디젤오염 지하수 정화를 위한 공기주입정화법 칼럼 실험

장순웅,이시진,송정훈,권수열 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12

Bio sparging experiments were conducted in a laboratory column to investigate the potential removal of diesel contaminated groundwater. The objectives in this study were (a) to determine the extent of diesel degradation in laboratory columns under supplement of nutrient; (b) to determine the effect of variation of air flow in the removal of diesel and (c) to evaluate the potential enhancement of diesel degradation as a function of temperature. Our results showed that the nutrient supplement and higher air flow greatly enhanced diesel degradation. However, the variation of water temperature examined slightly increased degradation rate of diesel fuel.

위암종과 Epstein-Barr 바이러스와의 연관성에 대한 연구

심광용,김호영,김효열,백순구,권상옥,조미연,이창훈,이종인 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Objectives: Epstein-Barr virus (EBV) has been known to be linked to a spectrum of neoplastic conditions, including nasopharyngeal carcinoma, Burkitt's lymphoma, peripheral T-cell lymphoma and Hodgkin's disease. This study aims to investigate the association of EBV with gastric carcinoma in Korea. Methods: Fifty-three cases of gastric adenocarcinoma were studied for evidence of EBV infection by EBV-encoded small RNA (EBER) in situ hybridization (ISH) on the paraffin sections and amplifying the EBV genome encoding envelop glycoprotein (gp220) with polymerase chain reaction (PCR) in fresh gastric cancer specimens. Results: EBER was detected in 7 (13.2%) of 53 gastric carcinomas and all cases were male. In 6 (85.7%) of 7 EBER-positive cases, the tumors were located in the upper and middle part of the stomach. EBER ISH study showed strong positivity in all the tumor cells, but negativity in surrouning lymphocytes, stromal cells and normal gastric mucosa. DNA PCR was positive in 23 (43.4%) of 53 gastric carcinomas, including all of 7 EBER-positive cases. Conclusion: We could observe some association of EBV with gastric carcinoma, and our findings about the charateristics of EBV-positive gastric cancers involving sex, site and histological type are similar to those in Japan. However, EBV-positive rate of gastric cancer is higher than in Japan and lower than in Western countries. Further studies to elucidate oncogenic mechanism of EBV in gastric cancer should be performed.

‘Summer Dream’, Early-Season and Excellent Quality New Korean Apple Having a Crisp and Juicy

Soon-Il Kwon,Mok-Jong Kim,Sang-Jo Kang,Gye-Jun Lee,Ho-Youl Kim,Yong-Uk Shin,Pong-Nyeol Paek,Jong-Chul Nam,Jae-Kwon Jung 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Antitumor Activity of Pyridazine Derivative in Nude Mice

Chai, Hee-Youl,Sin, Ji-Soon,Kim, Tae Myoung,Kwon, Woon,Cho, Young Min,Choi, Ehn-Kyoung,Hwang, Seock-Yeon,Kim, Yun-Bae,Moon, Aree,Kwon, Soon-Kyoung,Kang, Jong-Koo 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1

In vitro cytotoxicity and in vivo growth-inhibitory effect of 3-methoxy-6-allylthiopyridazine (K6), an allylthiopyridazine derivative, were evaluated in human hepatocellular carcinoma Hep-G2 cell line and in nude mouse xenograft model, respectively, in comparison with doxorubicin. In vitro cytotoxicity, K6 (5-2,000μM) and doxorubicin (0.05-10μM) decreased tetrazolium conversion by viable cells to formazan in a dose-dependent manner. From a mechanistic study, the Hep-G2 cells exposed to K6 or doxorubicin underwent morphological changes, displaying elongation with filamentous protrusions. In addition, the cells showed chromatin condensation and fragmentation, producing apoptotic bodies. In vivo solid tumor xenograft model, the growth rate of tumor mass was significantly suppressed to the half level by daily oral administration of K6 (20-100mg/kg), which is comparable to the effect of intravenous treatment with doxorubicin (2mg/kg), resulting in the decrease in final tumor weights to 0.78 and 0.50 g by K6 (100mg/㎏) and doxorubicin, respectively, compared with 1.32 g of control. Also, mean survival time of mice of control group (14.4 days) was doubled by treatment with K6 (27.2-29.4 days) or doxorubicin (28.8 days), leading to 100% increase in life span. Interestingly, daily oral treatment with a high dose (100mg/kg) of K6 did not induce testicular toxicity, in contrast to full degenerations of germ cells in atrophic testes intravenously exposed to doxorubicin at 4-6-day intervals, in addition to the emaciation and decrease in body weights of the animals. Taken together, K6, an allylthiopyridazine derivative originated from dially sulfide in garlic oil, could be a promising candidate for chemotherapy of hepatocellular carcinomas as an oral regimen.

