선형적 위상배열 코일구조의 시뮬레이션을 통한 민감도지도의 공간 해상도 및 필터링 변화에 따른 MR-SENSE 영상재구성 평가

이동훈,홍철표,한봉수,김형진,서재준,김소현,이춘형,이만우,Lee, D.H.,Hong, C.P.,Han, B.S.,Kim, H.J.,Suh, J.J.,Kim, S.H.,Lee, C.H.,Lee, M.W. 대한의용생체공학회 2011 의공학회지 Vol.32 No.3

Parallel imaging technique can provide several advantages for a multitude of MRI applications. Especially, in SENSE technique, sensitivity maps were always required in order to determine the reconstruction matrix, therefore, a number of difference approaches using sensitivity information from coils have been demonstrated to improve of image quality. Moreover, many filtering methods were proposed such as adaptive matched filter and nonlinear diffusion technique to optimize the suppression of background noise and to improve of image quality. In this study, we performed SENSE reconstruction using computer simulations to confirm the most suitable method for the feasibility of filtering effect and according to changing order of polynomial fit that were applied on variation of spatial resolution of sensitivity map. The image was obtained at 0.32T(Magfinder II, Genpia, Korea) MRI system using spin-echo pulse sequence(TR/TE = 500/20 ms, FOV = 300 mm, matrix = $128{\times}128$, thickness = 8 mm). For the simulation, obtained image was multiplied with four linear-array coil sensitivities which were formed of 2D-gaussian distribution and the image was complex white gaussian noise was added. Image processing was separated to apply two methods which were polynomial fitting and filtering according to spatial resolution of sensitivity map and each coil image was subsampled corresponding to reduction factor(r-factor) of 2 and 4. The results were compared to mean value of geomety factor(g-factor) and artifact power(AP) according to r-factor 2 and 4. Our results were represented while changing of spatial resolution of sensitivity map and r-factor, polynomial fit methods were represented the better results compared with general filtering methods. Although our result had limitation of computer simulation study instead of applying to experiment and coil geometric array such as linear, our method may be useful for determination of optimal sensitivity map in a linear coil array.

경계요소법을 이용한 위상변이 마스크의 단차 효과 분석

이동훈,김현준,이승걸,이종웅,Lee, Dong-Hoon,Kim, Hyun-Jun,Lee, Seung-Gol,Lee, Jong-Ung 대한전자공학회 1999 電子工學會論文誌, D Vol.d36 No.11

3차원 위상변이 마스크의 단차 효과를 분석하기 위해 투명 경계조건, 주기적인 경계조건, 및 연속조건을 가진 경계요소법을 광 리소그래피 공정 시뮬레이션에 새로이 적용하였으며, 해석적인 해와 참고문헌의 결과와 비교함으로써 구현된 모듈의 정확성을 검증하였다. 또한, 기존의 rigorous coupled wave analysis에 의한 방법에 비해 수렴성과 계산 시간 측면에서 경계요소법을 이용하는 것이 더 효율적임을 확인하였다. 끝으로 비교적 간단한 위상변이 마스크와 다층-위상변이 마스크에 대한 최적 설계 과정을 기술하였다. The boundary element method was newly implemented into an optical lithography simulator so that it could evaluate rigorously the topological effects of 2dimensional phase-shifting masks. Both transparent and periodic boundary conditions were applied for the method, and the continuity conditions were used for treating interface nodes. The accuracy of the module developed for simulating aerial images was verified by comparison with analytic solutions and published results. In addition, it was found that our simulator would be more efficient than the conventional method based on the rigorous coupled wave analysis in views of the convergence and the calculation speed. Finally, the optimal design of two phase-shifting masks was performed.

