항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

활성 알루미나의 제조방법에 관한 연구

남영우,김현철,황희연 崇實大學校 生産技術硏究所 1994 論文集 Vol.24 No.-

Aluminum hydroxide gels were formed from aluminum salts by precipitation method. These gels were aged and calcined to get γ- alumina. The effects of aging condition for aluminum hydroxide gels on the physical properties of γ- alumina were tested varying aging pH, time and temperature using aluminum sulfate as starting materials. The effect of starting materials were tested using aluminum sulfate, nitrate and chloride salts. Activated alumina prepared from Boehmite aged under the condition of pH 11 and 170℃ showed high surface area and large pore volume. Aging time above 1 day showed a little effect on the properties of activated alumina. Optimum aluminum salt concentration for high surface area and large pore volume was 4 wt%.

MWPC 위치검출기의 X-선 천체물리학에의 응용

남욱원,최철성,문신행,강희동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

1983 년경 국내에서도 과학탐사 로케트와 인공위성이 발사될 예정에 있으며 이에 따라 X-선 천체물리학을 위한 방사선 센서의 국내 개발이 시급히 요청되는 바이다. 따라서 현재 방사선계측에 많이 이용되고 있는 방사선 센서들 중 국내에서 개발되어온 MWPC위치검출기를 소개하고 인공위성 혹은 과학탐사로케트에 탑재되어 X-선 천체물리학연구에 이용될 경우 연구 개발되어 나가야 할 방향을 제시하고자 한다. Domestic sounding rocket and scientific satellite are scheduled to launch around 1993. The development of radiation sensor is required to observe X-rays coming from celestial bodies by the use of those space vehicleS. In this study we introduce the multi-wire position sensitive detector and the future works of onboard detector for X-ray astrophysics.

우묵사스레피(Eurya emarginata)의 플라보노이드 화합물의 분리 및 동정

양홍철,박수영,강희경,이남호 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

The extracts of Eurya emarginata showed inhibitory effect on the growth of HL-60 leukemia cells. So, 80% methanol(MeOH) extract of its leaves was partitioned to hexane, ethyl acetate, n-butanol and residual water fractions. The ethyl acetate fraction, which showed desirable activities, was further purified using SiO2 column chromatography(CC) followed by reverse phase silica gel CC, then another normal CC to give fraction 4-1-8 as a pure compound. The compound 4-1-8 was analyzed by NMR spectrometry using 1H, 13C, DEPT, HMQC and HMBC spectra, and finally proved to be well-known flavono glycoside, Quercitrin.

PILOMATRICOMA 치험 1례

김은철,이창우,임창준,이동근,김수남,양희창 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

The pilomatricoma (calcifying epithelioma of Malherbe) is rare benign hard, spherical and freely movable cutaneous tumor, which was differentiated from hair cells, particulary hair cortex cells. It is usually occured as a single, asymptomatic, 0.5 cm to 3.0 cm sized, deep seated, firm nodule, covered by normal or pink skin. It arises chiefly in young people, including children, and most often in the head, neck and upper extrimites. The authers experienced a case of pilomatricoma which occured in preauricular region. This case was summarized as follows. 1. 10 years old female has suffered from hard subepidermal mass on preauricular area and she visited our out patient clinic. So we performed surgical extirpation and the excised specimen was pathologically examined. 2. Grossly the tumor measures 2.0 cm in diameter and firm, bosselated, spherical shaped which covered by a thin layer of fibrous tissue. On cut section, it shows spicular gritty surfaces, well encapsulation, interwoven and keratotic lamellae. 3. Histopathologically, the epithelial masses of the tumor are composed of two type of cells, basophilic cells and shodow cells. The basophilic cells resemble hair matrix cells which posses round or elogated, deeply basophilic nuclei and scanty cytoplasm.The shadow cells show a central, unstained shadow at the site of the lost nucleus. Gradual development of basophilic cells into shadow cells can be observed. Foci of calcification are present within the lobule of shadow cells. The stroma of the tumor shows a considerable foreign body giant cell reaction adjacent to the shadow cells. 4. No recurrence was observed until post - operative 40 months.

