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Cholelithiasis complicated with biliary sludge and urolithiasis in a dog
Seung-gon Lee,Dong-gun Kim,Joon-seok Lee,Ho-hyun Kwak,Hyun-sook Nam,Heung-myong Woo*, In-Chul Park**, Changbaig Hyun1,In-chul Park,Chang-baig Hyun 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.3
A 10-year-old intact female Miniature Schnauzer dog was referred with the primary complaint of persistentanorexia, remittent fever, vomiting and abdominal pain. Hemogram suggested a chronic inflammatory disease. Serumbiochemistry showed moderate hepatobiliary cellular damage with severe cholestasis. Abdominal radiography andultrasonography revealed hepatomegaly, choleliths and sludges in gall bladder and small stones in urinary bladder. Basedcholecystectomy and cystectomy, choleliths and uroliths were removed from gall bladder and urinary bladder,respectively. The clinical condition was dramatically improved after surgery.
울금(鬱金)에서 분리된 demethoxycurcumin이 백서의 혈관재협착에 미치는 효과
길인호,정명수,신창호,배현옥,정헌택,이기남,Kil, In-Ho,Chong, Myong-Soo,Shin, Chang-Ho,Pae, Hyun-Ock,Chung, Hun-Taeg,Lee, Ki-Nam 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3
The pathobiologic process of arterial stenosis following balloon angioplasty continues to be an enigmatic problem in clinical settings. This study investigates the ability of demethoxycurcumin, a curcuminoid isolated from Radix Curcumae, to attenuate balloon injury-induced neointima(NI) formation in the rat carotid artery. It was found that demethoxycurcumin induced inducible heme oxygenase(HO-1) expression and inhibited dose-dependently cellular proliferation in rat vascular smooth muscle cells. Perivascular application of demethoxycurcumin immediately following injury significantly reduced NI area and NI thickness 2 weeks post-injury. Interestingly, treatment with tin-protoporphyrin IX, a HO inhibitor, reversed the effects of demethoxycurcumin on NI formation. These results implicate demethoxycurcumin as a potent new therapeutic agent that is capable of reducing post-angioplasty arterial stenosis through induction of the HO-1 expression.
남궁기,조현상,김병천,현명호,안혜리,이희상,유계준 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5
목적 및 방법 : 본 연구에서는 알코올 의존으로 진단된 남자 환자 75명을 대상으로 MMPI 점수를 이용하여 군집 분석으로 아형 분류를 시도한 후, 사회인구학적 특성과 음주와 관련된 변인으로 그 분류가 판별 타당성이 있는지를 알아보았다. 결 과 : 군집 분석 결과 전체 대상은 6(Pa)-7(Pt)-8(Sc) 프로파일의 정신병적 아형(21.4%), 2(D)-3(Hy)-1(Hs) 프로파일의 신경증적 아형(49.3%), 그리고 정상 프로파일 아형(29.3%)의 세 아형으로 분류되었다. 이 세 아형간의 연령, 학력, 결혼 상태, 음주로 인한 입원 경력, 주당 평균 음주 일수, 음주시 평균 음주량, 음주 시작 연령, 직계가족상의 알코올리즘의 가족력 유무의 차이를 비교한 결과 통계적으로 유의한 차이는 없었다. 결 론 : 본 연구의 결과는 통계학적으로 유의한 세 아형으로 분류되었으나 이 아형 분류가 판별 타당성을 갖추지 못했음을 시사한다. Obects & Methods : The authors tried to classify 75 male patients with alcohol dependence by using cluster analysis of their MMPI data, to identify the characteristics of each subtype classified through that process and to evaluate the discriminant validity of the classification. Results : The subjects were divided into 3 subtypes by K-means cluster analysis of MMPI scores : a psychotic subtype of 6(Pa)-7(Pt)-8(Sc) profile(21.4%), a neurotic subtype of 2(D)-3(Hy)-1(Hs) profile(49.3%), a normal subtype(29.3%). But, there were no statistically significant differences of age, educational level, marital status, admission history due to alcoholic problems, number of drinking day per week, average amount of ethanol consumed per drinking occasion, age at onset of drinking and family history of alcoholism among these three subtypes. Conclusion : It seems that the subjects with alcohol dependence could be classified into three subtypes with statistical significance, but this statistical classification does not constitute any evidence of discriminant validity.
인도메타신 소프트 하이드로겔로 부터 약물 방출에 미치는 피부투과촉진제의 영향
남현규,이치호,신영희 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1
We prepared a novel dosage form, peel-off type soft hydrogel using poly(vinyl alcohol), and evaluated the effect of skin penetration enhancer on the indomethacin release from soft hydrogel by in vitro permeation and in vivo absorption test. In this study, we used four enhancers-urea, dimethyl urea, 1,1,3,3-tetramethyl urea, and pirotiodecane (1[2(decylthio)ethyl]azacyclopentane-2-one, HPE-101^??. In addition, we evaluated the primary skin irritation test of soft hydrogel using rabbit. From these results, we could find the pirotiodecane was a prominent enhancer, and soft hydrogel seemed to be safe and have no irritancy.
