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Expression of VEGF, p53, Apaf-1 and Caspase-9 in Head and Neck Squamous Cell Carcinoma
이성학,강여주,조의주,이연수,강창석,Lee, Sung Hak,Kang, Yeo Ju,Jo, Ui Ju,Lee, Youn Soo,Kang, Chang Suk The Korean Society for Head and Neck Oncology 2012 대한두경부 종양학회지 Vol.28 No.2
배 경 편평상피암은 두경부의 악성종양 중 가장 흔하며, 임상적인 경과가 불량하다. 따라서 나쁜 예후를 가지는 환자군을 조기에 선별하여 더 적극적인 치료의 시행을 결정짓는 표지자의 필요성이 대두된다. 우리는 일련의 두경부 편평세포암 검체에서 몇몇 분자 표지자의 예후적 유용성을 평가하고자 하였다. 방 법 23예의 두경부 편평세포암 검체를 대상으로 VEGF, p53, Apaf-1, caspase-9의 발현과 몇몇 임상병리학적 지표들간의 연관성을 면역조직화학염색을 통해 조사하였다. 결 과 환자군은 남성이 더 많았으며 평균연령은 63.7세였다. 1기가 5예, 2기가 2예, 3기가 8예, 4기가 8예였다. 평균생존기간은 37.3개월이었다. VEGF단백 발현은 종양의 크기와 통계적으로 유의한 연관성을 보였다. 이와 더불어 VEGF단백 발현은 병기, 그리고 림프관 침습과 연관적인 경향성을 보였다. 그러나 VEGF단백 발현과 생존기간과는 관련성이 없었다. 또한, Apaf-1과 caspase-9의 단백발현은 다른 임상지표, 환자의 생존기간과는 관련이 없었다. 결 론 VEGF단백 발현은 두경부 편평세포암 환자에서 나쁜 임상경과를 예측할 수 있게 하는 표지자로서의 역할을 할 수 있다. 또한 본 연구는 두경부 편평세포암에서 별로 연구되지 않은 Apaf-1과 caspase-9의 발현상태를 밝힌 점에서 의의가 있다.
광역 영상 재생을 위한 순응 밝기 특성 기반의 다중 광도 영상 합성 기법
이성학(Sung-Hak Lee) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.9
HDR image synthesis is a method for reproducing an actual visual scene on a display by capturing a scene with a wide luminance range. Generally, HDR images are reproduced by captured images in various camera exposure conditions and synthesizing various images through blending. First, multiple exposure images are converted into a radiation map. Several images are mixed according to the exposure ratio or the camera transfer function. The radiation map is reproduced as a visual HDR image using a tone mapping function. The conventional method requires reference display samples and several exposure images for CRF calculation and has some errors accumulated due to various synthesis steps. In this paper, we proposed an HDR image synthesis algorithm based on visual brightness function using 2 exposed images. It improves boundary errors, color balance, blurring and noises due to blending as compared with other methods.
시각의 공간 주파수 응답을 고려한 고속 바이래터럴 필터 분할 영역에서의 HDR 베이스 및 세부 계층 분리
이성학(Sung-Hak Lee),권혁주(Hyuk-Ju Kwon) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.7
In order to effectively preserve detail information, high dynamic range(HDR) imaging methods use a method of separated detail processing. In HDR tone mapping, HDR images are usually rendered through base-detail separations due to the large difference between the input and output dynamic range. The representative detail preserved algorithm iCAM06 has a tendency to reduce the sharpness of images including dim surround because of the discrete calculation of the fast-bilateral filter(FBF). This paper proposes a noble base-detail separation and detail compensation technique using the contrast sensitivity function(CSF) in the segmented frequency domain. Experimental results show that the proposed rendering method has better sharpness features than previous methods correlated by the human visual system.
청소년의 방과 후 스포츠 활동 참여가 심리적 변인(우울증, 공격성, 불안)에 미치는 영향
이성학(Sung Hak Lee),원주연(Joo Yeon Won),권정두(Jung Du Kwon) 한국청소년문화연구소 2012 청소년 문화포럼 Vol.- No.31
This study is aimed at studying the effect of After-school Sport Participation on Youth`s psychological variable(Depression, Aggression, Anxiety). The experiment carried out 619(middle school students) for 4hours per week for 12weeks through soccer, basketball, netball. After the experiment, data were collected by questionnaire. Through analyzing SPSS 14.0 statistical program, the results were as follows. 1, According to the studying of After-school Sports Participation on Youth`s Depression, statistically significant results appeared(p<.001). In Depression change between boys and girls, they are significant influenced by After-school Sport Participation but there is no change between each grade(p<.05). 2, According to the studying of After-school Sports Participation on Youth`s Aggression, statistically significant results appeared(p<.05) before and after this experiment. In Aggression change between grade, second grade students are higher than first grade students(p<.01). In Youth`s Aggression change between boys and girls, statistically significant results didn`t appear. 3, According to the studying of After-shool Sports Participation on Youth`s Anxiety, statistically significant results didn`t appear before and after this experiment. In Youth`s Anxiety change between boys and girls, statistically the level of girls is lower than boys(p<.01). In Anxiety change between grade, second grade students are lower than first grade(p<.01) In short, After-school Sports Participation have a positive effect on Youth`s psychological variable (Depression, Aggression, and Anxiety).