재발성 류마티즘 환자에서 발작의 유발인자

주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.

6개원소로 이루어진 짝이중결합화합물과 AsCl_3와의 반응

주완철,육명화,김용주 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.2

6개의 원소로 이루어진 오르토히드록시짝이중결합화합물, 즉 시남알데히드-오르토-히드록시아닐(cinnam-aldehyde-ortho-hydroxyanil), 벤질모노히드록시아닐(benzil-mono-hydroxyanil), 오르토-히드록시벤잘아세톤페논(ortho-hydroxy benzalacetophenone)과 알진트리클로라이드(AsCI_3)와의 반응으로부터 고체반응생성물을 분리해 냈다. 이들 반응생성물의 적외선 및 자외선분광학으로부터, 이들 모든 반응생성물은 비소의 전하이동착물임을 획인했다. 이 반응으로부터 3원자가 비소화합물의 화학적거동이 인의 3원자가 화합물과 유사하지 않다는 것을 알 수 있었다. Solid products were isolated by the reaction of orthohydroxy-6-membered conjugated system such as cinnamaldehyde-ortho-hydroxyanil, benzil-mono-orthohydroxyanil and ortho-hydroxybenzalacetophenon with AsCl_3. All of these products were confirmed to be Charge-transfer complexes of As from the examination of IR and UV spectra. It could be found that the chemical behavior of trivalent As is not analogous with that of triv alent P.

현훈 환자 Neuron Specific Enolase의 임상적 의의

김원주,김선곤,유철형,김원찬,김용덕,최영철,이명식 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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一部 鍍金作業者의 淋巴球 姉妹染色分體交換 出現에 關한 硏究

崔榮珠,金永煥,車喆煥 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

Since the sister chromatid exchange(SCE) technique was developed by Taylor in 1958, it has been modified and utilized in the fields of mutagenicity, teratogenicity and carcinogenicity evaluation not only for academic purpose but also occupational medicine. In Korea, however, very rare approaches to mutagenicity of toxic agents were performed. And no research on SCE in human lymphocytes was reported in relation to occupational working environment up to date in Korea. Therefore this study was designed to know the possibility of utilizing the SCE as an index which could evaluate the effect of toxic chemicals on the health of industrial workers. A total of 32 metal plating workers using chromium which was proved having mutagenicity and carcinogenicity were selected as an experimental group for this studies. The SCE in peripheral lymphocytes of the workers was studied including the amount of chromium excretion in urine, the smoking amount and working years. The results were as follows; 1. The average number of SCE per lymphocyte was significantly higher in plating workers than nonexposure group showing the rate of 1.6 (5.7 v/s 3.6). 2. The difference in SCE status by smoking habit was not statistically significant both in exposure and unexposure groups. There was no difference in SCE status by career of exposed workers. 3. The higher the concentration of chromium in working environment, the higher the number of SCE per lymphocyte in exposed workers was showed, which revealed a clear dose-response relationship. 4. The correlation between number of SCE per cell and amount of chromium in urine was statistically significant with the coefficient of 0.661 showing Y= 0.23X + 3.0 (P<0.01), in which Y indicates number of SCE per cell and X indicates chromium concentration in urine by ㎍/1.

폐흡충증으로 확진된 고립성 폐결절 1예

유영권,김규식,김윤현,나국주,김경수,임성철,김영철,박경옥 全南大醫大 2001 전남의대학술지 Vol.37 No.2

1-Silacyclopentadiene으로부터 Silylene을 합성하는데 대한 연구

공영건,주완철 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.1

1-Spiro(tetraphenyl-1-silacyclopentadiene) was obtained from the reaction of 1, 2, 3, 4-tetraphenylbutadiene anion with tetrachlorosilane in ether. This spiro compound is treated with phenylacetylene at 350℃ in sealed tube. From this reaction, pentaphenylbenzene and polymer like silicon compound which are byproducts of silylene formation, are isolated. The reaction product which must be formed from the reaction of silylene and phenylacetylene, is now under investigation.

