위암 환자에서 절제된 림프절 수의 차이와 관련이 있는 인자

정귀애,박정희,변익건,김경종,장정환,김권천,민영돈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Purpose: By the definition of UICC TNM classification (fifth edition), the nodal stage of gastric cancer is based on the number of metastatic lymph nodes, which is influenced by the number of resected lymph nodes. And individual differences in the number of resected lymph nodes had been observed in patients with gastric cancer. The aim of this study is to verify the factors which are associated with the difference in the number of resected lymph nodes in patients with gastric cancer. Methods: We reviewed 613 patients with gastric cancer who underwent curative resection and D2 lymph node dissection with 15 or more resected lymph nodes. The number of resected lymph nodes was analyzed according to the characteristics of patients, the types of operation and prognostic factors of gastric cancer. Results: The mean number of resected lymph nodes per patient was 33.0 (median: 31.0, range: 15-88). The number of resected lymph nodes was significantly associated with the types of operation, the location and size of tumor, macroscopic types, depth of tumor invasion and the number of metastatic lymph nodes. Patient's age, gender and the histopathological finding's had no relationship with the number of resected lymph nodes. Conclusions: The number of resected lymph nodes from gastric cancer was different in each patient despite of same D2 lymph node dissection and it was associated with several prognostic factors of gastric cancer.

鈴木 治의 作品에 관한 硏究

원경환,조수정 홍익대학교 산업디자인 연구소 2002 미술디자인 논문집 Vol.- No.7

치료 저항성 환청을 나타내는 만성 정신분열병 환자에서 측두두정부 반복 경두개자기자극의 효과

정경희,최충식,박진수,이규항,함웅,이승환,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on left and right temporopahetal cortex in schizophrenic patients with treatment-resistant auditory hallucination. Methods : Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly a1-located to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20 international system at 1 Hz for 20 minutes per day for 101reatment days. A Figure of eight TMS coil with a solid core was used for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment. Results : Ten days administration of l-Hz rTMS to temporopahetal cortex significant improved frequency (p<0.001) and attentional salience (p=0.038) of auditory hallucination, Positive (p<0.001) and negative symptom (p=0.02), and CGI-impro-vement (p<0.001). There were no significant differences between right and left side stimulations. Conclusion : These results suggest that the low frequency rTMS on temporopahetal cortex may be useful in treating Schizo-phrenic patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option.

活性슬럿지法에 의한 炭化水素 함유 廢水의 淨化

고정삼,김재하,강경수,고영환 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

Activated sludge process which has been widely applied to the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3%(W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21%(W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A.calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

퍼지알고리즘를 이용한 유도전동기 속도제어에 관한 연구

조정민,전기영,함년근,이승환,이훈구,한경희 명지대학교 대학원 1999 대학원논문집 Vol.3 No.-

The conventional PI controller are fragile in parameter variation and load-variation. Therefore, in this paper, a speed control algorithm based on the Fuzzy PI controller is proposed for the high performance speed control of a voltage ?? inverter to drive 3-phase induction motors. The computer simulation and experiment results show that the proposed controller are more excellent control characteristics than conventional PI controller in transient-state and steady-state response.

이종접합재 접합 계면근방 균열의 응력 및 파괴특성

오정국,차용훈,오환섭,박준건,박경식 朝鮮大學校 機械技術硏究所 1998 機械技術硏究 Vol.1 No.1

현재까지 이종마찰압접재의 강도측정은 실험 (7)-(15)에 의해 구해져 왔다. 하지만 최근 이종마찰압접재의 효율성을 인정하여 여러 실용 부품에 응용하려는 연구가 한창 진행중이다. 이종마찰압접재에 대한 저자들(1)-(6)의 기초실험결과 일반적인 단종재와는 상이한 파괴거동(3)이 관찰되었고, 파괴역학적인 관점에서 정성적인 data 확보가 필요하게 되었다. 따라서 본 연구에서는 인장시험시 이종마찰압접재의 접합강도와 미소균열들에 의한 파괴거동을 파괴역학적 관점에서 해석적으로 고찰하여 보고자 경계요소법(BEM ; Boundary Element Method)을 이용하여 접합계면을 포함하는 접합부를 중심으로 계면상의 응력분포와 계면의 중앙에 결함이 균열로써 존재하는 경우의 응력분포와 인장시험시 열영향부에서 관찰된 균열의 모델링을 통한 균열선단에서의 응력해석을 행하였고, 그 결과 얻어진 중요한 내용을 요약하면 다음과 같다. 계면의 중앙에 균열이 존재하는 접합계면의 표면부에서 응력의 특이성이 발생하며 탄성계수의 비가 증가할수록 특이성이 증가함이 관찰되었다. 탄성계수의 비가 일정한 경우 균열의 크기가 변화하여도 계면의 표면부에서 발생하는 특이성은 거의 같은 값을 갖게 되며, 탄성계수의 비가 증가할수록 표면부의 응력 특이성의 크기는 증가한다. 이종마찰압접재의 인장시험시 관찰된 균열을 모델링 하여 해석한 결과 최대 응력 기준으로 살펴볼 때 인접한 균열선단에서의 응력분포는 균열을 합체시키는 방향으로 작용함을 알 수 있다. In this study stress distribution on the interface and stress near tip of the sub-interface crack in the dissimilar friction welded material is analyzed by using of BEM( Boundary Element Method). Stress singularity near surface of model to analyze is observed for various crack length and ratio of elastic modulus. Tensile and shear stress distribution near two neithbor sub-interface crack tips are analyzed. Existance of singularity near surface on the interface is particular situation so that we need to investigate for dissimilar friction welded materials by means of numerical analysis method.