기업 경쟁력 강화를 위한 e-Learning기반의 6시그마 컨텐츠 개발사례
정남호,조일현 忠州大學校 2007 한국교통대학교 논문집 Vol.42 No.-
The Concept of Six-sigma was introduced at and popularized by Motorola in its quest to reduce defects of manufactured electronics products. When used as a metric, six sigma technically means having no more than 3.4 defects per million opportunities in any process, product, or services. More important than the technical definition is the concept of the six sigma as a disciplined, quantitative approach for improvement of defined metrics in manufacturing, service, or financial processes. In this research especially presents the detail process of development 6 sigma green belt contents through e-Learning and the success story of that.
마그네슘, 칼슘과 불포화지방산과의 상호작용이 3-Hydroxy-3-Methylglutaryl Co-A reductase 활성에 미치는 영향
남현근,김승호 광주보건대학 1984 論文集 Vol.9 No.-
Interaction of dietary Magnesium, Calcium, and polyunsaturated fatty acids (vegetable oils) on 3-Hydroxy-3-Methylglutaryl Co-A reductase activity was studied for as period of 30 days using isocalories and isonitrogenous as a basal dist. The subjed rabbits were divided into 18 feeding groups. The results are summaried as follows: 1. The ratio of α₁-lipoprotein per lipalbumin is 0.34 for control group, 0.38, the highest, group fed 0. lM ㎎(Ⅱ) (10㎖) plus perilla oil and basal diet, the lowest, 0.25, group fed 0. lM ㎎(Ⅱ) (5㎖) pisu sesame oil and basal diet. 2. The ratis of α₂-lipoprotein per lipalbumin is 0.64 for control group, 0.95, as she highest for the group fed 0. lM Ca( Ⅱ ) (15㎖) plus sesame oil and basal diet, 0.25, as the lowest, for the groups fed 0.lM ㎎(Ⅱ) (5, 10㎖) plus Soybean oil and basal diet, 0.lM Ca(Ⅱ) (5㎖) plus perilla oil and basal diet. 3. The ratio of β-lipoprotein per lipalbumin is 0.71 for control group, the highest, 0.80 for the groups fed 0. lM ㎎(Ⅱ) (10㎖) plus sesame oil and basal diet, the louest, 0.37 for the group fed 0. lM ㎎(Ⅱ) (15㎖) plus Soybean oil and basal diet. 4. In serum triglyceride, control group was 129.5㎎%, the highest, 155.4㎎% for the group fed 0.lM Ca(Ⅱ) (5㎎) plus sesame oil and basal diet, the lowest, 85.7㎎% for the group fed 0.lM ㎎(Ⅱ) (10㎖) plus Soybean oil and basal diet. 5. In serum cholesterol, control group was 96.7㎎%, the hightest, 152.5㎎% for the group fed 0.lM Ca(Ⅱ) (10㎖) plus sesame oil and basal diet, the lowest, 80.5㎎% for the group fed 0.lM ㎎(Ⅱ) (15㎖) plus soydean oil and basal diet. 6. In case of H㎎-Co A reductase activity, control group was 0.95, the highest, 0.98 fer the group fed 0.lM Ca(Ⅱ) plus soybean oil and basal diet, the lowest, 0.82, for the group fed 0. lM ㎎(Ⅱ) (10㎖) plus seame oil and basal diet. 7. Interaction betueen Metal ions and polyunsaturated fatty acid(vegetable oil) are soybean oil>sesame oil>perilla oil for ㎎(Ⅱ), soybean oil>perilla oil>sesame oil for Ca(Ⅱ). Therefore, It is investigated that the interaction between metal ion and polyunsaturated fatty acid is the higher, the cholesterol level is the lower, and HMG-Co A reductase activity is increased.
낮은 Pr수를 갖는 순수 물질에서의 진동대류에 관한 수치 해석
현명택,홍남호,이동원 濟州大學校工科大學産業技術硏究所 1997 尖端技術硏究所論文集 Vol.8 No.1
Numerical study was investigated to the transient natural convection in a square cavity. The cavity is filled with the pure substance of a low Prandtl number and the vertical walls are constantly maintained different temperature, while the horizontal boundaries are adiabatic. A control volume approach with a central difference scheme is used to formulate the finite difference equations. The results were presented transient Nusselt number, stream function and temperature distribution. It was found that the flow pattern and heat transfer exhibit time-periodic oscillation at various conditions. The average Nusselt number, the amplitude and the frequency of oscillation increases as the Rayleigh number is increased. The increment of Prandtl number makes that the amplitude and the frequency of oscillation reduced, and average Nusselt number increased.