항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

Association of 20 potential ATP2B1‐interacting genes with blood pressure in Koreans

Kyung‐Won Hong,Hyun‐Seok Jin,Ji‐Eun Lim,Bermseok Oh 한국유전학회 2011 Genes & Genomics Vol.33 No.3

Plasma membrane calcium‐transporting ATPase 1 (ATP2B1)is associated significantly with blood pressure in Caucasians and Asians. ATP2B1 regulates calcium homeostasis and belongs to the P‐type calcium pump family; several studies have identified diverse proteins that bind to ATP2B1. We hypothesized that ATP2B1 regulates blood pressure through ATP2B1‐interacting genes. To this end, 20 potential ATP2B1‐interacting genes were selected, 197 SNPs of which were analyzed for their association of systolic and diastolic blood pressure. These 20 genes were categorized into 2 groups: ATP2B1‐binding genes and ATP2B1‐cleaving calpain family members. Three ATP2B1‐binding genes (CALM1, NOS1, and PDLIM1)were associated with blood pressure, and a SNP in CALM1(rs2401887) generated the strongest association signal (beta=‐3.60±0.92, p=8.9×10^(‐5) for systolic blood pressure and beta=‐1.40±0.62, p=0.02 for diastolic blood pressure). Of the calpain family members, 3 genes (CAPN6, CAPN9, and CAPN10)were associated with blood pressure, and the CAPN10 SNP rs4676348 yielded the strongest association signal (beta=‐0.88±0.27, p=0.001 for systolic blood pressure and beta=‐0.58±0.18, p=0.015 for diastolic blood pressure). Further, the interaction of CALM1 to ATP2B1 was examined using the blood pressure of individuals who carried both variants of CALM1and ATP2B1 genes. Similarly the interaction of CAPN10 to ATP2B1 was also examined. The CALM1 variant (rs2401887)and CAPN10 variants (rs4676348) appear to decrease blood pressure further in addition to the decrease by the variant (rs17249754) of ATP2B1, which suggests that ATP2B1 might regulate blood pressure through the ATP2B1‐interacting genes CALM1 and CAPN10.

Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

억제대 적용지침 개발을 통한 불필요한 억제대 적용율 감소활동

곽경선,김성은,배은경,이은숙,이은혜,최윤정,이윤경 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 억제대 적용에 대한구체적 적용지침 없이 의례적으로 억제대를사용함으로 인해 환자들의 신체적 또는 정신적 안전을 위협할 수 있다. 목적: 완전 진정상태 이거나 근력이 약하여 발관능력이 없는 환자에 대한 예방적 적용, 바빠서 환자를볼수 없 는경우, 간호사본인의 판단이 없이 타인의 요구에 따르는등의 불필요한 억제대 적용이 증가하는 원인을 파악하여 중환자실의 특수성에 맞는 억제대 적용및 제거 지침을 마련하고자 한다. 의료기관: 인천광역시에 소재한 의과대학 소속병원의 집중치료실 개선효과: 억제대 적용에 대한중환자실 간호사에게 미치는 영향을 보면 태도 정도 p=0.09(p<0.1), 올바른 수행 능력은 p= 0.005 (p <0.0히로통계적으로유의한것으로 나타났다. 지식 정도 p=0.172(p<0.05) 통계적으로 유의 하지는 않지만 모든항목이 개선 활동전 에 비해 2,3차 개선 활동후에 향상한 것으로 나타났다. 개선활동전에 8.1%였던 간호 기록, 0.7%였던 간호중재, 0%였던 의사처방율이 3차 개선 활동 후 3가지 모두 100% 달성되었다. 이는 억제대 적용율 갑소 및 부적절한 억제대 적용율은 유의하게 감소하였다. 교훈: 중환자실 간호사의 억제대 적용에 대한태도, 지식, 올바른 간호 수행 능력은 지속적으로 재평가 되어지고, 교육내용은좀더 나은 간호제공을 위하여 개발 되어져야 할 것이다. 억제대 적용 기준과 제거 기준을 Check List 하여 객관성의 유지를 위한 개선 활동은계속적으로 Feedback 되어야 할 것이다.

근대계몽기 『경향신문』의 편집 전략과 독자 수용 정책

전은경(Jun, Eun-Kyung) 한국어문학회 2015 語文學 Vol.0 No.127

The purpose of this paper is to examine the policy for readers and literatures of the newspaper Kyunghyang during modern enlightenment period. It was very important for modern newspapers to improve readers’ reading. The newspaper Kyunghyang had also played an important role for forming new novels and modern readers. Actually, the newspaper Kyunghyang had been published for Korean Catholics. However editors had also the strategy for general readers who were not Catholics. They had divided newspapers into two types. One was the outside paper for general readers, who could have got general information and articles. The other was the inside paper for Catholics, who could have got religious doctrines for Catholic. The newspaper Kyunghyang had posted 〈the readers’ column〉 so called 〈Gongham〉 that means a public box. Readers of the newspaper had came to understand each other and participated in the process for making the news. Therefore the newspaper Kyunghyang had an important effect on forming readers acting and reading.