활성슬럿지법에 의한 탄화수소 함유 폐수의 정화

고영환,강경수,김재하,고정삼 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

Activated sludge process which has been widely applied t o the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3% (W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21% (W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A. calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

이성 경뇌막외농양 : Two Cases Report

김정배,권현오,오경균,김중환 중앙대부설한국의과학연구소 1984 한국의과학 Vol.16 No.4

흰쥐 침샘의 Nitric Oxide Synthase에 관한 면역전자현미경적 연구

이영환,고정식,박대균,박경호 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3

산화질소는 생물체내에서 생리적이나 병리학적으로 중요한 역할을 한다고 알려져 있으며, 특히 침샘조직에서 침분비작용과 샘혈류 조절에 중요한 인자의 하나로 관여함이 알려져 있다. 산화질소합성효소 (nitric oxide synthase, NOS)는 동위효소로서 내피산화질소합성효소 (endothelial NOS, eNOS), 신경산화질소합성 효소 (neuronal NOS, nNOS)와 유도산화질소합성효소 (inducible NOS, iNOS)가 있으며, 세포내에서 내인성산화질소를 합성한다고 알려져 있다. 그러나 산화질소합성효소의 세포내 분포에 관한 전자현미경적 연구는 매우 드물며, 흰쥐 침샘에서의 산화질소생산효소(NOS)에 대한 전자현미경적 연구는 없었다. 흰쥐 침샘에서 NOS의 세포내 분포를 규명하기 위하여 면역전자현미경방법을 이용한 금입자표지법을 시행하여 아래와 같은 결과를 얻었다. eNOS에 양성 면역반응을 보이는 구조는 침샘의 분비세포 중장액세포에 있는 전자밀도가 높은 분비과립이었으며, 점액분비세포의 점액분비과립에서는 비교적 약한 면역반응성이 관찰되었다. 즉 턱밑샘과 혀밑샘을 구성하고 있는 두 종류의 분비세포 중장액세포의 분비과립에 금입자가 비교적 많이 표지되었으며, 점액세포의 분비과립에서는 적은 수의 금입자가 관찰되었고, 침샘의 소엽속관(intralobular duct)의 전자밀도가 높은 분비과립에서도 금입자가 표지된 것이 관찰되었다. 귀밑샘에서도 장액세포의 분비과립과 소엽속관의 분비과립에 금입자가 표지되었다. nNOS의 양성 면역반응은 턱밑샘에서 점액세포의 분비과립에서만 약간의 금입자가 관찰되었으며, 턱밑샘, 혀밑샘 및 귀밑샘의 분비세포와 분비관세포에서는 iNOS에 대한 양성 면역반응이 관찰되지 않았다. 흰쥐 침샘에서 산화질소합성효소 중 eNOS는 침샘분비세포의 분비과립에 존재하며, 특히 전자밀도가 높은 장액성분비과립에 주로 분포하고 있으며, 분비관 중에서 소엽속관에도 분포하고 있는 것이 관찰되었으나, 다른 동위효소인 nNOS와 iNOS는 거의 관찰되지 않았다. 산화질소합성효소가 흰쥐 침샘분비세포의 분비과립과 소엽속관의 분비과립에 분포하고 있는 것으로 보아 침샘에서 산화질소가 침의 생산과 분비에 중요한 역할을 담당하는 것으로 생각된다. Endogenous nitric oxide (NO) has been known to regulate many physiological and pathological processes, especially the glandular secretion and blood flow. However, nitric oxide synthase (NOS) responsible for NO synthesis has not been well studied ultrastructurally in rat salivary gland. The present study was performed to investigate the distribution of nitric oxide synthase isoforms (endothelial, neuronal, and inducible NOS). Immunoelectron microscopic study, using monoclonal mouse anti-endothelial NOS, anti-neuronal NOS, and anti-inducible NOS, was performed in the salivary gland of rat. Endothelial NOS (eNOS)-positive immunoreactivities were most prominent in the secretory granules of serous cells of the salivary gland of the rat. Immunoreactivities were well concentrated on serous secretory granules in the serous cells. However, weak eNOS-positive immunoreactivity was observed in the mucous secretory granules of the mucous cells. Positive endothelial NOS (eNOS) immunoreactivities were most prominent in the secretory granules of intralobular ducts. Ductal secretory granules and acinar serous secretory granules have a similar pattern of labeling as eNOS suggestings. Neural NOS (nNOS)-positive immunoreactivity was not detected in duct systems or in acinar cells. Inducible NOS (iNOS)-positive immunoreactivity was not seen in acinar and ductal cells. These results reveal the presence of eNOS in the salivary gland of the rat, which may be related with regulation of the glandular secretion and blood flow through the gland.

인공 치아우식 발생 모델에서 디지털 방사선 공제술을 이용한 인접면 치아우식증의 진단

박정훈,최용석,황의환,이기자,최삼진,박영호,김경숙,진현석,홍경원,오범석,박헌국 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Materials and Methods : Digital radiographies of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size #2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. Results : In artificial caries activity model, the range of lesional depth was 572-1,374 μm and the range of lesional area was 36.95-138.52mm². The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. Conclusion : The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.