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이달의 X-선 : 중엽증후군과 폐렴을 유발한 기관지의 성장을 보이는 기관지 지방종 1예
박세종 ( Se Jong Park ),장경순 ( Kyung Soon Jang ),김도민 ( Do Min Kim ),권재성 ( Jae Sung Kwon ),이성근 ( Sung Geun Lee ),김명선 ( Myung Sun Kim ),강종렬 ( Jong Yeal Kang ),김응수 ( Eung Soo Kim ),이병두 ( Byung Doo Lee ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.4
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김지현 ( Ji Hyun Kim ),남영진 ( Young Jin Nam ),권미란 ( Mi Ran Kwon ),이찬희 ( Chan Hee Lee ),한성훈 ( Seong Hoon Han ),박원도 ( Won Do Park ),이병두 ( Byung Doo Rhee ),이윤우 ( Yun Woo Lee ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Central diabetes insipidus is caused by the insufficient secretion of vasopressin and has been reported in great variety of disorder of brain tumor, systemic infiltrative disease such as histiocytosis, amyoidosis and vasculitis, leukemia, and other autoimmune diseases. But there has been reported only 3 cases of systemic lupus erythematosus (SLE) associated with central diabetes insipidus. The exact pathophysiologic process of pituitary gland involvement in SLE has been unknown, although there are some evidence that vascular impairment and autoantibodies to pituitary gland may be contributory factors. Here, we report a case of central diabetes insipidus complicated by neuropsychiatric systemic lupus erythematosus.
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김현철,신동훈,김병엽,김철우,김도형,한승혜,오명돈,이재용,이민영,김상억,김학찬,오인균,이병두,최강원 대한내과학회 2002 대한내과학회지 Vol.62 No.2
Non-Hodgkin's lymphoma (NHL) is the secondary most common tumor in HIV-infected individuals. The AIDS-related lymphomas are a late manifestation of HIV infection and may increase in frequency as patients live longer with highly active antiretroviral therapy and effective prophylaxis of opportunistic infections. Histologically AIDS-related NHL are either high (2/3) or intermediate (1/3) grade lymphoma. We report a case of gastric Non-Hodgkin's lymphoma in AIDS patient. Two years ago, she was diagnosed as HIV-infected individual in public hospital. She presented with epigastric pain and mass-like sensation. Under the impression of gastric cancer, subtotal gastrectomy was done. But, she diagnosed as diffuse large B cell lymphoma by histologic finding, immunohistochemical study. This is the first report of gastric Non-Hodgkin's lymphoma from AIDS patients in Korea(Korean J Med 62:223-229, 2002)
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한국인 그레이브스병 환자의 비타민 D 수용체 3′ 말단부위 유전자 다형성
황재경,김경원,김태용,이회수,박영주,신찬수,박도준,박경수,이병두,김성연,이홍규,조보연 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1
연구배경: 한국인 그레이브스병 환자를 대상으로 비타민 D 수용체 유전자 다형성을 조사하여 연관성을 살펴보고, 유전자형과 임상상 및 갑상선수용체자가항체 사이에 연관성이 있는지를 알아보고자 하였다. 방법: 새로 진단된 그레이브스병 환자 117명과 건강한 성인 156명을 대상으로 하였다. 비타민 D 수용체 3' 말단부위 유전자 다형성은 각각 ApaI, BsmI, TaqI 제한효소로 잘라 제한분절길이다형성 방법으로 유전자형을 비교 분석하였다. 절단부위가 존재하는 경우를 각각 a, b, t라 하였고, 존재하지 않는 경우를 A, B, T라 명명하였다. 결과: 제한효소 ApaI에 대한 유전자형의 분포는 각각 AA형 17.1%, Aa형 50.4%, aa형 32.5%이었고, BsmI의 경우는 BB형이 7.1%, Bb형이 35.4%, bb형이 57.5%이었고, TaqI 유전자형은 TT형이 92.6%, Tt형이 6.2%, tt형이 1.2%이었다. 이러한 분포는 정상인과 통계학적으로 유의한 차이를 보이지 않았다. 유전자형에 따른 그레이브스병 환자군의 임상상의 차이를 살펴보았을 때에, 모든 유전자형에서 연령, 성별, 갑상선종의 크기, 안구병증에는 유의한 차이를 보이지 않았다. aa유전자형에서 TBII(aa 55.9±18.3 vs. Aa 43.2±23.4, p<0.05; aa 55.9±18.3 vs. AA and Aa 42.9±23.5, p<0.05)와 WT-CHO TSAb (aa 620±829 vs. AA and Aa 353±306, p<0.05)가 높고, bb유전자형에서 Anti-thyroglobulin antibody가 높으며 (BB and Bb 31.9±38.9 vs. 51±42.8, p<0.05), b 유전자를 포함하는 군에서 혈청 alkaline phosphatase가 높은 결과를 보였다 (Bb and bb 139±68 vs. BB 82.2±15.5, p<0.05). 결론: 한국인에서 비타민 D 수용체 3' 말단부위의 유전자 다형성은 그레이브스병과 연관성이 없었다. 향후, 비타민 D 수용체 유전자와의 연관성을 확실히 규명하기 위해서는 3' 말단부위이외의 다른 부분의 유전자 다형성에 대한 연구가 필요할 것이다. Background: The aim of this study was to evaluate the association of vitamin D receptor (VDR) gene polymorphisms with Graves' disease in Koreans. We also investigated the association of VDR gene polymorphisms with the clinical characteristics and titers of TSH receptor antibodies in patients with Graves' disease. Subjects and Methods: The VDR gene polymorphisms were evaluated in 117 patients with Graves' disease and 156 normal controls. The polymorphisms were represented according to restriction fragment length polymorphism; Aa(ApaI), Bb(BsmI), and Tt(TaqI), with the capital letters signifying the absence, and small letters the presence of restriction sites. Results: The distribution of the ApaI polymorphism genotype was: AA(17.1%), Aa(50.4%)and aa(32.5%). The BsmI polymorphism genotype distribution was: BB(7.1%), Bb(35.4%) and bb(57.5%); and the TaqI polymorphism genotype distribution was: TT(92.6%), Tt(6.2) and tt(1.2%). No significant differences in either genotypic or allelic distributions were observed, between the patients with Graves' disease and the normal controls, associated with the VDR gene polymorphisms. No significant differences were observed with age, sex, size of goiter or the presence of ophthalmopathy, in patients with Graves' disease associated with the VDR gene polymorphisms. However, the titers of the TBII were significantly higher in the aa than the Aa genotype, and were also higher in the group without the A allele than in groups with(aa 55.9±18.3 vs. Aa 43.2±23.4, p<0.05; aa 55.9±18.3 vs. AA and Aa 42.9±23.5, p<0.05). Thyroid stimulating antibodies measured with a CHO cell transfected with a wild type of human TSH receptor, were also higher in patients without the A allele than in those with(aa 620±829 vs. AA and Aa 353±306, p<0.05). The titers of the anti-thyroglobulin antibodies were significantly higher in the groups not containing the B allele than in the group that did(bb 50.9±42.8 vs. BB and Bb 319.±38.9, p<0.05). The serum alkaline phosphatase activities were higher in the group having the b allele than in the group that did not(Bb and bb 139±68 vs. BB 82.2±15.5, p<0.05). Conclusions: The VDR gene 3' end polymorphism was not associated with susceptibility to Graves' disease in Koreans. The studies of other polymorphism sites of the VDR gene might be required to elucidate the association of VDR gene polymorphism with Graves' disease in Koreans (J Kor Soc Endocrinol 18:12∼23, 2003).
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