Acetyl CoA carboxylase의 활성 조절에 있어서 Covalent phosphorylation과 Deploymerization간의 상관관계에 관한 연구

권경렬,김은영,배동훈 단국대학교 신소재기술연구소 1995 신소재 Vol.5 No.-

지방산 합성계의 지배 효소인 Acetyl CoA carboxylase의 활성조절에는 hormone에 의한 covalent modification과 세포내 대사물질에 의한 조절이 관여하는 것으로 알려져 왔다. Allosteric regulation과 covalent modification 두 경우 모두 중합체와 이량체로서 상호전환 되며 효소활성이 변환된다. BSA를 효소의 인산화과정에 함께 사용하였을 경우는 특이하게도 효소의 인산화는 일어나나 이량체로서의 분해는 일어나지 않는다. 이러한 사실로부터 효소 활성조절은 직접적으로 polymerization-depolymerization 변환에 의해 나타내며 인산화-탈인산화는 효소의 4차 구조를 변환시키기 위한 도구로서 사용되며 인산화-탈인산화에 의하여 활성이 직접적으로 변화하지는 않는다. Acetyl CoA carboxylase, the rate-limiting enzyme in long chain fatty acid synthesis, exhibits complex regulatory properties. Hormonal regulation of the carboxylase activity and thus fatty acid sythesis is mediated by the covalent modification of the enzyme, and cellular metabolites regulate the carboxylase activity through polymerization-depolymerization of the enzyme. In this paper, we show the evidences that the covalent modification of Acetyl CoA carboxylase is a means of changing the quaternary structure of the carboxylase and not the activity per se.

중년여성 기성복 하의의 착용실태 및 맞음새에 관한 연구 : 만 34세에서 59세까지 For women aged 34 to 59

김은경,최혜선,이경미 대한가정학회 2003 Family and Environment Research Vol.41 No.3

This study was conducted to analyze the actual wearing conditions and body fit preferences of the middle-aged women's ready-to-wear lower body clothing. The aim was also to analyze lower body recognition, lower body satisfaction, fit preferences and size satisfaction according to age and degree of girth size. A questionnaire was developed and administered to 300 middle-aged women aged 34 to 59. Statistical tests such as descriptive analysis, crosstabs, and χ^2-tests were coducted to anaylze thdata and ascertain the differences between the ages. Lower body satisfaction and recognition were compared by T-test. Also Anova was used to analyze lower body recognition, satisfaction, fit preferences, and size satisfaction according to age and degrees of girth size. The results indicated that women aged 50 to 59 were more dissatisfied with the ready-to-wear sizing system and because of their body shapes had changed, their need for a larger size range system had also increased. Moreover, the element that most affected their purchase of ready-to-wear lower body clothing was the design followed by the size. The women, especially of the ages 50 to 59, showed a tendency to be dissatisfied with their lower bodies and they recognized that lower bodies had thichened compared to women aged 34 to 39 and 40 to 49. Analysis of body satisfaction, recognition, and fit preference according to girth size showed that the group of larger girth size recognized that their lower bodies were thicker and were more dissatisfied and preferred looser fittings than the groups of smaller women.

수업관찰을 통한 초등학교 열린교육 연구

성은경,윤명희 東義大學校 生活科學硏究所 1999 生活科學論集 Vol.3 No.-

The purpose of this study is to investigate the characteristics of open education by observational methods in elementary school. Because the observational methods provide a picture of the spontaneous characteristics in the teaching and learning setting, and informations about interactions between teacher and children, observation is used combined with quantitative analysis. The systematic observation of classroom was performed in two types of schools, open and traditional schools. The criteria for observation are teaching-learning methods, interactions between teacher and students, classroom environment, and evaluation. Through literature review, open education was defined, and factors for construction the open education were analyzed. Behaviors which are related to open education were classified in terms of four criteria, and the checklist for open education was made. Then trained observers watched and recorded behaviors in natural settings. To observe behaviors more objectively, both descriptive and checklist methods were used. 6 elementary schools in Pusan City were sampled for this study. The open and traditional classrooms are compared at each criterium. Even though the results can not be generalized to a total open education system, in open education, the children seemed to be treated more individually and specifically and were enjoying their activities in their classroom.