Characteristics of Meniscus Tear in Tibial Plateau Fractures

이동훈,김병국,김재화,정주환,이인성,이준구,이순철,Lee, Dong-Hoon,Kim, Byung-Kuk,Kim, Jae-Hwa,Chung, Ju-Hwan,Lee, In-Sung,Lee, Jun-Ku,Lee, Soon-Chul Korean Arthroscopy Society 2012 대한관절경학회지 Vol.16 No.1

목적: 경골 고평부 골절은 슬관절에 다양한 문제를 발생시킨다. 본 연구는 관절경하 경골 고평부 골절에서 반월상 연골 손상 양상을 확인하고자 한다. 대상 및 방법: 2007년 3월부터 2010년 3월까지 경골 고평부 골절을 진단 받은 39명의 환자 중 33명 환자를 대상으로 골절 고정 시내 관절경을 시행하였다. Schatzker 분류에 따르면 1명의 I형(3.3%), 19명의 II형(53.3%), 4명의 III형(13.3%), 2명의 IV형(6.6%), 2명의 V형(6.6%), 5명의 VI형(20%) 소견을 보였다. 결과: 25명의 환자(75.8%)에서 외측 반월상 연골 파열 소견을 보였다. Schatzker II형 환자 19명 중 18명의 환자(94.7%)가, Schatzker III형 환자 4명 중 3명의 환자(75%)가, Schatzker VI형 환자 5명 중 4명의 환자(80%)가 반월상 연골 파열 소견을 보였다. 반월상 연골 중 가장 많이 손상된 부분은 외측 연골의 전각부분이다(22/25). 25명의 반월상 연골 파열 환자 중, 한 명을 제외한 모든 환자에서 반월상 연골 변연부 수직 종파열 양상을 보였으며, 이는 대부분의 경우에 있어 관절경하 봉합술을 시도할 수 있었다. 결론: 경골 고평부 골절에 있어 관절경하 반월상 연골 손상에 대한 파악 및 치료에 유용하며, 경골 고평부 골절환자에서 관절경을 권한다. Purpose: Tibial plateau fractures cause a variety of problems in the knee joint. The purpose of this study was to investigate the characteristics of the meniscus injuries in tibial plateau fracture arthroscopically. Materials and Methods: Thirty-three out of 39 consecutive patients diagnosed with tibial plateau fractures underwent arthroscopy between March 2007 and March 2010. According to Schatzker classification, there were 1 type I (3.3%), 19 type II (53.3%), 4 type III (13.3%), 2 type IV (6.6%), 2 type V (6.6%) and 5 type VI (20%) fracture patterns in 33 patients. Results: Twenty-five cases (75.8%) had lateral meniscus tears. There were 18 meniscal tears in 19 cases of Schatzker type II fractures (94.7%), 3 meniscal tears out of 4 cases of Schatzker type III fractures (75%) and 4 meniscal tears out of 5 cases of Schatzker type VI fractures (80%). The most commonly affected site (22/25) was the anterior horn of the lateral meniscus. Of the 25 documented meniscal tears, all but one were vertical longitudinal tear at meniscocapsular junction so most cases are amenable to arthroscopic repair. Conclusion: Arthroscopy for the meniscal injuries in tibial plateau fractures is a valuable diagnostic and treatment tool, we recommend arthroscopy in tibial plateau fracture.

Primary Leiomyosarcoma of the Submandibular Gland

이동훈,김영,이재운,이준규,Lee, Dong Hoon,Kim, Young,Lee, Jae Woon,Lee, Joon Kyoo The Korean Society for Head and Neck Oncology 2013 대한두경부 종양학회지 Vol.29 No.2

평활근육종은 주로 사지와 몸통에 주로 발생하며, 악하선의 원발성 평활근육종은 매우 드물다. 악하선의 원발성 평활근육종은 증상과 방사선 검사 모두에서 비특이적이며, 치료는 광범위 절제술이다. 최근 저자들은 악하선에 발생한 원발성 평활근육종을 광범위 적출술을 시행한 후에 술후 방사선 치료를 시행하여 치험하였기에 문헌 고찰과 함께 보고하는 바이다. 악하선의 평활근육종은 드물지만, 방사선 검사에서 경계가 분명하고 조영 증강이 잘되며, 세침흡입검사에서 방추세포가 발견될 경우에 감별 진단으로 고려해야 한다.