Fluoxetine이 Schedule-Induced Polydipsia가 유발된 백서 뇌에서 Tyrosine Hydroxylase 발현에 미치는 영향

이기철,이정호,최영민,정주호,정홍경,이용민,김도형,이대환 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: Fluoxetine은 serotonin을 매개하여 간접적으로 dopamine 신경전달기능을 억제한다고 추정되고 있다. 또한 운동장애에서 운동기능의 악화를 유발한다고 알려져 있다. 그러나 신경세포체에서 fluoxetine이 dopamine에 어떠한 영향을 주는지는 아직까지 확실치 않다. 저자들은 schedule-induced polydipsia를 유발시킨 백서 뇌의 흑질, 복부피개영역, 미상핵에서 tyrosine hydroxylase(TH) 발현이 저하됨을 발견하였다. 이를 통해서 fluoxetine이 백서 뇌의 dopamine 기능에 긍정적인지 혹은 부정적인지를 규명하고자 하였다. 방법: 4주간의 schedule-induced polydipsia 과정을 거친 백서에서 면역죄치화학적인 방법으로 흑질, 복부피개영역, 미상핵의 tyrosine hydroxylase 발현이 저하됨을 확인한 후, 실험동물들에게 fluoxetine 10mg/kg를 3주간 복강내 주사하였다. 실험백서들을 희생시켜 뇌 조직을 적출하여, TH 면역조직화학 염색법을 이용하여 흑질, 복부피개영역, 그리고 미상핵의 TH 면역반응세포를 관찰하고 이를 정상백서와 비교하였다. 결과: 1) 다갈증이 유발된 백서의 흑질, 복부피개영역, 미상핵에서 tyrosine hydroxylase 발현이 정상백서 보다 저하됨을 관찰하였다. 2) 3주간에 걸친 fluoxetine 투여후 흑질, 복부피개영역, 미상핵의 tyrosin hydroxylase 발현이 다시 증가하는 소견을 보였다. 결론: Fluoxetine 만성투여가 흑질, 복부피개영역 그리고 미상핵의 tyrosin hydroxylase를 증가시키는 소견을 얻었다. 이러한 결과는 임상에서 dopamine 결핍과 연관된 질환들에서 fluoxetine을 만성투여하면 운동기능을 포함한 증상들의 개선을 가져올 수도 있다고 추정된다. Objective: It has been suggested that fluoxetine inhibits the dopaminergic neurotransmission by serotonergic mediation. And also, it has been shown to inhibit synthesis of DOPA in dopamine-rich areas of the rat forebrain. These dopamine-antagonistic capacity of fluoxetine is only supported by anecdotal report that the increased amount of motor disability in patients with idiopathic Parkinson's disease after exposure to fluoxetine. However, there is still no evidence of the direct effect of fluoxetine on dopaminergic neuronal cell body in the substantia nigra, VTA, caudate & putamen. This study was designed to evaluate the effects of fluoxetine in rat brain which showed decreased numbers of dopaminergic neuronal cell body induced by schedule-induced polydipsia(SIP). Method: We incidentally found that 4 weeks of schedule-induced polydipsic rats revealed the suppression of tyrosine hydroxylase expression in the substantia nigra, VTA, caudate & putamen with the immunohistochemistric measures. After 3 weeks of intraperitoneal injection of 10mg/kg of fluoxetine to the schedule induced polydipsic rats, the tyrosine hydroxylase expression was also measured with immunohistochemistry. We compared the tyrosine hydroxylase expression among the normal control, the polydipsic rats, and the rats with fluoxetine treatment. Results: 1) By contrast with the control, the polydipsic rats revealed the evidence of decreased tyrosine hydroxylase expression in the substantia nigra, VTA, caudate & putamen. 2)After daily injection of fluoxetine for 3 weeks, the polydipsic rats showed increment of tyrosine hydroxyase expression in those areas. Conclusions: In previous studies, a great deal of results suggest that fluoxetine negatively influence the dopaminergic systems indirectly via serotonergic activation such as inhibition of dopamine synthesis or transport system. Although our results are obtained from rodents, we suggest that fluoxetine directly and positively enhance the dopamine system in the substantia nigra, VTA, caudate & putamen. The chronic adminstration of fluoxetine may be helpful to dopamine-depleted condition in clinical situations. We anticipate the replication studies of our findings and well-controlled clinical trial.

