 까지 평균 유병기간은 8.5±6.8년으로 나타났다. 2. 동반 질환으로는 고지혈증 12례, 신장질환 10례, 고혈압 12례, 비만 8례, 당뇨 2례 등이었다. 3. 이환된 관절은 단관절 침범이 19례(59.4%), 다관절 침범이 13례 이었으며, 최초 이한된 관절은 족무지 중족골지골 관절로 19례(59.4%)로 가장 많았고, 통풍 결절은 20례(62.5%)에서 관찰되었으며, 유병기간이 10년 이상된 12례중 11례 (91.7%)에서 결절이 관찰되었다. 4. 평균 혈중 요산치는 9.17±1.75 ㎎/dl이었으며, 8.0 ㎎/dl에서 9.9 ㎎/dl 사이가 19명으로 전체의 59.4%를 차지하였다. Objective: The gout is a heterogeneous group of diseases resulting from tissue deposition of monosodium urate or uric acid crystals from extracellular fluids supersaturated with respect to this end product of human purine metabolism. The clinical manifestations are such as hyperuricemia, gouty arthritis, gouty nephropathy, uric acid nephrolithiasis. We analyze of clinical manifestations and associated factors in gout. Method: We have reviewed the medical records, radiologic findings and clinical results of thirty-two patients admitted at our department from April 1996 to July 1997. Result: 1) All patients were male. The mean age at initial attack was 43.8 years old, ranging from 24 to 72 years old. 2) The mean level of serum uric acid was 9.17mg/dl on admission. 3) The first metatarsopharyngeal joint was involved in 19 cases (59.4%). Tophus was observed in 20 cases (62.5%). 4) Hyperuricemia was associated with hypertension, obesity, nephrolithiasis and hyperlipidemia.

P-Aminophenyl 4-Amino-4-Deoxy-β-D-Galactopyranoside의 합성

윤신숙,김동성,남정이 崇實大學校 1988 論文集 Vol.18 No.-

Methyl 4-azido-2, 3, 6-tri-O-benzoyl-4-deoxy- α-D-galacto pyranoside (2)로 부터 p-nitrophenyl 4-azido-2, 3, 6-tri-O-benzoyl-4-deoxy- β-D-galactopyranoside (5)가 세 단계를 거쳐서 합성되었다. 4-azido-2, 3, 6-tri-D-benzoyl-1-Chloro-1, 4-dideoxy- α-D-galactopyranose (4)는 chloroform-nitromethane (2 = 1, V/V) 용액에서 p-nitrophenyl. Ag₂CO₃와 함께 Konig-Knorr 반응을 하여 화합물 5를 43%수율로 주었다. 또한 p-nitrophenyl 4-azido-4-deoxy- β-D-galacto pyranoside (6)은 methanol 용액중에서 NiCl₂·6H₂O/NaBH₄에 의해 쉽게 환원되어 p-aminophenyl 4-amino-4-deoxy- β-D-galactopyranoside (1)을 만든다. 화합물 1은 D-galactose 변형효소들의 작용메카니즘 연구에 중요한 가치가 예견되는 물질이다. p-Nitrophenyl 4-azido-4-deoxy-2,3,6-tri-O-benzoyl- β-D-galactopyranoside has been synthesized from methyl 4-azido-4-deoxy-2,3,6-tri-O-benzoyl- α-D-galactopyranoside via three steps; Konig-Knorr reaction on 4-azido-2,3,6-tri-O-benzoyl-1-chloro-1,4-dideoxy- α-D-galactopyranose with p-nitrophenyl in the presence of Ag₂CO₃, chloroform and nitromethane (2:1, v/v) produced the above mentioned compound (in 43% yield). p-Nitrophenyl 4-azido-4-deoxy- β-D-galactopyranoside was reduced in the presence of NiCl₂·6H₂O/NaBH₄in methanol to give p-aminophenyl 4-amino-4-deoxy- β-D-galactopyranoside which is known to be a useful compound for the studies of the action mechanism of D-galactose modifying enzymes.

스포츠의 정치화 과정에 관한 연구

윤상화,남동현 龍仁大學校 體育科學硏究所 1996 體育科學硏究論叢 Vol.6 No.1

The growth in popularity of sports over the past several decades has brought increased attention from government and new possibilities for sport management. This study considered the relationship between sports and politics, and the effects that demographic characteristics have on opinion of this relationship. The research provided and extensive discussion of the theoretical and historical connections between sports and politics. survey analysis were conducted to test whether Korean students at three major colleges in Pusan, Korea, saw the connections between sports and politics, what factors determined their views on these relationships, and if their view affected their opinions on appropriate sports management policy. The study found that there was significant support for the claim that sports and politics were related. It showed that the people who were most likely to see the connections were well-educated, less active on a daily basis in either sports or politics, desirous of having integrated government involvement in sport management, older, socially aware, politically liberal in their desire that government meet citizens' needs, involved in sports for physical fitness or entertainment, and male.

한국 여성스포츠 활성화를 위한 연구

윤상화,남동현,조임형 龍仁大學校 1997 용인대학교 논문집 Vol.13 No.-

Historically women have been discriminated not only in sports but also in another fields of social life according to the social cultural backgrounds and customes. This sex discrimination is due to the lack of the opportunity to participate sports, the ideological prejudice of male diversionism and the systematic inequality uttered in the nomological, institutional, environmental aspects of society. And the social conception on male adventage and female dependence enforces the present discrimination in the women sports. Theoletically, discussion on women sports has been focused on the dogma that man governs woman in the sense of sex inequility in sports, limitation of female opportunity in sports, inequility of conservative system and the relative deprival of employment opportunity from the point of liberal, marxist, radical, socialist view. The sex discrimination is due to the social, cultural circumstance of a specific society and prejudicial cultural tradition. The cultural tradition form the idea that woman can play the role only through the family and companion because of her biological and depentent character and enforce such a sex role and social training. The social-role prejudice which began in the family and companion would be enforced and magnified through the discrimitive management of the curriculum and phisical education program at school. The sex discrimination has such a tendency of aggravation and perpetuity because of male-prejudicial news and scarcity of role-model, which have been discussed in many researches. But woman's sports were advanced quite much in accordance with feminism movements and the change of social/cultural definition on woman. In spite of all of these, there still appears to be some prejudice in the psyological, social-psychological, institutional realms. To sum up the factors which prevent woman's sports activate, Firstly, negative cognition of common people on woman's sports. Secondly, the prejudice that women are not adquite for sports activity. Thirdly, women themselves have the prejudice that sports activity makes their body manly. And to sum up the important theoletical factors concerned with the woman's sports activation, Firstly, woman has psychologically the stronger emotional intentionality than man. Secondly, woman has the weaker motivation for sports psychologically, which is due to her parents' indifference and the incorrect belief of 'womanlikehood' or 'out to be womanlike' and so on. Thirdly, because woman's participating the sports activity is influenced by intermediate group like family, the opportunity-situation became the important variable. Some conclusion for activation of Women's Sports Activation acquired in the study is as shown in the followings. Firstly, We must change the ineffective sports activities in the whole society, including the system, which places the importance in the examination at the existing school, and the physical education program which lays stress on the sudents to comply with the characteristics and interests of women in the scope of life-time sports, and the education on the leader who controls these programs effectively is urgent. Secondly,Mass Media must be interested in the sports, physical education activities of women, and show the positiveness on the program related to the women's own improvement and culture and on the public-information related to the concrete practical method.