兒童 個人的 變因 및 家庭環境的 變因과 兒童의 場獨立性

김경연,신은영 부산대학교 가정대학 1990 家政大學硏究報告 Vol.16 No.-

The relations between Children's Field-Independency and personal factors as age and sex, environmental factors as socioeconomic status and mother's parenting attitude were investigated in the present study. We also examined the relative effects of these independent variables on children's Field-independency. The subjects were 267 First, Third and sixth graders of elementary school and their mother (N=267) who are resident in Pusan. Children's Field-Independency was assessed with CEFT (Children's Embedded Figures Test) in individually held interview. Lee Won Yong' MBRI (Maternal Behavior Research Instrument) was employed for measure Mother's Parenting Attitudes. Results showed that all personal and environmental factors employed in this study related to children's Field-Independency. It seemed that Children's Field-Independency enhanced as they grow older. Children's sex had a partial relationship with Children's Field-Independency. Boys showed higher Field-Independency than girls only in 6th graders(t=2.24, p<.05). There was clear relationship between socioecomonic status and children's Field-Independency(r=.411, p<.001). It showed that Mothers affectionate attitude and non-controlling attitude can increase Children's Field-Independency in 3rd(r=.340, p<.001, r=-.201, p<.05) and 6th (r=.238, p<.05, r=-.235, p<.05) graders but not in 1st graders. The order of relative power of 4 independent variables is grade, socioeconomic status, sex and mother's affectionate attitude.

피부 적용 겔제제의 첨가제에 의한 수분 보유력 평가

이은미,박종희,경기열,전일순,조혜정,지웅길 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

The aim of this study was to improve the moisturizing and water retaining effects of a gel containing poloxamer 407, glycerin, sod hyaluronate, sorbo(sorbitol 70%). Topical preparations were formulated as a gel containing different concentration poloxamer 407, glycerin, sod. hyaluronate, sorbo(sorbito1 70%), lipid(ceramide. sphingosine ratio 1:l). We tested a various combination of different additives for the moisturizing effect The water holding capacity of the mixture was measured using a moisture analyzer. In vivo test was carried out on human skin using Skicon-200 and water retaining effect was increased by addition of lipid. Water evaporation test was performed by various concentration of additives and water evaporation characteristics of the preparations were determined using the moisture analyzer. Moisturizing and water retaining effects was increased by adequate combination of various additives with topical gel formulations.

연쇄알구균 감염에 의한 급성 인후염 후 반응성 관절염 1예

박은하,도연실,양정채,강미라,서현주,정숙인,손준성,기현균,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

연쇄알구균에 의한 급성 인후염 후 발생한 반응성 관절염은 급성 류마티스열의 개정된 진단기준을 충족하지 못하면서, 지속적 혹은 재발성의 비이동성 관절염과 발열, 홍반성 결절, 일시적 간기능 이상 등을 보이면서 심장염과 무도증을 드물게 동반하는 질환이다. 따라서, 발열을 동반한 급성 관절염 환자에서 감별해야 할 질환 중의 하나이며, 심근염 예방을 위한 페니실린 요법의 적응증 및 기간에 대해서는 아직 이론이 많은 상황으로, 보다 광범위한 연구가 필요하다. 저자들은 연쇄알구균에 의한 급성 인후염 1주 후에 발생한 하지의 다발성 비이동성 관절염과 함께 결절홍반 및 일시적 간기능 이상을 보인 환자에서 PSRA로 진단하고 비스테로이드성 항염증제 및 스테로이드로 성공적인 치료를 하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Poststreptococcal reactive arthritis (PSRA) is associated with recent streptococcal infections. However, PSRA is distinct from acute rheumatic fever by its clinical manifestations: non-migrating arthritis, erythema nodosum or erythema multiforme, and transient elevation of serum transaminases. We experienced a 33-year-old man who presented with fever, arthritis of both knees and ankles, and erythema nodosums on extensor surfaces of lower legs which developed 6 days after the onset of pharyngitis symptoms. Blood and urine cultures were negative. Throat culture was negative for group A β-hemolytic streptococcus. The ASO titers increased up to 2080 IU/mL in sequential monitoring. The result of bone scan was compatible to arthritis of both knees and ankles. There were no signs or symptom of carditis. He showed clinical improvement with anti-inflammatory drugs (naproxen 1,000 mg/day and prednisolone 7.5 mg/d). PSRA should be included in the differential diagnosis of patients presenting with arthritis combined with fever.

