악교정 수술과 심미성

김태열,윤규호,전인성,고성준 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

There are so many reasons why patient selects orthodontic and orthognathic treatment, but most of them want functional improvement. Sometimes patients are not satisfied though functionally improved. It is apparent that they want esthetic improvement too. Satisfaction and happiness are influenced by on self-evaluation, emotional state, expectation and so on. Clinicians have difficulty in estimating and treating the patients by psychological norm. Therefore, we study the relation between orthognathic surgery and aesthetics.

대전 연극의 현황과 개선방안

김상열 대전대학교 인문과학연구소 2001 人文科學論文集 Vol.32 No.-

선천성 일측성 폐정맥 폐쇄증 1 예

김철호,이계영,심영수,김건열,한용철,한성구,정희순,임정기,박재형 대한내과학회 1988 대한내과학회지 Vol.35 No.3

Unilateral pulmonary vein atresia is a rare congenital disease and is frequently associated with intracardiac anomalies. It is usually diagnosed in childhood and is very rarely diagnosed in adulthood. A case of unilateral pulmonary vein atresia in a 20-year old female is de- scribed. The relevant findings were symptoms of exertional dyspnea, roentgenographic evidence of decreased lung volume, increased interstitial infiltration with septal lines in the involved side (right), and aoscence of blood flow in a radionuclide perfusion scan. Pulmonary angiography showed an extremely small right pulmonary artery and thining of the peripheral branches, and nonvisualization of the draining pulmonary veins. Bronchial arteriography showed rommunication between the bronchial artery and the right pulmonary artery and it was drained to the left pulmonary artery. Cardiac catheterization showed no intracardiac anomaly. The right bronchography was normal; pulmonary function studies showed a pure restrictive pattern and markedly in creased physiologic dead space. MRI showed no visible right pulmonary vein.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

ZnO 박막 센서의 DMA 가스 검지 특성

김성우,최우창,류지열,박성현,최혁환,이명교,권태하 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

The DMA(Dimethylamine) gas sensors were fabricated with the ZnO-based thin films grown by a RF magnetron sputtering method. We investigated the sensitivity and response time according to temperature variation and DMA gas concentration. The ZnO-based thin film sensors sputtered in oxygen atmosphere showed higher sensitivity than those sputtered in argon atmosphere. The ZnO-based thin film sensors doped with Al_(2)O_(3), In_(2)O_(3) and V_(2)O_(5) and sputtered in oxygen atmosphere showed the maximum sensitivity of 218(working temperature, 250 ℃, DMA gas, 160 ppm) and speedy response time. The ZnO-based thin film sensors doped with Al_(2)O_(3), In_(2)O_(3), TiO_(2) and V_(2)O_(5), sputtered in oxygen atmosphere and aged at 330 ℃ showed the maximum sensitivity of 156(working temperature, 250 ℃, DMA gas, 160 ppm).

Ga_2Se_3 및 Ga_2Se_3 : Ni^2+ 單結晶의 光學的 Energy Gap의 溫度依存性 Ni^2+ single crystals

김진희,이상열,최성휴 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

Optical absorption properties of Ga_2Se_3 and Ga_2Se_3:Ni^2+ single crystals grown by the Bridgman method were investigated over the temperature range from 21 K to 296 K (or 292 K). The crystal structure of these compounds determined by X-ray diffraction analysis was α-type, cubic structure, and lattice constant a_o=5.410 A for Ga_2Se_3 single crystal, and a_o=5.408 A for Ga_2Se_3:Ni^2+ single crystal. It is confirmed from the optical absorption spectrum that Ga_2Se_3 single crystal has an allowed direct transition and the temperature dependence of the direct band gap of these compounds is well satisfied with Varshni equation. The constants of Varshni equation have the values of E_g(0)=2.093 eV, α=-5x10^-4 eV/K, β-488 K for Ga_2Se_3 single crystal, and E_g(0)=1.438 eV, α=2.63x10^-4 eV/K, β=-609K for Ga_2Se_3:Ni^2+(1mole%) single crystal, respectively.