수직냉각면을 가진 함수정방형내에서 초기온도가 동결량에 미치는 영향에 관한 실험적 연구

김병철,주동인,손정배,박영훈 조선대학교 에너지.자원신기술연구소 1997 에너지·자원신기술연구소 논문지 Vol.19 No.2

The effect of initial temperature on freezing with vertical cold wall in rectangular cavity was studied. When the initial temperature was below the 4℃, the frozen thickness in the upper part was thicker than that of lower part from the beginning of freezing and above the 4℃, at beginning the frozen thickness in the upper part was thinner than that of lower part but with time the frozen thickness in the upper part was thicker than that of lower part. And when it was above the 8℃, at the beginning of freezing the upper part of frozen thickness was thinner than that of lower part with concave but with time the concave in the upper part became thicker and the frozen thickness in the upper part was thicker than that of lower part too. The effect of initial temperature had no effect on the increasing of ice volume with time because in the beginning of freezing the more initial temperature was low, the more frozen thickness grew but the heat resistance increased in proportion as the frozen thickness grew.

알콜리즘에서 Buspirone에 대한 Cortisol과 Prolactin 반응

심주철,이정구,김정익,이유철,김영훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 본 연구는 buspirone에 대한 cortisol과 prolactin 반응을 통해 알콜리즘에서 5-HT1A 수용체기능을 조사하고자 하였다. 방법: 알콜리즘 환자군은 DSM-IV의 알콜리즘 진단기준에 부합되고 금주기간이 최소 3개월 이상이며 우울 및 불안증상이 없는, 한 정신병원 알콜 센터에 입원한 22명의 남자 환자였다. 대조군은 정상성인 남자 15명이었다. 이들에게 오전 9시에 5-HT□ 효현제인 buspirone 30mg을 경구 투여한 후 0, 30 , 60, 90, 120, 150분의 혈청 cortisol과 prolatine 농도를 측정한다. 결과: 환자군과 대조군간에 cortisol 기저치에는 유의한 차이가 없었다. Buspirone 투여 후 혈청 cortisol 농도는 정상대조군에서는 기저치에 비해 유의한 증가를 보였으나(p<0.01) 환자군에서는 유의환 증가가 없었다. 혈중 cortisol 농도는 buspiron 투여 60분 이후부터 환자군에서 정상 대조군에 비해 유의하게 저하되어 있었다(p<0.05). Buspirone에 대한 혈청 prolactin 반응은 환자군과 정상대조군간에 유의한 차이가 없었다. 결론: Buspirone 투여 후 둔마된 혈청 cortisol 반응을 통해 알콜리즘에 5-HT1A 수용체 반응성이 둔마되어 있음을 확인할 수 있었다. Objectives: The purpose of this study was to evaluate the prolactin and cortisol responses to 5-HT1A receptor activation by buspirone in alcoholics. Methods: The subjects were twenty two male alcoholic patients meeting the DSM-IV criteria for alcohol dependency and abstaining for more than 3 months. Patients were free from overt anxiety and depressive symptoms. Controls were fifteen male normal volunteers, with no psychiatric and medical illness. Blood samples for the measurement of serum cortisol and prolactin levels were drawn 0, 30, 60, 90, 120, 150 minutes after oral administration of 30mg buspirone hydrochloride at 9:00a.m. Results: The baseline cortisol levels were not significantly different between alcoholics and controls. Serum cortisol levels of controls after buspirone administration were significantly increased over time(p<0.01), but those of alcoholics did not increased. After 60 minutes following buspirone administration, cortisol levels were significantly lower in alcoholics than in contrlos(p<0.05). Prolactin responses to buspirone were not significantly different between the two groups. Conclusions: Our results suggested that 5-HT1A receptor function is decreased in alcoholic patients.