일부 수영장 욕수 및 이용객 urine내 Trihalomethane 농도

문경환,손종렬,김영환,변상훈,배은상 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

Chlorination of swimming pool water leads to many chlorinated products. The most frequent derivative is trihalomethane(THMs). This study was performed to investigate the distribution of THMs in swimming pool water and ambient air, and to determine whether THMs concentrations in swimmers' urine Were influenced significantly after swimming. Water samples were collected from 22 indoor and outdoor swimming pools. Concentrations of THMs in swimmers' urine determined before and after their stay in swimming pools. Results of the study as follows. 1. The concentrations of THMs in the indoor swimming pools water(41.85±73.22㎍/L) were significantly increased(p<0.05) in comparison with that of outdoor swimming pools (10.15±15.45㎍/L). The average concentration of THMs in indoor ambient was 51.2㎍/㎥, which was significantly higher than that of air quality. 2. As a results of regression analysis between THMs and water quality factors, the concentration of pH, residual chlorine and KMnO₄ consumption were highly correlated in indoor swimming pools. 3. In almost all cases, only CHCl₃ was quantifiable. The proportions of THMs in urine correlated roughly with those in water and the secretion of THMs increased significantly after swimming in the pools.

염산 독세핀 외용제의 피부 전달 시스템을 위한 제제 설계 및 평가

이은미,김정수,경기열,이계원,지웅길 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

Doxepin hydrochloride(Dox) is a dibenzoxepin-derivative tricyclic antidepressant and used topically for the short-term relief of moderately severe pruritus associated with atopy dermatitis. Dox topical emulsion(or liposome) formulations were evaluated with respect to their rheological properities, permeation through excised skin of hairless mouse and in vitro/in vivo accumulation in the skin. The apparent viscosity was increased according to the concentration of glycerin and decreased with an increase in the concentration of phosphatidylcholine(PC). The permeation rate of formulation increased with a high concentration of PC and showed no relationship with the change of formulations. Amount of accumulated drug in the excised skin of hairless mouse was decreased with a high concentration of glycerin, but increased according to PC concentration.

청소년의 여가활동 실태에 관한 연구

김도경,전민정,조은아 경희대학교 부설 디자인연구원 2002 예술· 디자인학연구 Vol.5 No.1

In this study, the status of teenager's leisure activity has been understood, examined and analyzed. The purpose of this study is to examine the status of teenager leisure activity and to provide way to improve the leisure space. The study has been based on questionnaire on middle and high school student, both male and female, in Seoul. The analysis was done by SPSSWIN Program Ver 11.0. Frequency, percentage,-test were methods of analysis. The results are as follows. Teenager are wasting their leisure time because of insufficient facilities for productive activities. They use the time, when analyzed in one week, for visiting shops, playing in the ground and playing in the game rooms. And when analyzed in a month, they use time for meeting friends in coffee shops, visiting restaurants, playing in the game rooms and visiting sports facilities. Teenagers' leisure time were different according to sex and age. Students hoped the leisure spaces to be healthy and active leisure activity, and facilities they wanted, were sports facilities, game rooms and parks. It is necessary that teenager have opportunities to learn how to use their leisure time healthy in the leisure space. This study was invested the status of teenager leisure activities, that were only divided sex, age among various social and environmental fators. Consquently, questions on that and arguments of different visual angles should be remained the study subject, later. This study was only composed of language levels, self-recorded method questionaire research. But, to get a result exactly is required the observation and interview

신규간호사의 역할개념 양상

안은경,오경옥 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

The purpose of the this study was to analyze nursing role conceptions and test the relationships between nursing role conceptions and general characteristics among selected new nurses. The subjects of this study were consisted of 106 practising new nurses. The data was collected from August 7 to 31, 1995. Subscale of Nursing Role Conceptions (Pieta, 1976) were used to measure bureaucratic, professional, and service role conceptions. Data were analyzed by SPSS/PC+ program. The result of this study were summarized as follows: 1. Score of normative role conception is higher than that of categorial role conception in three role conceptions (p<.01). In the normative&categorial role conceptions, three role conception score is high in sequence of service, professional, bureaucratic role conceptions (p<.01). 2. Baccalaureate graduates had significantly higher professional normative role conception scores (p<.05) and professional and service role discrepancies (p<.01); associate nurses had significantly higher professional categorial (p<.05) and service categorial role conception scores (p<.Ol) 3. There was no relationship between experiences and bureaucratic and service role conception. Professional normative role conception scores were gradually increased as experiences were increased but decreased after 10 months (p<.01). 4. There was a statistically significant increase in the categorial service role conception in the intensive care unit nurses (p<.05).There was a statistically increase in the service role discrepancy in the operating room nurses (p<.05). The findings indicates that degree of the discrepancy between normative and categorial role should be minimized. Therefore, further studies are necessary to repeat the longitudinal&qualitative research for exploring new nurses' role conceptions.