실험쥐 모델에서 림프구 주입을 이용한 동종 장기이식에 대한 관용 유도

김정아,홍성열,김춘추 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2

연구배경: Mixed chimerism 상태에서는 공여 장기에 대해 특이적인 관용효과가 유도되어 면역억제제를 투여하지 않아도 거부반응이 나타나지 않는다. 본 연구에서는 조직적합항원(major histocompatibility complex)이 일치하지 않는 실험쥐를 대상으로 전신방사선조사나 이식 전 동종림프구를 주입하는 방법으로 donor chimerism 상태를 만들어 이식장기에 대한 관용효과를 유도하고자 하였다. 방법: C57BL/6 (H-2^(b))를 전처치 방법에 따라 7 Gy의 전신방사선조사를 시행한 군(1군)과 BALB/c (H-2^(d)) 비장 세포를 간문맥 내로 주입하여 이식세포에 대한 관용을 유도한 군(2군)으로 나눈 뒤 BALB/c 골수세포를 주사하여 유도된 chimerism을 분석하고 MLR을 시행하였으며, BALB/c 피부를 이식하여 생착 여부를 확인하였다. 결과: 1군에서는 말초혈액 내에서 donor chimerism이 확인되었고 2군에서는 PCR 방법으로 말초혈액뿐만 아니라 각 장기에서 microchimerism이 확인되었다 MLR 방법으로 1, 2군 모두에서 BALB/c 세포에 대해 동종림프구의 증식반응이 저하되었으며, 동종피부이식편이 평균 생착기간도 대조군의 6.6±0.8일에 비해 1군에서는 평균 90일 이상, 2군에서는 16.3±1.2일로 현저하게 증가된 것을 확인할 수 있었다. 결론: 방사선조사나 공여림프구 투여로 동종세포에 대한 면역학적 관용효과를 유도할 수 있었으며, 동종피부이식편의 생착을 증가시킬 수 있었다. Background: Because mixed allogeneic chimerism results in donor-specific tolerance, rejection doesn't occur without immunosupression. In this study, we investigate the induction of immune tolerance on mouse skin allograft in MHC-mismatched hosts that developed donor chimerism after conditioning with total body irradiation or a portal vein injection of donor splenocytes (SPLc), followed by an infusion of donor bone marrow cells (BMCs). Methods: In BALB/c (H-2^(d)) to C57BL/6 (H-2^(b)) combination, C57BL/6 recipients were irradiated at 7 Gy total body irradiation (TBI) prior to BMC infusion (Group 1) and given a portal vein injection with SPLc of BALB/c prior to BMCs infusion (Group 2). BMCs were infused from BALB/c donors to C57BL/6 recipients. Flow cytometry and PCR were used to assess donor-chimerism and standard skin grafting and mixed lymphocyte reaction (MLR) were used to assess donor-specific tolerance. Results: Under this protocol, it was confirmed that mixed chimerism was induced in group 1 and microchimerism was induced in group 2. The proliferation of lymphocyte was reduced in both group 1 and group 2 using MLR analysis. The graft survivals in group 1 (>90 days) and group 2 (16.33±1.2 days) were longer than the control (6.6±0.8 days), which suggested that tolerance was induced across the MHC barrier without further need for immunosuppression. Conclusion: In this donor chimerism model, functional tolerance was induced across the MHC barrier with combined protocol of total body irradiation/ donor BMC infusion and donor SPLc/ dornor BMC infusion. Mechanisms responsible for this tolerance induction require future elucidation.