Unusual Late Life-Threatening Arterial Bleeding after Salvage Total Laryngectomy Following Chemotherapy and Radiotherapy

이동훈,김록영,이재운,이준규,Lee, Dong-Hoon,Kim, Rok-Young,Lee, John Jae-Woon,Lee, Joon-Kyoo The Korean Society for Head and Neck Oncology 2012 대한두경부 종양학회지 Vol.28 No.1

본방사선 치료 후에 후두 절제술을 시행할 경우 인두피부누공, 감염, 출혈 등 상처부위 합병증의 가능성이 높다. 저자들은 최근에 항암치료와 방사선 치료 후에 재발한 성문상부암에 대해 후두 전적출술을 시행하였고, 수술 66일째 생명을 위협하는 인두의 동맥 출혈을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Goltz 증후군 1례

이동훈,박철한,박지민,박샛별,김흥식,류영욱,이규석,이희정,Lee, Dong Hoon,Park, Chul Han,Park, Ji Min,Park, Set Byul,Kim, Heung Sik,Ryoo, Young Wook,Lee, Kyu Suk,Lee, Hee Jung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.6

저자들은 특징적인 진찰 소견과 피부 조직 생검에서 제 I형 교원질 유전자 발현의 감소를 보인 Goltz 증후군 1례를 경험하였기에 보고하는 바이다. Goltz syndrome(focal dermal hypoplasia) is a rare disorder characterized by ectodermal and mesodermal dysplasia described in 1962 by Goltz. In Korea, one case of Goltz syndrome was reported in 1994. The inheritance mode is mostly X-linked dominant. Skin abnormality is the most common manifestation including hypoplasia of the dermis. Skeletal involvement such as syndactyly, polydactyly, scoliosis, kyphosis and spina bifida occulta may be present, also ocular and dental abnormalities are reported. Radiologic findings are the osteopathy and striation of the long bone. We experienced a case of Goltz syndrome in a 9-year old female who was presented with right side hypotrophy, focal dermal hypoplasia, ocular(anidria, microcornea), dental(oligodontia, amelogenesis) and skeletal(syndactyly) abnormalities. Skin biopsy was performed and showed decreased expression of type I collagen gene with Northern blotting.

Simultaneous subtyping and pathotyping of the 2010-2011 South Korean HPAI outbreak strain by using a diagnostic microarray

이동훈,Ji-Hoon Kim,이유나,박재균,Seong-Su Yuk,정진욱,황승용,Youn-Jeong Lee,Hyun-Mi Kang,Jun-Gu Choi,Joong-Bok Lee,Seung-Yong Park,최인수,송창선 한국바이오칩학회 2011 BioChip Journal Vol.5 No.4

The highly pathogenic avian influenza (HPAI) subtype H5N1 virus has caused continuous outbreaks in the poultry industry with devastating economic losses and is a severe threat to public health. In the present study, we developed a low-density microarray for the rapid detection and identification of avian influenza virus hemagglutinin subtypes H5, H7, and H9 and neuraminidase subtypes N1, N2, and N3. We evaluated this diagnostic microarray using 6 HPAI H5N1 clade 2.3.2 viruses that caused the South Korean outbreaks during the 2010-2011 winter season. Cy3- labeled DNA targets were generated by reverse transcription polymerase chain reaction (RT-PCR) using Cy3-labeled universal primers. The Cy3-labeled RTPCR products were then hybridized to the microarray. All subtypes and pathotypes were correctly determined and were found to be identical to the nucleotide sequencing results. This diagnostic microarray has enormous potential for the rapid subtyping and pathotyping of avian influenza viruses.

Rapid hemagglutinin subtyping of novel avian-origin influenza A(H7N9) virus using a diagnostic microarray

이동훈,송창선,김지훈,육성수,권정훈,조현석,황승용,강현미,Youn-Jeong Lee,이상원,최인수 한국바이오칩학회 2014 BioChip Journal Vol.8 No.1

An epidemic of human H7N9 influenza virus infection has recently emerged in China, caused by the novel reassortant avian-origin influenza A virus subtype H7N9. The ability to readily identify novel strains will allow a more rapid response, in order to reduce the spread of the disease and minimize the chance of a worldwide flu pandemic. We developed a low-density microarray for the rapid detection and identification of avian influenza virus subtypes H5, H7, and H9 in a previous study. In the present study, we evaluated this diagnostic microarray using an artificially synthesized novel H7N9 virus hemagglutinin gene and Korean H7 viruses isolated from wild bird habitats. Cy3-labeled DNA targets were generated by reverse transcription polymerase chain reaction using Cy3-labeled universal primers, and labeled amplicons hybridized to the microarray. All subtypes were correctly determined and identical to nucleotide sequencingresults. This diagnostic microarray has enormous potential for the rapid detection of H7N9 viruses.

