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      • KCI등재후보

        울금(鬱金)에서 분리된 demethoxycurcumin이 백서의 혈관재협착에 미치는 효과

        길인호,정명수,신창호,배현옥,정헌택,이기남,Kil, In-Ho,Chong, Myong-Soo,Shin, Chang-Ho,Pae, Hyun-Ock,Chung, Hun-Taeg,Lee, Ki-Nam 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3

        The pathobiologic process of arterial stenosis following balloon angioplasty continues to be an enigmatic problem in clinical settings. This study investigates the ability of demethoxycurcumin, a curcuminoid isolated from Radix Curcumae, to attenuate balloon injury-induced neointima(NI) formation in the rat carotid artery. It was found that demethoxycurcumin induced inducible heme oxygenase(HO-1) expression and inhibited dose-dependently cellular proliferation in rat vascular smooth muscle cells. Perivascular application of demethoxycurcumin immediately following injury significantly reduced NI area and NI thickness 2 weeks post-injury. Interestingly, treatment with tin-protoporphyrin IX, a HO inhibitor, reversed the effects of demethoxycurcumin on NI formation. These results implicate demethoxycurcumin as a potent new therapeutic agent that is capable of reducing post-angioplasty arterial stenosis through induction of the HO-1 expression.

      • 紅花 추출물의 카드뮴 독성 해독 효과 연구

        孫仁煥,길인호,李鐘燮,李起男 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2

        A study on the antitoxic effects of Flos Carthami against Cadmium Chloride Toxicity in Live and Kidney of Rats. This study was performed to find out the effect of Flos Carthami against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of Flos Carthami and cadmium. Rat were given pellets administration with three dosage of Flos Carthami such as 4mg/kg body weight for four weeks. The results were summarized as follows on: 1. The simultaneously administration of Flos Carthami and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone(p<O.05). 2. The simultaneously administration of Flos Carthami and cadmium significantly more increased metallothionein concentration in liver and kidney tissues compared to administration alone(p<O.05).

      • KCI등재

        강활속단탕(羌活續斷湯)이 골세포(骨細胞) 기능(機能)에 미치는 영향(影響)

        이택준,홍지우,최현주,길인호,정선충,황귀서,이기남,Lee Taek-Jun,Hong Ji-Woo,Choi Hyun-Ju,Gil In-Ho,Jeong Sun-Chung,Hwang Gui-Seo,Lee Ki-Nam 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.2

        This study was performed to evaluate the effect of Kangwhal-Sokdan tang(KS) on osteoblast function and gene expression. The osteoblast separated from the murine calvariae and MG-63 cell were cultivated to evaluate the cell function and gene expression. The results were summarized as followes. 1) KS increased cell proliferation of murine calvarial cell. 2) KS increased protein synthesis, collagen synthesis and ALP activity of murine calvarial cell. 3) KS increased the survival rate of murine calvarial cell. 4) KS increased the expression of calcitonin receptor and PTH receptor. 5) KS increased the expression of PKA and PKC. 6) KS decreased the expression of $PLA_2$, COX, $PGE_2$ synthase, but increased prostacyclin synthase. 7) KS increased the expression of collagen(type IV) gene. It is concluded that KS might improve the osteoporosis resulted from augumentation of osteoblast proliferation and gene expression.

      • KCI등재

        원적외선과 음이온이 인체에 미치는 효과

        김완겸,김성삼,유승현,길인호,권소희,이기남,Kim, Wan-Gyeom,Kim, Seong-Sam,You, Seung-Hyun,Kil, In-Ho,Kwon, So-Hee,Lee, Ki-Nam 대한예방한의학회 2005 대한예방한의학회지 Vol.9 No.2

        A survey was performed for 2 weeks in October 2004 in order to examine the effects and changes of far infrared and anion of office workers aged 40 and older before and after wearing the underwear. In the survey, questionnaires and photoplethysmography were used to measure the difference between the two tests conducted with one week interval. The findings could be summed up as follows: 1. There was no statistically significant difference in changes of vascular aging points and photoplethysmogram wave form before and after wearing the far infrared and anion underwear but the points showed the increasing tendency(p>0.05). 2. A statistically significant difference was confirmed since the total points of each item in the questionnaires increased after wearing the underwear(p<0.001). 3. In connection with the systemic symptoms, a significant difference was found with increased points in all items except for no. 6 after wearing the underwear(p<0.05). 4. With regard to the difference before and after wearing the underwear depending on the Kidney symptoms, there was a significant difference with increased points in all items except for item no. 1 after wearing the underwear(p<0.05). In conclusion, to put on the underwear with effect of far infrared and anion is believed to smooth metabolism and blood circulation, contributing by thus to promoting health and preventing disease. Further studies with wider sampling of subjects are requested to diversify and refine the findings from this sectional study.

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