Usefulness of the Real-Time Elastography to Reflect the Histologic Characteristics of Hepatocellular Carcinoma

( Soon Woo Nam ),( Jong Youl Lee ),( Young Chul Yoon ),( Jun Suh Lee ),( Sun Hong Yoo ),( Jung Hyun Kwon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: The real-time histography (RTH) is known to predict the liver fibrosis in chronic liver disease. For the resectable hepatocellular carcinoma (HCC) within the same stage, there is limited prognostic information before the operation. This study aimed to investigate the usefulness of RTH for the reflection of characteristics of HCC. Methods: Thirty-one consecutive patients who underwent surgical resection and RTH between September 2015 and March 2017 in Incheon St. Mary’s hospital were analyzed. Using RTH, the patients were checked both the tumor area and non-tumor area before the surgical resection. The value of RTH was investigated whether results of RTH and histologic characteristics of HCC were compared. We also analyzed the risk factor for HCC recurrence. Results: The mean age the patients was 56.74 years (SD: 8.90 years), and 28 (90.3%) were male. Of the 31 patients, 23 (74.2%) had hepatitis B virus and 2 (6.5%) had hepatitis C virus. Regarding tumor characteristics, 30 patients (96.8%) were TNM stage 1 and 1 patient (3.2%) were stage 3. The value of RTH in tumor was significantly high that in non-tumor (5.94 vs 3.62, p = 0.0001). According to the tumor stage, there was no difference of RTH. In non-tumor area, RTH index was correlated with Fibrosis(FIB)-4 index. After the histologic examination of resected HCC, RTH was associated with histologic cell type of HCC: hepatic cell (n=20); clear cell (n=10), (6.15 vs. 5.34, p = 0.007). The AUC for detecting hepatic cell in HCC was 0.785 (95% CI 0.610-0.960). The optimal cut-off value for detecting hepatic cell was 5.69 with a sensitivity of 75% and a specificity 70%. However, there was no different between Edmondson grading, vessel invasion or lymphatic invasion. During the follow-up period (median 7.1 months (range, 0.5 - 15.3)), 4 patients experienced HCC recurrence. In univariate analysis, Glisson’s capsule invasion was the only associated factor with HCC recurrence (p = 0.046, HR 10.148, 95% CI 1.041-98.944). However, higher RTH (p = 0.906) and cell type of HCC (p = 0.377) were not associated with HCC recurrence. Conclusions: This study suggests that RTH might help identify the histologic characteristics of HCC before the surgical resection. In future, there will be needed RTH can predict the long-term outcomes of HCC in respect of histologic characteristics.

Granulicatella adiacens에 의한 패혈증 1예

권오건,박순덕,어영,윤갑준,권상옥,김효열 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

Granulicatella adiacens는 과거에 nutritionally variantst reptococci로 분류되었던 균종으로 Streptococcus adjacens, Abiotrophia adiacens로 명명되기도 했다. Granulicatella는 구강 및 상기도, 요생식기, 위장관 등의 상재균으로 임상에서는 주로 심내막염에서 발견된다. G. adiacens에 의한 심내막염은 사망률이 높은데 잘 배양되지 않아 주의를 요한다. 저자들은 선행질환으로 간경변증과 만성신부전이 있는 52세 여자 환자의 혈액배양에서 G. adiacens를 분리하였기에 문헌고찰과 함께 보고하는 바이다. Granulicatella adiacens was first described as nutritionally variant streptococci, and named as Streptococcus adjacens and Abiotrophia adiacens. Granulicatella species are flora of oral cavity, upper respiratory, urogenital, and gastrointestinal tracts, and are normal often isolated from patients with infective endocarditis. G. adiacens endocarditis is associated with high mortality, but the species hardly grow in the ordinary growth media. We report a case of septicemia caused by G. adiacens in a 52-year-old woman with liver cirrhosis and chronic renal failure.