방사선종양학과 의료정보관리시스템 개발

이동훈,Lee, Dong-Hoon 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.3

로터스 노츠 서버/클라이언트 시스템을 통하여 방사선종양학과에서 방사선치료를 받는 환자의 선상 정보, 모의 조사, 질병 정보 및 방사선치료와 관련된 모든 정보를 전산화하기 위한데이터 베이스를 구축하고 정보 입출력을 위한 사용자 인터페이스를 개발하였다. 방사선종양학과 내 전자차트의 개발을 통하여 그 동안 문서상에서 운영되던 진료 및 치료 업무를 전산화하고 과내의 업무를 유기적으로 연결함으로서 치료자가 치료 정보를 쉽게 얻고 분석하여 치료의 정확성, 환자대기 시간의 단축, 진료예약 및 치료업무의 편리성을 도모하고자 한다. By using lotus notes server-client system, the database related to general information of cancer patients, radiation treatment simulation, cancer treatment information and all kinds of information of radiation oncology department need to be developed for effective information management and also user interface was developed for input and output of information. This database also could be used for clinical study, patient care research and medical education. By the development of this electronic chart of the department of radiation oncology, the clinic datum and medical information management could be connected effectively and treatment information according to treatment machine also could be acquired and contributed for improving treatment efficiency, cutting down the waiting time for clinic.

Peptide isolated from Hermetia illucens larvae inhibits mice from Klebsiella pneumoniae infection in the kidney

이동훈,주기백,강해지,이수화,전복실,Lee, Dong-Hun,Chu, Ki-Back,Kang, Hae-Ji,Lee, Su-Hwa,Quan, Fu-Shi Korean Society of Applied Entomology 2019 한국응용곤충학회지 Vol.58 No.4

항생제의 오남용은 세균의 항생제 내성을 증가시켜 세균감염에 의한 질병 치료에 어려움을 초래한다. 본 연구에서는 동애등애유충으로부터 분리된 펩타이드의 신장에서의 폐렴간균 감염 억제 효능을 관찰하였다. 마우스는 비강을 통해 폐렴간균을 감염시키고 1일 후 펩타이드를 마우스에 근육 주사로 투여하였다. 10일 후 마우스를 희생하여 신장에서 세균 감염증을 조사하였다. 대조군에 비해 펩티드를 투여한 마우스의 신장에서 세균 감염증상, 몸무게의 감소가 유의하게 억제되었고 생존률이 농도 의존적으로 증가하는 것으로 나타났다. 이러한 결과들은 동애등애로부터 분리된 펩타이드가 폐렴 간균의 신장에서의 감염증상을 억제할 수 있음을 보여준다. 따라서 동애등애로부터 분리된 펩타이드는 효과적인 항생제 개발에서 가능성 높은 후보물질이 될 수 있을 것이다. Overuse of antibiotics has significantly contributed to an increase in microbial antibiotic resistance, causing difficulties in the suppression of microbe-borne infectious diseases. In this study, we determined the anti-Klebsiella pneumoniae effect in the kidneys of mice induced by peptides isolated from H. illucens larvae. Mice were intranasally infected with a high dose of K. pneumoniae and 1 day later, peptides were introduced through the intramuscular route. Mice were sacrificed on day 10 upon K. pneumoniae infection to determine the bacterial loads in the kidneys. Mice receiving peptide treatment demonstrated significantly reduced bacterial loads, reduced bodyweight loss, and higher survival in a dose-dependent manner compared to control. These results indicate that peptide isolated from H. illucens larva inhibits K. pneumoniae infection in the kidney. The peptide from H. illucens larva could be a potential candidate for the development of an effective antibacterial drug.