枾根이 PE로 유발된 家兎의 수축혈관에 미치는 영향

김희철,남창규 世明대학교 한의학연구소 2002 韓醫學硏究所 論文集 Vol.4 No.-

This study was undertaken to define the effect of Diospyros Kaki L. Radix on the phenylephrine-induced arterial contraction and the mechanism of Diospyros Kaki L. Radix-induced relaxation. In order to investigate the effect of Diospyros kaki L. Radix on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Diospyros kaki L. Radix induced relaxation, Diospyros kaki L. Radix extract infused into contracted arterial strips induced by phenylephrine after treatment of indomethacin, N_(t) nitro-_L-arginine, or tetraethylammonium chloride, and Ca^++ infused into contracted arterial strips by phentlephrineafter treatment of Diospyros kaki L. Radix in a CA^++ free solution. Diospyros kaki L. Radix relax arterial strip with or without endothelium contracted by phenylephrine, but in the strips without endothelium, Diospyros kaki L. Radix-induced relaxation was significantly inhibited. The endothelium-dspendent relaxtion induced by Diospyros kaki L. Radix was decreased by the pretreatment of N_(t) nitro-_L-arginine, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When Ca^++ was applicated the strips which were contracted by phenylephrine in a Ca^++ free solution, arterial contraction was increased. But pretreatment of Diospyros kaki L. Radix inhibited contractile response to Ca^++. We suggest that Diospyros kaki L. Radix may directly suppress influx of extra-cellular Ca^++ and indirectly suppress influx of extra-cellular Ca^++ though the formation of nitric oxide in the vascular endothelial cells.

움직임 추정과 웨이블릿 변환을 적용한 비디오 디코더용 3D 적응 comb 필터링에 관한 연구

한희철,김진상,조원경,김남섭 경희-다반 ASIC 설계교육센터 2002 경희-다반 ASIC센터 논문집 Vol.3 No.-

NTSC 비디오 신호에서 comb 필터링은 라인과 프레임 사이의 위상차를 이용하여 Y와 C를 분리하는 기술이다. comb 필터링의 가장 중요한 부분은 기준 라인을 가지고 가장 높은 상관관계를 가지는 라인을 찾는 것이다. 본 논문에서는 프레임 안에 라인 사이의 유사성을 계산하기 위해 움직임 추정과 웨이블릿 변환을 적용한 새로운3D Y/C 분리 방법을 제안한다 제안한 알고리즘을 comb 필터링에 적용하였을 때, 화질은 기존의 시간 영역의 3D comb 필터링보다 약 1~2dB 향상되었다. 차후 연구 과제로 NTSC 비디오 신호의 유사성 검출에 효율적인 웨이블릿을 찾는 것과 잡음에 대한 내성을 강화해야 하며 최종적으로 하드웨어로 구현하는 것이다.

여성의 피부관리실태와 관련요인

구재희,남철현,최연희,배향선,신옥순,양숙희,이명옥 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

This study was conducted to analyze aspects of women's skin care and related factors in order to contribute to community residents's right skin care. The subjects of this study was 800 women who were 15 to 65 years old. Data were collected in Daegu City and Kyungsan City from June 21, 2002 to August 18, 2002. The results of this study can be summarized as follows. 1. According to socio-demographic characteristics of the respondents, 26.8% of them were in twenties. 50.9% of them was students at colleges or graduated from collges. 38.3% was students and 37.5% was housewives. 55.5% belonged to the middle economic class. 2. 47.9% of the respondents replied that they were in good health. 57.2% of them had fair skin, while 25.1% had dark skin. According to health condition of face skin, 61.5% was in regular condition, while 26.0% was in bad condition. 29.9% had drying face skin and 21.3% had neutral or complex character of face skin. 3. Among the reasons they had trouble with face skin, the proportion of having the rough skin was highest (25.0%). 16.6% replied that they had trouble with a lot of wrinkles and 16.3% replied that they had trouble with dark face skin. 25.4% responded that their face skin was too tight. 13.3% replied that they had trouble with scars. 4. The factors significantly influencing the experience of skin care were age, education level, residence, experience of side effect of cosmetics, experience of skin diseases on face or body, experience of trouble after receiving skin care, and experience of trouble with acne. From above results, it can be concluded that selection of proper skin care rooms is important in receiving desirable skin care and preventing side effect related to skin care. The women also must be cautious in selecting and using cosmetics and massage pack. The government, related organizations, and skin and beauty specialists must make efforts to develop education programs for healthy skin care.

은 첨가 복합산화물 촉매에 의한 벤젠의 산화제거반응

김성희,김영철,김덕중,박남국 全南大學校 觸媒硏究所 1998 觸媒硏究 論文集 Vol.20 No.-

Complex metal oxide catalysts were tested for the removal of benzene from 150℃ to 300℃ in an atmospheric fixed bed flow reactor. Supported Mn and Ag increased catalytic activity. Particularly Mn had an effect on catalytic activity when it was a little an caused decreasing of catalytic activity when it was much because metallic Ag was decreased. La didn't have an effect on catalytic activity but stability. Supported Ag plated an important role in catalytic activity when it was metallic Ag which was present at low calcination temperature(400℃) but caused decreasing of catalytic activity at high calcination temperature(800℃) because it was transformed into Ag₂MnO₄.

Carbamazepine에 의해 발생한 다형 홍반, 독성 간염, 백혈구 및 혈소판 감소증 1례

김희철,정성원,박영남,정철호,김정범 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.1