Sensitization of Vanilloid Receptor Involves an Increase in the Phosphorylated Form of the Channel

Lee Soon-Youl,Lee Jae-Hag,Kang Kwon Kyoo,Hwang Sue-Yun,Choi Kang Duk,Oh Uhtaek The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.4

A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Putative endogenous activators (anandamide and metabolites of arachidonic acid) are weak activators of VR1 compared to capsaicin and RTX, and the concentrations of the physiological condition of those activators are not sufficient to induce significant activation of VR1. One way to overcome the weak activation of endogenous activators would be the sensitization of VR1, with the phosphorylation of the channel being one possibility. The phosphorylation of VR1 by several kinases has been reported, mostly by indirect evidence. Here, using an in vivo phosphorylation method, the VR1 channel was shown to be sensitized by phosphorylation of the channel itself by multiple pathways involving PKA, PKC and acid. Also, in sensitizing VR1, BK appeared to show activation of PKC for the sensitization of VR1 by phosphorylation of the channel.

교량배수시스템 개선 연구를 통한 유지보수비용 절감

권순정(Soon-Jung Kwon),전일식(Il-Sik Jeon),맹주철(Joo-Cheol Maeng),이승열(Syeung-Youl Lee) 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.5

자갈이 부설된 궤도의 경우 배수가 잘 안 되는 역구내, 교량, 접속부 그리고 토공절토부 구간에는 지속적으로 분니현상이 발생하여 유지보수 작업량 증가 및 차량 승차감 저하를 가져오고 있다. 배수 및 노반토가 불량한 경우 현재 분니 대책공법으로 가장 많이 사용되고 있는 자갈치기 및 도상자갈 교환 등의 분니대책공법은 약 6~10개월 후 다시 분니가 발생하는 등 영구적인 해결방법이 아니다. 본 연구에서는 유도상 교량상에 발생하는 분니현상을 저감하는 여러 대책방법 중 분니가 발생한 유도상교량에 드레인보드를 시험 설치한 후 강우에 의한 배수상태를 계측하여 그 효과를 검증하고 장기적으로 유지보수비용 절감을 생애주기비용 방법으로 비교 분석하였다. In the case of ballast-laid tracks, in areas where there is no adequate drainage – particularly, station areas, bridges, transitional zones, and earthwork areas – mud pumping occurs on a regular basis. Consequently, more work is required for maintenance as well as ride comfort being lessened. Currently, ballast cleaning and ballast exchange are the measures most resorted to when coping with mud pumping due to poor drainage and sub-grade soils. However, such measures are not permanent solutions because mud pumping reoccurs six to ten months after the measures have been taken. This study has investigated the installation of drain boards on ballasted track bridge as a method for reducing mud pumping on ballasted track bridges. The effectiveness of the boards were validated by measuring the drainage status after rainfall. Furthermore, LCC (life cycle cost) method was employed to conduct a comparison analysis to investigate how the drain boards cut maintenance costs in the long run.

Cyclopolymerization of α-Methylbenzyl Dipropargylamine by Transition Metal Catalysts

Yeong Soon Gal,Won Chul Lee,Sung Ho Jin,Kwon Taek Lim,Sang Hee Jang,Won Seok Lyoo,Eung Nak Han,Sang Youl Kim 한국고분자학회 2007 Macromolecular Research Vol.15 No.3

Isolation of Gibberellins-Producing Fungi from the Root of Several Sesamum indicum Plants

( Wha Youl Choi ),( Soon Ok Rim ),( Jin Hyung Lee ),( Jin Man Lee ),( In Jung Lee ),( Kang Jin Cho ),( In Koo Rhee ),( Jung Bae Kwon ),( Jong Guk Kim ) 한국미생물생명공학회 2005 Journal of microbiology and biotechnology Vol.15 No.1