의료 폐기물의 처리에 관한 연구

김용수,배성렬,김영채,박우용,공성호 한양대학교 에너지 ·환경기술연구소 1995 에너지·環境技術論文集 Vol.2 No.-

의료기관의 증가에 따라서 발생되는 폐기물의 증가 또한 매우 심각한 형편이다. 하지만 우리나라에서는 아직 의료 폐기물의 법적인 규제나 처리기술의 개발이 매우 미흡한 상태이다. 의료 폐기물은 일반적으로 일반 폐기물과 감염성 폐기물로 나뉘며 특히 감염성 폐기물은 발생 후부터 일반 폐기물과 분리하여 수거, 운반, 보관 및 처리하는 것이 매우 중요하다. 발생된 감염성 의료 폐기물은 일반적으로 멸균을 거쳐야 하며 최종적으로 회전식 소각로, 공기 조정식 소각로 또는 로타리킬른 등이 소각로를 이용, 소각처리 후 최종처리를 하도록 한다. 이에 따라 대기오염 방지시설 또한 적절히 설치·운영되도록 한다. Due to increasing numbers of medical facilities, wastes regarding medical activities are also increasing recently medical wastes are generally categorized an infectious wastes and non-infectious wastes. Infectious medical wastes should be separated from non-infectious wasted right after generation. A sterilization process should be applied before further treatment of infectious wastes. An incineration process is usually used for final treatment of wastes. Therefore, air pollution control devices are carefully designed for incinerators.

미세혈관문합시 헤파린의 국소 및 전신 투여가 혈전 형성에 미치는 영향

김성열,오희균 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

The need of microvascular anastomosis or vascular graft has been increased gradually to reconstruct the maxillofacial defects. Despite advances in microsurgical technique, instrumentation and experience gained in clinical microvascular surgery, thrombosis of small veins may lead to the failure of microvascular surgery. A variety of anticoagulant agents have been used in either experimental or clinical microvascular surgery in order to decrease the failure rate of microvascular anastomosis and to prevent the need of reoperation. Heparin, which has been known to be effective in preventing thrombosis and in improving patency after microvascular anastomosis, is used locally or systematically. However, their effects is controversial. This study was performed to evaluate the effect of topical and intravenous heparin on thrombosis and patency in the microvascular anastomosis of the traumatized veins. Nine white rabbits wishing about 2 kg were used. After exposure of both femoral veins, the veins were crushed by the jaws of smooth needle holder in order to create a thrombosis model. Transectional incision was made in the vein. The animals were then divided into 3 groups based on the administration method of heparin: 1) Experimental Group 1, topical irrigation of lumen with heparin saline solution (n=6); 2) Experimental Group 2, topical irrigation of lumen with heparin saline solution and intravenous injection of heparin (0.75 mg/kg) via the marginal ear vein for 3 days; 3) Control Group. topical irrigation of lumen with saline solution (n=6). The veins were anastomosed utilizing microvascular technique with 10-0 Ethilon. The vascular patency was evaluated with empty-and-refill test 30 minutes and 3 days after microvascular anastomosis. The amount of thrombus was evaulated by surgery microscope 3 days after microvascular anastomosis and histologic findings were observed. The results are as follows: 1. Thirty minutes after microvascular anastomosis, the patency of all Experimental Groups was better than Control group. However, there was no significant difference among groups. 2. Three days after anastomosis, the patency of all Experimental Groups was much more improved than that of Control Group (p<0.05). There was no significant difference between Experimental Group 1 and 2. 3. Three days after anastomosis, the amount of thrombus in all Experimental Groups was much less than that of Control Group (p<0.05). 4. In histologic findings a lot of luminal thrombus were observed around sutured area in Control Groups. Few luminal thrombus was observed in all Experimental Groups. Mild necrosis in the vessel wall was observed around sutured area in all specimens. These results indicate that topical irrigation of heparin may improve the patency and inhibit the formation thrombus in the microvascular anastomosis of the traumatized veins.

극작실기 교육방안에 대한 연구

김상열 대전대학교 인문과학연구소 2001 人文科學論文集 Vol.31 No.-