계류 유산 후 한방치료 위해 내원한 환자의 Heart Rate Variability(HRV) 특성 연구

유은실 ( Eun Sil Yoo ),김민영 ( Min Young Kim ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),장준복 ( Jun Bok Jang ),이경섭 ( Kyung Sub Lee ),이창훈 ( Chang Hoon Lee ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.3

Objectives: This study aims to analyze Heart Rate Variability (HRV) in women after missed abortion compared with healthy women Methods: We studied 35 women who visited Kang-Nam Kyung-Hee Korean Hospital after missed abortion from 01 January 2012 to 28 February 2015 (missed abortion group) and 35 normal women visiting medical examination center from 1 January 2014 to 31 December 2014 (Normal Group). We measured HRV of each women and investigated the difference of HRV between two groups. Results: The standard deviation of NN intervals (SDNN) in Missed abortion group is lower than normal group. The square root of the mean square difference of successive NNs (RMSSD) in Missed abortion group is lower than normal group. However there was no significant difference. Total Power (TP) and Low frequency power (LF) is significantly lower in Missed abortion group compared with normal group. High frequency power (HF), Very low frequency power (VLF) and LF/HF ratio in missed abortion group is lower than normal group. but There was no significant difference. Conclusions: Missed abortion group is lower in function of overall autonomic nervous system, especially sympathetic nerve.

사상체질과 신체형태지수와의 연관성

박경아,김희진,허경석,안수경,이성호,이종은,이원택 대한췌담도연구회 2000 대한췌담도연구회지 Vol.5 No.4

(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

The Naebang Gasa Revisited : Yangban Women's Discourse as a Means for the Confirmation Self-identity

Shin, Eun Kyung Research Institute of Asian Women Sookmyung Women' 2005 Asian Women Vol.21 No.-

The naebang gasa or "inner-room gasa" is widely believed to be a poetic genre written in hangŭl, which was mainly composed by yangban women of Yŏngnam Province and flourished in the late Chosŏn period. As the social ranking system was destabilized in this period for various reasons, the yangbans or the ruling class began to feel a sense or crisis in maintaining their social status and already-acquired privileges. It was, therefore, needed for the ruling class to strengthen the Confucian practical ethic of personal autonomy and responsibility, distribute and infuse it to the commoners in order to facilitate their governing act and overcome the critical situation. The yŏllyŏ jŏn ("Biographies of Faithful Women") by yangban male literati and the naebang gasa by yangban women, both of which appeared in large quantities in this period, need to be understood as a way to find the solution of the critical situation. The gyenyŏ ga and the jatan ga, two subtypes of the naebang gasa, differ from each other in that the focus of the former is put to foreground the role of mother and that of the latter is placed to display the laments of an individual woman. On this basis, we can characterize the gyenyŏ ga as "the song of 'I' as a mother" who successfully completed her entry into the position of a matriarch, and the jatan ga as "the song of 'I' as a woman" who, in a sense, failed to carry out the task. If the former has greater affinity with "a sense of family," the latter with "the rise of self-consciousness." The naebang gasa secures a significant position in Korean literary history, because it functioned as a means for the confirmation of women's "sense of existence as a mother or as a woman."

사랑서사와 박경리 문학

김은경 ( Eun Kyung Kim ) 서울대학교 인문학연구원 2012 人文論叢 Vol.67 No.-

In this essay, I discuss the fact that ``love between a man and woman`` is of great importance in the novels of Park Kyung-ri. The fact that the narrative of ``love`` includes extra-marital affairs and marriage relationships shows the viewpoint of the author which is based in reality. The various relations of love and marriage (family), poses problems on love itself, the family system, and marriage. I discover four kinds of extra-marital affairs in the novels of Park Kyung-ri which illustrate the intricate relationships between men and women: 1) extra-marital affairs derived from marriage disorders, 2) extra marital affairs between close relatives (elder brother`s wife and brother- in-law), 3) extra-marital affairs based on mutual feelings of love between the subjects of adultery, and 4) extra-marital affairs that pursue benefit and lust. Type 1) shows that ``the exclusiveness of romantic love``, meaning that only love can lead to marriage, can not be true within the boundaries of the institution. In type 2), the elder brothers` wives lead the adultery with their brothers-in-law. The elder brothers` wives who are widows or do not love their husbands (i.e. do not receive their husband`s love) recover the damaged relationship of ``love`` and ``marriage (family)`` in the family system. Types 1) and 2) result from the undifferentiated rela- tionship between ``love`` and ``marriage (family)``. Types 3) and 4) show how loveless marriages bring about adultery. In type 3), the husbands who married as a means of social success fall in love with the adultery subject. In type 4), the wives form the adultery relationship as a means of enjoying material, emotional and sexual pleasure, and exercising power. Through these narratives of adultery, the author shows the limitations of ``romantic love`` and criticizes loveless marriage. And she also shows the position of the female character that remains within the family system. These issues are discussed in Chapter 2. In Chapter 3, I discuss the issue of ``selective marriage``. The four types of extra-marital affairs do not derive from an intersection between love and the system of family. With selective marriage comes a true harmonization of love and the system of family, by differentiating the two values of ``love`` and ``marriage (family)``. The aspects facilitating ``selective marriage`` are as follows: 1) the female character has the position of a social being that does not stay within the system, 2) the characters accept the plural loves that are growing loves (or possibly growing loves), which I call the ``love of companion``, and 3) characters who experience the unnatural death of family put ``marriage (family)`` above ``love``. Through these discussions, I can reveal that ``the narratives of love`` represent the problem of ``love`` and ``marriage (family)`` in keeping with the realistic view. Park focuses on the continuation of the system of family through the narrative on extra-marital affairs. The novels of Park do not contain an overthrowing of the nature of the affairs or a beautification of love. They contain, rather, her insights on the limitations of female characters in the family system. This essay suggests that ``selective marriage`` is a feministic alternative to this.